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Comparison of the clinical effects of dual-modality endoscopy and traditional laparotomy for the treatment of intra-and extrahepatic bile duct stones

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 759-767页

作者： wei Wang hui Xia Bin Dai Department of Hepatobiliary Surgery Wuhan No.1 HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND Bile duct stones(BDSs)may cause patients to develop liver cirrhosis or even liver ***,the success rate of surgical treatment for intrahepatic and extrahepatic BDSs is not satisfactory,and there is a risk of postoperative *** To compare the clinical effects of dual-modality endoscopy(duodenoscopy and laparoscopy)with those of traditional laparotomy in the treatment of intra-and extrahepatic *** Ninety-five patients with intra-and extrahepatic BDSs who sought medical services at Wuhan No.1 Hospital between August 2019 and May 2023 were selected;45 patients in the control group were treated by traditional laparotomy,and 50 patients in the research group were treated by dual-modality *** following factors were collected for analysis:curative effects,safety(incision infection,biliary fistula,lung infection,hemobilia),surgical factors[surgery time,intraoperative blood loss(IBL)volume,gastrointestinal function recovery time,and length of hospital stay],serum inflammatory markers[tumor necrosis factor(TNF)-α,interleukin(IL)-6,and IL-8],and oxidative stress[glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),malondialdehyde(MDA),and advanced protein oxidation products(AOPPs)].RESULTS The analysis revealed markedly better efficacy(an obviously higher total effective rate)in the research group than in the control *** addition,an evidently lower postoperative complication rate,shorter surgical duration,gastrointestinal function recovery time and hospital stay,and lower IBL volume were observed in the research ***,the posttreatment serum inflammatory marker(TNF-α,IL-6,and IL-8)levels were significantly lower in the research group than in the control *** with those in the control group,the posttreatment GSH-Px,SOD,MDA and AOPPs in the research group were equivalent to the pretreatment levels;for example,the GSH-Px and SOD levels were significantly higher,while the MDA and AOPP levels were

关键词： Dual-modality endoscopy Traditional laparotomy Intra-and extrahepatic bile duct stones Clinical efficacy

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Dendritic tip selection during solidification of alloys:Insights from phase-field simulations

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Chinese Physics B 2024年第9期33卷 467-472页

作者： Qingjie Zhang hui Xing Lingjie Wang wei Zhai School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

The effect of undercooling DT and the interface energy anisotropy parameter e4 on the shape of the equiaxed dendritic tip has been investigated by using a quantitative phase-field model for solidification of binary *** was found that the tip radius r increases and the tip shape amplitude coefficient A4 decreases with the increase of the fitting range for all *** dendrite tip shape selection parameter sdecreases and then stabilizes with the increase of the fitting range,and sincreases with the increase of *** relationship between sand e4 follows a power-law function sµea 4,and a is independent of DT but dependent on the fitting *** results demonstrate that the predicted sis consistent with the curve of microscopic solvability theory(MST)for e4<0.02,and sobtained from our phase-field simulations is sensitive to the undercooling when e4 is fixed.

关键词： phase-field simulations dendritic structure interface energy anisotropy tip shape selection parameter

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A comprehensive fluid-solid coupling dynamic simulation for spatiotemporal distribution of regression rate in hybrid rocket motors

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 100-112页

作者： wei, Tianfang Cai, Guobiao Tian, hui Meng, Xiangyu Jiang, Xianzhu Gu, Xiaoming Beihang Univ Sch Astronaut Beijing 100191 Peoples R China Minist Educ Key Lab Spacecraft Design Optimizat & Dynam Simula Beijing 100191 Peoples R China

The spatiotemporal distribution characteristics of the regression rate are crucial aspects of the research on Hybrid Rocket Motor (HRM). This study presents a pioneering effort in achieving a comprehensive numerical simulation of fluid dynamics and heat transfer in both the fluid and solid regions throughout the entire operation of an HRM. To accomplish this, a dynamic grid technique that incorporates fluid-solid coupling is utilized. To validate the precision of the numerical simulations, a firing test is conducted, with embedded thermocouple probes being used to measure the inner temperature of the fuel grain. The temperature variations in the solid fuel obtained from both experiment and simulations show good agreement. The maximum combustion temperature and average thrust obtained from the simulations are found to deviate from the experimental results by only 3.3% and 2.4%, respectively. Thus, it can be demonstrated that transient numerical simulations accurately capture the fluid-solid coupling characteristics and transient regression rate. The dynamic simulation results of inner flow field and solid region throughout the entire working stage reveal that the presence of vortices enhances the blending of combustion gases and improves the regression rate at both the front and rear ends of the fuel grain. In addition, oscillations of the regression rate obtained in the simulation can also be well corresponded with the corrugated surface observed in the experiment. Furthermore, the zero-dimension regression rate formula and the formula describing the axial location dependence of the regression rate are fitted from the simulation results, with the corresponding coefficients of determination (R-2) of 0.9765 and 0.9298, respectively. This research serves as a reference for predicting the performance of HRM with gas oxygen and polyethylene, and presents a credible way for investigating the spatiotemporal distribution of the regression rate. (c) 2024 Production and hosti

关键词： Hybrid Rocket Motor (HRM) Transient numerical simulation Fluid-solid coupling heat transfer Spatiotemporal distribution of regression rate Dynamic grid FLAME MODEL

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Establishing and Validating Refractive Error Reference Values for Myopia Prediction Among Children Aged 6–12 Years-Jiangsu Province,China,2018-2023

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China CDC weekly 2024年第32期6卷 804-810页

作者： Xiyan Zhang Chen-wei Pan wei Du Yonglin Zhou jie Yang Yan Wang Yiliang Xin wei Lu Hongxia Ma School of Public Health Nanjing Medical UniversityNanjing CityJiangsu ProvinceChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina School of Public Health Suzhou Medical College of Soochow UniversitySuzhou CityJiangsu ProvinceChina School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina

Summary What is already known about this topic?Previously,it has been proved that a simplified model that uses refraction error value provides a robust and efficient means of predicting myopia for non-myopic *** targeting non-myopic children with alert refraction errors(or insufficient hyperopia reserve)holds significant importance in reducing the incidence rate of *** is added by this report?This study,comprising two phases(surveillance and cohort studies),was aiming to pinpoint the precise refractive error value for the onset of myopia prediction among non-myopic children in Jiangsu *** are the implications for public health practice?First,when conducting myopia screenings using pupil dilation for non-myopic populations:the cycloplegic 50th percentile refractive error emerges as a more precise predictive ***,when conducting myopia screenings without pupil dilation:this study advocates for the incorporation of axial length(AL)and corneal curvature(CC)values as supplementary indicators in screenings.

关键词： precise dating holds

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Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1469-1476页

作者： wei Zhou hui Zhou Yuan-Yuan Liu Meng-Xuan Li Xiao-Han Wu Jiao Liang Jing Hao Sheng-Nan Liu Chun-jie Jin Department of Ophthalmology Tianjin Medical University General HospitalTianjin 300052China Department of Ophthalmology Shanxi Yuncheng Tongde HospitalYuncheng 044000Shanxi ProvinceChina Department of Information Tianjin Medical University General HospitalTianjin 300052China

AIM:To describe the multimodal imaging features,treatment,and outcomes of patients diagnosed with adultonset Coats ***:This retrospective study included patients first diagnosed with Coats disease at≥18 years of age between September 2017 and September *** patients received anti-vascular endothelial growth factor(VEGF)therapy(conbercept,0.5 mg)as the initial treatment,which was combined with laser photocoagulation as *** the patients underwent best corrected visual acuity(BCVA)and intraocular pressure examinations,fundus color photography,spontaneous fluorescence tests,fundus fluorescein angiography,optical coherence tomography(OCT),OCT angiography,and other *** alterations and multimodal image findings in the affected eyes following treatment were compared and the prognostic factors were ***:The study included 15 patients who were aged 24-72(57.33±12.61)y at *** hypertension was the most common associated systemic condition,occurring in 13(86.7%)*** BCVA ranged from 2.0 to 5.0(4.0±1.1),which showed improvement following treatment(4.2±1.0).Multimodal imaging revealed retinal telangiectasis in 13 patients(86.7%),patchy hemorrhage in 5 patients(33.3%),and stage 2B disease(Shield’s staging criteria)in 11 patients(73.3%).OCT revealed that the baseline central macular thickness(CMT)ranged from 129 to 964μm(473.0±230.1μm),with 13 patients(86.7%)exhibiting a baseline CMT exceeding 250μ***,8 patients(53.3%)presented with an epiretinal membrane at baseline or during ***-reflective scars were observed on OCT in five patients(33.3%)with poor visual *** deteriorated in one patient who did not receive *** vision was stable in three patients who received laser treatment,whereas improvement was observed in one of two patients who received anti-VEGF therapy *** addition,8 of 9 patients(88.9%)who received laser treatment and conbercept exhibited sta

关键词： adult-onset Coats disease multimodal imaging anti-vascular endothelial growth factor conbercept

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How R&D investment promotes green technology innovation in the context of digitalization?-An empirical analysis based on provincial panel data

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Ecological Economy 2024年第1期20卷 39-52页

作者： LIU jie LI Zhi-hui wei Fang-xin School of Business Beijing Union UniversityBeijing 100025CHINA China Railway 22^(nd) Bureau Group Second Engineering Co. LtdBeijing 100041CHINA Center for Nuclear and Radiation Safety Ministry of Ecology and EnvironmentBeijing 100082CHINA

Green technology innovation is an important driving force and source to promote my country’s high-quality development,and it is the core path to achieve sustainable *** paper uses my country’s provincial panel data from 2016 to 2019 to study the impact mechanism of R&D investment on green technology innovation,and introduces the level of digitization,using the panel threshold model to discuss its role in the impact mechanism of R&D investment on green technology *** study found that when the level of digitalization in a region is low,increasing R&D investment does not necessarily improve the ability of green technology innovation;when the level of digitalization is relatively high,R&D investment has a positive role in promoting green technology ***,it is necessary to improve policies to encourage enterprises to increase investment in research and development;at the same time,it is necessary to promote the coordinated development of digital foundation,digital investment,digital literacy,digital economy and digital application,and promote the deep integration of digitalization and green technology innovation.

关键词： green technology innovation R&D investment digital level panel model

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Carbon-based nanomaterials cause toxicity by oxidative stress to the liver and brain in Sprague-Dawley rats

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Nuclear Science and Techniques 2024年第6期35卷 54-64页

作者： Ying-Ying Xu Chan Jin Meng Wu Jian-Ye Zhou hui-Ling wei Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China

Carbon-based nanomaterials have important research significance in various disciplines,such as composite materials,nanoelectronic devices,biosensors,biological imaging,and drug ***,the human and ecological risks associated with carbon-based nanomaterials have received increasing ***,the biological safety of carbon based nanomaterials has not been systematically *** this study,we used different types of carbon materials,namely,graphene oxide(GO),single-walled carbon nanotubes(SWCNTs),and multiwalled carbon nanotubes(MWCNTs),as models to observe their distribution and oxidative damage in *** results of Histopathological and ultrastructural examinations indicated that the liver and lungs were the main accumulation targets of these ***-μ-XRF analysis revealed that SWCNTs and MWCNTs might be present in the *** shows that the three types of carbon-based nanomaterials could cross the gas-blood barrier and eventually reach the liver *** addition,SWCNTs and MWCNTs could cross the blood-brain barrier and accumulate in the cerebral *** increase in ROS and MDA levels and the decrease in GSH,SOD,and CAT levels indicated that the three types of nanomaterials might cause oxidative stress in the *** suggests that direct instillation of these carbon-based nanomaterials into rats could induce ROS *** addition,iron(Fe)contaminants in these nanomaterials were a definite source of free ***,these nanomaterials did not cause obvious damage to the rat brain *** deposition of selenoprotein in the rat brain was found to be related to oxidative stress and Fe *** information may support the development of secure and reasonable applications of the studied carbon-based nanomaterials.

关键词： Carbon-based nanomaterials Oxidative stress Trace element distribution TEM SR-μ-XRF

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Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity

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Defence Technology（防务技术） 2024年第2期32卷 45-54页

作者： Jian Wang jie Chen Yaofeng Mao Yongjun Deng wei Cao Fude Nie Jun Wang Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621999PR China Shock and Vibration of Engineering Materials and Structures Key Lab of Sichuan Province Mianyang 621010PR China

Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy ***,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical ***,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion *** reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb *** to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of *** reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to *** work offers a promising approach to design and prepare high-performance energetic materials for the practical applications.

关键词： HMX/B/Al/PTFE 3D microspheres Surface etching Reaction mechanism

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pH-sensitive KHA/CMC-Fe^(3+)@CS hydrogel loading and the drug release properties of riboflavin

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Particuology 2024年第3期86卷 13-23页

作者： jie Song Xi Li Yuhua Niu Lijun Chen Zhiqiang wei Yidan Li Youqian Wang Shaanxi University of Science&Technology Xi'an710021China

To improve drug utilization,reduce the drug administration frequency,increase the release time,and reduce the drug side effects in the human body,we prepared(KHA/CMC-Fe^(3+))@CS hydrogel spheres using green and natural potassium humate(KHA),carboxymethyl cellulose(CMC),and chitosan(CS)as raw materials and Fe3+as a crosslinking agent,and loaded them with riboflavin for drug sustainedrelease study using the drop ball *** tests with FTIR,SEM,TG,and X-ray diffractometer showed that the coordination among KHA,CMC,and Fe^(3+)formed a three-dimensional network structure,where cs was encapsulated on the surface of the hydrogel spheres via noncovalent bonding,resulting in good thermal *** stability,drug loading,swelling,and in vitro release of the(KHA/CMC-Fe^(3+))@CS hydrogel spheres were *** results showed that the hydrogel spheres were significantly pH-sensitive,with 11.16 g/g higher swelling in an alkaline environment(pH=7.4)than that in an acidic environment(pH=1.2).The swelling and drug release process of the hydrogel spheres were analyzed using mathematical models,concluding that the hydrogel swelling follows Schott second-order swelling kinetics,and the drug release mechanism was Fickian delivery mode.

关键词： Potassium humate Hydrogel spheres pH-sensitive Drugsustained-release Drug release model

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Enhanced Ion-Selective Diffusion Achieved by Supramolecular Interaction for High Thermovoltage and Thermal Stability

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Energy & Environmental Materials 2024年第2期7卷 200-208页

作者： Jiale Ke Xing Zhao jie Yang Kai Ke Yu Wang Mingbo Yang wei Yang College of Polymer Science and Engineering Sichuan UniversityState Key Laboratory of Polymer Materials EngineeringChengdu 610065China

Thermoelectric(TE)generators capable of converting thermal energy into applicable electricity have gained great popularity among emerging energy conversion ***-based ionic thermoelectric(i-TE)materials are promising candidates for energy conversion systems because of their wide sources,innocuity,and low manufacturing ***,common physically crosslinked biopolymer gels induced by single hydrogen bonding or hydrophobic interaction suffer from low differential thermal voltage and poor thermodynamic ***,we develop a novel i-TE gel with supramolecular structures through multiple noncovalent interactions between ionic liquids(ILs)and gelatin molecular *** thermopower and thermoelectric power factor of the ionic gels are as high as 2.83 mV K-1 and 18.33μW m^(-1)K^(-2),*** quasi-solid-state gelatin-[EMIM]DCA i-TE cells achieve ultrahigh 2 h output energy density(E_(2h)=9.9 mJ m^(-2))under an optimal temperature ***,the remarkable stability of the supramolecular structure provides the i-TE hydrogels with a thermal stability of up to 80℃.It breaks the limitation that biopolymer-based i-TE gels can only be applied in the low temperature range and enables biopolymer-based i-TE materials to pursue better performance in a higher temperature range.

关键词： biopolymer gel ionic liquid multiple noncovalent interactions supramolecular structure thermoelectric conversion

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