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Impact of baseline steroids on the efficacy of neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3887-3897页

作者： Yuan-Heng Huang guo-Zhen Yang hui-guo chen Xiao-Jun Li Yong-hui Wu Kai Zhang Jian-Nan Xu Jian Zhang Department of Cardiothoracic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Guangdong Esophageal Cancer Institute Guangzhou 510060Guangdong ProvinceChina

BACKGROUND Immunochemotherapy involving the combination of programmed cell death 1/programmed cell death ligand 1 inhibitors with chemotherapy has advanced the treatment of locally advanced esophageal squamous cell carcinoma(ESCC).The use of corticosteroids as pretreatment might reduce immunotherapy *** To investigate the impact of baseline corticosteroid use on neoadjuvant immunochemotherapy(nIC)outcomes in locally advanced ESCC *** Patients with locally advanced ESCC who received nIC at Sun Yat-sen University Cancer Center and the Third Affiliated Hospital of Sun Yat-sen University were *** were divided into dexamethasone and antihistamine groups on the basis of the administered *** efficacy and safety were evaluated,as well as its impact on short-term efficacy[complete pathological response(pCR),major pathological response(MPR)]and long-term efficacy[overall survival(OS),progression-free survival(PFS)]of *** From September 2019 to September 2023,142 patients were *** severe treatment-related adverse events or deaths were *** occurrence was greater in the antihistamine group(P=0.014).Short-term efficacy was not significantly different:The pCR rates were 29.9%and 40.0%,and the MPR rates were 57.9%and 65.7%in the dexamethasone and antihistamine groups,*** long-term efficacy was not significantly different:The 2 years OS rates were 95.2%and 93.5%,and the 2 years PFS rates were 90.3%and 87.8%.Subgroup analysis revealed no difference in OS between the 20 mg dexamethasone group and the<20 mg dexamethasone group,but PFS was significantly greater in the 20 mg dexamethasone group(93.9%vs 56.4%,P=0.001).CONCLUSION Dexamethasone or antihistamines can be used before nIC in locally advanced ESCC without affecting short-or long-term *** 20 mg dexamethasone before nIC may improve PFS in ESCC.

关键词： Esophageal squamous cell carcinoma Neoadjuvant immunochemotherapy Dexamethasone Antihistamines Treatment efficacy

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Clinical characteristics of sudden hearing loss during pregnancy

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 165-172页

作者： Xiao-Nan Wu Hong-Yang Wang Xiao-Long Zhang guo-hui chen Jing Guan Yun Gao Da-Yong Wang Qiu-Ju Wang Senior Department of Otolaryngology-Head&Neck Surgery The Sixth Medical Center of PLA General HospitalChinese PLA Medical SchoolBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina

Objective:The objective of this study was to explore the clinical characteristics and management of sudden hearing loss(HL)during pregnancy,thus better guiding the clinical ***:The clinical and follow-up data of 17 patients(17 ears)with sudden HL during pregnancy were analyzed retrospectively(the observe group).Twelve nonpregnant female patients(12 ears)with sudden HL of similar clinical characteristics were selected as the control *** prognosis of the two groups was *** the patients were followed up after delivery,and two of them were readmitted to the hospital 1–2 months after ***:The observe group had better improvement in hearing and a higher response rate compared to the control *** pure tone hearing and speech recognition rate of patients could still be improved after the readmitted treatment,and the hearing could partially recover spontaneously during *** laboratory indicators that affect the inflammatory response and coagulation pathway were significantly different between the two ***:The hearing condition of sudden HL during pregnancy is severe,and the prognosis of these patients is better than nonpregnant patients of similar clinical *** treatment is still effective,and some patients showed self-healing with time during *** inflammatory response and coagulation function may affect the hearing of patients through a metabolic pathway.

关键词： management pregnancy prognosis sudden hearing loss

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Primary small cell esophageal carcinoma,chemotherapy sequential immunotherapy:A case report

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World Journal of Clinical Cases 2021年第22期9卷 6478-6484页

作者： Yong-hui Wu Kai Zhang hui-guo chen Wei-Bin Wu Xiao-Jun Li Jian Zhang Department of Cardiothoracic Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Thoracic Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Primary small cell esophageal carcinoma(PSCEC)is aggressive and rare,with a worse prognosis than other subtypes esophageal *** definitive and optimum standard guidelines are established for treating ***,we report a case of PSCEC,including a current literature review of *** SUMMARY A 79-year-old male was diagnosed PSCEC with multiple lymph node metastasis thorough computed tomography,positron emission tomography-computed tomography,endoscopy and *** was not suitable for this *** was treated with etoposide 100 mg/m2 and cisplatin 25 mg/m2 on days 1-3,every 3 wk for 4 *** tumor and lymph nodes became smaller and dysphagia and vomiting symptoms *** patient could not tolerate subsequent chemotherapy(CT)because of hematological toxicity;therefore,we performed immunotherapy(durvalumab,1500 mg)every 4 *** present the patient has received 12 cycles immunotherapy over about 1 *** is still receiving treatment and *** PSCEC with multiple lymph nodes metastasis does not always indicate *** may extend survival time and improve the quality of life in the absence of *** or immunotherapy plus CT may also work as a treatment for PSCEC.

关键词： Primary small cell esophageal carcinoma Diagnosis Chemotherapy Immunotherapy Case report

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Combining surgery with 125I brachytherapy for recurrent mediastinal dedifferentiated liposarcoma: A case report and review of literature

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World Journal of Clinical Cases 2020年第5期8卷 939-945页

作者： hui-guo chen Kai Zhang Wei-Bin Wu Yong-hui Wu Jian Zhang Li-Jia Gu Xiao-Jun Li Department of Cardiothoracic Surgery the Third Affiliated Hospital of Sun Yat-sen University

BACKGROUND Dedifferentiated liposarcoma in the mediastinum is an extremely rare malignant neoplasm.A few previous case reports indicate that surgical resection is the major treatment,but frequent recurrence occurs *** to its rarity,its clinical characteristics,optimal treatment and clinical outcomes remain ***,we report a case of multifocal recurrent dedifferentiated liposarcoma in the posterior mediastinum treated by combining surgery with 125I brachytherapy,and summarize its clinical features,treatment and *** SUMMARY A 75-year-old man was admitted to our hospital with a history of gradual dysphagia for one year and aggravated dysphagia for 3 ***-enhanced computed tomography(CT)revealed several large cystic-solid masses with lipomatous density,and calcification in the posterior-inferior *** patient received a wide excision by video-assisted thoracoscopic *** analysis confirmed the tumors were dedifferentiated *** tumor locally relapsed 24 mo later,and another operation was performed by video-assisted thoracoscopic *** months after the second surgery,the tumor recurred again,and the patient received CT-guided radioactive seeds 125I *** 8 mo,follow-up chest CT showed an enlarged ***,his condition exacerbated with severe dysphagia and dyspnea,and he died of respiratory failure in July *** We reviewed the literature,and suggest that surgical resection provides beneficial effects for dedifferentiated liposarcoma in the mediastinum,even in cases with local recurrence.125I brachytherapy may be beneficial for recurrent unresectable patients.

关键词： Dedifferentiated liposarcoma Mediastinal neoplasms Recurrence Reoperation 125I brachytherapy Case report

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Synthesis and Enhanced Acetone-sensing Properties of Ordered Large-pore Mesoporous Nickel Oxides with Ultrathin Crystalline Frameworks

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Chemical Research in Chinese Universities 2024年第3期40卷 521-528页

作者： SHAO chen guo Ru LI hui WANG Xiaozhong YANG Qingfeng LAI Xiaoyong State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021P.R.China

Acetone is a tracer for monitoring air quality and a potential breath maker for diabetes. It remains a great challenge for current portable sensors to sensitively and selectively detect acetone at low-ppb (part per billion) level. Herein, we present an ordered mesoporous nickel oxide (NiO) with both large mesopores and ultrathin crystalline frameworks for the detection of low-ppb acetone. The ordered mesoporous NiO replicas with predominant large mesopores of 11 nm, high specific surface areas of 121–128 m2/g and ultrathin crystalline frameworks of 5 nm were synthesized by the nanocasting method and the crystalline properties of NiO frameworks were adjusted by changing the annealing temperature from 300℃ to 750℃, which resulted in different contents of oxygen deficient on the surface of ultrathin frameworks. The gas-sensing properties for all the NiO samples were investigated and the ordered large-pore mesoporous NiO (NiO-600) with maximum oxygen deficient obtained at 600℃ exhibited the highest response (R_(gas)/R_(air)−1=2.9) toward acetone (1 ppm, ppm: part per million), which is 3.4 and 30 times larger than those for common mesoporous NiO obtained at 300℃ and bulk NiO. Notably, a low detection limit (2 ppb), good selectivity and cycling stability were also observed in NiO-600.

关键词： Mesoporous semiconductor NiO Gas sensing Acetone

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Controls on the organic carbon content of the lower Cambrian black shale in the southeastern margin of Upper Yangtze

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Petroleum Science 2018年第4期15卷 709-721页

作者： Yu-Ying Zhang Zhi-Liang He Shu Jiang Shuang-Fang Lu Dian-Shi Xiao guo-hui chen Jian-Hua Zhao School of Geosciences China University of Petroleum (East China) Petroleum Exploration and Production Research Institute SINOPEC Energy and Geoscience Institute University of Utah

Control of various factors, including mineral components, primary productivity and redox level, on the total organic carbon(TOC) in the lower Cambrian black shale from southeastern margin of Upper Yangtze(Taozichong, Longbizui and Yanbei areas) is discussed in detail in this article. Mineral components in the study strata are dominated by quartz and clay minerals. Quartz in the Niutitang Formation is mainly of biogenic origin, and the content is in positive correlation with TOC, while the content of clay minerals is negatively correlated with TOC. Primary productivity, represented by the content of Mobio(biogenic molybdenum), Babio(biogenic barium) and phosphorus, is positively correlated with TOC. The main alkanes in studied samples are nCC, and odd–even priority values are closed to 1(0.73–1.13), which suggest the organic matter source was marine plankton. Element content ratios of U/Th and Ni/Co and compound ratio Pr/Ph indicate dysoxic–anoxic bottom water, with weak positive relative with TOC. In total, three main points can be drawn to explain the relationship between data and the factors affecting organic accumulation:(1) quartz-rich and clay-mineral-poor deep shelf–slope–basin environment was favorable for living organisms;(2) high productivity provided the material foundation for organic generation;(3) the redox conditions impact slightly on the content of organic matter under high productivity and dysoxic–anoxic condition.

关键词： Upper Yangtze Lower Cambrian Black shale Total organic carbon

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ANALYSIS ON POVERTY IN MOUNTAIN AREAS BASED ON OFF-FARM INDUSTRIES

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Chinese Geographical Science 2003年第4期13卷 359-363页

作者： WANG Qing, LI hui-xia, chen guo-jie, chen Yong(Institute of Mountain Hazards and Environment,Chinese Academy of Sciences,chengdu 610041,P. R. China) Institute of Mountain Hazards and Environment Chinese Academy of Sciences Chengdu P. R. China

This paper reveals that agricultural growth trend in China is strongly correlated with the growth of off-farm industries-the curve of net income from off-farm industries reflects the general characteristics of net income of households. That means the increase of net income of farm households is chiefly from off-farm industries,more than from agriculture. The authors therefore conclude that the "poverty" in mountain areas or the gap between mountain areas and plain areas lies in the underdevelopment of off-farm industries in mountain areas. Finally,the authors make suggestions of strategic adjustment of economic structure: 1) present situation of mountain areas in China should be fully considered; 2) a full industrial system is not our desire; 3) advantageous industries should be promoted to create famous products; 4) industrialization and urbanization in mountain areas should be promoted and so on.

关键词： regional developmental difference off-farm industry per capita net income mountain areas of China

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Regulations of m^(6)A and other RNA modifications and their roles in cancer

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Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-hui chen Kun-Xiong guo Jing Li Shu-hui Xu huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

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Emerging direct current triboelectric nanogenerator for high-entropy mechanical energy harvesting

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Science China(Technological Sciences) 2024年第5期67卷 1297-1316页

作者： chen Jie guo RuiLong guo HengYu College of Physics and Electronic Engineering Chongqing Normal UniversityChongqing 401331China Department of Applied Physics Chongqing UniversityChongqing 401331China

In the era of the Internet of Things(IoT),the provision of sustainable power to distributed,mobile,and low-power-consumption electronic devices is a critical *** overcome this challenge,the triboelectric nanogenerator(TENG),a highly efficient high-entropy mechanical energy harvesting device,was developed in *** device enables the direct conversion of irregular and low-frequency mechanical energy into pulsed alternating current(AC)***,the incompatibility of most electronic devices with AC signals necessitates rectifier circuits or generators that deliver direct current(DC)*** recent years,DC-TENGs have undergone extensive development,achieving significant milestones in various application fields while also facing crucial challenges that require *** this review,three categories of DC-TENG devices with distinct operating mechanisms are comprehensively explored:multiphase coupling,mechanical rectification,and air *** typical structures and working mechanisms are thoroughly discussed,and specific output performance limitations,along with corresponding optimization strategies,are ***,the applications of DC-TENGs in various scenarios are ***,the challenges faced by DC-TENGs and potential solutions are analyzed to guide further advancements in this technology.

关键词： TENG direct current working mechanisms output performance limitations optimization strategies

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Screening for Bioactive Compounds from Mulberry Leaves Combining Bio-Affinity Ultrafiltration with α-Glucosidase and Pancreatic Lipase

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Journal of Analysis and Testing 2024年第3期8卷 315-326页

作者： hui Zhang Guilin chen Yongli Zhang Felix Wambua Muema Jun Ding Mingquan guo CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo Cixi Institute of Biomedical Engineering

With the growing prevalence of diabetes and obesity worldwide, the role of α-glucosidase and lipase inhibitors has gained increasing concentration. Mulberry, a functional medicinal and edible plant, has been reported extensively in alleviating both diabetes and obesity. However, there is still a lack of refined research on its active ingredients and mechanisms. In our study, the inhibitory activities of mulberry leaf against α-glucosidase and pancreatic lipase reached 191.37 ± 14.46 and 775 ± 68.60 μg/mL, respectively. Meanwhile, it also promoted glucose consumption in the HepG2 cells model. Subsequently,four α-glucosidase ligands and four pancreatic lipase ligands were identified through bio-affinity ultrafiltration combined with liquid-chromatography-mass spectrometry(UF-HPLC–MS/MS). In vitro inhibition assays confirmed the inhibitory potential of these representative ligands. Molecular docking suggested that these possible ligands could be inserted into the active pocket of the target enzyme through multiple intermolecular forces. Our findings indicated that the polyphenols in mulberry leaves may contribute significantly to their hypoglycemic and hypolipidemic properties. Furthermore, our study provides valuable insights for the screening of active ingredients in other medicinal and edible plants, which could help in the development of new therapies for diabetes and obesity.

关键词： Bio-affinity ultrafiltration Diabetes Mulberry leaves Obesity

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