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Research in Astronomy and Astrophysics 2018年第1期18卷 1-10页

作者： Gui-Yun Liang hui-gang wei Da-wei Yuan Fei-Lu Wang Ji-Min Peng Jia-Yong Zhong Xiao-Long Zhu Mike Schmidt Günter Zschornack Xin-Wen Ma gang Zhao Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Astronomy Beijing Normal University Beijing 100875 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China DREEBIT GmbH 01109 Dresden Germany

Spectra are fundamental observation data used for astronomical research,but understanding them strongly depends on theoretical models with many fundamental parameters from theoretical *** models give different insights for understanding a specific ***,laboratory benchmarks for these theoretical models become *** electron beam ion trap is an ideal facility for spectroscopic benchmarks due to its similar conditions of electron density and temperature compared to astrophysical plasmas in stellar coronae,supernova remnants and so *** this paper,we will describe the performance of a small electron beam ion trap/source facility installed at National Astronomical Observatories,Chinese Academy of *** present some preliminary experimental results on X-ray emission,ion production,the ionization process of trapped ions as well as the effects of charge exchange on the ionization.

关键词： X-ray:general atomic processes line:formation method:laboratory:atomic

Laboratory astrophysics with laser-driven strong magnetic fields in China

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High Power Laser Science and Engineering 2016年第3期4卷 67-70页

作者： Fei-Lu Wang Xiao-Xing Pei Bo Han hui-gang wei Da-wei Yuan Gui-Yun Liang gang Zhao Jia-Yong Zhong Zhe Zhang Bao-Jun Zhu Yan-Fei Li Fang Li Yu-Tong Li Si-Liang Zeng Shi-Yang Zou Jie Zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Astronomy Beijing Normal University Beijing National Laboratory of Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Institute of Applied Physics and Computational Mathematics Shanghai Jiao Tong University

In this paper, the recent studies of laboratory astrophysics with strong magnetic fields in China have been *** the Shenguang-II laser facility of the National Laboratory on High-Power Lasers and Physics, a laser-driven strong magnetic field up to 200 T has been achieved. The experiment was performed to model the interaction of solar wind with dayside magnetosphere. Also the low beta plasma magnetic reconnection(MR) has been studied. Theoretically, the model has been developed to deal with the atomic structures and processes in strong magnetic field. Also the study of shock wave generation in the magnetized counter-streaming plasmas is introduced.

关键词： Laboratory astrophysics laser strong magnetic fields

GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： wei JU Yiyang GU Zhengyang MAO Ziyue QIAO Yifang QIN Xiao LUO hui XIONG Ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang Jian Wu hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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浅谈高速公路养护施工安全管理措施

价值工程 2018年第28期37卷 80-81页

作者：惠钢伟陕西西禹高速公路有限公司西安710000

进入新时期后,各地都在着眼于建设规模较大的高速路,而与之相应的高速路养护举措也获得了突显的优化与改进。然而不应忽视,当前仍有某些部门倾向于忽视全方位的高速路日常养护,以至于埋下了潜在性的公路运行隐患。在情形严重时,高速路... 详细信息

进入新时期后,各地都在着眼于建设规模较大的高速路,而与之相应的高速路养护举措也获得了突显的优化与改进。然而不应忽视,当前仍有某些部门倾向于忽视全方位的高速路日常养护,以至于埋下了潜在性的公路运行隐患。在情形严重时,高速路还可能表现为多种多样的行车事故,进而显著威胁到最根本的交通安全。由此可见,有关部门针对高速公路有必要施行全过程的公路养护施工,因地制宜探求可行性的安全管理举措。

关键词：高速公路养护施工安全管理措施

TRRE发动机关键技术分析及推进性能探索研究

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推进技术 2017年第2期38卷 298-305页

作者：韦宝禧凌文辉冮强魏祥庚秦飞何国强北京动力机械研究所高超声速冲压发动机技术重点实验室北京100074 西北工业大学燃烧热结构与内流场重点实验室陕西西安710072

对TRRE发动机关键技术难点及技术途径进行了初步分析,对北京动力机械研究所原理样机研制进展进行了简要介绍,并结合原理样机流道设计与数值仿真研究获得的性能数据,开展了TRRE发动机推进性能探索研究,初步验证了TRRE发动机在兼具加速、... 详细信息

对TRRE发动机关键技术难点及技术途径进行了初步分析,对北京动力机械研究所原理样机研制进展进行了简要介绍,并结合原理样机流道设计与数值仿真研究获得的性能数据,开展了TRRE发动机推进性能探索研究,初步验证了TRRE发动机在兼具加速、巡航、机动等方面的性能优势。研究结果表明,在适当兼顾低马赫数大推力需求和Ma=6纯冲压工况高比冲需求的情况下,发动机在宽马赫数工作范围具有较大范围、灵活便捷的推力调节能力,可满足高低速通道平稳接力需求,表现出极具优势的加速、机动飞行和高马赫数巡航的适应性。

关键词：临近空间及空天飞行器组合发动机性能分析

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai Xiang Wen-hui wei Shu-hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-wei Wang Jing-Shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： Yi Jing Xin-Ran Liu Xing-Hua Wang hui Han Sha-Sha Liang Xi-Meng Chen Dong-hui wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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