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Unusual early-stage pancreatic sarcomatoid carcinoma

World Journal of Gastroenterology 2013年第43期19卷 7820-7824页

作者： Chuan-Li Ren Ping Jin Chong-Xu Han Qin Xiao Dao-Rong Wang lin Shi Da-Xin Wang hui Chen Laboratory Medicine and Pathology Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University Pathology Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University Abdominal Surgery Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University Transonogram Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University Laboratory Medicine Centre Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University Geratology Department Northern Jiangsu People’s Hospital and Clinical Medical College of Yangzhou University

Sarcomatoid carcinoma of the pancreas(SCP)is a very rare pathological type of carcinoma that usually has a poor *** pathogenesis has not been *** herein report a case of an early-stage SCP involving successful treatment and a good *** patient was a 48-year-old Chinese man with a5-mo history of vague abdominal *** revealed a 93 mm×94 mm×75 mm mass of mixed echogenicity in the tail of the *** test results were within the normal range,with the exception of an obviously increased pretreatment neuron-specific enolase *** plasma transforming growth factor(TGF)β1 and interleukin-11 levels were obviously increased according to enzyme-linked immunosorbent ***,the excised tumor tissue comprised cancer cells and mesenchymal *** analysis was positive forα-1-antichymotrypsin,pan-cytokeratin,cytokeratin 19,cytokeratin 8/18,and vimentin and negative for CD68and *** pathogenetic mechanism of this case shows that TGFβ1 may regulate the epithelial-tomesenchymal transition in *** early eradication of the tumor and systemic therapy,this patient has been alive for more than 3 years without tumor recurrence or distant *** case is also the first to show that TGFβ1 may regulate the epithelial-tomesenchymal transition in early-stage SCP.

关键词： Sarcomatoid carcinoma of the pancreas Transforming growth factorβ1 Epithelial-to mesenchymal transition Interleukin-11 Vimentin

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Light People:Professor lin Li

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Light(Science & Applications) 2021年第8期10卷 1388-1394页

作者： hui Wang Heng Gu Department of International Cooperation Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of Sciences3888 Dong Nan Hu Road130033 ChangchunChina School of Mechanical Engineering Jiangsu UniversityJiang SuChina

Editorial How to deal with climate change,how to mitigate or even reverse it,maybe the hottest scientific topic of the 21st *** you know that a Chinese scientist and his team contributed to climate change control by reducing PM2.5 in diesel car exhaust by 35-40%?That scientist is *** Li,a Fellow of the Royal Academy of Engineering and founder of the Laser Processing Research Centre at The University of Manchester,United *** course,this is only one example of Professor Li's scientific *** a pioneer of microsphere super-resolution lens,his team,in collaboration with Singapore colleagues,broke the optical diffraaion limit in optical microscopic imaging,making real-time observation of biological viruses without interference *** also used lasers to synthesize new nanomaterials which kill drug-resistant bacteria while remaining harmless to healthy human cells,which led to the development and breakthrough of related research *** are much honored to have Professor lin Li for an exclusive interview in which he recalls his years of scientific research experience and talks about the future development trend of laser material processing.

关键词： optical breakthrough interview

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基于虚拟激励法的车桥系统车速影响分析

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铁道学报 2011年第4期33卷 93-99页

作者：张志超张亚辉林家浩大连理工大学运载工程与力学学部工业装备结构分析国家重点实验室辽宁大连116024 中国铁道科学研究院机车车辆研究所北京100081

本文基于虚拟激励法提出列车-桥梁耦合系统的非平稳随机振动分析的新方法,并借此重点分析车速对系统随机振动的影响。列车每节车辆考虑27个自由度,桥梁模型采用空间Euler梁单元,轨道不平顺假设为多点异相位平稳随机激励。根据时变系统... 详细信息

本文基于虚拟激励法提出列车-桥梁耦合系统的非平稳随机振动分析的新方法,并借此重点分析车速对系统随机振动的影响。列车每节车辆考虑27个自由度,桥梁模型采用空间Euler梁单元,轨道不平顺假设为多点异相位平稳随机激励。根据时变系统的虚拟激励法,推导得到方向、高低和水平三类轨道不平顺作用下车桥系统响应的时变功率谱及标准差,并采用精细积分法进行迭代计算,最后以高斯型随机变量的三倍标准差为误差范围给出系统响应最大值估计。在数值算例中,用时间历程法验证本文方法的正确性和有效性,并重点讨论列车速度的影响。

关键词：车桥系统随机振动虚拟激励法精细积分法轨道不平顺

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Autoimmune encephalitis after surgery for appendiceal cancer:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2576-2581页

作者： Yan-hui Mao Lu Li Li-Ming Wen jia-Min Qin Ya-ling Yang Li Wang Fan-Rong Wang Yi-Zhou Zhao Department of Gastroenterology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Pathology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Medical Imaging Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Primary cancer of the appendix is rare and often difficult to diagnose preoperatively due to the lack of specific clinical symptoms. Autoimmune encephalitis(AIE) is the most common cause of non-infectious encephalitis. The etiologies of AIE include tumors(paraneoplastic), infections(parainfections), or recessive infections. The tumors that have been reported to cause AIE include thymomas, ovarian teratomas, lung cancers, and breast cancers. However, there are no reports of AIE occurring after surgery for appendiceal cancer. This report describes the diagnosis and treatment of a patient with an appendiceal cancer and postoperative *** SUMMARY We report the case of a 47-year-old man who was transferred to our hospital due to a recurrent low intestinal obstruction. Abdominal enhanced computed tomography was used to consider the possibility of a terminal ileal tumor with serous infiltration and lymph node metastasis. A right hemi-colectomy was performed under general anesthesia with an ileo-transcolon anastomosis and laparoscopic exploration. The postoperative pathologic evaluation revealed a high-grade goblet cell carcinoma of the appendix, accompanied by mesangial and abdominal lymph node metastases, and neural tube and vascular infiltration. The operation was completed without complication. The patient developed restlessness on postoperative day 4, and gradually developed a disturbance of consciousness on postoperative day 6. He was transferred to West China Hospital of Sichuan University and diagnosed with *** Albeit rare, the occurrence of neurologic and psychiatric symptoms in patients with an appendiceal cancer postoperatively suggests the possibility of AIE.

关键词： Appendiceal cancer Goblet cell carcinoma Repeated ileus Postoperative Autoimmune encephalitis Case report

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Probing the peripheral self-generated magnetic field distribution in laser-plasma magnetic reconnection with Martin-Puplett interferometer polarimeter

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Chinese Physics B 2024年第4期33卷 129-134页

作者：张雅芃姚嘉文刘正东马作霖仲佳勇 Department of Astronomy Beijing Normal UniversityBeijing 100875China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China

Magnetic reconnection of the self-generated magnetic fields in laser-plasma interaction is an important laboratory method for modeling high-energy density astronomical and astrophysical *** use the Martin-Puplett interferometer(MPI)polarimeter to probe the peripheral magnetic fields generated in the common magnetic reconnection configuration,two separated coplanar plane targets,in laser-target *** introduce a new method that can obtain polarization information from the interference pattern instead of the sinusoidal function fitting of the intensity.A bidirectional magnetic field is observed from the side view,which is consistent with the magneto-hydro-dynamical(MHD)simulation results of self-generated magnetic field *** find that the cancellation of reverse magnetic fields after averaging and integration along the observing direction could reduce the magnetic field strength by one to two orders of *** indicates that imaging resolution can significantly affect the accuracy of measured magnetic field strength.

关键词： laser-plasma experiment polarimeter self-generated magnetic field magnetic reconnection

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Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

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Nano-Micro Letters 2021年第7期13卷 105-117页

作者： Yong Yang Yusi Peng Chenglong lin Li Long Jingying Hu Jun He hui Zeng Zhengren Huang Zhi-Yuan Li Masaki Tanemura jianlin Shi John R.Lombardi Xiaoying Luo State Key Laboratory of High-Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050People’s Republic of China Graduate School of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032People’s Republic of China Anhui Provincial Center for Disease Control and Prevention Hefei 12560AnhuiPeople’s Republic of China Public Health Research Institute of Anhui Province Hefei 12560AnhuiPeople’s Republic of China Shanghai Yangpu Hospital of Traditional Chinese Medicine Shanghai 200090People’s Republic of China Department of Frontier Materials Nagoya Institute of TechnologyNagoya 466-8555Japan Department of Chemistry The City College of New York160 Convent AvenueNew YorkNY 10031USA

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 ***,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus *** a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS ***,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of ***,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus.

关键词： SERS SARS-CoV-2 Human ACE2 “Virus-trap”nanostructure Single-virus detection

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Residual solvent extraction via chemical displacement for efficient and stable perovskite solar cells

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Journal of Energy Chemistry 2021年第10期30卷 8-14,I0001页

作者： Min Fang Lei Tao Wen Wu Qi Wei Yingdong Xia Ping Li Xueqin Ran Qi Zhong Guichuan Xing lin Song Peter Müller-Buschbaum hui Zhang Yonghua Chen Key Laboratory of Flexible Electronics(KLOFE)&Institution of Advanced Materials(IAM) Nanjing Tech University(Nanjing Tech)Nanjing 211816JiangsuChina Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072ShaanxiChina Key Laboratory of Advanced Textile Materials&Manufacturing Technology Ministry of EducationZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Institute of Joint Key Laboratory of the Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipa 999078MacaoChina Lehrstuhl für Funktionelle Materialien Physik DepartmentTechnische Universität München.James-Franck-Str.185748 GarchingGermany Heinz Maier-Leibnitz Zentrum(MLZ) Technische Universität MünchenLichtenbergstr.185748 GarchingGermany

Solvent residue is inevitable to occur in solution processed thin films,but its influence on the thin film quality has not been identified and addressed to *** acetate(MAAc)ionic liquid has recently been realized as an environmentally friendly solvent for solution processed *** specific high viscosity,low vapor pressure and strong association with perovskite precursor of the MAAc solvent is a double-edged sword,which endowed an advantageously ambient air operational and anti-solvent free perovskite deposition,but the MAAc is likely to be retained within the film and bring in detrimental effects on device performance of the corresponding solar ***,we reported a novel route to eliminate the residual solvent via a facial hydrochloric acid(HCl)annealing post-treatment(HAAP).In particular,chemical displacement reaction between the incorporated HCl and residual MAAc can be initiated to form volatile MACl and HAc,efficiently extracting MAAc *** the meanwhile,the stimulated mass transport via downward penetration and upward escape can trigger secondary perovskite growth with enlarged grain size and smoothened surface,leading to reduced defect state and improved interfacial contact intimacy,and also partial chloride ions are able to enter the crystal lattice to stabilize perovskite phase *** a result,a champion efficiency up to20.78%originating from enhanced Voc was achieved,and more than 96%of its initial efficiency can be maintained after 1000 h shelf-storage.

关键词： Perovskite Solar cells Solvent residue Methylammonium acetate Post-treatment Chemical displacement

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Engineering surface framework TiO6 single sites for unprecedented deep oxidative desulfurization

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National Science Review 2024年第5期11卷 303-314页

作者： Shen Yu Zhan Liu jia-Min Lyu Chun-Mu Guo Xiao-Yu Yang Peng jiang Yi-Long Wang Zhi-Yi Hu Ming-hui Sun Yu Li Li-Hua Chen Bao-Lian Su Laboratory of Living Materials at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Nanostructure Research Center Wuhan University of Technology School of Chemistry Chemical Engineering and Life ScienceWuhan University of Technology Laboratory of Inorganic Materials Chemistry University of Namur

Catalytic oxidative desulfurization（ODS） using titanium silicate catalysts has emerged as an efficient technique for the complete removal of organosulfur compounds from automotive fuels. However, the precise control of highly accessible and stable-framework Ti active sites remains highly challenging. Here we reveal for the first time by using density functional theory calculations that framework hexa-coordinated Ti（TiO6） species of mesoporous titanium silicates are the most active sites for ODS and lead to a lower-energy pathway of ODS. A novel method to achieve highly accessible and homogeneously distributed framework TiO6active single sites at the mesoporous surface has been developed. Such surface framework TiO6species exhibit an exceptional ODS performance. A removal of 920 ppm of benzothiophene is achieved at60°C in 60 min, which is 1.67 times that of the best catalyst reported so far. For bulky molecules such as4,6-dimethyldibenzothiophene（DMDBT）, it takes only 3 min to remove 500 ppm of DMDBT at 60°C with our catalyst, which is five times faster than that with the current best catalyst. Such a catalyst can be easily upscaled and could be used for concrete industrial application in the ODS of bulky organosulfur compounds with minimized energy consumption and high reaction efficiency.

关键词： electrostatic interactions framework hexa-coordinated Ti site oxidative desulfurization mesoporous materials self-assembly

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基于HPLC-MS/MS法研究马兜铃酸Ⅰ和马兜铃酸Ⅱ的大鼠肝微粒体酶S9体外代谢

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质谱学报 2017年第1期38卷 30-36页

作者：周慧付佳蔡宗苇吉林大学珠海学院广东珠海519041 香港浸会大学化学系中国香港特别行政区

马兜铃酸Ⅰ和马兜铃酸Ⅱ广泛存在于马兜铃属植物中,具有肾损伤毒性和致癌致突变毒性。为了研究马兜铃酸类化合物的毒性产生机制,建立了马兜铃酸Ⅰ和马兜铃酸Ⅱ及其大鼠肝微粒体酶S9代谢物分离与鉴定的高效液相色谱-串联质谱(HPLC-MS/MS... 详细信息

马兜铃酸Ⅰ和马兜铃酸Ⅱ广泛存在于马兜铃属植物中,具有肾损伤毒性和致癌致突变毒性。为了研究马兜铃酸类化合物的毒性产生机制,建立了马兜铃酸Ⅰ和马兜铃酸Ⅱ及其大鼠肝微粒体酶S9代谢物分离与鉴定的高效液相色谱-串联质谱(HPLC-MS/MS)分析方法。采用体外代谢法分别研究了有氧和厌氧孵育条件下,马兜铃酸Ⅰ和马兜铃酸Ⅱ在大鼠肝微粒体酶S9作用下的代谢行为,并对各代谢物进行结构表征。研究结果显示:马兜铃酸Ⅰ在有氧条件下生成的代谢产物为马兜铃酸Ⅰa,在厌氧条件下生成的代谢产物为马兜铃内酰胺Ⅰ;马兜铃酸Ⅱ只在厌氧条件下生成了马兜铃内酰胺Ⅱ。马兜铃内酰胺类化合物的生成是马兜铃酸Ⅰ和马兜铃酸Ⅱ在肝微粒体酶S9代谢过程中毒性产生的主要原因。该结果对于更好地理解马兜铃酸Ⅰ和马兜铃酸Ⅱ的毒性作用机制,控制毒副反应的发生具有一定意义。

关键词：马兜铃酸Ⅰ 马兜铃酸Ⅱ 肝微粒体代谢高效液相色谱-串联质谱(HPLC-MS/MS)

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A novel differential velocity modulation laser spectroscopy

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Chinese Science Bulletin 2001年第2期46卷 173-176页

作者： LIU Yuyan GAO hui LIU Hongping DUAN Chuanxi lin Jieli GUO Yuanqing LIU Xiaoyong HUANG Guangming LI Jinrui LI Fengyan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsWuhan 430071China Department of Physics East China Normal UniversityShanghai 200062China Department of Physics Huazhong Normal UniversityWuhan 430079China Deparment of Physics Wuhan UniversityWuhan 430072China

Experimental investigation of a novel differential velocity modulation laser spectroscopy is reported and demonstrated with the spectra of N2+A2IIm-X2∑g+ Meinel system. The S/N ratio excesses 500 : 1, about 60 times higher than that with the traditional non-differential *** this technique, we obtained the high-resolution electronic absorption spectra of A2II-X2∑+(1,0) vibration-al band of CS+ for the first time. It is confirmed that this technique will be a powerful method and receive wide application in studies of new molecular ions.

关键词： velocity modulation differential technique molecular spectroscopy.

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