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Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

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Science China Chemistry 2025年第01期 297-307页

作者： bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding Pan Pan Li Bo Peng Hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

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Alcohol Cessation in Late Life is Associated with Lower Risk of Cognitive Impairment among the Older Adults in China

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Biomedical and Environmental Sciences 2021年第7期34卷 509-519页

作者： ZHANG Xiao Chang GAO Xiang lyu Yue bin ZHOU Jin hui WEI Yuan YIN Zhao Xue MA Ji Xiang MAO Chen SHI Xiao Ming National Institute of Environmental Health Chinese Center for Disease Control and PreventionBeijing 100021China Division of Non-communicable Disease and Ageing Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Nutritional Epidemiology Lab Pennsylvania State UniversityPhiladelphia 16801PAUSA Center for Disease Control and Prevention of Shandong Province Jinan 250014ShandongChina Division of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective Evidence regarding alcohol consumption and cognitive impairment is *** cessation of drinking alcohol by non-dependent drinkers alters the risk of cognitive impairment remains *** study prospectively evaluated the potential association between the history of lifetime alcohol cessation and risk of cognitive *** This study included 15,758 participants age 65 years or older,selected from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)that covered 23 provinces in *** alcohol use status,duration of alcohol cessation,and alcohol consumption before abstinence were self-reported by participants;cognitive function was evaluated using Mini-mental State Examination(MMSE).Causespecific hazard models and restricted cubic splines were applied to estimate the effect of alcohol use on cognitive *** Among the 15,758 participants,mean(±SD)age was 82.8 years(±11.9 years),and 7,199(45.7%)were *** a mean of 3.9 years of follow-up,3,404 cases were identified as cognitive *** with current drinkers,alcohol cessation of five to nine years[adjusted HR,0.79(95%CI:0.66-0.96)]and more than nine years[adjusted HR,0.82(95%CI:0.69-0.98)]were associated with lower risk of cognitive *** A longer duration of alcohol cessation was associated with a lower risk of cognitive impairment assessed by *** cessation is never late for older adults to prevent cognitive impairment.

关键词： Cognition Alcohol abstinence Alcohol drinking Epidemiology Aging

Numerical investigation of the cavitation noise around a marine propeller focusing on the influence of ventilation

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Journal of Hydrodynamics 2023年第4期35卷 630-648页

作者： Shu-jian lyu bin Ji Xin-cheng Wang Zhi-wen Zhan Da-hai Zhang State Key Laboratory of Water Resources Engineering and Management Wuhan UniversityWuhan430072China China Ship Development and Design Center National key laboratory on ship Vibration and NoiseWuhan430064China

Cavitation noise around propellers has many adverse *** is still very limited nowadays to inhibit propeller cavitation noise in *** this study,the cavitation noise around a PPTC propeller is simulated using the large eddy simulation(LES)coupled with the porous Ffowcs Williams-Hawkings(PFW-H)*** investigation aims to find a strategy to suppress cavitation noise and analyze the noise suppression *** predicted hydrodynamic results agree well with the experimental data and are utilized in the hydroacoustic *** hydroacoustic results indicate that the pseudo-thickness noise dominates the dominant frequency component of the total cavitation noise due to the effect of cavity evolution,which is one of the reasons why the pseudo-thickness noise dominates the total cavitation noise.A method is found to weaken the cavitation noise through ventilation at the generation location of the sheet cavity(SC).It is worth noting that ventilation inhibits the generation and development of SC by changing the pressure distribution on the suction surface of the blade and pushing away the cavities around the ventilation ***,cavity evolution noise dominates the fluid volume evolution noise under the ventilated cavitating *** significantly attenuates the vapor volume pulsation and thus the cavity evolution noise,which leads to a reduction in pseudo-thickness noise and total cavitation *** ventilation mainly reduces noises at the dominant frequency of the pseudo-thickness noise and the total cavitation noise.

关键词： Cavitation noise ventilation porous Ffowcs Williams-Hawkings(PFW-H)equation large eddy simulation(LES) PPTC propeller

中华民族现代文明:理论内涵、时代要求与世界意义

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海南大学学报（人文社会科学版） 2025年第1期43卷 1-7,F0002页

作者：董慧华中科技大学马克思主义学院湖北武汉430074 华中科技大学国家治理研究院湖北武汉430074

建设中华民族现代文明谱写了全面推进强国建设、民族复兴的新篇章,“新”就新在它既是一个新概念、一种新问题,也代表着一种新思维,彰显了习近平总书记对文化建设的深入思考。中华民族现代文明作为中国式现代化的文明成果,是党的百年文... 详细信息

建设中华民族现代文明谱写了全面推进强国建设、民族复兴的新篇章,“新”就新在它既是一个新概念、一种新问题,也代表着一种新思维,彰显了习近平总书记对文化建设的深入思考。中华民族现代文明作为中国式现代化的文明成果,是党的百年文化建设的宏阔升华,它厚植于中华文明与马克思主义融通结合的沃土,体现了对全人类共同价值的时代追寻。习近平文化思想为建设中华民族现代文明提供根本的理论指引、思想指引、精神指引和使命指引。建设中华民族现代文明,是对时代问题的积极回应,必须坚定文化自信、深化文明互鉴、推进文化传播,推动中华文明焕发时代荣光。

关键词：中华民族现代文明中华文明文化自信中国式现代化

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Ultrafast photocatalytic degradation of nitenpyram by 2D ultrathin Bi2WO6:mechanism,pathways and environmental factors

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Rare Metals 2022年第7期41卷 2439-2452页

作者： Yuan-Hao Cheng Juan Chen hui-Nan Che Yan-hui Ao bin Liu Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education College of EnvironmentHohai UniversityNanjing 210098China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore

As a common insecticide,nitenpyram(NTP)seriously threatens the human health and environmental *** this work,a visible-light-responsive photocata-lyst two-dimensional(2D)Bi_(2)WO_(6) was synthesized and applied to degrade *** with bulk Bi_(2)WO_(6),the 2D Bi_(2)WO_(6)exhibits better photocatalytic performance for NTP degradation under visible-light *** enhanced activity can be ascribed to the unique 2D struc-ture which would induce to higher efficiency of carrier ***,hole(h+)plays a major role(and·O^(2-))in the degradation of *** on the interme-diates detected by high-performance liquid chromatogra-phy-mass spectrometry(HPLC-MS),the degradation pathway of NTP was *** addition,the influence of typical environmental factors(pH,water matrix,inorganic cations and common anions)on the degradation of NTP was also *** work not only helps people to understand the degradation of pesticides in actual water bodies,but also provides reference for the subsequent treatment of agricultural wastewater.

关键词： Photocatalysis Two-dimensional(2D)Bi_(2)WO_(6) Nitenpyram Degradation pathway

Therapeutic potential of iron chelators in retinal vascular diseases

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1899-1910页

作者： Yan Li Zi-Xuan Cheng Ting Luo Hong-bin lyu Department of Ophthalmology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology the People’s Hospital of JianyangChengdu 641400Sichuan ProvinceChina

Iron is one of the necessary metal elements in the human *** are numerous factors that control the balance of iron metabolism,and its storage and transportation mechanisms are *** one of the most energyintensive tissues in the body,the retina is susceptible to iron *** occurrence of iron overload in the retina leads to the generation of a significant quantity of reactive oxygen *** will aggravate local oxidative stress and inflammatory reactions and even lead to ferroptosis,eventually resulting in retinal *** blood-retinaretinal barrier is eventually harmed by oxidative stress and elevated inflammation,which are characteristics of retinal vascular *** pathophysiology of retinal vascular disorders may be significantly influenced by ***,iron-chelating agents have been found to have antioxidative and anti-inflammatory actions in addition to iron ***,iron neutralization is considered to be a new and potentially useful therapeutic *** article reviews the iron overload in retinal vascular diseases and discusses the therapeutic potential of iron-chelating agents.

关键词： iron overload oxidative stress inflammation blood–retinal barrier ferroptosis iron-chelating agent

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

Optimization of kinetic mechanism for hydrogen combustion based on machine learning

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FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 2024年第11期18卷 136页

作者： Cao, Shuangshuang Zhang, Houjun Liu, Haoyang lyu, Zhiyuan Li, Xiangyuan Zhang, bin Han, You Tianjin Univ Sch Chem Engn & Technol Tianjin 300072 Peoples R China Sichuan Univ Sch Chem Engn Chengdu 610065 Peoples R China Shanghai Jiao Tong Univ Sch Aeronaut & Astronaut Shanghai 200240 Peoples R China

The reduced mechanism based on the minimized reaction network method can effectively solve the rigidity problem in the numerical calculation of turbulent internal combustion engine. The optimization of dynamic parameters of the reduced mechanism is the key to reproduce the experimental data. In this work, the experimental data of ignition delay times and laminar flame speeds were taken as the optimization objectives based on the machine-learning model constructed by radial basis function interpolation method, and pre-exponential factors and activation energies of H2 combustion mechanism were optimized. Compared with the origin mechanism, the performance of the optimized mechanism was significantly improved. The error of ignition delay times and laminar flame speeds was reduced by 24.3% and 26.8%, respectively, with 25% decrease in total mean error. The optimized mechanism was used to predict the ignition delay times, laminar flame speeds and species concentrations of jet stirred reactor, and the predicted results were in good agreement with experimental results. In addition, the differences of the key reactions of the combustion mechanism under specific working conditions were studied by sensitivity analysis. Therefore, the machine-learning model is a tool with broad application prospects to optimize various combustion mechanisms in a wide range of operating conditions.

关键词： hydrogen combustion machine learning chemical kinetics mechanism optimization

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银基催化剂调控及其甲醛催化氧化性能研究

大连理工大学学报 2025年第1期65卷 17-22页

作者：黄彬曲振平大连理工大学环境学院辽宁大连116024

银基催化剂具有较好的氧化能力,在环境催化领域具有良好的应用前景.采用等体积浸渍法制备银基催化剂,考察了助剂种类、预处理气氛和温度、载体孔道结构等制备工艺条件对银基催化剂上甲醛(HCHO)催化氧化性能的影响.实验结果表明,在6%的Ag... 详细信息

银基催化剂具有较好的氧化能力,在环境催化领域具有良好的应用前景.采用等体积浸渍法制备银基催化剂,考察了助剂种类、预处理气氛和温度、载体孔道结构等制备工艺条件对银基催化剂上甲醛(HCHO)催化氧化性能的影响.实验结果表明,在6%的Ag/SBA-15催化剂中添加3%的Fe助剂能显著提高催化剂的HCHO催化氧化性能,先后采用O_(2)和H_(2)处理有助于提高催化剂活性,载体孔道结构对HCHO催化氧化活性影响较小,采用共浸渍法制备的银基催化剂的性能优于两步浸渍法制备的催化剂的性能.其中采用共浸渍法制备的AgFe/SBA-15催化剂,在O_(2)(600℃)和H_(2)(400℃)先后处理后,表现出良好的HCHO催化氧化性能,在75℃时可将HCHO完全转化为CO_(2)和H_(2)O.

关键词：甲醛催化氧化银基催化剂制备工艺条件