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Optimization of Fermentation Medium for Epothilones Production with Sequential Statistical Approach

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Chemical Research in Chinese Universities 2010年第1期26卷 86-91页

作者： MENG Fan-xin LI You-xin GUO Wei-liang LU jia-hui DU lin-na TENG Li-rong College of Life Science Jilin University Changchun 130012 P. R. China

A sequential statistical approach was applied to optimizing the fermentation medium of epothilones（Epos） production by means of a mutant which was obtained by treating polyangium cellulosum ATCC 15384 with nitrite and ultraviolet. The effects of different carbon sources and nitrogen sources on the fermentation medium were tested, and the suitable ones were selected. Then a uniform design was employed to design the experiments. A linear model was developed for identifying the significant components in fermentation medium, while a third degree polynomial model was used for studying the relationship between the concentration of the components in fermentation medium and the yield of Epos（YEPs）. A pattern search method was used for searching the optimum fermentation medium in the test space, which was as follows（g/L）： potassium nitrate 8.00, soybean peptone 17.60, potassium hydrogen phos- phate 1.00, beef extraction 6.46, yeast extraction 1.00, calcium chloride 0.25, sodium chloride 1.00 and ferric chloride 0.02. The optimum fermentation medium was expected to result in a yield of Epos（YEPs） of 2.48 mg/L. The validation experiments with the optimum medium were performed in triplicate and the average yield of Epos was 2.45 mg/L which was 7.78 times higher than that of Epos prepared without optimization.

关键词： Statistical approach Epothilones Uniform design Optimization of fermentation medium

CH_(4) and C0_(2) observations from a melting high mountain glacier,Laohugou Glacier No.12

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Advances in Climate Change Research 2022年第1期13卷 146-155页

作者： Zhi-Heng DU Lei WANG Zhi-Qiang WEI Jing-Feng LIU Peng-lin lin jia-hui lin Yan-Zhao LI Zi-Zhen JIN Ji-Zu CHEN Xiao-Xiang WANG Xiang QIN Cun-De XIAO State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Zhuhai Branch of State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityZhuhai 519087China College of Geography and Environment Science Northwest Normal UniversityLanzhou 730000China Qilian Shan Station of Glaciology and Ecological Environment State Key Laboratory of Cry ospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

With global warming,glaciers in the high mountains of China are retreating ***,few data have been reported on whether greenhouse gases from these glaciers are released into the atmosphere or absorbed by glacial *** this study,we collected meltwater and ice samples from Laohugou Glacier No.12 in western China and measured CH_(4)and CO_(2)*** from the glacier terminus was continually sampled between 3 and 5 August 2020 to measure CH_(4)and CO_(2)*** results demonstrated that meltwater is a source of CH_(4)because the average saturations are over 100%.It could be con eluded that CH_(4)in the atmosphere can be released by glacial ***,the CO_(2)saturations are various,and CO_(2)fluxes exhibit positive(released CO_(2))or negative(absorbed CO_(2))values because the water and atmospheric conditions are *** importantly,the CH_(4)and CO_(2)concentrations were higher in meltwater samples from the glacier terminus than in samples from the surface ice(including an ice core)and a surface *** the meltwater effect from the upper part of the glacier cannot be excluded,we speculated that subglacial drainage systems with an anaerobic environment may represent the CH_(4)source,but it needs to be further investigated in the ***,high mountain glaciers are currently ignored in global carbon budgets,and the increased melting of glaciers with global warming may accelerate the absorption of much more CO_(2)and lead to the release of CH_(4).

关键词： CO_(2) CH_(4) Source and sink:Subglacial drainage systems Laohugou glacier No.12

Facile synthesis of V-doped CoP nanoparticles as bifunctional electrocatalyst for efficient water splitting

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Journal of Energy Chemistry 2019年第12期28卷 182-187页

作者： Jun-Feng Qin jia-hui lin Tian-Shu Chen Da-Peng Liu Jing-Yi Xie Bao-Yu Guo Lei Wang Yong-Ming Chai Bin Dong State Key Laboratory of Heavy Oil Processing Institute of New EnergyChina University of Petroleum(East China)Qingdao 266580ShandongChina Shandong Key Laboratory of Biochemical Analysis College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina

Adjusting the intrinsic activity and conductivity of electrocatalysts may be a crucial way for excellent performance for water ***,the rational design of vanadium element doped cobalt phosphide(V-doped CoP)nanoparticles has been investigated through a facile gaseous phosphorization using cobalt vanadium oxide or hydroxide(Co-V hydr(oxy)oxide)as *** physical characterization shows that the homogeneous dispersion of V element on V-doped CoP nanoparticles have obtained,which may imply the enhanced electrocatalytic activity for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The electrochemical measurements of the prepared V-doped CoP in alkaline electrolyte demonstrate the superior electrocatalytic activity for both HER(overpotential of 235 mV@10 mA cm^-2)and OER(overpotential of 340 mV@10 mA cm^-2).Further,V-doped CoP nanoparticles used as anode and cathode simultaneously in a cell require only 370 mV to achieve a current density of 10 mA cm^-*** outstanding electrocatalytic activity may be ascribed to the improved conductivity and intrinsic activity owing to phosphating and the doping of V *** addition,the long-term stability of V-doped Co P has been ***,metal doping into transition metal-based phosphides may be a promising strategy for the remarkable bifunctional electrocatalyst for water splitting.

关键词： V element Doping Bifunctional Phosphorization Electrocatalyst Water splitting

CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-lin jiang Bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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用电磁辐射法监测预报矿山采空区顶板稳定性

煤炭学报 2006年第1期31卷 16-19页

作者：王恩元贾慧霖李忠辉何学秋刘贞堂中国矿业大学能源与安全工程学院江苏徐州221008

对坚硬煤岩层的电磁辐射特性进行了实验研究,对煤矿回采过程中煤岩体电磁辐射变化规律进行了监测分析,在此基础上提出了电磁辐射监测预报顶板稳定性的技术方法,并在煤矿进行了试验应用.研究结果表明:在矿山采掘过程中,伴随顶板活动会产... 详细信息

对坚硬煤岩层的电磁辐射特性进行了实验研究,对煤矿回采过程中煤岩体电磁辐射变化规律进行了监测分析,在此基础上提出了电磁辐射监测预报顶板稳定性的技术方法,并在煤矿进行了试验应用.研究结果表明:在矿山采掘过程中,伴随顶板活动会产生明显的电磁辐射信号,顶板垮落前电磁辐射有异常反映,表现为异常增大或呈现增长趋势,用电磁辐射法监测预报顶板垮落是可行的,且具有快捷、方便、准确率高的优点.

关键词：电磁辐射监测预报采空区项板稳定性

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掘进工作面前方电磁辐射分布规律研究

中国矿业大学学报 2007年第2期36卷 142-147页

作者：李忠辉王恩元何学秋刘贞堂晋树青贾慧霖中国矿业大学能源与安全工程学院江苏徐州221008 晋城煤业集团凤凰山矿山西晋城048006

为了研究煤矿掘进工作面前方煤体内不同深度的煤岩电磁辐射分布规律,利用KBD5电磁辐射监测仪对工作面前方煤体电磁辐射进行了现场测试,基于煤岩电磁辐射力电耦合规律,对煤岩变形破裂过程与电磁辐射强度的相关性进行了理论分析.结果表明... 详细信息

为了研究煤矿掘进工作面前方煤体内不同深度的煤岩电磁辐射分布规律,利用KBD5电磁辐射监测仪对工作面前方煤体电磁辐射进行了现场测试,基于煤岩电磁辐射力电耦合规律,对煤岩变形破裂过程与电磁辐射强度的相关性进行了理论分析.结果表明:电磁辐射变化与煤体应力状态有较好的对应关系,工作面煤体内部具有多种应力状态和变形破裂状态.文中给出了比较典型的4种电磁辐射分布类型:煤体长期暴露的电磁辐射分布、防突措施后电磁辐射分布、新揭露煤体电磁辐射分布、有构造煤层的电磁辐射分布.

关键词：掘进工作面电磁辐射分布应力分布煤与瓦斯突出

Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong jianhong Dong Ziwei Fan Mengxian jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China： A Multi-center Study

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Chinese Medical Journal 2015年第20期128卷 2743-2750页

作者： hui-jia lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li jian-Guo Zhou Bing Yi ling Liu Yun-Bing Chen Qiu-Fen Wei hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang lin Li Liu jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang Department of Neonatal Intensive Care Unit Children's Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310053 China Department of Neonatology Anhui Provincial Hospital Hefei Anhui 230001 China Department of Pediatrics Peking University Third Hospital Beijing 100191 China Department of Neonatology BaYi Children's Hospital of the General Military Hospital of Beijing People's Liberation Army Beijing 100000 China Department of Neonatology Children's Hospital of Fudan University Shanghai 200032 China Department of Neonatology Gansu Provincial Maternity and Children-care Hospital Lanzhou Gansu 730050 China Department of Neonatotogy Guiyang Maternal and Child Health Care Hospital Guiyang Guizhou 550003 China Department of Neonatology Women and Children Hospital of Guangdong Province Guangzhou Guangdong 510010 China Department of Neonatology Guangxi Maternal and Child Health Hospital Nanning Guangxi 530003 China Department of Neonatology The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510150 China Department of Neonatology Harbin Children's Hospital Harbin Heilongjiang 150010 China Department of Neonatology Children's Hospital of Hebei Province Shijiazhuang Hebei 050031 China Department of Neonatology Hunan Children's Hospital Changsha Hunan 410007 China Department of Neonatology Hubei Maternity and Child Heath Hospital Wuhan Hubei 430070 China Department of Pediatrics Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Neonatology The First Hospital of Jilin University Changchun Jilin 130021 China Department of Neonatology Jiangxi Provincial Children's Hospital Nanchang Jiangxi 330006 China Department of Pediatric First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China Department of Neonatotogy Nanjing Children's Hospital of Nanjing Medical University Nanjing Jiangsu 320100 China De

Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW）〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.

关键词： Extremely Low Birth Weight Infant Mortality National Survey

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan Zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie jia Jing Zhang Yongzheng Zhang Yunjian Liu Hongzhen lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition