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Inhibitory effect of maspinon neovascularization in diabetic retinopathy

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World Journal of Diabetes 2021年第12期12卷 2050-2057页

作者： Feng Qiu hui-juan Tong Department of Ophthalmology Shenyang Fourth People’s HospitalShenyang 110031Liaoning ProvinceChina Department of Nursing Shenyang Medical CollegeShenyang 110034Liaoning ProvinceChina

BACKGROUND Diabetic retinopathy(DR)is a serious and potentially blinding complication of diabetes *** neovascularization is one of the main pathological features of proliferative DR,and inhibiting retinal neovascularization is a research *** The aim was to evaluate the effect of intravitreal injection of recombinant human maspin on neovascularization in *** An oxygen-induced retinopathy(OIR)mouse model was used to simulate neovascularization in *** born C57BL/6J mice were randomly divided to a normal control group,a maspin injection OIR group,and an OIR *** mice in the maspin injection OIR group were injected with recombinant human maspin in the bilateral vitreous cavity on postnatal day P12,and those in the OIR group were injected with sterile phosphate buffered *** protein expression of vascular endothelial growth factor(VEGF)and hypoxia-inducible factor 1-alpha(HIF-1α)in the retina was measured by western blotting,and the mRNA expression of VEGF and HIF-1αwas measured by real-time polymerase chain *** vascular cell nuclei that broke through the inner limiting membrane(ILM)were counted in haematoxylin-eosin stained retinal *** It was found that the number of vascular cell nuclei breaking through the ILM was 31.8±8.75 in the OIR group,which was significantly more than that in the normal control group(P<0.001).The number of vascular cell nuclei breaking through the ILM was 6.19±2.91 in the maspin injection OIR group,which was significantly less than that in OIR group(P<0.01).The relative protein and mRNA expression of VEGF and HIF-1αwas significantly lower in the retinas in the maspin injection OIR group than in those in the OIR group(P<0.01).CONCLUSION Maspin inhibited neovascularization in DR by modulating the HIF-1α/VEGF pathway,which provides a potential and effective strategy for the treatment of DR.

关键词： Maspin Diabetic retinopathy Neovascularization Vascular endothelial growth factor Hypoxia-inducible factor 1-alpha

Reduced representation genome sequencing reveals patterns of genetic diversity and selection in apple

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Journal of Integrative Plant Biology 2017年第3期59卷 190-204页

作者： Baiquan Ma liao liao Qian Peng Ting Fang hui Zhou Schuyler S. Korban Yuepeng Han Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden of the Chinese Academy of Sciences Wuhan 430074 China Graduate University of Chinese Academy of Sciences 19A Yuquanlu Beijing 100049 China Sino-African Joint Research Center Chinese Academy of Sciences Wuhan 430074 China Department of Biology University of Massachusetts Boston Boston Massachusetts 02184 USA

Identifying DNA sequence variations is a fundamental step towards deciphering the genetic basis of traits of interest. Here, a total of 20 cultivated and lo wild apples were genotyped using specific-locus ampli- fied fragment sequencing, and 39,635 single nucleotide polymorphisms with no missing genotypes and evenly distributed along the genome were selected to investi- gate patterns of genome-wide genetic variations between cultivated and wild apples. Overall, wild apples displayed higher levels of genetic diversity than culti- vated apples. Linkage disequilibrium （LD） decays were observed quite rapidly in cultivated and wild apples, with an r2-value below 0.2 at 440 and 280 bp, respectively. Moreover, bidirectional gene flow and different distribu- tion patterns of LD blocks were detected betweendomesticated and wild apples. Most LD blocks unique to cultivated apples were located within QTL regions controlling fruit quality, thus suggesting that fruit quality had probably undergone selection during apple domes- tication. The genome of the earliest cultivated apple in China, Nai, was highly similar to that of Malus sieversii, and contained a small portion of genetic material from other wild apple species. This suggested that introgres- sion could have been an important driving force during initial domestication of apple. These findings will facilitate future breeding and genetic dissection of complex traits in apple.

关键词： Hongya Gu Peking University China

Enhancing (de)hydrogenation kinetics properties of the Mg/MgH_(2) system by adding ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) alloys via ball milling

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Journal of Rare Earths 2021年第8期39卷 1010-1016页

作者： Wenfang liao Wenbin Jiang Xu-Sheng Yang hui Wang Liuzhang Ouyang Min Zhu Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China China-Australia Joint Laboratory for Energy&Environmental Materials Key Laboratory of Fuel Cell Technology of Guangdong ProvinceGuangzhou 510641China Advanced Manufacturing Technology Research Centre Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China

Magnesium(Mg)-based alloys have already been widely studied as the hydrogen storage materials because of their high reversible hydrogen storage capacity,low cost,light weight,***,the poor de/hydrogenation kinetic properties dramatically hinder the practical *** this work,the MgH_(2)-ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) composites were prepared by a high-energy ball milling *** can effectively refine the particle size thus improving the kinetic *** results reveal that the MgH_(2)-ANi_(5) composites mainly consist of Mg_(2)NiH_(4),MgH_(2) and rare earth(RE) hydride,which will be dehydrogenated to form Mg_(2)Ni,Mg and stable RE hydride ***,the asmilled MgH_(2)-ANi_(5)(A=Ce,Nd,Pr,Sm,and Y) composites with various A-elements can respectively contribute to a reversible hydrogen storage capacity of 6.16 wt%,5.7 wt%,6.21 wt%,6.38 wt%,and 6.5 wt%at a temperature of 300℃,and show much better kinetic properties in comparison to the pure MgH_(2) without any ***-situ formed Mg_(2) Ni and stable RE hydride(such as CeH_(2.73) and YH_(2)) might act as effective catalysts to significantly improve the hydrogen storage properties of MgH_(2).The present work provides a guideline on improving the kinetic properties of the Mg-based hydrogen storage alloys.

关键词： Mg-based hydrogen storage alloy Kinetic properties ANi_(5) Additives Rare earths

Initiation and Kinematic Process of Debris Flow with the Existence of Terraced Fields at the Sources

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Journal of Earth Science 2024年第5期35卷 1613-1625页

作者： Liang Yang Yang Wang Kang liao Longfei Zhang Aiyun Chen juan Du Faculty of Engineering China University of GeosciencesWuhan 430074China China Railway Siyuan Survey and Design Group Co. LTD.Wuhan 430063China

A debris flow,with terraced fields as the source area,broke out on June 25th,2018 in the Xiaotuga area of Yunnan Province,China,and this kind of debris flow is rarely *** purposes in this study:(1)the influence of flow drag force on slope stability;(2)back-analyze the movement process of debris ***,the geological background and movement of this debris flow were described based on a field ***,drag force,calculated by the laminar flow theory,is added to the slope stability calculation model,which elaborates the initiation process of this ***,dynamic simulation software(DAN3D)was used to simulate the kinematic process of the debris flow with a variety of combination *** study shows that the terrace area can quickly produce surface runoff and create a drag force under rainfall conditions,which is the essential reason for the initiation of debris *** addition,the use of the FVV(Frictional-Voellmy-Voellmy)model is found to provide the best performance in simulating this type of debris flow,which reveals that it lasts approximately 200 s and that the maximum velocity is 12 m/s.

关键词： debris flow initiation process kinematic process terraced fields engineering geology

Entanglement of Non-symmetric Two Charge Qubits Induced by a Damped Cavity

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Communications in Theoretical Physics 2007年第4期47卷 643-646页

作者： LI Zhao-Xin LI Jun-Gang LI juan-juan CUI hui-Ping Department of Applied Physics School of Science Shandong University of Science and Technology Qingdao 266510 China Department of Physics School of Science Beijing Institute of Technology Beijing 100081 China

Two charge qubits being coupled to a damped cavity with different couplings are considered. The dynamical evolution of the entanglement between the two qubits is demonstrated analytically or numerically. It is found that with the cavity dissipation, the steady entanglement between the two qubits can be achieved. The two qubits being initially in the separable and most mixed state can be easily induced to a steady entangled state, and the relative difference of the couplings can be used to enhance the steady entanglement between the two charge qubits.

关键词： charge qubit entanglement dissipation

Parents' experience of caring for children with type 1 diabetes in China's Mainland: A qualitative study

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World Journal of Clinical Cases 2021年第11期9卷 2478-2486页

作者： hui-juan Tong Feng Qiu Ling Fan Department of Nursing Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Nursing School Shenyang Medical UniversityShenyang 110034Liaoning ProvinceChina Department of Ophthalmology Shenyang Fourth People’s HospitalShenyang 110034Liaoning ProvinceChina

BACKGROUND Parents of children with type 1 diabetes mellitus(T1DM)are under heavy caregiving stress,and parental caregivers'experience can affect the health outcomes of children with *** To describe the true inner feelings of parents caring for children with *** Descriptive research methods were used to classify and summarize parents'experience when adapting to the role of caregivers for children with *** data was sorted and analyzed using content *** of parents'experience caring for children with T1DM were refined,and their feelings were deeply *** A total of 4 themes and 12 subthemes were identified:(1)Desire for information(disease-related information,home care information,and channels of information acquisition);(2)Skill guidance needs(insulin injection techniques,skills required for symptom management,and skills for parent-child communication);(3)Seeking emotional support(family support,peer support from other parents of children with T1DM,and professional support);and(4)Lack of social support(needs for financial support and needs for social security).Exploring the true experience of parents caring for children with T1DM is of great significance for helping them adapt to their role as *** should provide professional guidance in terms of information,skills,emotion,and social support to parental caregivers.

关键词： Type 1 diabetes Children Parents Care experience Qualitative study Family management

Analysis of the 1S and 2S states of Λ_(Q) and Ξ_(Q) with QCD sum rules

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Chinese Physics C 2021年第1期45卷 109-118页

作者： Zhi-Gang Wang hui-juan Wang Department of Physics North China Electric Power UniversityBaoding 071003China

In this article,we study the ground states and the first radial excited states of the flavor antitriplet heavy baryon states ∧Q and ΞQ with the spin-parity JP=1/2+ by carrying out operator product expansion up to vacuum condensates of dimension 10 in a consistent *** observe for the first time that the higher dimensional vacuum condensates play an important role,and obtain very stable QCD sum rules with variations of the Borel parameters for the heavy baryon *** predicted masses 6.08±0.09 GeV,2.78±0.08 GeV,and 2.96±0.09 GeV for the first radial excited states ∧b(2 S),∧c(2 S),and Ξc(2 S),respectively,are in excellent agreement with the experimental data and support assigning ∧b(6072),∧c(2765),and Ξc(2980/2970) to be the first radial excited states of ∧b,∧c,and Ξc,*** predicted mass 6.24±0.07 GeV for Ξb(2 S) can be confirmed using experimental data in the future.

关键词： heavy baryon states QCD sum rules

Effect of hospital discharge plan for children with type 1 diabetes on discharge readiness,discharge education quality,and blood glucose control

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World Journal of Clinical Cases 2021年第4期9卷 774-783页

作者： hui-juan Tong Feng Qiu Ling Fan Department of Nursing Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Ophthalmology Shenyang Fourth People’s HospitalShenyang 110034Liaoning ProvinceChina

BACKGROUND Type 1 diabetes is one of the most common chronic diseases in *** number of type 1 diabetes patients in China still ranks fourth in the ***,children with type 1 diabetes in China are a group that needs *** management of type 1 diabetes mellitus(T1DM)involves many aspects of daily *** is extremely challenging for children and their families.T1DM children have complex medical care *** the continuous development of therapeutic medicine and treatment technologies,blood glucose control in children with T1DM is still not *** and their parents need to acquire more knowledge and skills before being *** To explore the influence of hospital discharge plan based on parental care needs of children with T1DM on discharge readiness,quality of discharge education and blood glucose control *** In total,102 parents of children with type 1 diabetes were divided into control group and intervention group according to admission *** cases from February to June 2019 were selected as the control group,and 52 cases from July to October 2019 were selected as the intervention group to implement the discharge *** Readiness for Hospital Discharge Scale,Hospital Discharged Education Quality Scale and children's blood glucose metabolism indicators were used to compare the differences in discharge preparation,discharge education quality and blood glucose control between the two groups of children and their *** On the day of discharge,the two groups of children had the following scores of readiness for discharge:The intervention group score was 225.34±32.47,and the control group score was 208.68±*** P value was 0.007,and the difference was statistically *** discharge education quality scores were as follows:The intervention group score was 135.11±19.86,the control group score was 124.13±15.56,the P value was 0.002 and the difference was statistically *** month

关键词： Type 1 diabetes Hospital discharge plan Hospital discharge readiness Blood glucose control Children Parents

In situ growth of NiSe@Co_(0.85)Se heterointerface structure with electronic modulation on nickel foam for overall water splitting

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Rare Metals 2021年第6期40卷 1373-1382页

作者： Wen-Long Ding Yan-hui Cao hui Liu Ao-Xuan Wang Cui-juan Zhang Xue-Rong Zheng Key Laboratory for Green Chemical Technology of Ministry of Education State Key Laboratory of Chemical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA Tianjin Kaben New Materials Technology Co. Ltd.Tianjin 300350China

Constructing heterointerface engineering has becoming an effective and general strategy for developing highly efficient and durable nonnoble electrocatalysts for catalyzing both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).In this work,we synthesized a self-supporting heterogeneous NiSe@Co_(0.85)Se/NF electrocatalyst using a facile in situ selenization of transition metal precursors that coated on the nickel foam(NF)in polyol *** NF was used as both conductive substrate and nickel source,ensuring superior electronic conductivity for *** NiSe@-Co_(0.85)Se/NF exhibited remarkable bifunctional electrocatalytic activities with HER overpotential of 168 mV and OER overpotential of 258 mV to achieve 10 mA·*** water splitting system using NiSe@Co_(0.85)Se/NF as both anode and cathode electrodes achieved a current density of 10 mA·cm^(-2) at 1.61 V with nearly 100% faradaic efficiency and impressively long-term *** efficient bifunctional catalytic performance of NiSe@-Co_(0.85)Se/NF should be attributed to the electronic modulation and synergistic effect between NiSe and Co_(0.85)Se,the intrinsic metallic conductivity and the enlarged active sites *** work provides a facile method for developing heterogeneous bifunctional catalysts for advanced electrochemical energy conversion technologies.

关键词： NiSe@Co_(0.85)Se/NF Heterointerface structure Electronic modulation Bifunctional electrocatalyst Overall water splitting