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Carbon emission reduction: Contribution of karst carbon sinks and practice in China

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China Geology 2023年第4期6卷 759-761页

作者： Liang wang dong-hui wang Qiong Xiao Natural Resources Integrated Survey Command Center China Geological SurveyMinistry of Natural ResourcesBeijing 100055China Chengdu Center China Geological SurveyMinistry of Natural ResourcesChengdu 610200China Institute of Karst Geology Chinese Academy of Geological SciencesGuilin 541004China

Carbonate rocks, as soluble rocks, will dissolve and experience karstification driven by flowing water. This process consumes CO_(2)from the air and converts atmospheric CO_(2) and CO_(3)^(2-)of rocks into HCO_(3)^(-), resulting in the transfer of carbon from the atmosphere to the hydrosphere. Part of those dissolved HCO3-in the groundwater and surface water will degrade as CO_(2) and return to the atmosphere.

关键词： prospecting Eastern karst

In-situ Mg_(77)Cu_(12)Zn_5Y_6 bulk metallic glass matrix composite with extraordinary plasticity

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Chinese Science Bulletin 2006年第2期51卷 229-234页

作者： hui Xidong dong Wei wang Meiling LIU Xiongjun YU Jialing CHEN Guoliang State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

We report experimental evidence of in-situ Mg77Cu12Zn5Y6 bulk metallic glass (BMG) ma- trix composite with extraordinary plastic strain of 18.5% and specific strength of 4.31×105 N·m·kg?1, which are the highest plasticity and specific strength in Mg base BMG alloys reported to date. The excel- lent mechanical properties are attributed to the for- mation of the composite structure which is composed of amorphous matrix and hexagonal-close-packed (hcp) Mg solid solution needle phase with a width less than 500 nm. As plastic phase, the Mg needles not only possess the capability of deformation but also have work hardening phenomenon effect. They give rise to multiple shear bands, and hinder the propagation of local shear band in amorphous matrix.

关键词： Mg77Cu12Zn5Y6 金属玻璃定向凝固共晶体复合材料塑性强度系数

Analysis of Simple Sequence Repeats in Genomes of Rhizobia

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Agricultural Sciences in China 2008年第10期7卷 1189-1195页

作者： GAO Ya-mei HAN Yi-qiang TANG hui SUN dong-mei wang Yan-jie wang Wei-dong College of Life Science and Technology Heilongjiang August First Land Reclamation University Daqing 163319 P.R.China

Simple sequence repeats （SSRs） or microsatellites, as genetic markers, are ubiquitous in genomes of various organisms. The analysis of SSR in rhizobia genome provides useful information for a variety of applications in population genetics of rhizobia. We analyzed the occurrences, relative abundance, and relative density of SSRs, the most common in Bradyrhizobium japonicum, Mesorhizobium loti, and Sinorhizobium meliloti genomes se- quenced in the microorganisms tandem repeats database, and SSRs in the three species genomes were compared with each other. The result showed that there were 1 410, 859, and 638 SSRs in B. japonicum, M. loti, and S. meliloti genomes, respectively. In the genomes of B. japonicum, M. loti, and S. meliloti, tetranucleotide, pentanucleotide, and hexanucleotide repeats were more abundant and indicated higher mutation rates in these species. The least abundance was mononucleotide repeat. The SSRs type and distribution were similar among these species.

关键词： rhizobium genome simple sequence repeat

Synthesis,Biological Evaluation and Molecular Modeling of Cyclic Tetrapeptide Based Inhibitors HDAC

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Chemical Research in Chinese Universities 2012年第6期28卷 1011-1016页

作者： LI Xiao-hui WEI Ying-dong wang Shi-miao wang Meng-nan HUANG Da-wei XIU Zhi-long School of Life Science and Biotechnology Dalian University of Technology Dalian 116024 P. R. China

Histone deacetylases（HDACs） are considered to be among the most promising targets for the development of anti-cancer drugs,and HDAC inhibitors（HDACIs） have become a promising class of anti-cancer *** explore whether thioacetyl group as the zinc binding group（ZBG） and a slight change in the hydrophobicity of the recognition domain of HDACIs could alter their activities,we synthesized a series of cyclo[-L-Am7（SAc）-Aib-L-Phe（n-Cl）D-Pro-] and evaluated their HDAC-inhibitory and antiproliferative *** results show that these peptides could inhibit HDAC at 10-9 mol/L level,and could selectively inhibit the proliferation of three human cancer cell lines with IC 50 at 10-6 mol/L *** study was conducted to examine the mechanisms by which these peptides interact with *** appeared that a zinc ion in the active site of HDAC was coordinated by the carbonyl oxygen atom of the ZBG in the *** the ZBG domain of all the peptides and the surface recognition domain of cyclo[-L-Am7（SAc）-Aib-L-Phe（o-Cl）-D-Pro-] and that of cyclo[-L-Am7（SAc）-Aib-L-Phe（m-Cl）-D-Pro-] interacted with HDAC2 via hydrogen *** interaction has been considered to provide favorable contributions to stabilizing the complexes,and the introduction of a chlorine atom at the aromatic ring on the L-Phe position of these peptides affected the interaction between each of these inhibitors and the enzyme,resulting in slight change in the structure of the surface recognition domain of the peptides.

关键词： Histone deacetylase(HDAC) Histone deacetylase inhibitor(HDACI) Cyclic tetrapeptide Anti-cancer agent Antiproliferative activity Docking

A 4H–SiC betavoltaic battery based on a ^(63)Ni source

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Nuclear Science and Techniques 2018年第11期29卷 295-303页

作者： Yu-Min Liu Jing-Bin Lu Xiao-Yi Li Xu Xu Rui He hui-dong wang College of Physics Jilin University

A 4H–SiC–^(63)Ni p–n-junction-based betavoltaic battery is investigated. The Monte Carlo method is used to simulate the self-absorption effect of the ^(63)Ni source, the backscattering process, and the transport of beta particles in 4H–SiC material. The main factors that affect the energy conversion efficiencies of the cell are analyzed. Based on the simulation results, it can be calculated that, when the thickness of the ^(63)Ni source increases from 2 ×10^(-3) to10 lm, the theoretical maximum device conversion efficiency increases from 16.77 to 23:51% and the total conversion efficiency decreases from 16.73 to 1:48%.Furthermore, a feasible design with a maximum output power density of 0:36 μW=cm^2 and an optimal device conversion efficiency of 23:5% is obtained.

关键词： 4H–SiC–63Ni betavoltaic battery p–n junction Energy conversion efficiency

Role of activin A in carbon tetrachloride-induced acute liver injury

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World Journal of Gastroenterology 2013年第24期19卷 3802-3809页

作者： dong-hui wang Yi-Nan wang Jing-Yan Ge Han-Yan Liu Hong-Jun Zhang Yan Qi Zhong-hui Liu Xue-Ling Cui Department of Immunology Norman Bethune College of Medicine Jilin University Translational Medical Research Institute First Hospital of Jilin University Department of Immunology Mudanjiang Medical University Department of Genetics Norman Bethune College of Medicine Jilin University

AIM: To investigate the expression and role of activin A in a mouse model of acute chemical liver injury. METHODS: Acute liver injury in C57BL/6 male mice was induced by intraperitoneal injection with carbon tetrachloride (CCl4 ) (0.5 mL/kg, body weight) dissolved in olive oil (1:19 v/v). Mice were sacrificed 1, 3, 5 and 7 d after the treatment. The levels of alanine aminotrans-ferase (ALT) and aspartate aminotransferase (AST) in serum were examined and pathological changes of liver observed by hematoxylin and eosin staining to evaluate the liver injury. Activin A protein levels in serum and hepatic tissue homogenate of mice were detected by enzyme-linked immunosorbent assay, and the expres-sion pattern of activin A protein in livers of mice was examined by immunohistochemistry. Activin type Ⅱ A receptor (ActRⅡA) and Smad3 expressions in the liver were analyzed by real-time quantitative reverse transcription-polymerase chain reaction. In order to further investigate the role of activin A, we also utilized activin A blocking experiment by anti-activin A antibody (500 μg/kg, body weight) injection into mouse tail vein. RESULTS: In CCl4-treated mice, serum ALT and AST levels were significantly increased, compared with that in control mice (P<0.01). Furthermore, the serious necrosis was observed around hepatic portal areas in CCl4-treated mice. Simultaneously, activin A levels in serum and hepatic tissue homogenate of mice treated with CCl4 for 1, 3 and 5 d increased significantly, com-pared with that in control mice (P<0.01). Activin A protein expression in hepatocytes not within the ne-crotic area was also upregulated in mice following CCl4 treatment. Not only activin A, but also ActRⅡA and activin signaling molecule Smad3 mRNA expressions in injury liver induced by CCl4 were significantly higher than that in control liver. In addition, levels of serum ALT and AST in CCl4-treated mice were significantly decreased by injection of anti-activin A antibody to block endoge

关键词： Liver injury Carbon tetrachloride Activin A Immunohistochemistry

Azopyridine-imidacloprid derivatives as photoresponsive neonicotinoids

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Chinese Chemical Letters 2016年第5期27卷 635-639页

作者： Shen Li Run-Jiang Song dong-hui wang Xue Tian Xu-Sheng Shao Zhong Li Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology Shanghai 200237 China College of Life Science Perking University Beijing 100871 China

A series of imidacloprid derivatives containing an azopyridine motif as a photoswitchable functional group were designed and synthesized. The new version of photoresponsive imidacloprid analogues showed improved solubility in comparison with their azobenzene analogues. 1.2 to 2-fold activity difference was observed for these azopyridine-imidacloprids against house fly （Musca domestica） and cowpea aphid （Aphis craccivora） upon irradiation.

关键词： Azopyridine Photoresponsive Imidacloprid Solubility Insecticide

Improving the Performance and Energy Efficiency of Phase Change Memory Systems

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Journal of Computer Science & Technology 2015年第1期30卷 110-120页

作者：王琪李佳芮王东辉 Digital System Integration Laboratory Institute of Acoustics Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

Phase change memory （PCM） is a promising technology for future memory thanks to its better scalability and lower leakage power than DRAM （dynamic random-access memory）. However, adopting PCM as main memory needs to overcome its write issues, such as long write latency and high write power. In this paper, we propose two techniques to improve the performance and energy-efficiency of PCM memory systems. First, we propose a victim cache technique utilizing the existing buffer in the memory controller to reduce PCM memory accesses. The key idea is reorganizing the buffer into a victim cache structure （RBC） to provide additional hits for the LLC （last level cache）. Second, we propose a chip parallelism-aware replacement policy （CPAR） for the victim cache to further improve performance. Instead of evicting one cache line once, CPAR evicts multiple cache lines that access different PCM chips. CPAR can reduce the frequent victim cache eviction and improve the write parallelism of PCM chips. The evaluation results show that, compared with the baseline, RBC can improve PCM memory system performance by up to 9.4% and 5.4% on average. Combing CPAR with RBC （RBC＋CPAR） can improve performance by up to 19.0% and 12.1% on average. Moreover, RBC and RBC＋CPAR can reduce memory energy consumption by 8.3% and 6.6% on average, respectively.

关键词： phase change memory systems performance energy efficiency

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： Shun Xing dong-hui wang Hai-Feng Zhang Li-Dan Liu Cheng-Ce Li Chao Wei Jun-Yu Liu Nai-Jian Ge Xuan-Yong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer