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Chinese Chemical Letters 2009年第11期20卷 1319-1320页

作者： hui fang pi Peng zhang han li ruan yong hui zhang han Dong Sun ji zhou wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Hubei Key Laboratory of Natural Medicinal Chemistry and Resources Evaluation Wuhan 430030 China

A new alkaloid was isolated from the bulbs of Lycoris aurea （L＇Herit.） Herb. Its structure was established as 3-o-ethyltazettinol through chemical and spectroscopic studies including 2D NMR.

关键词： Lycoris aurea 3-o-Ethyltazettinol

A new hopane triterpenoid from Saxiglossum angustissimum

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Chinese Chemical Letters 2008年第7期19卷 835-836页

作者： hui fang pi Zhi Hong Zhong han li ruan Peng zhang yong hui zhang ji zhou wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 PR China

A new hopane triterpenoid, hopane 22, 29-diol-29-formate （1）, has been isolated from the whole herbs of Saxiglossum angustissimum （Cries.） Ching and its structure has been successfully determined on the basis of s... 详细信息

关键词： Saxiglossum angustissimum Hopane Hopane-22 29-Diol-29-formate

A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis

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Chinese Chemical Letters 2007年第4期18卷 418-420页

作者： hui fang pi Peng zhang Tian Zhu han li ruan yong hui zhang han Dong Sun ji zhou wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Kunming 650204 China

A new triterpenoid has been isolated from the leaves and stems of Fritillaria hupehensis Hsiao et K.C. Hsia. Its structure was established as （2329-9,19-cycloart-23-ene-3α,25-diol 1 through chemical and spectroscopi... 详细信息

关键词： Fritillaria hupehensis Cycloartane triterpenoids (23Z)-9,19-Cycloart-23-ene-3α,25-diol

Cytotoxic Diarylheptanoids from Pericarps of Juglans Cathayensis Dode

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Chemical Research in Chinese Universities 2008年第4期24卷 427-429页

作者： li Yi-xiu ruan han-li zhou Xue-feng zhang yong-hui pi hui-fang wu ji-zhou Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 P R. China

A novel diarylheptanoid, named Jugcathanin（1）, along with two known diarylheptanoids（2,3）, were isolated from the fresh pericarps ofduglans Cathayensis Dode. A known triterpene（4） and a known aphthaoquinone（5） were also isolated from the plant. Their structures were elucidated on the basis of spectroscopic studies. All the compounds exhibited moderate cytotoxicities against human Hela, HepG2, and HL-60 cell lines.

关键词： duglans Cathayensis Dode Jugcathanin Antitumor activity

Two new ent-kaurane diterpenoids from the aerial parts of Isodon excisoides

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Chinese Chemical Letters 2014年第1期25卷 131-133页

作者： Ke jiao Huo-Yun li Peng zhang hui-fang pi han-li ruan ji-zhou wu Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation Tongji School of Pharmaceutical SciencesHuazhong University of Science and Technology

Two new ent-kaurane diterpenoids, ent-7α,14β-dihydroxykaur-16-en-15-one-20-oic acid （1） and 1,7α,12β,14β-tetrahydroxy-1,10-seco-ent-kaur-10,16-dien-15-one （2）, together with six known ones （3-8）, were isolated from the EtOAc extract of the aerial parts of lsodon excisoides. Their structures were elucidated on the basis of 1D NMR and 2D NMR analyses as well as HR-ESI-MS experiments.

关键词： lsodon excisoides ent-Kaurane Diterpenoid

Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

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Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： Qian-zhuo liu hui han Xin-ru fang Lu-yao Wang Dan Zhao Miao-zhu Yin Nian zhang Peng-yu jiang Zhi-hui ji li-min wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress

Hyperthermia differentially affects specific human stem cells and their differentiated derivatives

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Protein & Cell 2022年第8期13卷 615-622页

作者： Si Wang fang Cheng Qianzhao ji Moshi Song Zeming wu Yiyuan zhang Zhejun ji Huyi Feng Juan Carlos Izpisua Belmonte Qi zhou jing Qu Wei li Guang-hui liu Weiqi zhang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China State Key Laboratory of Membrane Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Beijing 100101 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Aging Translational Medicine Center International Center for Aging and Cancer Xuanwu Hospital Capital Medical University Beijing 100053 China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China China National Center for Bioinformation Beijing 100101 China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies La Jolla CA USA Chongqing Renji Hospital University of Chinese Academy of Sciences Chongqing 400062 China

Dear Editor,The human body operates optimally at a core temperature of 37 degrees *** at this temperature is essential for cellular and physiological functions(Cheshire,2016).However,infectious diseases,inflammation,injury,neoplasia,and elevated climate temperature can cause a regulated rise in body core temperature,i.e.,fever(Pasi-khova et al,2017).Indeed,an acute or chronic increase in temperature leads to detrimental effects on vasculature by altering a number of indices of vascular structure and function(DuBose et al.,1998).

关键词： elevated inflammation acute

Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

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Journal of Integrative Medicine 2024年第3期22卷 279-285页

作者： jia-jia wu Tian-yi zhang Ying-hui Qi Min-yan Zhu Yan fang Chao-jun Qi li-ou Cao ji-fang Lu Bo-han Lu Lu-min Tang jian-xiao Shen Shan Mou Department of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Department of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable ***:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with ***,setting,participants and interventions:This is a prospective,double-blind,multicenter,randomized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization ***,caregivers and investigators assessing the outcomes were blinded to group *** in the YQPY group received 36 g YQPY granules twice a day for 28 *** in the placebo group received a placebo in the same dose as the YQPY *** outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of *** secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of endpoint events,defined as eGFR increasing by more than 25%above baseline,eGFR>75 mL/min per1.73 m2or the composite endpoint,which was defined as the sum of patients meeting either of the above ***:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were *** mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two *** further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2in the YQPY group and 5.78 mL/min per1.73 m2in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(P<0.001).Thirteen(59.1%)patients in the YQPY group and 5(16.1%)in the placebo g

关键词： Chinese herbal medicine Randomized controlled trial Acute kidney injury Renal function

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湖北大戟化学成分研究

中国中药杂志 2006年第9期31卷 742-744页

作者：阮汉利张悦张勇慧皮慧芳吴继洲华中科技大学同济医学院药学院湖北武汉430030

目的:研究湖北大戟Euphorbia hylonoma根的化学成分。方法:采用色谱技术进行分离和纯化,通过IR,1H和13C-NMR,2D-NMR,MS等方法及与对照品和文献数据对照等方法进行鉴定。结果:分离并鉴定了6个化合物:正壬烷(1)、bis(2-ethylhexyl)phthala... 详细信息

目的:研究湖北大戟Euphorbia hylonoma根的化学成分。方法:采用色谱技术进行分离和纯化,通过IR,1H和13C-NMR,2D-NMR,MS等方法及与对照品和文献数据对照等方法进行鉴定。结果:分离并鉴定了6个化合物:正壬烷(1)、bis(2-ethylhexyl)phthalate(2)、大戟醇(3)、β-谷甾醇(4)、碳50长链脂肪醇(5)和β-胡萝卜苷(6)。结论:化合物1,2,3,5和6为首次从该植物中得到。

关键词：大戟属湖北大戟化学成分