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Optimized Combinatorial Properties of an AlMgSi(Cu) Alloy Achieved by a Mechanical-Thermal Combinatorial Process

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Acta Metallurgica Sinica(English Letters) 2020年第5期33卷 751-758页

作者： Li-Mei liu Yu-Xiang Lai chun-hui liu Jiang-Hua Chen Center for High-Resolution Electron Microscopy College of Materials Science&EngineeringHunan UniversityChangsha 410082China Hunan Province Key Laboratory for Spray Deposition Technology and Application Hunan UniversityChangsha 410082China

Enhancing combinatorial properties,such as excellent corrosion resistance,high strength and good ductility combined,is an important issue for manufacturing high-quality AlMgSi(Cu)***,we show that this can be achieved by optimizing a combinatorial process consisting of pre-ageing,cold-rolling and post-ageing to tailor the hierarchical microstructures of the *** electron microscopy analysis reveals that the enhanced combinatorial properties of corrosion resistance,strength and ductility are owing to modification of grain boundary microstructure in good association with changes of precipitate microstructures and a more homogenous distribution of solute atoms,as compared with the microstructures of the alloy processed by thermal ageing only.

关键词： Al alloy Corrosion resistance Mechanical property Ageing Deformation

Cloning and functional analysis of a novel ascorbate peroxidase(APX) gene from Anthurium andraeanum

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第12期14卷 1110-1120页

作者： hui-chun liu Dan-qing TIAN Jian-xin liu Guang-ying MA Qing-cheng ZOU Zhu-jun ZHU College of Agriculture & Biotechnology Zhejiang University Research & Development Center of Flower Zhejiang Academy of Agricultural Sciences School of Agricultural and Food Science Zhejiang A&F University

An 888-bp ful-length ascorbate peroxidase （APX） complementary DNA （cDNA） gene was cloned from Anthurium andraeanum, and designated as AnAPX. It contains a 110-bp 5′-noncoding region, a 28-bp 3′-noncoding region, and a 750-bp open reading frame （ORF）. This protein is hydrophilic with an aliphatic index of 81.64 and its structure consisting ofα-helixes,β-turns, and random coils. The AnAPX protein showed 93%, 87%, 87%, 87%, and 86% similarities to the APX homologs from Zantedeschia aethiopica, Vitis pseudoreticulata, Gossypium hirsutum, Elaeis guineensis, and Zea mays, respectively. AnAPX gene transcript was measured non-significantly in roots, stems, leaves, spathes, and spadices by real-time polymerase chain reaction （RT-PCR） analysis. Interestingly, this gene expression was remarkably up-regulated in response to a cold stress under 6 °C, implying that AnAPX might play an important role in A. andraeanum tolerance to cold stress. To confirm this function we overexpressed AnAPX in tobacco plants by transformation with an AnAPX expression construct driven by CaMV 35S promoter. The transformed tobacco seedlings under 4 °C showed less electrolyte leakage （EL） and malondialdehyde （MDA） content than the control. The content of MDA was correlated with chilling tolerance in these transgenic plants. These results show that AnAPX can prevent the chilling challenged plant from cellmembrane damage and ultimately enhance the plant cold tolerance.

关键词： AnAPX Gene expression Cold stress Anthurium andraeanum

Anemia and risk of periprocedural cerebral injury detected by diffusion-weighted magnetic resonance imaging in patients undergoing transcatheter aortic valve replacement

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World Journal of Emergency Medicine 2022年第1期13卷 32-39页

作者： Stella Ng Qi-feng Zhu Ju-bo Jiang chun-hui liu Jia-qi Fan Ye-ming Xu Xian-bao liu Jian-an Wang Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang University School of Medicine Hangzhou 310058China

BACKGROUND: Anemia is prevalent in patients undergoing transcatheter aortic valve replacement(TAVR) and has been linked to impaired outcomes after the procedure. Few studies have evaluated the impact of anemia and new ischemic lesions post ***: We prospectively enrolled 158 patients who received TAVR in our center. Anemia was defined according to the World Health Organization criteria as hemoglobin <12 g/dL in women and <13 g/dL in men. All patients underwent diffusion-weighted magnetic resonance imaging(DW-MRI) procedure before and within 4–7 days after TAVR. RESULTS: Anemia was present in 85(53.8%) patients who underwent TAVR, and 126(79.7%) patients had 718 new DW-MRI positive lesions with a mean of 4.54±5.26 lesions per patient. The incidence of new ischemic lesions was 81.2% in patients with anemia versus 78.1% in patients without anemia(P=0.629). Moreover, anemic patients had bigger total volume/lesions in the anterior cerebral artery/middle cerebral artery(ACA/MCA) and MCA regions compared to the non-anemic patients(31.89±55.78 mm^(3) vs. 17.08±37.39 mm^(3), P=0.049;and 54.54±74.72 mm^(3) vs. 33.75±46.03 mm^(3), P=0.034). Anemia was independently associated with the volume/lesion in the ACA/MCA(β=16.796, 95% confidence interval [95% CI] 2.001 to 31.591, P=0.026) and in the MCA zone(β=0.020, 95% CI 0.001 to 0.040, P=0.041). CONCLUSIONS: Patients with pre-procedural anemia may have bigger total volume/lesions in the ACA/MCA and MCA regions compared to the non-anemic patients. Whether the consequences of bigger total volume/lesions impact neurological and cognitive outcomes remains to be investigated.

关键词： Aortic stenosis Anemia Cerebral ischemic lesions Transcatheter aortic valve replacement

Combination of percutaneous radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma: observation of clinical effects

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Chinese Journal of Cancer Research 2014年第4期26卷 471-477页

作者： hui-chun liu Er-Bo Shan Lei Zhou Hao Jin Pei-Yuan Cui Yi Tan Yi-Min Lu Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical College

Objective： To observe the clinical effect of radiofrequency ablation （RFA） combined with transcatheter arterial chemoembolization （TACE） for advanced hepatocellnlar carcinoma （HCC）. Methods： A total of 92 eases of advanced primary liver cancer underwent TACE and RFA treatment from June 2005 to 2011 at the Department of Hepatobiliary Surgery, the First Affiliated Hospital of Bengbu Medical College. A total of 88 cases with complete clinical treatment and follow-up data were divided into two groups： 43 patients treated with TACE （TACE group） and 45 patients that received TACE combined with RFA treatment （TACE ＋ RFA group）. After clinical data assessment, tumor size and survival status were not significantly different between the groups as determined by stratified analysis. Results： Before and after surgery, spiral CT radiography and color comparison observed ablation conditions. The tumor necrosis rates after treatment （CR ＋ PR） were 67.4% （29/43） and 91.1% （41/45） for the TACE and combined treatment groups, respectively, and the difference was statistically significant （P〈0.05）. The quality of life was significantly improved for patients undergoing TACE ~ RFA compared with the control group. Survival duration was not significantly different in patients undergoing TACE ~ RFA compared with the control group. Conclusions： In this study, the effect of RFA combined with TACE treatment was better than TACE alone in treating advanced HCC.

关键词： Liver cancer radiofrequency ablation (RFA) transcatheter arterial chemoembolization (TACE) quality of life survival period

A New Peptide with Membrane-permeable Function Derived from Human Circadian Proteins

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Acta Biochimica et Biophysica Sinica 2004年第9期36卷 629-636页

作者： Tao PENG, Ying-hui liu, chun-Lei YANG, Chao-Min WAN, Yao-Qi WANG, and Zheng-Rong WANG* Department of Biomedical Engineering, School of Basic Medicine and Forensic, Sichuan University, Chengdu 610041, China Department of Biomedical Engineering School of Basic Medicine and Forensic Sichuan UniversityChengdu 610041 China

Basic peptides such as human immunodeficiency virus type 1 (HIV-1) Tat-(48-60) and Droso- phila Antennapedia-(43-58) have been reported to have a membrane permeability and a carrier function for intracellular protein delivery. Based on the fluorescence microscopic observations of the vascular endothelial cells (ECV-304) and the primary cultured neuroglial cells, we found that human Clock protein DNA-binding peptide [residue 35–47, hClock-(35-47)] had a translocation activity very similar to Tat-(48-60). The cellular uptake of hClock-(35-47) increases with the increase of incubation time and concentration. The internalization effect at 4 °C was same as that at 37 °C. Internalization of hClock-(35-47) was saturable and could be inhibited by the excess of the other MPPs. Moreover, The uptake of these peptides were significantly inhibited in the presence of heparan sulfate. These results strongly suggested that the hClock-(35-47) shared a common or very similar internalization pathway with other MPPs. Furthermore, we injected rat through the common carotid artery with hClock-(35-47)-FITC peptide, and cryostat sections of the brain were prepared and observed using a fluorescence microscope. Result showed that the peptide had the ability to translocate through the blood-brain barrier. It is promising to provide a new safe carrier for the intracellular and encephalic treatment.

关键词： membrane-permeable peptide (MPP) cell membrane hClock DNA-binding peptide blood-brain barrier

Majorana Corner Modes and Flat-Band Majorana Edge Modes in Superconductor/Topological-Insulator/Superconductor Junctions

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Chinese Physics Letters 2023年第9期40卷 87-92页

作者：陈晓婷刘春晖许东辉陈垂针 Institute for Advanced Study and School of Physical Science and Technology Soochow UniversitySuzhou 215006China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics Chongqing UniversityChongqing 400044China Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 400044China

Recently,superconductors with higher-order topology have stimulated extensive attention and research ***-order topological superconductors exhibit unconventional bulk-boundary correspondence,thus allow exotic lower-dimensional boundary modes,such as Majorana corner and hinge ***,higher-order topological superconductivity has yet to be found in naturally occurring *** investigate higher-order topology in a two-dimensional Josephson junction comprised of two s-wave superconductors separated by a topological insulator thin *** find that zero-energy Majorana corner modes,a boundary fingerprint of higherorder topological superconductivity,can be achieved by applying magnetic *** an in-plane Zeeman field is applied to the system,two corner modes appear in the superconducting ***,we also discover a two-dimensional nodal superconducting phase which supports flat-band Majorana edge modes connecting the bulk ***,we demonstrate that zero-energy Majorana corner modes are stable when increasing the thickness of topological insulator thin film.

关键词： field topological superconductors

“Hepatic hilum area priority,liver posterior first”:An optimized strategy in laparoscopic resection for type Ⅲ-Ⅳ hilar cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2167-2174页

作者： Xiao-Si Hu Yong Wang Hong-Tao Pan Chao Zhu Shi-Lei Chen Shuai Zhou hui-chun liu Qing Pang Hao Jin Department of Hepatopancreatobiliary Surgery Anhui No.2 Provincial People's HospitalHefei 230041Anhui ProvinceChina

BACKGROUND In recent years,pure laparoscopic radical surgery for Bismuth-Corlette type Ⅲ and Ⅳ hilar cholangiocarcinoma(HCCA)has been preliminarily explored and applied,but the surgical strategy and safety are still worthy of further improvement and *** To summarize and share the application experience of the emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”in pure laparoscopic radical resection for patients with HCCA of Bismuth-Corlette types Ⅲ and *** The clinical data and surgical videos of 6 patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ who underwent pure laparoscopic radical resection in our department from December 2021 to December 2023 were retrospectively *** Among the 6 patients,4 were males and 2 were *** average age was 62.2±11.0 years,and the median body mass index was 20.7(19.2-24.1)kg/m^(2).The preoperative median total bilirubin was 57.7(16.0-155.7)μmol/*** patient had Bismuth-Corlette type Ⅲa,4 patients had Bismuth-Corlette type Ⅲb,and 1 patient had Bismuth-Corlette type Ⅳ.All patients successfully underwent pure laparoscopic radical resection following the strategy of“hepatic hilum area dissection priority,liver posterior separation first”.The operation time was 358.3±85.0 minutes,and the intraoperative blood loss volume was 195.0±108.4 *** of the patients received blood transfusions during the perioperative *** median length of stay was 8.3(7.0-10.0)*** bile leakage occurred in 2 patients,and all patients were discharged without serious surgery-related *** The emerging strategy of“hepatic hilum area dissection priority,liver posterior separation first”is safe and feasible in pure laparoscopic radical surgery for patients with HCCA of Bismuth-Corlette types Ⅲ and Ⅳ.This strategy is helpful for promoting the modularization and process of pure laparoscopic radical surgery for complicated HCCA,shortens the learning curve,and

关键词： Hilar cholangiocarcinoma Bismuth-Corlette typesⅢandⅣ Laparoscopy Radical resection Strategy

Preparation of Polymeric Monolithic Column and Application to the Resolution of Aromatic Compounds in Capillary Electrochromatography

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Chinese Chemical Letters 2004年第12期15卷 1477-1479页

作者： Xia WANG Wen Zhi LI chun hui liu Yong Min LI Li Ren CHEN Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, LanZhou 730000 College of Chemistry and Chemical Engeering,Liaocheng University, Liaochang 252059 Lanzhou Inst. of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China Coll. of Chem. and Chem. Engeering Liaocheng University Liaocheng 252059 China

Polymeric monolithic capillary column-poly(GMA-co-EDMA-co-AMPS) was prepared andused for resolution of aromatic compounds (benzalcohol, 2-phenylethanol, toluene, ethylbenzene).

关键词： Polymeric monolithic column aromatic compounds c apillary electrochromatography.

First-in-man implantation of the retrievable and repositionable VenusA-Plus valve

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World Journal of Emergency Medicine 2018年第1期9卷 64-66页

作者： Xian-bao liu Yu-xin He chun-hui liu Li-han Wang Feng Gao Lei Yu Ai-qiang Dong Min-jian Kong Ji-fang Chen Yong Xu Qi-jing Zhou Min Yan Jian-an Wang Department of Cardiology the Second Affiliated Hospital Zhejiang University School of Medicine Department of Cardiovascular Surgery the Second Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology the Second Affiliated Hospital Zhejiang University School of Medicine Department of Radiology the Second Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND: No retrievable and repositionable second generation transcatheter aortic valve is available in China. Here, we report the first-in-man implantation of the retrievable and repositionable VenusA-Plus valve. METHODS: A 76-year-old patient with symptomatic severe aortic stenosis and high surgical risk(STS 13.8%) was recommended for transcatheter aortic valve replacement(TAVR) by heart valve team. Type 0 bicuspid aortic valve with asymmetric calcification was identified by dual source computed tomography, and the unfavorable anatomies increased the possibility of malposition and paravalvular leakage during TAVR. Therefore, we used the retrievable and repositionable Venus APlus valve for the ***: Transfemoral TAVR was performed under local anesthesia with sedation, and a 26-mm VenusA-Plus valve was successfully implanted. No transvalvular pressure gradient and trace paravalvular leakage were found. CONCLUSION: The successful first-in-man implantation indicates the retrievable and repositionable Venus A-Plus valve is feasible in complicated TAVR cases such as bicuspid aortic valve.

关键词： Transcatheter aortic valve replacement Venus A-Plus valve Retrievable Repositionable Bicuspid aortic valve