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miRNA-103: Molecular link between insulin resistance and nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第2期21卷 511-516页

作者： Qian Xu Ying Li Yong-fang Shang hui-Ling Wang Min-Xiu yao Department of Endocrinology the Second Affiliated Hospital of Medical College of Qingdao University

AIM: To investigate the associations between miRNA-103(mi R-103) and insulin resistance and nonalcoholic fatty liver disease(NAFLD).METHODS: Serum samples were collected from 50 NAFLD patients who were overweight or obese(NAFLD group) and from 30 healthy subjects who served as controls(normal control group). Quantitative polymerasechain reaction was used to detect expression of mi R-103. Fasting plasma glucose, fasting insulin, and triglyceride(TG) levels were measured. Homeostasis model assessment was used to evaluate basal insulin resistance(HOMA-IR). Patient height and weight were measured to calculate body mass index(BMI).RESULTS: Compared with the normal control group, higher serum levels of mi R-103 were expressed in the NAFLD group(8.18 ± 0.73 vs 4.23 ± 0.81, P = 0.000). When P = 0.01(bilateral), mi R-103 was positively correlated with HOMA-IR(r = 0.881), TG(r = 0.774) and BMI(r = 0.878), respectively. mi R-103, TG and BMI were all independent factors for HOMAIR(β = 0.438/0.657/0.251, P = 0.000/0.007/0.001). mi R-103, TG, BMI and HOMA-IR were all risk factors for NAFLD(odds ratio = 2.411/16.196/1.574/19.11, P = 0.009/0.022/0.01/0.014).CONCLUSION: mi R-103 is involved in insulin resistance and NAFLD, and may be a molecular link between insulin resistance and NAFLD and a therapeutic target for these disorders.

关键词： mi RNA-103 Insulin resistance Nonalcoholic fatty l

Neighborhood diversity structure and neighborhood species richness effects differ across life stages in a subtropical natural secondary forest

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Forest Ecosystems 2022年第6期9卷 790-801页

作者： Haonan Zhang Shuifei Chen Xiao Zheng Xiaomin Ge yao Li Yanming fang Peng Cui hui Ding Research Center for Nature Conservation and Biodiversity State Environmental Protection Scientific Observation and Research Station for Ecology and Environment of Wuyi MountainsState Environmental Protection Key Laboratory on BiosafetyNanjing Institute of Environmental SciencesMinistry of Ecology and Environment of China(MEE)Nanjing210042China Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentKey Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity ConservationNanjing Forestry UniversityNanjing210037China

Natural secondary forest has a strong capacity to regrow naturally and recover biodiversity rapidly on abandoned ***,at the neighborhood scale,which can truly reflect the facilitative or competitive interactions among individual plants,the local diversity spatial structure in secondary forest and the feedback effects of neighborhood diversity on natural regeneration remain unclear,and this may be the key to properly understand the mechanisms of natural secondary forest species diversity *** this end,this study established a dynamic plot in a rehabilitated secondary forest after disturbance and conducted a comprehensive survey of 68,336 individual plants with repeated measurements at 5-year interval to assess the characteristics of neighborhood diversity structure across life history stages and link the neighborhood species richness(NSR)effect translated by species interactions at species diversity structure with individual trees recruitment/mortality in secondary forest *** results showed that,compared with tropical and temperate natural forests,a higher proportion of diversity accumulators and a lower proportion of repellers in subtropical secondary forests resulted in neighborhood diversity structures characterized by heterospecific or high-diversity patches,which are beneficial to the maintenance or restoration of *** an important supplement to the research on the relationship between diversity and productivity,our findings show a positive diversity-survival relationship in subtropical secondary ***,we observed that the neighborhood diversity structure exhibited a trend of accumulator-dominated to neutral-dominant changes with life stage from sapling to adult,which,in turn,determined the direction and strength of NSR effects on recruitment/***,diverse local neighborhoods at a later successional stage characterized with‘neutral’species-species interactions can act as a‘welfare net’by off

关键词： Secondary forest restoration Individual species area relationship Diversity accumulator species Neighborhood species richness effect Life history stages Heterospecific crowding

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高温下HMX热分解反应分子动力学模拟

原子与分子物理学报 2025年第2期42卷 105-110页

作者：陈芳贾方硕陈瑶李天浩郭国琦董羚中北大学化学与化工学院太原030051

本文采用ReaxFF-lg反应分子动力学方法研究了奥克托金(HMX)在六种不同温度下的初始反应热分解过程,验证了ReaxFF-lg势函数对HMX体系的适用性,计算了不同温度下HMX体系势能、总物种演化趋势、初始反应产物以及指前因子和活化能.结果表明,... 详细信息

本文采用ReaxFF-lg反应分子动力学方法研究了奥克托金(HMX)在六种不同温度下的初始反应热分解过程,验证了ReaxFF-lg势函数对HMX体系的适用性,计算了不同温度下HMX体系势能、总物种演化趋势、初始反应产物以及指前因子和活化能.结果表明,HMX热分解过程主要有三种初始分解机理:N-NO_(2)键的断裂,HONO的解离和主环上C-N键的断裂,计算得到的初始分解阶段活化能Ea和指前因子ln(A),与实验值相吻合.

关键词： HMX 反应分子动力学(RMD) ReaxFF-lg 热分解温度

Immunomodulation of artemisinin and its derivatives

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Science Bulletin 2016年第18期61卷 1399-1406页

作者： Wenbo yao Feng Wang hui Wang Key Laboratory of Food Safety Research Institute for Nutritional Sciences Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences School of Life Science and Technology ShanghaiTech University Key Laboratory of Food Safety Risk Assessment Ministry of Health

In the 1970 s, artemisinin(‘‘qinghaosu'' in Chinese), a sesquiterpene lactone with an unusual peroxide bridge, was isolated from Artemisia annua L. It showed promising antimalarial activity, particularly by eliminating parasites resistant to chloroquine. For more than 30 years,artemisinin has contributed to worldwide health as a new type of antimalarial drug. Artemisinin and its analogs, such as dihydroartemisinin, artemether, artesunate, artemiside,artemisone, and arteether, possess not only potent antimalarial activity but also anti-viral, antifungal, anticancer,and anti-inflammatory properties. In this review, we discuss the current understanding of how artemisinin and its analogs affect the immune system and immune-related diseases.

关键词： Artemisinin Immune system Immune-related diseases Macrophage T-cell B-cell

IMAGE SEGMENTATION BY PIECEWISE CONSTANT MUMFORD-SHAH MODEL WITHOUT ESTIMATING THE CONSTANTS

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Journal of Computational Mathematics 2006年第3期24卷 435-443页

作者： Xue-cheng Tai Chang-hui yao CIPR Department of Mathematics University of Bergen Norway Department of Mathematics University of Bergen Norway

In this work, we try to use the so-called Piecewise Constant Level Set Method （PCLSM） for the Mumford-Shah segmentation model. For image segmentation, the Mumford-Shah model needs to find the regions and the constant values inside the regions for the segmen- tation. In order to use PCLSM for this purpose, we need to solve a minimization problem using the level set function and the constant values as minimization variables. In this work, we test on a model such that we only need to minimize with respect to the level set function, i.e., we do not need to minimize with respect to the constant values. Gradient descent method and Newton method are used to solve the Euler-Lagrange equation for the minimization problem. Numerical experiments are given to show the efficiency and advantages of the new model and algorithms.

关键词： PCLSM Image Segmentation Mumford-Shah model.

Neural Network-based Adaptive State-feedback Control for High-order Stochastic Nonlinear Systems

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自动化学报 2014年第12期40卷 2968-2972页

作者： MIN hui-fang DUAN Na School of Electrical Engineering & Automation Jiangsu Normal University

This paper focuses on investigating the issue of adaptive state-feedback control based on neural networks(NNs)for a class of high-order stochastic uncertain systems with unknown nonlinearities. By introducing the radial basis function neural network(RBFNN) approximation method, utilizing the backstepping method and choosing an approximate Lyapunov function, we construct an adaptive state-feedback controller which assures the closed-loop system to be mean square semi-global-uniformly ultimately bounded(M-SGUUB). A simulation example is shown to illustrate the effectiveness of the design scheme.

关键词：径向基函数神经网络状态反馈控制器随机非线性系统自适应高阶 Lyapunov函数非线性问题不确定系统

Chemically synthesizing exchange-coupled SmCo_(5)/Sm_(2)Co_(17) nanocomposites

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Rare Metals 2021年第3期40卷 575-581页

作者： yao-hui Xu Qiang Jiang Kun Li Zhen-hui Ma School of Physics and Electronic Engineering Laboratory for Functional MaterialsLeshan Normal UniversityNanjing 211189China Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments School of Mechanical EngineeringSoutheast UniversityNanjing 211189China College of Materials Science and Engineering Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China Department of Chemistry Brown UniversityProvidenceRI 02912USA

A new strategy to chemically synthesize exchange-coupled SmCo_(5)/Sm_(2) Co_(17) nanocomposites by in situ decomposition of SmCox(5 详细信息

A new strategy to chemically synthesize exchange-coupled SmCo_(5)/Sm_(2) Co_(17) nanocomposites by in situ decomposition of SmCox(5

关键词： SmCo_(5) Nanocomposites Exchange coupling Coercivity

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan fang Li-hui Li Ming-Qian He Yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

Two Novel {Ti_(6)P_(2)} Clusters Decorated with Inorganic Acids

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Chinese Journal of Structural Chemistry 2021年第3期40卷 277-282,271页

作者： ZHENG Ai-Ping GAO Mei-Yan fang Wei-hui KANG yao College of Chemistry Fuzhou UniversityFuzhou 350100China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Two inorganic acids decorating titanium-oxo clusters (PTCs),Ti_6O_4(O~iPr)_(10)(O_(3)P-Phen)_(2)(NO_(3))_(2)(PTC-251) and Ti_6O_4(O~iPr)_(10)(O_(3)P-Phen)_(2)(HSO_4)_(2) (PTC-252)(H_(2)O_(3)P-Phen=phenylphosphinic acid) have been synthesized under solvothermal *** a result of the labile coordination sites of the{Ti_6P_(2)}unit,nitrite and sulfate adopt different capping ***,they also present different space *** photocatalytic H_(2)evolution activities of these obtained PTCs have been studied,with sulfate decorating PTC-252 presenting a maximum H_(2) production rate up to 110.95μmol·g^(-1)·h^(-1).

关键词： polyoxo-titanium clusters inorganic acid labile coordination sites water-splitting