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Photoionization and Dissociative Photoionization Study of Cholesterol by I R Laser Desorption/Tunable Synchrotron VUV Photoionization Mass Spectrometry

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Chinese Journal of Chemical Physics 2009年第2期22卷 129-133页

作者： Yang Pan Li-dong Zhang hui-jun guo Hao Yin Fei Qi National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China

Elementary cholesterol was analyzed with IR laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry. An exclusive molecular ion of cholesterol is observed by near threshold single-photon ionization with high efficiency. Fragments are yielded with the increase of photon energy. The structures of various fragments are determined with commercial electron ionization time-of-flight mass spectrometry. Dominant fragmentation pathways are discussed in detail with the aid of ab initio calculations.

关键词： Cholesterol Mass spectrometry Laser desorption Photoionization Ab initio

In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He jun guo hui Huang Zhong-Cheng guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6

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World Journal of Gastroenterology 2017年第8期23卷 1434-1442页

作者： jun-hui guo guo-Lan Xing Xin-hui Fang hui-Fang Wu Bo Zhang Jin-Zhong Yu Zong-Min Fan Li-Dong Wang Henan Province Hospital of TCM The Second Affiliated Hospital of Henan University of Chinese Medicine Henan Key Lab For Esophageal Cancer Res The First Affiliated Hospital of Zhengzhou University Henan Province People’s Hospital The Second Affiliated Hospital of Zhengzhou University

AIM To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. METHODS Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor-adjacent normal esophageal epithelium collected from fetuses of different gestational age, or esophageal cancer patients from a high-risk area of esophageal cancer in China. Immunohistochemistry(avidin-biotin-horseradish peroxidase complex method) was used to detect the expression of peroxiredoxin(PRX)6 in 91 cases of esophageal cancer, tumoradjacent normal esophageal tissue, basal cell hyperplasia, dysplasia, and carcinoma in situ, as well as 65 cases of esophageal epithelium from fetuses at a gestational age of 3-9 *** After peptide mass fingerprint analysis and search of protein databases, 21 differential proteins were identified; some of which represent a protein isoform. Varying degrees of expression of PRX6 protein, which was localized mainly in the cytoplasm, were detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend(P < 0.05). In fetal epithelium from fetuses at gestational age 3-6 mo, PRX6 protein expression showed a declining trend with age(P < 0.05). PRX6 protein expression was significantly higher in well-differentiated esophageal cancer tissues than in poorly differentiated esophageal cancer tissues(P < 0.05).CONCLUSION Development and progression of esophageal cancer result from interactions of genetic changes(accumulation or superposition). PRX6 protein is associated with fetal esophageal development and cancer differentiation.

关键词： Fetal esophageal epithelium Esophageal squamous cell carcinoma Tumor-adjacent esophageal epithelium Proteomics

The misfit mitral valve

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Journal of Geriatric Cardiology 2021年第10期18卷 855-856页

作者： Sebastian Alejandro Mikulic JoséRamón Rivas hui-jun guo Khadeeja Esmail Internal Medicine University of Florida Health JacksonvilleFloridaUSA Division of Cardiology University of Florida Health JacksonvilleFloridaUSA

A 70-year-old female with history of rheumatic fever as a child with resultant surgical mitral valve replacement with bioprosthetic valve ten years prior presented to the hospital with worsening shortness of breath of two days *** symptoms included orthopnea,dry cough,and lower extremity *** the Emergency Room,the patient was afebrile and hemodynamically stable;however,she was tachypneic and hypoxic requiring non-rebreather.

关键词： valve mitral breath

Stable stripe and vortex solitons in two-dimensional spin-orbit coupled Bose-Einstein condensates

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Communications in Theoretical Physics 2024年第6期76卷 26-33页

作者： Yuan guo Muhammad Idrees Ji Lin hui-jun Li Institute of Nonlinear Physics and Department of Physics Zhejiang Normal UniversityJinhua 321004China Zhejiang Institute of Photoelectronics and Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua 321004China

We present a flexible manipulation and control of solitons via Bose-Einstein *** the presence of Rashba spin-orbit coupling and repulsive interactions within a harmonic potential,our investigation reveals the numerical local solutions within the *** manipulating the strength of repulsive interactions and adjusting spin-orbit coupling while maintaining a zero-frequency rotation,diverse soliton structures emerge within the *** include plane-wave solitons,two distinct types of stripe solitons,and odd petal solitons with both single and double *** stability of these solitons is intricately dependent on the varying strength of spin-orbit ***,stripe solitons can maintain a stable existence within regions characterized by enhanced spin-orbit coupling while petal solitons are unable to sustain a stable existence under similar *** rotational frequency is introduced to the system,solitons undergo a transition from stripe solitons to a vortex array characterized by a sustained *** rotational directions of clockwise and counterclockwise are non-equivalent owing to spin-orbit *** a result,the properties of vortex solitons exhibit significant variation and are capable of maintaining a stable existence in the presence of repulsive interactions.

关键词： Bose-Einstein condensate spin-orbit coupling rotation frequency stripe solitons vortex array

Clinical effects of apatinib mesylate for treatment of multiple brain micrometastases:Two case reports

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World Journal of Clinical Cases 2020年第7期8卷 1326-1336页

作者： jun-hui guo Yuan-Yuan Wang Jiang-Wei Zhang Pei-Min Liu Yan-jun Hao Hai-Rui Duan Department of Oncology The Second Affiliated Hospital of Henan University of Chinese MedicineHenan Province Hospital of TCMZhengzhou 450002Henan ProvinceChina

BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase *** has demonstrated encouraging antitumor *** study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain *** SUMMARY We report two patients with multiple brain micrometastases after failure of second-line *** patients had extracerebral *** the patients took 250 mg/d apatinib orally,the intracerebral lesions *** extracerebral lesions were partially *** patients had a progressionfree survival of more than 12 mo and were still *** safety was *** main adverse events(AEs)were mild hypertension and proteinuria,which could be *** Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.

关键词： Esophageal squamous cell carcinoma Cervical adenocarcinoma Brain micrometastases Apatinib Tyrosine kinase inhibitor Vascular endothelial growth factor

Isolation and Identification of a Subgroup A Avian Leukosis Virus from Imported Meat-type Grand-parent Chickens

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Virologica Sinica 2010年第2期25卷 130-136页

作者： Qing-chan ZHANG Dong-min ZHAO hui-jun guo Zhi-zhong CUI College of Veterinary Medicine Shandong Agricultural University Taian 271018 China

An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that SDAU09C1 fell into subgroup A; it had homology of 88.8%-90.3% to 6 reference strains of subgroup A, much higher compared to other subgroups including subgroup B. This is the first report for ALV of subgroup A isolated from imported breeders.

关键词： Avian leukosis virus(ALV) Subgroup A Envelope gp85 Imported Chicken Breeders

Vasospastic angina with J waves formation in patients with sudden loss of consciousness

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Journal of Geriatric Cardiology 2015年第3期12卷 313-318页

作者： Dan ZHU Yi-Ming LUO Ke-Hu A Ling-Yun ZU Yan-hui ZHANG Li-jun guo Wei GAO Yuan ZHANG Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Department of Cardiology Peking University Third Hospital Beijing China

Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, which can present with a wide spectrum of clinical scenario. We report the cases of two patients diagnosed with vasospastic angina, with one of which presenting with sudden cardiac arrest, while the other presenting with a relatively benign syncope. But both of them have J waves formation on ECG during active ischemia. The diagnosis and management of vasospastic angina, as well as the proposed clinical significance of J waves during coro- nary soasm are discussed.

关键词： Angina Consciousness loss J wave Osbom wave

Improved discriminative training for generative model

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 126-130页

作者： WU Ya-hui,guo jun,LIU Gang Laboratory of Pattern Recognition and Intelligent System,Beijing University of Posts and Telecommunications,Beijing 100876,China Laboratory of Pattern Recognition and Intelligent System Beijing University of Posts and Telecommunications Beijing 100876 China

This article proposes a model combination method to enhance the discriminability of the generative model. Generative and discriminative models have different optimization objectives and have their own advantages and drawbacks. The method proposed in this article intends to strike a balance between the two models mentioned above. It extracts the discriminative parameter from the generative model and generates a new model based on a multi-model combination. The weight for combining is determined by the ratio of the inter-variance to the intra-variance of the classes. The higher the ratio is, the greater the weight is, and the more discriminative the model will be. Experiments on speech recognition demonstrate that the performance of the new model outperforms the model trained with the traditional generative method.

关键词： model combination discriminability generative model training speech recognition