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Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong Wen-Jian zhu Yi-Fan hui Wen-Li Qiu Yan Wu Xuan Li Fei Ke Liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

Characterization and correlation of engineering properties with microstructure in peanuts:A microscopic to macroscopic analysis

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Journal of Integrative Agriculture 2025年第1期24卷 339-352页

作者： Fei Xiang Zhenyuan Li Yichen Zheng Caixia Ding Benu Adhikari Xiaojie Ma Xuebing Xu Jinjin zhu Bello Zaki Abubakar Aimin Shi hui Hu Qiang Wang Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Comprehensive Utilization Laboratory of Cereal and Oil ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193China Wilmar(Shanghai)Biotechnology Research&Development Center Co. Ltd.Shanghai 200137China School of Science RMIT UniversityMelbourne 3083VICAustralia School of Food Science and Engineering Nanjing University of Finance and Economics/Jiangsu Modern Food Circulation and Safety Collaborative Innovation CenterNanjing 210023China College of Food Science and Pharmacy Xinjiang Agricultural UniversityUrumqi 830052China Department of Agricultural Extension and Rural Development Faculty of AgricultureUsmanu Danfodiyo UniversitySokoto 840101Nigeria

Peanut varieties are diverse globally,with their characters and nutrition determining the product ***,the comparative analysis and statistical analysis of key quality indicators for peanut kernels across the world remains relatively limited,impeding the comprehensive evaluation of peanut quality and hindering the industry development on a global *** study aimed to compare and analyze the apparent morphology,microstructure,single-cell structure,engineering and mechanical properties,as well as major nutrient contents of peanut kernels from 10 different cultivars representing major peanut-producing *** surface and cross-section microstructure of the peanut kernels exhibited a dense“blocky”appearance with a distinct cellular *** lipid droplets were predominantly spherical with a regular distribution within the *** single-cell structure of the kernels from these 10 peanut cultivars demonstrated varying morphologies and dimensions,which exhibited correlations with their mechanical and engineering ***,the mass loss versus temperature profiles of the peanut kernels revealed five distinct stages,corresponding to moisture loss,volatile loss,protein denaturation,and the degradation of various *** were also observed in the lipid,protein,and sucrose contents,texture,bulk density,true density,porosity,geometric mean diameter,and sphericity among the diferent peanut *** study establishes relationships and correlations among microstructure,engineering properties,and nutritional composition of commonly grown peanut varieties in major peanut-processing *** findings provide valuable insights into peanut quality evaluation,empowering the peanut industry to enhance their processing and product development efforts.

关键词： peanut kernels apparent morphology microstructure engineering properties mechanical properties

藏东南林线过渡带不同植被类型对土壤团聚体稳定性的影响

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草地学报 2025年第1期33卷 98-106页

作者：朱思洁张波付芳伟丁慧慧郭亮娜李江荣西藏农牧学院高原生态研究所西藏林芝860000 西藏高原森林生态教育部重点实验室西藏林芝860000 西藏林芝高山森林生态系统国家野外科学观测研究站西藏林芝860000 安徽农业大学资源与环境学院安徽合肥230000 中国科学院青藏高原研究所青藏高原地球系统与资源环境国家重点实验室北京100101

土壤团聚体结构对于维护土壤生态系统的稳定性和功能至关重要。为探究林线过渡带这一特殊区域内乔木、灌木和草甸等植被类型对土壤团聚体稳定性的影响,本研究以藏东南色季拉山阳坡的方枝柏林线过渡带为研究区,采用干筛法研究了急尖长苞... 详细信息

土壤团聚体结构对于维护土壤生态系统的稳定性和功能至关重要。为探究林线过渡带这一特殊区域内乔木、灌木和草甸等植被类型对土壤团聚体稳定性的影响,本研究以藏东南色季拉山阳坡的方枝柏林线过渡带为研究区,采用干筛法研究了急尖长苞冷杉林、方枝柏林、雪层杜鹃林和草甸4种植被类型下土壤团聚体的组成及土壤理化指标对团聚体稳定性的影响。结果表明:在4种不同植被类型下,粒径>0.25 mm的土壤团聚体含量显著高于<0.25 mm的团聚体含量;草甸和灌木林土壤团聚体稳定性始终高于乔木林,0~10 cm土层中方枝柏林土壤团聚体稳定性最差,10~20 cm土层中急尖长苞冷杉林土壤团聚体稳定性最差;土壤的多种理化性质共同作用于土壤团聚体的组成,进而对其稳定性产生显著影响。具体而言,土壤pH值越低、容重越小、有机质含量越高、毛管持水量越大或孔隙度越大,土壤团聚体稳定性就越好。本研究结果为深入了解高海拔山区土壤质量和结构提供了数据支撑。

关键词：植被类型林线过渡带干筛法团聚体稳定性

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针灸治疗慢性胃炎临床方法对比分析

针刺研究 2004年第4期29卷 310-313页

作者：马惠芳马文珠郭长青北京中医药大学针灸学院北京100029

本文就近 1 0年来针灸治疗慢性胃炎概况进行了综合分析与归纳 ,并对针灸治疗本病的疗效与安全性评价、针灸治疗规律及针灸临床研究重点进行了分析 ,以期为临床更好地治疗慢性胃炎提供参考资料。

关键词：慢性胃炎针灸疗法综合疗法安全性

Dual-Mode Colorimetric and Fluorescent Detection of Tumor Cells Based on Gold Nanoparticles-Loaded Phosphine Covalent Organic Frameworks

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Journal of Analysis and Testing 2025年第01期 21-31页

作者： Bilian Li Min Zhou Chun Zhao Lin Xiao Tianle Qi Hanbin Xu Linjiang Guo Guobao Ning Xiaokang Lu Keming zhu hui Zhao Can-Peng Li School of Chemical Science and Technology Yunnan University Affiliated Hospital of Yunnan University School of Life Science Yunnan University Laboratory for Conservation and Utilization of Bioresource Yunnan University

Circulating tumor cells(CTCs) are important markers for cancer. The part of tumor cells that are detached from the primary tumor or metastatic tumor and enter the blood circulation is called CTCs. It is crucial to develop a rapid, accurate, and easy-to-implement diagnostic system for CTCs for early tumor diagnosis and for monitoring progression of the disease. In this work, we reported a colorimetric and fluorescent dual-mode assay for the detection of CTCs. Our assay used magnetic nanoparticles and aptamer for CTCs capture and gold nanoparticles-loaded covalent organic frameworks(Au@COFs) for signal amplification, respectively. The magnetic nanoparticles were modified with folic acid to capture CTCs by interaction between folic acid and the folate receptor overexpressed on the surface of tumor cells. The covalent organic frameworks were engineered to have both nitro-reductase-like and glucose–oxidase-like activities. The nitro-reductase-like activity converted the substrate p-nitrophenol to p-nitroaniline for colorimetric detection, and the glucose-oxidase-like activity enabled fluorescence detection. Specifically, Au@COFs catalyzed glucose oxidation and generated hydrogen peroxide to oxidize Fe 2+to Fe 3+, which converted MIL(Al)-MOF to MIL(Fe)-MOF through ion exchange, resulting in the fluorescence quenching of MIL(Al)-MOF. Our assay showed high sensitivity with a detection limit of 17 cells/mL using MCF-7 cells as model cancer cells. This work provided an e fficient and ultrasensitive strategy for CTCs detection and has potential applications in cancer identification and diagnosis. Dual-mode detection system, combining colorimetric and fluorescent signals, integration of magnetic nanoparticles and aptamers for CTC capture, and utilization of covalent organic frameworks loaded with gold nanoparticles for signal amplification can improve sensitivity and accuracy.

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Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 322-322页

作者： Jing zhu Duy Nguyen Hong Ouyang Xiao-hui Zhang Xiao-Ming Chen Kang Zhang Department of Ophthalmology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Department of Ophthalmology and Shiley Eye Center and Institute for Genomic Medicine University of California San Diego La Jolla CA 92093 USA Beijing Institute of Ophthalmology Beijing Tongren Eye Center Capital Medical University Beijing 100005 China

We ourselves recently reviewed our article published in Int J Ophthalmol entitled“Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-βin ARPE-19”and would... 详细信息

关键词： submit Ophthal matrix

Macrophage scavenger receptor A1 promotes skeletal muscle regeneration after hindlimb ischemia

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Journal of Biomedical Research 2025年第1期39卷 23-35页

作者： Siying Wang Saiya Wang Wenhan Cai Jie Wang Jianan Huang Qing Yang hui Bai Bin Jiang Jingjing Ben Hanwen Zhang Xudong zhu Xiaoyu Li Qi Chen Department of Pathophysiology Key Laboratory of Targeted Intervention of Cardiovascular Disease and Molecular InterventionCollaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingJiangsu 211166China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

The macrophage-mediated inflammatory response is crucial for the recovery of skeletal muscle following ***,macrophage-based therapeutic targets need to be explored for ischemic *** the current study,we found that the mRNA levels of scavenger receptor A1(Sr-a1)were elevated in patients with critical limb ischemia,based on an analysis of the Gene Expression Omnibus *** then investigated the role and underlying mechanisms of macrophage SR-A1 in a mouse hindlimb ischemia(HLI)*** with the Sr-a1^(fl/fl)mice,the Lyz^(Cre+)/Sr-a1^(flox/flox)(Sr-a1~(ΔMΦ))mice showed significantly reduced laser Doppler blood flow in the ischemic limb on day seven after ***,histological analysis revealed that the ischemic limb of the Sr-a1~(ΔMΦ)mice exhibited more severe and prolonged necrotic morphology,inflammation,fibrosis,decreased vessel density,and delayed regeneration than that of the control Sr-a1~(fl/fl)***,restoring wild-type myeloid cells to the Sr-a1 knockout mice effectively improved the Doppler perfusion in the ischemic limb and mitigated skeletal muscle damage seven days after *** with these in vivo findings,co-cultivating macrophages with the mouse myoblast cell line C2C12 revealed that the Sr-a1^(-/-)bone marrow macrophages significantly inhibited myoblast differentiation in ***,SR-A1 enhanced the skeletal muscle regeneration in response to HLI by inhibiting oncostatin M production via suppression of the NF-κB signaling *** findings indicate that SR-A1 may be a promising candidate protein to improve tissue repair and regeneration in peripheral ischemic arterial disease.

关键词： scavenger receptor A1 macrophage hindlimb ischemia oncostatin M

Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-zhu Liu Zhi-Cong Xiao Jing-hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis TypeⅡdiabetes mellitus

不同结构苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物的性能研究

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橡胶工业 2025年第3期72卷 177-184页

作者：方辉中石化湖南石油化工有限公司橡胶部湖南岳阳414014

研究不同结构苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物(SEBS)的性能。结果表明:常规SEBS YH-503和YH-602的加工流动性差;在加入聚丙烯的条件下,线性结构充油YH-503的拉伸强度较大,适用于要求强度较高的制品,星形结构充油YH-602的弹性和加工... 详细信息

研究不同结构苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物(SEBS)的性能。结果表明:常规SEBS YH-503和YH-602的加工流动性差;在加入聚丙烯的条件下,线性结构充油YH-503的拉伸强度较大,适用于要求强度较高的制品,星形结构充油YH-602的弹性和加工性能较好,适用于弹性要求较高的制品;苯乙烯-丁二烯-苯乙烯嵌段共聚物氢化前聚丁二烯链段高1,2-结构含量(高于60%)的SEBS的拉伸强度适中、弹性好、熔体流动速率较大,无需充油即可加工应用;分子中间链段苯乙烯与丁二烯无规共聚的SEBS的硬度和拉伸强度较大,熔体流动性和透明性优良,与无机填料和有机极性材料相容性好;随着苯乙烯单体含量升高,分子链两端不含聚苯乙烯嵌段的氢化苯乙烯-丁二烯无规共聚物的SEBS的拉伸强度和拉断永久变形减小,该结构SEBS/乙烯-醋酸乙烯共聚物发泡材料具有高弹性、压缩变形和热收缩率小的特点。

关键词：苯乙烯-乙烯-丁烯-苯乙烯嵌段共聚物分子结构拉伸性能熔体流动速率