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Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging

National Science Review 2023年第6期10卷 60-63页

作者： Fu-hui Xiao Hao-Tian Wang Xiao-Qiong Chen Ming-Xia Ge Dongjing Yan Xing-Li Yang Li-Qin Yang Rong lin Rong-hui Guo Wen Zhang Nelson Leung-Sang Tang Yonghan He Jumin Zhou Wang-Wei Cai Qing-Peng Kong State Key Laboratory of Genetic Resources and Evolution Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Key Laboratory of Healthy Aging Study Kunming Institute of ZoologyChinese Academy of Sciences KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming College of Life Science University of Chinese Academy of Sciences Department of Biochemistry and Molecular Biology Hainan Medical College Department of Biology Hainan Medical College Department of Chemical Pathology and Laboratory for Genetics of Disease Susceptibility Li Ka Shing Institute of Health Sciences and School of Biomedical Sciences Faculty of Medicine The Chinese University of Hong Kong Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of Zoology CAS Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences

Centenarians,as excellent examples of extreme yet successful aging,not only display a much longer lifespan but can also delay or even escape major agerelated diseases,such as cardiovascular disorders,neurodegenerative diseases,and cancer [1].Studies have suggested that genetic factors account for 20%-30%of human longevity [2];however,only a handful of longevity-associated genes/mutations have been observed in long-lived individuals,even with the use of genome-wide scanning/sequencing assays [3,4].In contrast,evidence has shown the crucial roles of epigenetic alternations in aging and age-related diseases [5],suggesting that epigenetic modifications play central roles in human healthy ***,a comprehensive analysis of the epigenomic landscape of centenarians is urgently needed.

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Novel frameshift mutation in the AHDC1 gene in a Chinese global developmental delay patient:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7517-7522页

作者： Shuang-Zhu lin Hong-Yan Xie Yan-Lai Qu Wen Gao Wan-Qi Wang jia-Yi Li Xiao-Chun Feng Chun-Quan Jin Diagnosis and Treatment Center for Children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND Xia–Gibbs syndrome(XGS,OMIM:615829),caused by mutations within the ATHook DNA-binding motif-containing protein 1(AHDC1)gene(OMIM:615790),located on the short arm of chromosome 1 within the cytogenetic band 1p36.11,contains five noncoding 5 exons,a single 4.9-kb coding exon,and a noncoding 3 *** SUMMARY In this case report,we diagnosed and treated a 6-mo-old girl with *** primary clinical symptoms included global developmental delay,hypotonia,and mild dysmorphic *** high-throughput whole-exosome sequencing to sequence the patient and her parents,and the results showed a novel frameshift mutation of c.1155dupG(***386Alafs*3)in the AHDC1 *** paternal gene was wild *** This report extends the mutation spectrum of the AHDC1 gene to provide the diagnostic basis for genetic counseling in families with XGS.

关键词： Xia-Gibbs syndrome AT-Hook DNA-binding motif-containing protein 1 Children Global developmental delay Case report

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Paraplegia after transcatheter artery chemoembolization in a child with clear cell sarcoma of the kidney:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2332-2338页

作者： jia-Bin Cai Min He Fa-Liang Wang Jie-Ni Xiong Jun-Qing Mao Zhong-Hai Guan lin-Jie Li Jin-Hu Wang Department of Surgical Oncology The Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Transcatheter arterial chemoembolization(TACE)is a common treatment for inoperable malignant renal ***,a series of complications may follow the TACE *** cord injury caused by the embolization of intercostal or lumbar arteries is extremely *** SUMMARY We describe a case with quite uncommon spinal cord injury after TACE in a 3-year-old child with clear cell sarcoma of the *** impairment beneath the T10 dermatomes and paraplegia on the day after TACE were found in this ***,sustained paraplegia still existed for more than 2 mo after TACE despite the large dose of steroids and supportive *** We should draw attention to an uncommon complication of paraplegia after TACE treatment in malignant renal *** it is rare,the result is disastrous.

关键词： Complication Chemoembolization Spinal cord injury Clear cell sarcoma of the kidney Pediatric Case report

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An efficient approach for obtaining plant organelle genomes

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Oil Crop Science 2020年第3期5卷 129-135页

作者： Shifei Sang Desheng Mei Qamar U.Zaman jia Liu Hongtao Cheng Li Fu Wenxiang Wang hui Wang Qiong Hu Key Laboratory for Biology and Genetic Improvement of Oil Crops Ministry of Agriculture and Rural AffairsOil Crops Research InstituteChinese Academy of Agricultural SciencesWuhanChina

Plant organelle(plastid and mitochondrial)genomes contain substantial information for plant evolution and ***,it’s important to reveal plant whole-genome sequences including plastid and mitochondrial *** decode these sequences,it is required to efficiently separate organelle genomic DNA from nucleus genome,which is difficult and *** this study,an efficient procedure was established to obtain plant organelle genomes without extraction of plastid and *** DNA was extracted from three materials including Sinapis arvensis var.‘Yeyou 18’,a cytoplasmic male sterile line(Nsa CMS)and its corresponding maintainer line‘Zhongshuang 4’.DNA was sequenced by Roche 454 FLXt and Illumina Miseq *** genomes were assembled using the generated reads and public organelle genome *** research presented a procedure that efficiently assembled organelle genomes and subsequent fill gaps by extending the consensus contig *** method enabled us to assemble plant plastid and mitochondrial genomes *** obtained organelle genomes could accelerate understanding of mitochondrial rearrangements and laid a foundation for further study of Sinapis arvensis evolution and sterility gene of Nsa CMS.

关键词： Plastid Mitochondrial Genome sequence Nsa CMS organelle genome

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Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window

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Acta Pharmaceutica Sinica B 2023年第7期13卷 3008-3026页

作者： Shuai Xiong hui Xiao Meng Sun Yunjie Liu ling Gao Ke Xu Haiying Liang Nan jiang Yuhui lin Lei Chang Haiyin Wu Dongya Zhu Chunxia Luo Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical UniversityNanjing 211166China

Many efforts have been made to understand excitotoxicity and develop neuroprotectants for the therapy of ischemic *** narrow treatment time window is still to be *** that the ischemic core expanded over days,treatment with an extended time window is ***1(BEST1)belongs to a bestrophin family of calcium-activated chloride *** revealed an increase in neuronal BEST1 expression and function within the peri-infarct from 8 to 48 h after ischemic stroke in *** the protein expression or inhibiting the channel function of BEST1 by genetic manipulation displayed neuroprotective effects and improved motor functional *** electrophysiological recordings,we demonstrated that extrasynaptic glutamate release through BEST1 channel resulted in delayed ***,we confirmed the therapeutic efficacy of pharmacological inhibition of BEST1 during 6—72 h post-ischemia in *** delayed treatment prevented the expansion of infarct volume and the exacerbation of neurological *** study identifies the glutamatereleasing BEST1 channel as a potential therapeutic target against ischemic stroke with a wide time window.

关键词： BEST1 Ischemic stroke Glutamate release Delayed excitotoxicity Infarct expansion Neurological functions Calcium-activated chloride channels

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论丰富和发展中国特色社会主义理论体系的基本原则

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探索 2010年第2期 4-5,10页

作者：贾绘泽山西师范大学政法学院山西临汾041004

中国特色社会主义理论体系是一个发展的、开放的理论体系,要丰富和发展中国特色社会主义理论体系,必须始终遵循实践性原则、客观性原则、主体性原则和整体性原则,这是中国特色社会主义理论体系始终充满生机和活力的重要保证。

关键词：马克思主义中国化中国特色社会主义理论体系理论创新基本原则

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Evolutionary dynamics and comparative pathogenicity of clade 2.3.4.4b H5 subtype avian influenza viruses,China,2021–2022

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Virologica Sinica 2024年第3期39卷 358-368页

作者： Siru lin Junhong Chen Ke Li Yang Liu Siyuan Fu Shumin Xie Aimin Zha Aiguo Xin Xinyu Han Yuting Shi lingyu Xu Ming Liao Weixin jia National Avian Influenza Para-Reference Laboratory Guangdong Engineering Laboratory for Medicament of Zoonosis Prevention and ControlKey Laboratory of Zoonoses Prevention and Control of Guangdong ProvinceLaboratory for Lingnan Modern AgricultureCollege of Veterinary MedicineSouth China Agricultural UniversityGuangzhou510642China Key Laboratory of Zoonoses Key Laboratory of Animal Vaccine DevelopmentMinistry of AgricultureGuangzhou510642China Institute of Poultry Management and Diseases Yunnan Animal Science and Veterinary InstituteKunming650000China

The recent concurrent emergence of H5N1,H5N6,and H5N8 avian influenza viruses(AIVs)has led to significant avian mortality *** 2020,frequent human-animal interactions have been *** gain insight into the novel H5 subtype AIVs(i.e.,H5N1,H5N6 and H5N8),we collected 6102 samples from various regions of China between January 2021 and September 2022,and identified 41 H5Nx *** analyses on the evolution and biological properties of these isolates were *** analysis revealed that the 41 H5Nx strains belonged to clade 2.***.4.4b,with 13 related to H5N1,19 to H5N6,and 9 to *** based on global 2.***.4.4b viruses showed that all the viruses described in this study were likely originated from H5N8,exhibiting a heterogeneous evolutionary history between H5N1 and H5N6 during 2015–2022 worldwide.H5N1 showed a higher rate of evolution in 2021–2022 and more sites under positive selection pressure in 2015–*** antigenic profiles of the novel H5N1 and H5N6 exhibited notable *** hemagglutination inhibition assay suggested that some A(H5N1)viruses may be antigenically distinct from the circulating H5N6 and H5N8 *** challenge assays demonstrated that the H5N8 virus(21GD001_H5N8)displayed the highest pathogenicity in mice,followed by the H5N1 virus(B1557_H5N1)and then the H5N6 virus(220086_H5N6),suggesting a heterogeneous virulence profile of H5 AIVs in the mammalian *** on the above results,we speculate that A(H5N1)viruses have a higher risk of emergence in the ***,these findings unveil a new landscape of different evolutionary history and biological characteristics of novel H5 AIVs in clade 2.***.4.4b,contributing to a better understanding of designing more effective strategies for the prevention and control of novel H5 AIVs.

关键词： Avian influenza virus(AIV) H5 subtypes AIVs Evolutionary Pathogenicity

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Chinese expert consensus on organ protection of transplantation(2022 edition)

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 516-526页

作者： jian-hui Li Xiao Xu Yan-Feng Wang Hai-Yang Xie Jing-Yu Chen Nian-Guo Dong Mitesh Badiwala Li-Ming Xin Roberto Vanin Pinto Ribeiro Hao Yin Hao Zhang jian-Zheng Zhang Feng Huo jia-Yin Yang Hong-Ji Yang hui Pan Shao-Guang Li Yin-Biao Qiao jia Luo Hao-Yu Li Jun-Jun jia Hao Yu Han Liang Si-jia Yang Hao Wang Zhong-Yang Liu Li-Cheng Zhang Xiao-Yi Hu Hao Wu Yi-Qing Hu Pei-Fu Tang Qi-Fa Ye Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation Center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk Cardiac Centre Toronto General Hospital-University Health NetworkTorontoCanada School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant Center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation Center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 20th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the Collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2],which developed rapidly in static cold storage(SCS)*** remains the standard preservation technique for organ transplantation[2].

关键词： organ preservation transplantation

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Smart phosphorescence from solid to water through progressive assembly strategy based on dual phosphorescent sources

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Aggregate 2023年第5期4卷 224-234页

作者： Qing-Qing Xia Xing-Huo Wang jia-lin Yu Zhong-Yuan Chen Xin-Yue Lou Xiaomin Liu Ming-Xue Wu Ying-Wei Yang College of Chemistry and Chemical Engineering Qingdao UniversityShandongP.R.China International Joint Research Laboratory of Nano-Macro Architecture Chemistry College of ChemistryJilin UniversityChangchunP.R.China

Developing smart room-temperature phosphorescence(RTP)materials with facile and efficient strategies have attracted increasing ***,tunable RTP materials with two phosphorescent sources and stepwise enhanced phosphorescence in water are obtained through an in-situ self-assembly strategy based on the sensitization of phosphors by trimesic acid(TMA)through simple doping and the rigidification of phosphors by hydrogen-bonded organic frameworks(HOFs).As expected,doped TMA+phosphors simultaneously promote the RTP emission of phosphors and maintain TMA ***-situ assembled HOF(MATMA)@phosphors facilitate smart RTP emission in water due to the coexistence of phosphorescent HOF(MA-TMA)host and phosphors ***,such RTP materials with good processability demonstrate the application potential in information security,benefitting from their varied afterglow lifetimes and easy luminous recognition in the *** work will inspire the design of dual phosphorescent source RTP systems and provide new strategies for the development of smart RTP materials in water.

关键词： emissive materials hydrogen-bonded organic frameworks luminescence display room-temperature phosphorescence self-assembly

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Effects of mild moxibustion on intestinal microbiome and NLRP3 inflammasome in rats with 5-fluorouracil-induced intestinal mucositis

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Journal of Integrative Medicine 2021年第2期19卷 144-157页

作者： Bing-rong Li Shi-yun Shao Long Yuan Ru jia jian Sun Qing Ji Hua Sui Li-hong Zhou Yi Zhang hui Liu Qi Li Yan Wang Bi-meng Zhang Department of Acupuncture and Moxibustion Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Fudan UniversityShanghai 200433China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineDepartment of Medical Oncology&Cancer Institute of Integrative MedicineShuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objective:The present study investigated how mild moxibustion treatment affects the intestinal Microbiome and expression of NLRP3-related immune factors in a rat model of intestinal mucositis(IM)induced with 5-fluorouracil(5-Fu).Methods:Forty male Sprague-Dawley rats were randomly divided into control,chemotherapy,moxibustion and probiotics *** IM rat model was established by intraperitoneal injection of *** moxibustion treatment and intragastric probiotic administration were provided once daily for 15 *** morphology,serum levels of inflammatory factors and the expression levels of tight junction proteins,caspase-1,gasdermin D and NLRP3 were evaluated in colon tissue,through hematoxylin and eosin staining,electron microscopy,enzyme-linked immunosorbent assay,Western blotting,quantitative realtime reverse transcription polymerase chain reaction and *** microbiome profiling was conducted through 16 S rRNA amplicon ***:Moxibustion and probiotic treatments significantly increased the expression levels of tight junction proteins,reduced cell apoptosis and the expression levels of caspase-1,gasdermin D and NLRP3;they also decreased the serum levels of tumor necrosis factor-α,interleukin(IL)-6,IL-1βand IL-18,while increasing serum levels of *** and probiotic treatments also corrected the reduction inα-diversity andβ-diversity in IM rats,greatly increased the proportion of the dominant bacterial genus Lactobacillus and reduced the abundance of the genera Roseburia and Escherichia in chemotherapytreated rats to levels observed in healthy *** also found that these dominant genera were firmly correlated with the regulation of pyroptosis-associated proteins and inflammatory ***,moxibustion and probiotic treatments elicited similar effects in regulating intestinal host-microbial homeostasis and the expression of NLRP3 inflammasome-related ***:Moxibustion exerts its therapeutic

关键词： Chemotherapy Intestinal mucositis Moxibustion Rats Microbiome NLRP3

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