检索结果-南通市图书馆

Implications of left atrial volume index in patients with three-vessel coronary disease:A 6.6-year follow-up cohort study

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第4期137卷 441-449页

作者： Ru Liu Lei Song Ce zhang Lin Jiang Jian Tian Lianjun Xu Xinxing Feng Linyuan Wan Xueyan z.ao Ou Xu Chongjian Li Runlin Gao Rutai hui Wei z.ao Jinqing Yuan Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Respiratory and Pulmonary Vascular Disease Fuwai Yunnan Cardiovascular HospitalKunmingYunnan 650102China Department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Echocardiography Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Information Center Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China

Background:Risk assessment and treatment stratification for three-vessel coronary disease(TVD)remain *** study aimed to investigate the prognostic value of left atrial volume index(LAVI)with the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score II,and its association with the long-term prognosis after three strategies(percutaneous coronary intervention[PCI],coronary artery bypass grafting[CABG],and medical therapy[MT])in patients with ***:This study was a post hoc analysis of a large,prospective cohort of patients with TVD in China,that aimed to determine the long-term outcomes after PCI,CABG,or optimal MT alone.A total of 8943 patients with TVD were consecutively enrolled between 2004 and 2011 at Fuwai Hospital.A total of 7818 patients with available baseline LAVI data were included in the ***,procedural,and follow-up data were *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),which was a composite of all-cause death,myocardial infarction(MI),and *** endpoints included all-cause death,cardiac death,MI,revascularization,and ***-term outcomes were evaluated among LAVI quartile ***:During a median follow-up of 6.6 years,a higher LAVI was strongly associated with increased risk of MACCE(Q3:hazard ratio[HR]1.20,95%confidence interval[CI]1.06-1.37,P=0.005;Q4:HR 1.85,95%CI 1.64-2.09,P<0.001),all-cause death(Q3:HR 1.41,95%CI 1.17-1.69,P<0.001;Q4:HR 2.54,95%CI 2.16-3.00,P<0.001),and cardiac death(Q3:HR 1.81,95%CI 1.39-2.37,P<0.001;Q4:HR 3.47,95%CI 2.71-4.43,P<0.001).Moreover,LAVI significantly improved discrimination and reclassification of the SYNTAX score ***,there was a significant interaction between LAVI quartiles and treatment strategies for *** was associated with lower risk of MACCE than MT alone,regardless of LAVI *** patients in the fourth quartile,PCI was associated with significantly incre

关键词： Three-vessel coronary disease Left atrial volume index Coronary artery bypass grafting Percutaneous coronary intervention Myocardial ischemia Prognosis

New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第02期 161-170页

作者： SUN zeshi LIN Shan WU zhi-Li DONG Hong-Yuan XU Xi-Ke LI hui-Liang WANG Jinxin School of Pharmacy Second Military Medical University State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry

Our continued works on the chemical constituents of Ginkgo biloba(G. biloba) leaves has led to the isolation of two novel phenylbutenoids(1, 2), along with five previously unidentified terpene glycosides(3-7). Among them, compounds 1 and 2 represent unique(z)-phenylbutenoids, 3-6 are megastigmane glycosides, and 7 is identified as a rare bilobanone glycoside(Fig. 1). This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from G. biloba. The chemical structures of these compounds were elucidated through extensive spectroscopic analysis, including HR-ESI-MS and various 1D and 2D NMR experiments. Furthermore, the absolute configurations of these molecules were determined using Mosher's method, ECD experiments, and Cu-Kα X-ray crystallographic analyses.

关键词：

“全球中国音乐研究的回顾与展望国际学术研讨会”专栏主持人语

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

黄钟(武汉音乐学院学报) 2024年第2期 4-5页

作者：喻辉云南大学

“全球中国音乐研究的回顾与展望国际学术研讨会”及《牛津手册：中国与海外华人音乐》（The Oxford Handbook of Music in China and the Chinese Diaspora）1全球发布会于2023年11月3日至5日在南京师范大学音乐学院举行。来自美国密...

“全球中国音乐研究的回顾与展望国际学术研讨会”及《牛津手册：中国与海外华人音乐》（The Oxford Handbook of Music in China and the Chinese Diaspora）1全球发布会于2023年11月3日至5日在南京师范大学音乐学院举行。来自美国密歇根大学、匹兹堡大学、麦卡莱斯特学院以及爱尔兰国立科克大学、加拿大不列颠哥伦比亚大学、韩国中央大学和中国的香港大学、香港中文大学、香港科技大学、台湾大学、云南大学、南京师范大学、中央音乐学院、中国音乐学院、上海音乐学院、武汉音乐学院、南京艺术学院、云南师范大学、云南艺术学院、扬州大学等海内外高校的200余位中国音乐研究专家和研究生参加了为期两天的线下和线上会议。

关键词：

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第2期15卷 98-120页

作者： Shanshan Yang Chengyu Liu Mengmeng Jiang Xiaoqian Liu Lingling Geng Yiyuan zhang Shuhui Sun Kang Wang jian Yin Shuai Ma Si Wang Juan Carlos Izpisua Belmonte Weiqi zhang Jing Qu Guang-hui Liu Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Xuanwu Hospital Capital Medical University Beijing 100053China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Aging Biomarker Consortium Beijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Aging increases the risk ofliver diseases and systemic susceptibility to aging-related ***,cell type-specific changes and the underlying mechanism of liver aging in higher vertebrates remain incompletely ***,we constructed the first single-nucleus transcriptomic landscape of primate liver aging,in which we resolved cell type-specific gene expression fluctuation in hepatocytes across three liver zonations and detected aberrant cell-cell interactions between hepatocytes and niche *** in-depth dissection of this rich dataset,we identifed impaired lipid metabolism and upregulation of chronic inflammation-related genes prominently associated with declined liver functions during *** particular,hyperactivated sterol regulatory element-binding protein(SREBP)signaling was a hallmark of the aged liver,and consequently,forced activation of SREBP2 in human primary hepatocytes recapitulated in vivo aging phenotypes,manifesting as impaired detoxification and accelerated cellular *** study expands our knowledge of primate liver aging and informs the development of diagnostics and therapeutic interventions for liver aging and associated diseases.

关键词： single-nucleus RNA sequencing liver hepatocytes aging senescence SREBP2

A Machine Learning Made Catalog of FR-Ⅱ Radio Galaxies from the FIRST Survey

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第3期24卷 266-282页

作者： Bao-Qiang Lao Xiao-Long Yang Sumit Jaiswal Prashanth Mohan Xiao-hui Sun Sheng-Li Qin Ru-Shuang z.ao School of Physics and Astronomy Yunnan UniversityKunming 650091.China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030.China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China

We present an independent catalog(FRIIRGcat)of 45,241 Fanaroff–Riley TypeⅡ(FR-Ⅱ)radio galaxies compiled from the Very Large Array Faint Images of the Radio Sky at Twenty-centimeters(FIRST)survey and employed the deep learning *** them,optical and/or infrared counterparts are identified for 41,425 FR-Ⅱ*** catalog spans luminosities 2.63×10^(22)≤L_(rad)≤6.76×10^(29)W Hz^(-1)and redshifts up to z=*** spectroscopic classification indicates that there are 1431 low-excitation radio galaxies and 260 high-excitation radio *** the spectroscopically identified sources,black hole masses are estimated for 4837 FR-Is,which are in 10^(7.5)■M_(BH)■10^(9.5)M_(⊙).Interestingly,this catalog reveals a couple of giant radio galaxies(GRGs),which are already in the existing GRG catalog,confirming the efficiency of this FR-I ***,284new GRGs are unveiled in this new FR-I sample;they have the largest projected sizes ranging from 701 to1209 kpc and are located at redshifts 0.31z<***,we explore the distribution of the jet position angle and it shows that the faint Images of the FIRST images are significantly affected by the systematic effect(the observing beams).The method presented in this work is expected to be applicable to the radio sky surveys that are currently being conducted because they have finely refined telescope *** the other hand,we are expecting that further new methods will be dedicated to solving this problem.

关键词： radio continuum galaxies-galaxies active-galaxies jets-galaxies statistics

东亚地区栓皮栎叶片表皮毛空间变异特征及其与气孔的协同关系

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2024年第3期17卷 153-161页

作者： Yanhua zhu Ji zheng Hongzhang Kang Nan hui Shan Yin zhicheng Chen Baoming Du Chunjiang Liu School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Instrumental Analysis Center Shanghai Jiao Tong UniversityShanghai 200240China School of Design Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Urban Forest Ecosystem Research Station State Forestry AdministrationShanghai 200240China Shanghai Yangtze River Delta Ecoenvironmental Change and Management Observation and Research Station Ministry of Science and TechnologyShanghai 200240China Key Laboratory of Forest Ecology and Environment of National Forestry and Grassland Administration Ecology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎... 详细信息

理解植物功能性状的地理变异对预测全球气候变化下的植物响应至关重要。叶片表皮毛由表皮细胞发育而来,具有调节叶片温度和控制气体交换的功能,然而大的地理尺度上叶片表皮毛如何变异,以及它们与气孔之间的关系仍不清楚。本研究以栓皮栎(Quercus variabilis)为研究对象,分析了东亚地区44个种群叶片表皮毛密度,并评估了它们与气候因子和气孔等性状之间的相关性。同时,为了进一步检测环境变化下的表皮毛响应特征以及与气孔之间的协同关系,本研究利用其中15个种群开展了同质园试验。研究结果发现,栓皮栎叶片表皮毛密度平均值为459.78个mm^(−2),变异范围为325.79–552.38 mm^(−2)。表皮毛密度会随纬度增加而增加,随经度减少而减少,并且与温度和降水呈负相关。同时发现,无论是在野外还是在同质园,叶片表皮毛密度均与气孔密度呈正相关,并且两者均会随干旱强度的增加而增加。这些结果表明,面对环境变化叶片表皮毛密度具有高度的适应性变异,并且可与气孔协同适应这种变化。该研究结果对加深理解气候变化下植物适应策略以及叶片功能性状之间的协同互作具有重要意义。

关键词：叶片功能性状表皮毛气孔性状-性状关系性状-环境关系气候变化

具有两种感染模式和免疫反应的多时滞HIV模型的动力学分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工程数学学报 2024年第4期41卷 693-709页

作者：苗卉滕志东山西财经大学应用数学学院太原030006 新疆医科大学医学工程技术学院乌鲁木齐830011

研究了基于游离病毒和细胞–细胞两种传播机制和适应性免疫的多时滞HIV动力学模型,计算出模型存在五个平衡点和五个基本再生数。通过构造适当的Lyapunov函数,得到了模型的五个平衡点全局渐近稳定的充分条件。发现将一个时滞τ_(3)作为... 详细信息

研究了基于游离病毒和细胞–细胞两种传播机制和适应性免疫的多时滞HIV动力学模型,计算出模型存在五个平衡点和五个基本再生数。通过构造适当的Lyapunov函数,得到了模型的五个平衡点全局渐近稳定的充分条件。发现将一个时滞τ_(3)作为分支参数,可引起两个平衡点E_(2)和E_(4)失稳,并产生Hopf分支。结果说明τ_(3)可导致病毒载量出现周期振荡和免疫反应可降低感染风险。最后利用数值模拟验证所得结论,并对比了不同时滞参数对E_(2)和E_(4)的稳定性影响。

关键词： HIV感染模型适应性免疫细胞间感染 Lyapunov函数全局稳定性

在线全文

学校读者我要写书评

暂无评论

自监督对比的属性图联合表示聚类

计算机工程与应用 2024年第16期60卷 133-142页

作者：王静红王慧河北师范大学计算机与网络空间安全学院石家庄050024 河北省网络与信息安全重点实验室石家庄050024 供应链大数据分析与数据安全河北省工程研究中心石家庄050024

现实世界中越来越多的复杂数据被表示为具有属性节点的图,因此属性图聚类是图挖掘中的一个重要问题。图神经网络在图结构数据的编码表示方面取得较好性能,但基于卷积操作或者注意力机制的图神经网络方法存在节点噪声、特征过度平滑、网... 详细信息

现实世界中越来越多的复杂数据被表示为具有属性节点的图,因此属性图聚类是图挖掘中的一个重要问题。图神经网络在图结构数据的编码表示方面取得较好性能,但基于卷积操作或者注意力机制的图神经网络方法存在节点噪声、特征过度平滑、网络异质性、计算代价高昂等问题。基于深度学习方法如自编码器能够有效地提取节点属性表示,但不能包含丰富结构信息。因此提出了一种基于自监督训练和对比学习的图联合表示聚类方法(self-supervised contrastive graph joint representation clustering,SCRC)。使用自编码器预训练学习节点的属性表示,通过在图结构信息上增加对比损失信息,使用影响对比损失融合更加丰富的结构信息,联合图结构信息和属性表示,基于神经网络自监督训练机制迭代优化完成聚类任务。通过设计简单的线性模型,避免使用卷积和注意力机制,有效整合结构信息,使得运行速度更快。在广泛使用的引文网络数据上进行实验,对参数敏感性进行分析,验证了影响对比损失和自监督联合聚类的有效性。实验结果表明,所提出的方法取得了显著的性能提升,并且对节点噪声、特征过度平滑和网络异质性更具有鲁棒性。

关键词：属性图聚类自监督训练对比学习自编码器联合表示学习

Asymmetric expression of CA2 and CA13 linked to calcification in the bilateral mandibular condyles cause crossed beaks in chickens

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第7期23卷 2379-2390页

作者： Lei Shi Yanyan Sun Yunlei Li Hao Bai Jingwei Yuan hui Ma Yuanmei Wang Panlin Wang Aixin Ni Linlin Jiang Pingzhuang Ge Shixiong Bian Yunhe zong Jinmeng z.ao Adamu MIsa Hailai HTesfay Jilan Chen State Key Laboratory of Animal Biotech Breeding/Key Laboratory of Animal(Poultry)Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs/Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100193China College of Animal Science and Technology Hebei Agricultural UniversityBaoding 071001China Joint International Research Laboratory of Agriculture and Agri-Product Safety Ministry of Education/Institutes of Agricultural Science and Technology DevelopmentYangzhou UniversityYangzhou 225009China

Crossed beak is a complex mode of inheritance with prevalence ranging from 0.2 to 7.4% in at least 12 chicken strains *** reveal the intrinsic factors causing crossed beaks,genes expression patterns in bilateral mandibular condyle between affected and normal birds were characterized by RNA sequencing analysis in the present *** beak was induced by short length of unilateral mandibular ramus,and a total of 110differentially expressed genes were up-or down-regulated in the affected(short)mandibular condyle side as compared to the normal *** anhydrase 2(CA2)and Carbonic anhydrase 13(CA13)were enriched in the carbonate dehydratase activity,and high-expressed in mandibular condyle and osteoblasts(P<0.05).However,both were low-expressed in short mandibular condyle side of affected birds(P<0.05).The carbonate dehydratase inhibitor experiments confirmed that there is positive association between the calcification and carbonic anhydrase *** analysis with cetylpyridinium chloride showed a decrease in calcification when the cells were transfected with an anti-CA13 *** research suggested that CA2 and CA13 are down-calcified in shortside mandibular condyle,and caused mandibular ramus to grow ***2 and CA13 have the critical role in crossed beaks by regulating calcification of mandibular condyle.

关键词： chicken crossed beak carbonic anhydrase calcification CA2 CA13