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Aggregation-induced barrier to oxygen——a new AIE mechanism for metal clusters with phosphorescence

National Science Review 2022年第8期9卷 71-79页

作者： Yan Jin Qiu-Chen Peng Si Li hui-fang su Peng Luo Ming Yang Xin Zhang Kai Li Shuang-Quan Zang Ben Zhong Tang Thomas C.W.Mak Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou University Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringChinese University of Hong Kong The Hong Kong Branch of the Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Hong Kong University of Science and Technology Department of Chemistry Chinese University of Hong Kong

Metal clusters are useful phosphors, but highly luminescent examples are quite rare. Usually, the phosphorescence of metal clusters is hindered by ambient O2molecules. Transforming this disadvantage into an advantage for meaningful applications of metal clusters presents a formidable challenge. In this work, we used ligand engineering to judiciously prepare colour-tuneable and brightly emitting Cu(I)clusters that are ultrasensitive to O2upon dispersion in a fluid solution or in a solid matrix. When the O2scavenger dimethyl sulfoxide(DMSO) was used as the solvent, joint photo-and oxygen-controlled multicolour switches were achieved for the first time for metal cluster-based photopatterning and photo-anticounterfeiting. More importantly, an aggregation-induced barrier to oxygen, a new aggregation-induced emission mechanism for metal clusters, was proposed, providing a new pathway to realizing the intense emission of metal clusters in the aggregated state. These results are expected to promote the application of metal clusters and enrich the luminescence theory of metal cluster aggregates.

关键词： metal clusters aggregation-induced emission phosphorescence photoresponse O2 detection

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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高压Ar气对激光诱导土壤等离子体辐射的增强效应

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光谱学与光谱分析 2006年第5期26卷 798-801页

作者：史金超陈金忠魏艳红郭庆林怀素芳河北大学物理科学与技术学院河北保定071002

使用高能量钕玻璃脉冲激光器（～30J,0.7 ms）烧蚀土壤样品获得等离子体,通过对等离子体图像和光谱的采集,以及对烧蚀质量的测量,分析了高气压（0.2～1.1 MPa）Ar气环境对等离子体辐射强度的影响.结果表明,随着Ar气气压的升高等离子体... 详细信息

使用高能量钕玻璃脉冲激光器（～30J,0.7 ms）烧蚀土壤样品获得等离子体,通过对等离子体图像和光谱的采集,以及对烧蚀质量的测量,分析了高气压（0.2～1.1 MPa）Ar气环境对等离子体辐射强度的影响.结果表明,随着Ar气气压的升高等离子体的体积被压缩,温度升高,亮度明显增强.在实验条件下,等离子体发射光谱强度随着环境气压上升而不断提高,但是激光对样品的烧蚀质量却逐渐下降.结合实验过程对测量结果进行了适当的讨论.

关键词：激光诱导等离子体辐射强度土壤环境气体压力

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老年糖尿病患者合并感染后胰岛素泵强化治疗的有效性研究

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中华医院感染学杂志 2017年第5期27卷 1050-1053页

作者：戴慧芳苏小游吴朝明李海朱烈烈温州医科大学附属第二医院内分泌血管外科浙江温州325027 温州医科大学附属第二医院急诊科浙江温州325027

目的探讨老年糖尿病患者合并感染后胰岛素泵强化治疗的有效性,为老年糖尿病合并感染患者的治疗提供参考。方法选取2016年1月1日-6月30日诊治100例老年糖尿病合并感染患者,随机分为对照组与观察组,每组50例,观察组给胰岛素泵强化治疗,对... 详细信息

目的探讨老年糖尿病患者合并感染后胰岛素泵强化治疗的有效性,为老年糖尿病合并感染患者的治疗提供参考。方法选取2016年1月1日-6月30日诊治100例老年糖尿病合并感染患者,随机分为对照组与观察组,每组50例,观察组给胰岛素泵强化治疗,对照组常规胰岛素强化皮下注射治疗,观察两组患者治疗前、治疗3d时血糖(FPG、2hPG)、炎性因子(WBC、CRP、PCT)变化,以及治疗后血糖达标时间、胰岛素日用量、感染控制时间、低血糖发生情况。结果两组患者FPG、2hPG、WBC、CRP、PCT治疗后较治疗前明显下降(P<0.05),观察组指标低于对照组(P<0.05);观察组血糖达标时间、胰岛素日用量、感染控制时间分别为(4.75±2.22)d、(34.67±5.31)U/d、(5.61±2.04)d短于对照组(6.43±2.76)d、(42.94±6.65)U/d、(7.67±2.20)d,差异有统计学意义(P<0.05);对照组有8例低血糖发生,观察组有1例低血糖发生,差异有统计学意义(P<0.05)。结论老年糖尿病合并感染患者给予胰岛素泵强化治疗利于感染及血糖水平的及时控制,减少胰岛素用量,降低低血糖发生,是老年糖尿病合并感染时安全、有效的治疗方法。

关键词：糖尿病感染老年胰岛素泵强化治疗

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Adaptive Algorithms on Maximizing Monotone Nonsubmodular Functions

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Journal of the Operations Research Society of China 2024年第2期12卷 428-445页

作者： Bin Liu hui su Shu-fang Gong Qi-Zhi fang School of Mathematical Sciences Ocean Universityof ChinaQingdao266100ShandongChina

submodular optimization is widely used in large *** order to speed up the problems solving,it is essential to design low-adaptive algorithms to achieve acceleration in *** general,the function values are given by a value oracle,but in practice,the oracle queries may consume a lot of ***,how to strike a balance between optimizing them is *** this paper,we focus on maximizing a normalized and strictly monotone set function with the diminishing-return ratio under a cardinality constraint,and propose two algorithms to deal with *** apply the adaptive sequencing technique to devise the first algorithm,whose approximation ratio is arbitrarily close to 1-e^(-γ)in O(logn·log(log k/γ)) adaptive rounds,and requires O(logn^(2)·log(log k/γ)) *** by adding preprocessing and parameter estimation steps to the first algorithm,we get the second *** second algorithm trades a small sacrifice in adaptive complexity for a significant improvement in query *** the same approximation and adaptive complexity,the query complexity is improved *** the best of our knowledge,this is the first paper of designing adaptive algorithms for maximizing a monotone function using the diminishing-return ratio.

关键词： Approximation algorithm Adaptivity Nonsubmodular maximization Cardinality constraint

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职业使命感对大学生幸福感的影响及边界条件:一项元分析

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黑龙江高教研究 2025年第1期43卷 140-146页

作者：崔小雨李辉苏涛广东警官学院广东广州510230 中国人民公安大学北京100038 广东工业大学广东广州510520

为明晰职业使命感对大学生幸福感的影响及边界条件,基于29篇实证文献的44个独立研究、53个效应值、41819个独立样本,通过元分析方法对职业使命感与大学生幸福感的关系进行了系统量化综述。结果发现,就主效应而言,职业使命感对大学生幸... 详细信息

为明晰职业使命感对大学生幸福感的影响及边界条件,基于29篇实证文献的44个独立研究、53个效应值、41819个独立样本,通过元分析方法对职业使命感与大学生幸福感的关系进行了系统量化综述。结果发现,就主效应而言,职业使命感对大学生幸福感具有显著正向影响,且相较主观幸福感,职业使命感对大学生心理幸福感的影响更强。就边界条件而言,职业使命感对大学生幸福感的影响会因其所处地域、院校、年级而异:相较西方地域文化,职业使命感对东方地域文化下大学生幸福感、主观幸福感、心理幸福感的影响均更强;相较普通院校,职业使命感对行业特色院校大学生幸福感、主观幸福感、心理幸福感的影响均更强;相较高年级,职业使命感对低年级大学生心理幸福感的影响更强。

关键词：大学生职业使命感幸福感元分析调节效应

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan su Weitao Zhao Chang Chen Zhongying Gong huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Preparation and Characterization of Mesophase Pitch via Co-Carbonization of Waste Polyethylene/Petroleum Pitch

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Journal of Materials Science & Technology 2015年第8期31卷 857-863页

作者： Youliang Cheng Lu Yang Tao Luo Changqing fang Jian su Jian hui School of Printing and Packaging Engineering Xi'an University of Technology Petrochina Liaoyang Petrochemical Company China National Petroleum Corporation

The low-cost petroleum pitch and waste polyethylene （WPE） were used as raw materials to prepare the mesophase pitch by co-carbonization method and the forming mechanization of mesophase pitch was also investigated. Polarized microscopy, softening point, Fourier transform infrared spectroscopy （FTIR） and thermogravimetric analysis （TGA） were used to characterize and analyze the properties and struc- ture of the mesophase pitch. The results showed that the carbonization yield of the modified pitch was high when 1-2 wt% WPE was added and the property of mesophase pitch （MP1-450-4 and MP2-450-4） prepared by thermal polymerization was excellent. Moreover, when the treatment temperature was above 420 ~C, the mesophase development of the modified pitch may be entire and 100% streamline texture mesophase can form. During the co-carbonization of WPEJpetroleum pitch, a large number of naphthenic structures and methylene bridges may be generated, which can improve the properties of the obtained mesophase pitch.

关键词： Polarized light microscopy Microstructure Property Thermogravimetric analysis (TGA) Formation mechanism

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Simultaneous recovery of carbon and sulfur resources from reduction of CO_2 with H_2S using catalysts

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Journal of Energy Chemistry 2016年第1期25卷 110-116页

作者： hui su Yuyang Li Ping Li Yongxiu Chen Zhizhi Zhang Xiangchen fang State Key Laboratory of Chemical Engineering East China University of Science and Technology Fushun Research Institute of Petroleum & Petrochemicals Sinopec

An approach to the simultaneous reclamation of carbon and sulfur resources from CO2 and H2S has been proposed and effectively implemented with the aid of catalysts. A brief thermodynamic study reveals the potential of direct reduction of CO2 with H2S（15：15 mol% balanced with N2） for selective production of CO and elemental sulfur. The experiments carried out in a fixed-bed flow reactor over the temperature range of 400–800 °C give evidence of the importance of the employment of catalysts. Both the conversions of the reactants and the selectivities of the target products can be substantially promoted over most catalysts studied. Nevertheless, little difference appears among their catalytic performance. The results also prove that the presence of CO2 can remarkably enhance H2S conversion and the sulfur yield in comparison with H2S direct decomposition. A longtime reaction test on Mg O catalyst manifests its superior durability at high temperature（700 °C） and huge gas hourly space velocity（100,000 h-1）. Free radicals initiated by catalysts are supposed to dominate the reactions between CO2 and H2S.

关键词： Carbon dioxide Hydrogen sulfide Simultaneous recovery Reduction Catalyst

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阿片类药物诱导瘙痒的机制研究进展

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中国药理学通报 2025年第1期41卷 29-34页

作者：马芳周培岚苏瑞斌军事医学研究院国家安全特需药品全国重点实验室北京100850 南京中医药大学药学院江苏南京210046

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后... 详细信息

瘙痒是临床使用阿片类药物镇痛的患者普遍存在的严重不良反应之一。大量研究已经阐明阿片类药物的镇痛机制,但阿片类药物诱导瘙痒的机制尚不明确,瘙痒与镇痛之间的关系也模糊不清。目前的研究发现,阿片类药物作用于μ、κ及δ阿片受体后,直接或间接影响瘙痒关键受体——胃泌素释放肽受体的功能,进而影响瘙痒信息传递。神经介素B、神经肽Y、B型利钠肽等神经肽,以及其他受体如瞬时受体电位香草素1受体、N-甲基-D-天冬氨酸受体、5-羟色胺受体等,在吗啡诱导的瘙痒中也具有重要作用。此外,阿片类药物所致瘙痒的预防和治疗也是围手术期吗啡镇痛的难点和热点之一。因此,明确瘙痒的具体发生机制,对寻找新的研究思路及预防和治疗阿片类药物诱导的瘙痒具有重要意义。

关键词：阿片类诱导的瘙痒瘙痒与镇痛瘙痒机制阿片受体胃泌素释放肽受体瘙痒治疗

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