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Preliminary adipose removal did not prevent diet-induced metabolic disorders in mice

Chinese Medical Journal 2021年第6期134卷 716-724页

作者： lin Liu Chen-Xi Liang Xiao-Wei Wang Ke-Xin Pei Xin-Di Ma Chun-Xi Zhang Jing-hui Dong Ming-Ming Gao jia-Wei Liao Department of Biochemistry and Molecular Biology College of Basic MedicineHebei University of Chinese MedicineShijiazhuangHebei 050200China Laboratory of Lipid Metabolism Institute of Basic MedicineHebei Medical UniversityShijiazhuangHebei 050017China Department of Cardiology First Hospital of Hebei Medical UniversityShijiazhuangHebei 050031China Department of Physiology Hebei Medical UniversityShijiazhuangHebei 050017China Department of Cardiology Institute of Cardiovascular DiseasesFirst Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China

Background: Obesity is a fundamental factor in metabolic disorders such as hyperlipidemia, insulin resistance, fatty liver, and atherosclerosis. However, effective preventive measures are still lacking. This study aimed to investigate different surgical protocols for removing partial adipose tissue before the onset of obesity and determine whether, and by which protocol, preliminary adipose removal could exert potent preventive effects against diet-induced metabolic ***: Male low-density lipoprotein receptor (LDL-R) knockout (KO) mice were randomly divided into four groups and subjected to epididymal fat removal (Epi-FR) surgery, subcutaneous fat removal (suQ-FR) surgery, both subcutaneous and epididymal fat removal (Epi + suQ-FR) surgery, or sham-operation. After 1 week of recovery, all mice were given a high-fat diet (HFD) for 10 weeks to induce metabolic ***: In the Epi-FR group and the sham-operated group, the mean numbers of the residual subcutaneous fat were 28.59 mg/g and 18.56 mg/g, respectively. The expression of relative genes such asPparg, Cebpa, Dgat2, Fabp4 and Cd36 in the residual subcutaneous fat increased 2.62, 3.90, 3.11, 2.06, 1.78 times in the Epi-FR group compared with that in the sham-operated group. Whereas in the other fat-removal groups, the residual fat depots had no significant change in either size or gene expression, as compared with those of the sham-operated group. Plasma lipid and glucose levels and insulin sensitivity, as detected by the glucose tolerance test, were not significantly alleviated in the three fat removal groups. Liver mass or lipid content was not attenuated in any of the three fat removal groups. The atherosclerosis burdens in the entire inner aorta and aortic root did not decrease in any of the three fat removal ***: Our data suggest that removal of epididymal adipose or subcutaneous adipose alone or in combination before the onset of obesity did not protect against hyperlipi

关键词： Adipose removal Hyperlipidemia Insulin resistance Fatty liver Atherosclerosis

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A novel differential velocity modulation laser spectroscopy

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Chinese Science Bulletin 2001年第2期46卷 173-176页

作者： LIU Yuyan GAO hui LIU Hongping DUAN Chuanxi lin Jieli GUO Yuanqing LIU Xiaoyong HUANG Guangming LI Jinrui LI Fengyan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsWuhan 430071China Department of Physics East China Normal UniversityShanghai 200062China Department of Physics Huazhong Normal UniversityWuhan 430079China Deparment of Physics Wuhan UniversityWuhan 430072China

Experimental investigation of a novel differential velocity modulation laser spectroscopy is reported and demonstrated with the spectra of N2+A2IIm-X2∑g+ Meinel system. The S/N ratio excesses 500 : 1, about 60 times higher than that with the traditional non-differential *** this technique, we obtained the high-resolution electronic absorption spectra of A2II-X2∑+(1,0) vibration-al band of CS+ for the first time. It is confirmed that this technique will be a powerful method and receive wide application in studies of new molecular ions.

关键词： velocity modulation differential technique molecular spectroscopy.

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Autoimmune encephalitis after surgery for appendiceal cancer:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2576-2581页

作者： Yan-hui Mao Lu Li Li-Ming Wen jia-Min Qin Ya-ling Yang Li Wang Fan-Rong Wang Yi-Zhou Zhao Department of Gastroenterology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Pathology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Medical Imaging Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Primary cancer of the appendix is rare and often difficult to diagnose preoperatively due to the lack of specific clinical symptoms. Autoimmune encephalitis(AIE) is the most common cause of non-infectious encephalitis. The etiologies of AIE include tumors(paraneoplastic), infections(parainfections), or recessive infections. The tumors that have been reported to cause AIE include thymomas, ovarian teratomas, lung cancers, and breast cancers. However, there are no reports of AIE occurring after surgery for appendiceal cancer. This report describes the diagnosis and treatment of a patient with an appendiceal cancer and postoperative *** SUMMARY We report the case of a 47-year-old man who was transferred to our hospital due to a recurrent low intestinal obstruction. Abdominal enhanced computed tomography was used to consider the possibility of a terminal ileal tumor with serous infiltration and lymph node metastasis. A right hemi-colectomy was performed under general anesthesia with an ileo-transcolon anastomosis and laparoscopic exploration. The postoperative pathologic evaluation revealed a high-grade goblet cell carcinoma of the appendix, accompanied by mesangial and abdominal lymph node metastases, and neural tube and vascular infiltration. The operation was completed without complication. The patient developed restlessness on postoperative day 4, and gradually developed a disturbance of consciousness on postoperative day 6. He was transferred to West China Hospital of Sichuan University and diagnosed with *** Albeit rare, the occurrence of neurologic and psychiatric symptoms in patients with an appendiceal cancer postoperatively suggests the possibility of AIE.

关键词： Appendiceal cancer Goblet cell carcinoma Repeated ileus Postoperative Autoimmune encephalitis Case report

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基于HPLC-MS/MS法研究马兜铃酸Ⅰ和马兜铃酸Ⅱ的大鼠肝微粒体酶S9体外代谢

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质谱学报 2017年第1期38卷 30-36页

作者：周慧付佳蔡宗苇吉林大学珠海学院广东珠海519041 香港浸会大学化学系中国香港特别行政区

马兜铃酸Ⅰ和马兜铃酸Ⅱ广泛存在于马兜铃属植物中,具有肾损伤毒性和致癌致突变毒性。为了研究马兜铃酸类化合物的毒性产生机制,建立了马兜铃酸Ⅰ和马兜铃酸Ⅱ及其大鼠肝微粒体酶S9代谢物分离与鉴定的高效液相色谱-串联质谱(HPLC-MS/MS... 详细信息

马兜铃酸Ⅰ和马兜铃酸Ⅱ广泛存在于马兜铃属植物中,具有肾损伤毒性和致癌致突变毒性。为了研究马兜铃酸类化合物的毒性产生机制,建立了马兜铃酸Ⅰ和马兜铃酸Ⅱ及其大鼠肝微粒体酶S9代谢物分离与鉴定的高效液相色谱-串联质谱(HPLC-MS/MS)分析方法。采用体外代谢法分别研究了有氧和厌氧孵育条件下,马兜铃酸Ⅰ和马兜铃酸Ⅱ在大鼠肝微粒体酶S9作用下的代谢行为,并对各代谢物进行结构表征。研究结果显示:马兜铃酸Ⅰ在有氧条件下生成的代谢产物为马兜铃酸Ⅰa,在厌氧条件下生成的代谢产物为马兜铃内酰胺Ⅰ;马兜铃酸Ⅱ只在厌氧条件下生成了马兜铃内酰胺Ⅱ。马兜铃内酰胺类化合物的生成是马兜铃酸Ⅰ和马兜铃酸Ⅱ在肝微粒体酶S9代谢过程中毒性产生的主要原因。该结果对于更好地理解马兜铃酸Ⅰ和马兜铃酸Ⅱ的毒性作用机制,控制毒副反应的发生具有一定意义。

关键词：马兜铃酸Ⅰ 马兜铃酸Ⅱ 肝微粒体代谢高效液相色谱-串联质谱(HPLC-MS/MS)

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多孔纤维型重整微反应器的等效电阻网络建模

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浙江大学学报（工学版） 2021年第2期55卷 271-279页

作者：徐志佳余昌霖王清辉华南理工大学机械与汽车工程学院广东广州510640

针对应用于重整制氢微反应器的复杂多孔金属纤维载体(PFS)的流速场高效分析难题,建立载体中随机微通道的等效电阻网络分析模型.基于复杂随机纤维结构的统计网络模型,将纤维载体中三维联通的随机微通道结构及与之相连的进出口腔简化为规... 详细信息

针对应用于重整制氢微反应器的复杂多孔金属纤维载体(PFS)的流速场高效分析难题,建立载体中随机微通道的等效电阻网络分析模型.基于复杂随机纤维结构的统计网络模型,将纤维载体中三维联通的随机微通道结构及与之相连的进出口腔简化为规则的网络通道结构.借鉴基尔霍夫定律,建立纤维载体的等效电阻网络模型,并确定求解方法.纤维载体流速场实例分析的结果表明,基于等效电阻网络模型求解的纤维载体流速场与计算流体力学(CFD)方法的结果之间的皮尔森相关系数约为98%,且求解效率约为CFD方法的2.9×10~4倍.研究成果为多孔纤维型重整制氢微反应器的设计制造提供了新的支撑方案.

关键词：重整制氢多孔纤维等效电阻网络流速场高效

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DEKR-SPrior:An Efficient Bottom-Up Keypoint Detection Model for Accurate Pod Phenotyping in Soybean

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Plant Phenomics 2024年第3期6卷 655-668页

作者： Jingjing He lin Weng Xiaogang Xu Ruochen Chen Bo Peng Nannan Li Zhengchao Xie Lijian Sun Qiang Han Pengfei He Fangfang Wang hui Yu Javaid Akhter Bhat Xianzhong Feng Zhejiang Laboratory Hangzhou 311100ZhejiangChina School of Computer Science and Technology Zhejiang Gongshang UniversityHangzhou 310012ZhejiangChina Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102JilinChina

The pod and seed counts are important yield-related traits in ***-precision soybean breeders face the major challenge of accurately phenotyping the number of pods and seeds in a high-throughput *** advances in artificial intelligence,especially deep learning(DL)models,have provided new avenues for high-throughput phenotyping of crop traits with increased ***,the available DL models are less effective for phenotyping pods that are densely packed and overlap in insitu soybean plants;thus,accurate phenotyping of the number of pods and seeds in soybean plant is an important *** address this challenge,the present study proposed a bottom-up model,DEKR-SPrior(disentangled keypoint regression with structural prior),for insitu soybean pod phenotyping,which considers soybean pods and seeds analogous to human people and joints,*** particular,we designed a novel structural prior(SPrior)module that utilizes cosine similarity to improve feature discrimination,which is important for differentiating closely located seeds from highly similar *** further enhance the accuracy of pod location,we cropped full-sized images into smaller and high-resolution subimages for *** results on our image datasets revealed that DEKR-SPrior outperformed multiple bottom-up models,viz.,Lightweight-Open Pose,OpenPose,HigherH R Net,and DEKR,reducing the mean absolute error from 25.81(in the original DEKR)to 21.11(in the DEKR-SPrior)in pod *** paper demonstrated the great potential of DEKR-SPrior for plant phenotyping,and we hope that DEKR-SPrior will help future plant phenotyping.

关键词： bottom-up detection model accurate dekr-sprior efficient keypoint phenotyping soybean

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In situ polymerization of water-induced 1,3-phenylene diisocyanate for enhanced efficiency and stability of inverted perovskite solar cells

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Interdisciplinary Materials 2024年第2期3卷 316-325页

作者： Shiyao jia jiabao Yang Tong Wang Xingyu Pu hui Chen Xilai He Guangpeng Feng Xingyuan Chen Yijun Bai Qi Cao Xuanhua Li State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'anChina

In the realm of photovoltaics,organometallic hybridized perovskite solar cells(PSCs)stand out as promising contenders for achieving high-efficiency photoelectric conversion,owing to their remarkable performance ***,defects within the perovskite layer,especially at the perovskite grain boundaries and surface,have a substantial impact on both the overall photoelectric performance and long-term operational stability of *** mitigate this challenge,we propose a method for water-induced condensation polymerization of small molecules involving the incorporation of 1,3-phenylene diisocyanate(1,3-PDI)into the perovskite film using an antisolvent *** to this step,the introduction of water triggers the polymerization of[P(1,3-PDI)],thereby facilitating the in situ passivation of uncoordinated lead defects inherent in the perovskite *** passivation process demonstrates a notable enhancement in both the efficiency and stability of *** approach has led to the attainment of a noteworthy power conversion efficiency(PCE)of 24.66% in inverted ***,based on the P(1,3-PDI)modification,these devices maintain 90.15% of their initial efficiency after 5000 h of storage under ambient conditions of 25℃ and 50±5% relative ***,even after maximum power point tracking for 1000 h,the PSCs modified with P(1,3-PDI)sustain 82.05% of the initial *** molecules can rationally manipulate water and turn harm into benefit,providing new directions and methods for improving the efficiency and stability of PSCs.

关键词： antisolvent engineering defect passivation inverted perovskite solar cells

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Effect of Crossbreed on the Muscle Quality(Chemical Composition) in Yun-ling Black Goats

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Agricultural Sciences in China 2009年第1期8卷 108-114页

作者： jia Jun-jing TIAN Yun-bo ZHANG Xi HUANG Qi-chao WEN Sheng-ping GU Feng-ying GE Chang-rong CAO Zhen-hui CHENG Zhi-bin M. Jois Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Science Yunnan Agricultural University Kunming 650201 P.R.China College of Zhongkai Agricultural Technology and Science Guangzhou 510225 P.R. China College of Food Science and Technology Yunnan Agricultural University Kunming 650201 P.R.China Department of Agriculture School of Life Sciences La Trobe University Bundoora 3086 Victoria Australia

Twenty castrated male goats, each of Yun-ling Black goats （YLB goat）, N × YLB hybrid goats （Nubian ♂ ×Yun-ling Black goats 9） and B × YLB hybrid goats （Boer ♂× Yun-ling Black goats ♀）, were used to evaluate the effect of crossbreeding on the meat chemical composition in the YLB goats of China. After weaning of 90 days, all the experimental goats were reared on natural pasture when they were slaughtered at an age of 730 days. The longissimus dorsi （LD） and biceps femoris （BF） muscles were sampled from each carcass to determine chemical compositions. Both hybrid goats had higher protein content （P 〈 0.01） and lower fat content （P 〈 0.05） than the YLB goats in the two types of muscle. The inosinic acid contents of LD muscle for the YLB goats and the B × YLB hybrid goats were significantly higher （P 〈 0.05） than that for the N × YLB hybrid goats. The LD muscle from the YLB goats contained higher essential amino acid （P 〈 0.01）, total amino acid （P 〈 0.01）, and some individual amino acid （P 〈 0.05） than those from the hybrid goats. The concentration of unsaturated fatty acid （USFA） of LD muscle from the N × YLB hybrid goats was significantly higher than the other two goat breeds （P〈0.05） but did not differ between the other two goat breeds （P〉0.05）. The YLB goats had significantly higher （P〈0.05） concentrations of oleic acid （C18：1） and linolenic acid （C18：3） of LD muscle than the hybrid goats, had significantly higher （P 〈 0.05） proportion of mono-unsaturated （Sum for C 16：1 and C 18：1） than the B ×YLB hybrid goats, and tended to be higher than the N × YLB hybrid goats （P 〉 0.05）. In contrast, the proportion of poly-unsaturated in the YLB goats was significantly lower （P 〈 0.05） than that in the hybrid goats.

关键词： Yun-ling Black goat crossbreed muscle amino acids muscle fatty acids

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广义(3+1)维非线性Burgers系统孤波级数解

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物理学报 2010年第12期59卷 8311-8315页

作者：温朝晖莫嘉琪安徽财经大学应用数学研究所蚌埠233030 安徽师范大学数学系芜湖241003

研究了一类广义(3+1)维非线性Burgers系统.首先,利用同伦映射方法构造了相应的映射关系式.其次,利用迭代方法得到了扰动系统的一个孤波非行波的级数解.

关键词： Burgers系统非线性孤波解

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基于NIST评测的说话人分类及定位技术研究

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电子与信息学报 2011年第5期33卷 1234-1237页

作者：杨毅宋辉刘加清华大学电子工程系北京100084

该文针对美国国家标准与技术研究院(NIST)的NIST评测,构建了一套多距离麦克风说话人分类及定位语音处理系统,针对NIST富标注评测中提出的说话人分类问题,提出改进的结合时延估计和聚类的说话人分类方法,在保证稳定性的前提下降低说话人... 详细信息

该文针对美国国家标准与技术研究院(NIST)的NIST评测,构建了一套多距离麦克风说话人分类及定位语音处理系统,针对NIST富标注评测中提出的说话人分类问题,提出改进的结合时延估计和聚类的说话人分类方法,在保证稳定性的前提下降低说话人分类的复杂度并提高准确率;提出一种新的相邻阵元间时延构造矩阵方程算法,可得到多个说话人的方向角。实验在标准会议环境下采集真实语音数据进行算法验证,说话人分类算法的正确率接近目前主要说话人分类系统的正确率,定位方向角误差在3°以内。实验结果说明,适当条件下多距离麦克风系统可作为合适的语音信号输入设备应用于多人多方会议环境。

关键词：说话人分类说话人定位多距离麦克风时延聚类时延矩阵

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