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CCS Chemistry 2024年第9期6卷 2230-2240页

作者： Zhi-Bei Zhou hui-hui sun Qiao-Yan Qi Xin Zhao Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032

Exploring new linkage chemistry is of fundamental significance for covalent organic frameworks(COFs)to expand their structure and functional ***,we report a strategy for converting azine linkage into urea-and thiourea-based fused-ring connections in COFs by criss-cross[3+2]dipolar cycloaddition of azine with HNCO or *** as-prepared COFs with cyclized linkages exhibited enhanced chemical and thermal stability by locking the dynamic C=N linkages in the ***,functions could be introduced into the skeleton of COFs by this postsynthetic cyclization method,which enabled significant improvements in functionality,demonstrated by the studies on CO_(2)/N_(2) selective sorption,proton conduction,and Hg^(2+)*** use of this[3+2]cycloaddition strategy not only enriched the chemistry of linkage conversion for COFs but also offered a new way to fabricate fused-ring-linked COFs,thereby representing a high level of controllability on connectivity and functionality of COFs.

关键词： covalent organic frameworks linkage chemistry structural transformation [3+2]cycloaddition azine

WNT5A modulates cell cycle progression and contributes to the chemoresistance in pancreatic cancer cells

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 529-538页

作者： Wei Wei hui-hui sun Na Li Hong-Yue Li Xin Li Qiang Li Xiao-Hong Shen Department of Pathophysiology School of MedicineNankai University Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer

BACKGROUND： Although there are many studies on the mechanism of chemoresistance in cancers, studies on the relations between WNT5 A and chemoresistance in pancreatic cancer are rare. The present study was to examine the role of WNT5 A in the regulation of cell cycle progression and in chemoresistance in pancreatic cancer tissues and cell ***： Fresh pancreatic cancer and paracarcinoma tissues were obtained from 32 patients. The expressions of WNT5 A,AKT/p-AKT and Cyclin D1 were detected by immunohistochemistry,and the correlation between WNT5 A expression and clinicopathological characteristics was analyzed. The relationship between WNT5 A expression and gemcitabine resistance was studied in PANC-1 and MIAPaCa2 cell lines. The effect of WNT5 A on the regulation of cell cycle and gemcitabine cytotoxicity were investigated. The associations among the expressions of p-AKT,Cyclin D1 and WNT5 A were also analyzed in cell lines and the effect of WNT5 A on restriction-point（R-point） progression was ***： WNT5 A, p-AKT and Cyclin D1 were highly expressed in pancreatic cancer tissues, and the WNT5 A expression was correlated with the TNM stages. In vitroWNT5 A expression was associated with gemcitabine chemoresistance. The percentage of cells was increased in G0/G1 phase and decreased in S phase after knockdown of WNT5 A in PANC-1. WNT5 A promoted Cyclin D1 expression through phosphorylation of AKT which consequently enhanced G1-S transition and gemcitabine resistance. Furthermore, WNT5 A enhanced the cell cycle progression toward R-point through regulation ofretinoblastoma protein（pRb） and pRb-E2 F complex ***： WNT5 A induced chemoresistance by regulation of G1-S transition in pancreatic cancer cells. WNT5 A might serve as a predictor of gemcitabine response and as a potential target for tumor chemotherapy.

关键词： WNT5A pancreatic cancer chemoresistance cell cycle

NiO-Doped Fe_(2)O_(3)/MgO Properties for the Chemical Looping Oxidative Dehydrogenation of Ethane

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 27-33页

作者： Liang Hao Chen Junjie sun Jie sun hui Shenyang Ligong University Shenyang 110159China Fushun Ecology Environment Bureau Qingyuan County Branch Fushun 113399China

Ethane chemical looping oxidative dehydrogenation(CL-ODH)to ethylene is a new technology for ethylene ***_(2)O_(3)/MgO oxygen carrier was prepared using the co-precipitation *** influence of added NiO and its different loadings on Fe_(2)O_(3)/MgO were ***,a series of oxygen carriers were applied in the CL-ODH of the ethane cycle ***-Emmett-Teller(BET),X-ray diffractometry(XRD),X-ray photoelection spectroscopy(XPS),and H2-temperature programmed reduction(TPR)were used to characterize the physicochemical properties of these oxygen *** was confirmed that an interaction between NiO and Fe_(2)O_(3) occurred based on the XPS and H2-TPR *** on the CL-ODH activity performance tests conducted in a fixed-bed reactor,it was revealed that ethylene selectivity was significantly improved after NiO ***_(2)O_(3)-10%NiO/MgO showed the best activity performance with 93%ethane conversion and 50%ethylene selectivity at a reaction temperature of 650℃,atmospheric pressure,and space velocity of 7500 mL/(g·h).

关键词： chemical looping oxidative dehydrogenation oxygen carrier Fe_(2)O_(3)/MgO NiO

Evaluation of the Effectiveness of“5E”Comprehensive Injury Prevention Strategy for Fall Prevention Among the Rural Elderly—Six Pilot Villages,Yunnan Province and Chongqing Municipality,China,2018–2023

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China CDC weekly 2024年第14期6卷 277-281页

作者： Fujin sun Rong Luo hui Han National Center for Women and Children’s Health Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?The mortality rate and disease burden associated with falls among the elderly in China are on the *** can play a crucial role in preventing and managing *** is added by this report?The application of the“5E”injury prevention strategy led to a decrease in both the occurrence of falls and the likelihood of subsequent *** physical activity and maintaining a positive outlook were identified as protective measures against falls,while sleep issues and hearing impairment were found to increase the risk of *** are the implications for public health practice?The group-based comprehensive intervention strategy is crucial as it offers an innovative intervention model and empirical evidence for decreasing fall rates among elderly individuals living in rural areas.

关键词： Chongqing Rural prevention

Deep Reinforcement Learning-Based Task Offloading and Service Migrating Policies in Service Caching-Assisted Mobile Edge Computing

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China Communications 2024年第4期21卷 88-103页

作者： Ke Hongchang Wang hui sun Hongbin Halvin Yang School of Computer Technology and Engineering Changchun Institute of TechnologyChangchun 130012China College of Computer Science and Engineering Changchun University of TechnologyChangchun 130012China Department of Electronic and Electrical Engineering University College LondonLondonUK

Emerging mobile edge computing(MEC)is considered a feasible solution for offloading the computation-intensive request tasks generated from mobile wireless equipment(MWE)with limited computational resources and *** to the homogeneity of request tasks from one MWE during a longterm time period,it is vital to predeploy the particular service cachings required by the request tasks at the MEC *** this paper,we model a service caching-assisted MEC framework that takes into account the constraint on the number of service cachings hosted by each edge server and the migration of request tasks from the current edge server to another edge server with service caching required by ***,we propose a multiagent deep reinforcement learning-based computation offloading and task migrating decision-making scheme(MBOMS)to minimize the long-term average weighted *** proposed MBOMS can learn the near-optimal offloading and migrating decision-making policy by centralized training and decentralized *** and comprehensive simulation results reveal that our proposed MBOMS can converge well after training and outperforms the other five baseline algorithms.

关键词： deep reinforcement learning mobile edge computing service caching service migrating

Towards kernelizing the classifier for hyperbolic data

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Frontiers of Computer Science 2024年第1期18卷 17-31页

作者： Meimei YANG Qiao LIU Xinkai sun Na SHI hui XUE School of Computer Science and Engineering Southeast UniversityNanjing 210096China MOE Key Laboratory of Computer Science and Information Integration(Southeast University) Nanjing 210096China

Data hierarchy,as a hidden property of data structure,exists in a wide range of machine learning applications.A common practice to classify such hierarchical data is first to encode the data in the Euclidean space,and then train a Euclidean ***,such a paradigm leads to a performance drop due to distortion of data embedding in the Euclidean *** relieve this issue,hyperbolic geometry is investigated as an alternative space to encode the hierarchical data for its higher ability to capture the hierarchical *** methods cannot explore the full potential of the hyperbolic geometry,in the sense that such methods define the hyperbolic operations in the tangent plane,causing the distortion of data *** this paper,we develop two novel kernel formulations in the hyperbolic space,with one being positive definite(PD)and another one being indefinite,to solve the classification tasks in hyperbolic *** PD one is defined via mapping the hyperbolic data to the Drury-Arveson(DA)space,which is a special reproducing kernel Hilbert space(RKHS).To further increase the discrimination of the classifier,an indefinite kernel is further defined in the Krein ***,we design a 2-layer nested indefinite kernel which first maps hyperbolic data into the DA spaces,followed by a mapping from the DA spaces to the Krein *** experiments on real-world datasets demonstrate the superiority ofthe proposed kernels.

关键词： data hierarchy hyperbolic cgeometry drury-arveson space krein space

A novel mutation of RPGR in a Chinese family with X-linked retinitis pigmentosa

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1423-1430页

作者： hui-hui sun Jing-Cong Zhao Su-Ling Yang Jin-Dou Shi Yun-Shuo Wei Jian-Cang Wang Feng Gu Lu Chen Children's Hospital of Hebei Province Shijiazhuang 0050000Hebei ProvinceChina Hebei General Hospital Shijiazhuang 050000Hebei ProvinceChina School of Ophthalmology and Optometry Eye HospitalWenzhou Medical UniversityState Key Laboratory Cultivation Base and Key Laboratory of Vision ScienceMinistry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and OptometryWenzhou 325027Zhejiang ProvinceChina

·AIM:To identify potential mutations and elucidate the clinical findings of male patients and female carriers of X-Iinked retinitis pigmentosa(XLRP)in a Chinese family.·METHODS:A four generation pedigree was collected that consisted of 20 *** DNA was extracted from peripheral blood,and then the target fragments were amplified by PCR and sequenced *** addition,all affected patients and female carriers underwent comprehensively ophthalmic evaluation.·RESULTS:A novel mutation c.2865 G>A p.W955 X in RPGR gene was identified of this family,including four affected individuals and eight *** male patients,aging from 7 to 31 y,tended to have more various,even potentially deleterious clinical features of *** the same time,individuals with heterozygous mutations(carriers)manifested a wide spectrum of clinical ***,only two male patients and three female carriers manifested pathological myopia(PM).Among the female carriers,half of subjects who harbor poor visual acuity suffered esotropia or ***,16.7%and 66.7%of carriers had abnormal electroretinogram(ERG)and fundus,respectively.·CONCLUSION:In this study,a novel mutation of the RPGR gene is identified,which broadens the spectrum of RPGR mutations,and elaborates the relationship between genotype and phenotype.

关键词： X-linked retinitis pigmentosa RPGR nonsense mutation phenotype

Ligand-controlled electrochemiluminescence generation from CdSe/CdS/ZnS core/shell/shell quantum dots

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Nano Research 2024年第8期17卷 7776-7785页

作者： hui sun Zhiyuan Cao Haiyan Qin Xiaogang Peng Bin Su Key Laboratory of Excited-State Materials of Zhejiang Province Department of ChemistryZhejiang UniversityHangzhou 310058China

The CdSe/CdS/ZnS core/shell/shell quantum dots(QDs)with strong exciton confinement have manifested themselves as competitive light-emitting materials in electrochemiluminescence(ECL).However,cathodic ECL generation by these QDs requires the injection of electron and hole from solid electrode and electrogenerated radicals(for example SO_(4)•^(−)),which is inevitably influenced by not only the inorganic structure of QDs but also the organic ligands on the *** this work we aimed at studying the impact of surface organic ligands on ECL performance of CdSe/CdS/ZnS *** changing the surface ligand from oleate to acetate,we phenomenologically observed the positive shift of ECL onset potential by ca.200 mV and the increase of ECL intensity by~100 times,suggesting that a short ligand is more favorable for ECL *** further comprehend the ligand effect,we measured the charge injection kinetics using potential-modulated,time-resolved photoluminescence,and thinlayer spectroelectrochemistry *** electron and hole injection into QDs were found to be accelerated by 2–20 times if shortening the ligand from oleate to acetate,confirming the significant impact of surface ligands on ECL performance of *** study is expected to provide guidance on how to design surface functionalized QDs for specific applications such as ECL immunodiagnosis,photocatalysis,and photovoltaics.

关键词： electrochemiluminescence quantum dots spectroelectrochemistry surface ligands charge injection charge transfer

Synthesis,chemical bonding and reactivity of new medium-sized polyarsenides

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Chinese Chemical Letters 2024年第7期35卷 497-501页

作者： Xu-hui Yue Xiang-Wen Zhang hui-Min He Lei Qiao Zhong-Ming sun State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Institution Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Physics Institute of Computational and Applied PhysicsTaiyuan Normal UniversityJinzhong 030619China

Gaining an understanding of the growth mechanism from single atoms to clusters and bulk materials continues to present a ***,it is important to explore the evolving trends of clusters in the structure and properties during the size *** this work,we report the synthesis and characterization of two medium-sized chain-like polyarsenic anions.[As_(21)]^(3-)represents a trimeric example of polyarsenic anion assembled through oxidative coupling of As_(7)^(3-)*** anion As_(18)^(4-)included in[As_(18)MO_(2)(CO)_(8)]^(4-)is regarded as formed by two realgar-type As_(8)subunits connected by a dinuclear AsAs *** As_(18)cluster was previously predicted by theory,and this is the first time successfully synthesized using wet chemistry ***,small-sized polyarsenides As_(2)^(2-)and As_(10)^(2-)were found in compound[K(18-crown-6)]_(3)[As_(10)]_(0.5)[As_(4){Mo(CO)_(3)}_(2)]_(0.5)·*** these,the former exhibits coordination with metal ***-crystal X-ray diffraction combined with quantum chemical calculations revealed the formation of double bonded As_(2)^(2-)stabilized by metal carbonyl *** work demonstrates a novel synthetic approach for the preparation of new polyarsenides and highlights their intriguing bonding characteristics,laying the foundation for the synthesis of such compounds and paving the way for their potential applications.

关键词： Polyarsenide Zintl anions Chain-like cluster DFT calculations AdNDP

The BTB/TAZ domain-containing protein CmBT1-mediated CmANR1 ubiquitination negatively regulates root development in chrysanthemum

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Journal of Integrative Plant Biology 2024年第2期66卷 285-299页

作者： Lian-Da Du Zhang-Ji Guan Yan-Hong Liu hui-Dong Zhu Quan sun Da-Gang Hu Cui-hui sun Shandong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient Production College of Horticulture Science and EngineeringShandong Agricultural UniversityTaian 271018China

Roots are fundamental for plants to adapt to variable environmental *** development of a robust root system is orchestrated by numerous genetic determinants and,among them,the MADS-box gene ANR1 has garnered substantial *** research has demonstrated that,in chrysanthemum,CmANR1positively regulates root system ***,the upstream regulators involved in the CmANR1-mediated regulation of root development remain *** this study,we successfully identified bric-a-brac,tramtrack and broad(BTB)and transcription adapter putative zinc finger(TAZ)domain protein CmBT1 as the interacting partner of CmANR1 through a yeasttwo-hybrid(Y2H)screening ***,we validated this physical interaction through bimolecular fluorescence complementation and pull-down *** assays revealed that CmBT1 exerted a negative influence on root development in *** both in vitro and in vivo assays,it was evident that CmBT1mediated the ubiquitination of CmANR1 through the ubiquitin/26S proteasome *** ubiquitination subsequently led to the degradation of the CmANR1 protein and a reduction in the transcription of CmANR1-targeted gene CmPIN2,which was crucial for root development in *** analysis suggested that CmBT1 modulated root development,at least in part,by regulating the level of CmANR1 ***,these findings shed new light on the regulatory role of CmBT1 in degrading CmANR1 through ubiquitination,thereby repressing the expression of its targeted gene and inhibiting root development in chrysanthemum.

关键词： chrysanthemum MADS-box transcription factor root development