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Association of acute glycemic parameters at admission with cardiovascular mortality in the oldest old with acute myocardial infarction

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Journal of Geriatric Cardiology 2024年第3期21卷 349-358页

作者： hui-hui LIU Meng ZHANG Yuan-Lin GUO Cheng-Gang ZHU Na-Qiong WU Ying GAO Rui-xia XU Jie QIAN Ke-Fei DOU Jian-Jun LI Cardiometabolic Center State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES Stress-related glycemic indicators,including admission blood glucose(ABG),stress-hyperglycemia ratio(SHR),and glycemic gap(GG),have been associated with worse outcomes after acute myocardial infarction(AMI).However,data regarding their prognostic value in the oldest old with AMI are ***,this study aimed to investigate the association of stress-related glycemic indicators with short-and long-term cardiovascular mortality(CVM)in the oldest old(≥80 years)with *** In this prospective study,a total of 933 consecutive old patients with AMI admitted to FuWai hospital(Beijing,China)were *** admission,ABG,SHR,and GG were assessed and all participants were classified according to their ***-Meier,restricted cubic splines(RCS),and multivariate Cox regression analyses were performed to evaluate the association between these glycemic indicators and CVM within 30 days and long-term *** During an average of 1954 patient-years of follow-up,a total of 250 cardiovascular deaths were ***-Meier analyses showed the lowest CVM in quartile 1 of ABG and in quartile 2 of SHR and *** adjusting for potential covariates,patients in quartile 4 of ABG,SHR,and GG had a respective 1.67-fold(95%CI:1.03-2.69;P=0.036),1.80-fold(95%CI:1.16-2.79;P=0.009),and 1.78-fold(95%CI:1.14-2.79;P=0.011)higher risk of long-term CVM risk compared to those in the reference groups(quartile 1 of ABG and quartile 2 of SHR and GG).Furthermore,RCS suggested a J-shaped relationship of ABG and a Ushaped association of SHR and GG with long-term ***,we observed similar associations of these acute glycemic parameters with 30-day *** Our data first indicated that SHR and GG consistently had a U-shaped association with both 30-day and longterm CVM among the oldest old with AMI,suggesting that they may be useful for risk stratification in this special population.

关键词： admitted infarction shaped

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LSM6 promotes cell proliferation and migration regulated by HMGB1 in laryngeal squamous cell carcinoma

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Engineered Regeneration 2024年第2期5卷 247-254页

作者： Dengbin Ma Jiayi Li hui Li Yao tang xia Gao Hong Chen xiaoyun Qian xiaohui Shen Department of Otolaryngology Head and Neck Surgery Research Institute of OtolaryngologyNanjing Drum Tower HospitalJiangsu Provincial Key Medical DisciplineAffiliated Hospital of medical SchoolNanjing UniversityNanjing210008China Department of Otorhinolaryngology Minda Hospital of Hubei Minzu UniversityEnshi445000China Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan RoadNanjing210008China

Elevated levels of high mobility group protein B1(HMGB1)play a significant role in the pathogenesis of many diseases,but is particularly important for the formation of malignant ***,the function of HMGB1 and the underlying mechanism of laryngeal squamous cell carcinoma(LSCC)remain incompletely understood,causing *** we found immunohistochemistry from 97 LSCC tissues showed HMGB1 was upreg-ulated,which was associated with poor ***1 knockdown could significantly inhibit wound closure and colony *** full-genome gene expression microarray was performed to investigate the *** knockdown of HMGB1 by siRNA,among the expressed differential genes,10 genes were ran-domly selected for ***,shRNA lentivirus targeting these genes were constructed to explore their role in LSCC by cell proliferation ***6 downregulation was dramatically promoted by HMGB1 knockdown,resulting in higher expression in LSCC ***,downregulation of LSM6 could significantly suppress cell proliferation,migration and colony *** study indicated that HMGB1 promoted LSCC cell malig-nant phenotypes through regulation of *** anticipate that HMGB1-LSM6 could be a putative therapeutic target for LSCC.

关键词： HMGB1 LSM6 Laryngeal squamous cell carcinoma Cell proliferation Migration

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Ultra-homogeneous dense Ag nano layer enables long lifespan solid-state lithium metal batteries

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Journal of Energy Chemistry 2024年第9期96卷 110-119页

作者： Yaning Liu Tianqi Yang Ruyi Fang Chengwei Lu Ruojian Ma Ke Yue Zhen xiao xiaozheng Zhou Wenkui Zhang Xinping He Yongping Gan Jun Zhang Xinhui xia hui Huang Xinyong Tao Yang xia College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesChina Jiliang UniversityHangzhou 310018ZhejiangChina

The unstable electrolyte/lithium(Li)anode interface has been one of the key challenges in realizing high energy density solid-state lithium metal batteries(LMBs)***,a dense and uniform silver(Ag)nano interlayer with a thickness of∼35 nm is designed accurately by magnetron sputtering technology to optimize the electrolyte/Li anode *** Ag nano layer reacts with Li metal anode to in-situ form Li-Ag alloy,thus enhancing the physical interfacial contact,and further improving the interfacial wettability and *** particular,the Li-Ag alloy is inclined to form AgLi phase proved by cryo-TEM and DFT,effectively preventing SN from continuously“attacking”the Li metal anode due to the lower adsorption of succinonitrile(SN)molecules on AgLi than that of pure Li metal,thereby significantly reinforcing the interfacial ***,the enhanced physical and chemical stability of electrolyte/Li anode interface promotes the homogeneous deposition of Li^(+)and inhibits the dendrite *** Li-symmetric cell maintains stable operation for up to 1700 h and the cycling stability of LiFePO_(4)|SPE|Li full cell is remarkably improved at room temperature(capacity retention rate of 91.9%for 200 cycles).This work opens an effective way for accurate and controllable interface design of long lifespan solid-state LMBs.

关键词： Silvernano layer Poly(ethylene oxide) Solid polymer electrolyte Succinonitrile Lithium metal battery

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Surgical resection and neoadjuvant therapy in patients with gastric cancer and ovarian metastasis: A real-world study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2426-2435页

作者： hui-Ping Yan Hong-Rui Lu Yu-xia Zhang Liu Yang Zhe-Ling Chen School of Public Health Hangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina Cancer Center Department of Medical OncologyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou 310000Zhejiang ProvinceChina Affiliated Bijie Hospital Zhejiang Provincial People’s HospitalBijie 551700Guizhou ProvinceChina

BACKGROUND Regarding when to treat gastric cancer and ovarian metastasis(GCOM)and whether to have metastatic resection surgery,there is presently debate on a global *** purpose of this research is to examine,in real-world patients with GCOM,the survival rates and efficacy of metastatic vs non-metastasized *** To investigate the survival time and efficacy of metastatic surgery and neoadjuvant therapy in patients with *** This study retrospectively analyzed the data of 41 GCOM patients admitted to Zhejiang Provincial People’s Hospital from June 2009 to July *** diagnosis of all patients was confirmed by *** primary study endpoints included overall survival(OS),ovarian survival,OS after surgery(OSAS),disease-free survival(DFS),differences in *** This study had 41 patients in *** surgical group(n=27)exhibited significantly longer median OS(mOS)and median overall months(mOM)compared to the nonoperative group(n=14)(mOS:23.0 vs 6.9 months,P=0.015;mOM:18.3 vs 3.8 months,P=0.001).However,there were no significant differences observed in mOS,mOM,median OSAS(mOSAS),and median DFS(mDFS)between patients in the surgical resection plus neoadjuvant therapy group(n=11)and those who surgical resection without neoadjuvant therapy group(n=16)(mOS:26.1 months vs 21.8 months,P=0.189;mOM:19.8 vs 15.2 months,P=0.424;mOSAS:13.9 vs 8.7 months,P=0.661,mDFS:5.1 vs 8.2 months,P=0.589).CONCLUSION Compared to the non-surgical group,the surgical group’s survival duration and efficacy are noticeably *** efficacy and survival time of the direct surgery group and the neoadjuvant therapy group did not differ significantly.

关键词： Gastric cancer Prognosis Ovarian metastasis Neoadjuvant therapy Surgery

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New Discovery of the Jinshui Tin Deposit in the Middle Section of the East Kunlun Orogenic Belt,Northwestern China:Mineralization Age and Exploration Significance

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Journal of Earth Science 2024年第4期35卷 1373-1377页

作者： Xingkai Zhang Shao-Yong Jiang hui-Min Su Wei Wang Qinglin xia Yunpeng Liu Shien Li State Key Laboratory of Geological Processes and Mineral Resources Collaborative Innovation Center for Exploration of Strategic Mineral ResourcesSchool of Earth ResourcesChina University of GeosciencesWuhan 430074China Third Geological Exploration Institute of Qinghai Nonferrous Geological and Mineral Exploration Bureau Xining 810000China

Tin,as one of the most important critical metals,has at-tracted great attention worldwide(Jiang et al.,2023,2020).China has the largest amount of tin resources in the world,ac-counting for nearly one-fourth of the world’s total(Jiang et al.,2020;Chen and Sheng,2015).Tin deposits in China mainly occur in the Nanling Range in southern China,the Sanjiang Basin in southwestern China,and the Great Xing’an Range in northeastern China,which account for 98%of the country’s tin resources,whereas tin deposits are relatively rare in north-western China(Ni et al.,2023;Chen et al.,2014,1992).

关键词： Middle northeastern southwestern

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Effects of flue gas desulfurization gypsum and clover planting on qualities of soil and winter jujube in coastal saline-alkali orchard of north China

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Soil Ecology Letters 2024年第1期6卷 141-152页

作者： Qi Shao Xuejing xia Guihua Li hui Li Jitong Lin Yanhong Lou Quangang Yang hui Wang Zhongchen Yang Hong Pan Yuping Zhuge National Engineering Research Centerfor Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai'an271018China Tai'an City Management Comprehensive Service Center Tai'an 271021China

Flue gas desulfurization gypsum and clover planting alleviated the soil salinization *** pH and total phosphorus affected the bacterial *** phosphorus affected the fungal *** gas desulfurization gypsum and clover planting improved jujube *** coastal area of Shandong Province,characterized by coastal saline tidal soil,is one of the main production areas of winter jujube in ***,the low soil fertility and poor soil structure in jujube orchard restricted the development of the jujube *** objectives of this study were to 1)evaluate the effect of application of flue gas desulfurization(FGD)gypsum and clover planting on soil quality improvement and soil microbial community structure of jujube orchard;2)investigate the effects of two measures on the nutrition and quality of winter *** results showed that FGD gypsum reduced the soil total salt content by 65.6%,and clover planting increased the soil organic matter content by 30.7%,which effectively alleviated the soil salinization stress and improved the soil *** pH and total phosphorus(TP)were the main determinants influencing bacterial community composition,and TP was the dominant factor of the fungal community composition in the saline-alkali ***,FGD gypsum addition and clover planting significantly increased the sugar degree and Vc content of winter jujube,thus improved jujube quality,and further contributed to the ecological sustainable development of winter jujube industry.

关键词： saline-alkali soils winter jujube bacterial community fungal community fue gas desulfurization gypsum clover planting

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Effectiveness of Histopathological Examination of Ultrasound-guided Puncture Biopsy Samples for Diagnosis of Extrapulmonary Tuberculosis

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Biomedical and Environmental Sciences 2024年第2期37卷 170-177页

作者： GU Wen Fei SHI xia MA Xin YU Jun Lei XU Jin Chuan QIAN Cheng Cheng HU Zhi Dong ZHANG hui Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China School of Laboratory Medicine and Life Science Wenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Laboratory Medicine Zhejiang Putuo HospitalZhoushan 316100ZhejiangChina Zhongshan Hospital Fudan UniversityShanghai 200032China

Objective To evaluate the diagnostic value of histopathological examination of ultrasound-guided puncture biopsy samples in extrapulmonary tuberculosis(EPTB).Methods This study was conducted at the Shanghai Public Health Clinical Center.A total of 115patients underwent ultrasound-guided puncture biopsy,followed by MGIT 960 culture(culture),smear,Gene Xpert MTB/RIF(Xpert),and histopathological *** assays were performed to evaluate their effectiveness in diagnosing EPTB in comparison to two different diagnostic criteria:liquid culture and composite reference standard(CRS).Results When CRS was used as the reference standard,the sensitivity and specificity of culture,smear,Xpert,and histopathological examination were(44.83%,89.29%),(51.72%,89.29%),(70.11%,96.43%),and(85.06%,82.14%),*** on liquid culture tests,the sensitivity and specificity of smear,Xpert,and pathological examination were(66.67%,72.60%),(83.33%,63.01%),and(92.86%,45.21%),*** examination showed the highest sensitivity but lowest ***,we found that the combination of Xpert and histopathological examination showed a sensitivity of 90.80%and a specificity of 89.29%.Conclusion Ultrasound-guided puncture sampling is safe and effective for the diagnosis of *** with culture,smear,and Xpert,histopathological examination showed higher sensitivity but lower *** combination of histopathology with Xpert showed the best performance characteristics.

关键词： Extrapulmonary tuberculosis Diagnosis Biopsy Histopathological examination Puncture samples

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Rosemary extract improves egg quality by altering gut barrier function,intestinal microbiota and oviductal gene expressions in late-phase laying hens

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Journal of Animal Science and Biotechnology 2024年第1期15卷 295-312页

作者： Lianhua Zhang Junwei Ge Fei Gao Min Yang hui Li Fei xia Hongtong Bai xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Rosemary extract(RE)has been reported to exert antioxidant ***,the application of RE in late-phase laying hens on egg quality,intestinal barrier and microbiota,and oviductal function has not been systematically *** study was investigated to detect the potential effects of RE on performance,egg quality,serum parameters,intestinal heath,cecal microbiota and metabolism,and oviductal gene expressions in late-phase laying hens.A total of 21065-week-old“Jing Tint 6”laying hens were randomly allocated into five treatments with six replicates and seven birds per replicate and fed basal diet(CON)or basal diet supplemented with chlortetracycline at 50 mg/kg(CTC)or RE at 50 mg/kg(RE50),100 mg/kg(RE100),and 200 mg/kg(RE200).Results Our results showed that RE200 improved(P<0.05)Haugh unit and n-6/n-3 of egg yolk,serum superoxide dismutase(SOD)compared with *** significant differences were observed for Haugh unit and n-6/n-3 of egg yolk among CTC,RE50,RE100 and RE200 *** with CTC and RE50 groups,RE200 increased serum SOD activity on d 28 and *** with CON,RE supplementation decreased(P<0.05)total cholesterol(TC)***,RE100 and RE200 decreased(P<0.05)serum interleukin-6(IL-6)content compared with *** and RE200 increased jejunal m RNA expression of ZO-1 and Occludin compared with *** biomarkers of cecal microbiota and metabolite induced by RE 200,including Firmicutes,Eisenbergiella,Paraprevotella,Papillibacter,and butyrate,were closely associated with Haugh unit,n-6/n-3,SOD,IL-6,and ***2 analysis indicated that RE altered carbohydrate and amino acid metabolism of cecal microbiota and increased butyrate synthesizing enzymes,including 3-oxoacid Co A-transferase and butyrate-acetoacetate Co ***,transcriptomic analysis revealed that RE200 improved gene expressions and functional pathways related to immunity and albumen formation in the oviductal *** Dietary supplementation with 2

关键词： Intestinal health Laying hens Microbiota Oviductal function Phytochemicals Production

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Unlocking iron-based mixed-phosphate cathode for sodium-ion batteries through off-stoichiometry

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Nano Research 2024年第9期17卷 8119-8125页

作者： Zhaolu Liu Yongjie Cao Ning Wang hui Yang Hao Zhang Xinyue Xu Nan Wang Jie Xu Yao Liu Junxi Zhang Yongyao xia Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan UniversityShanghai 200433China School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002China Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China

The off-stoichiometric iron-based phosphate(Na_(3.12)Fe_(2.44)(P_(2)O_(7))_(2),denoted as Na3.12)as a low cost and high structure stability cathode material has been widely studied for sodium-ion batteries(SIBs).However,the lower theoretical specific capacity(117 mAh·g^(-1))has seriously limited its practical *** this work,we incorporate varying proportion of sodium-iron phosphate(NaFePO_(4))into the Na3.12 to form a series of new high specific capacity mixed-phosphates Na_(3.12+x)Fe_(2.44+x)(P_(2)O_(7))_(2)(PO_(4))x cathode materials for *** optimizing the introduction amount of NaFePO_(4)into Na_(3.12),the practical reversible of Na_(3.12+x)Fe_(2.44+x)(P_(2)O_(7))_(2)(PO_(4))_(x) increased from 92 to 125.2 mAh·g^(-1).The nano-size Na5.12Fe4.44(P_(2)O_(7))_(2)(PO_(4))_(2) cathode material shows a reversible specific capacity of 125.2 mAh·g^(-1)at 0.1 C in *** at 60 C,it still exhibits a reversible specific capacity of 93.3 mAh·g^(-1)and keeps a capacity retention ratio of 87%after 3000 cycles at 20 ***,we present a novel approach to design a series of off-stoichiometric mixed-phosphates cathode materials for SIBs.

关键词： sodium-ion batteries cathode material iron-based mixed-phosphates off-stoichiometric

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Overstory functional groups indicate the legacy of land use in a secondary tropical forest in southwestern China

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Journal of Forestry Research 2024年第5期35卷 91-105页

作者： Yun Deng Wenfu Zhang Min Cao Jinlong Dong hui Chen xiaobao Deng Jiajia Liu xiaoyang Song Shangwen xia Liqing Sha Shengdong Yuan Luxiang Lin CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303People’s Republic of China Center for Plant Ecology Core Botanical GardensChinese Academy of SciencesMengla 666303People’s Republic of China National Forest Ecosystem Research Station at Xishuangbanna Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303People’s Republic of China Department of Life Sciences Fudan UniversityShanghai 570228People’s Republic of China Department of Life Sciences University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

Anthropogenic disturbances are widespread in tropical forests and influence the species composition in the ***,the impacts of historical disturbance on tropical forest overstory recovery are unclear due to a lack of disturbance data,and previous studies have focused on understory *** this study,the purpose was to deter-mine the influence of historical disturbance on the diver-sity,composition and regeneration of overstory species in present *** the 20-ha Xishuangbanna tropical sea-sonal rainforest dynamics plot in southwestern China,the historical disturbance boundaries were delineated based on panchromatic photographs from *** that drove species clustering in the overstory layer(DBH≥40 cm)were analyzed and the abundance,richness and composition of these species were compared among different tree groups based on multiple regression tree *** coefficient of variation of the brightness value in historical panchro-matic photographs from 1965 was the primary driver of spe-cies clustering in the overstory *** abundance and richness of overstory species throughout the regeneration process were similar,but species composition was always *** the proportion of large-seeded and vigorous-sprouting species showed no significant differ-ence between disturbed and undisturbed forests in the tree-let layer(DBH<20 cm),the difference became significant when DBH *** findings highlight that historical disturbances have strong legacy effects on functional group composition in the overstory and the recovery of overstory species was *** group composi-tion can better indicate the dynamics of overstory species replacement during secondary succession.

关键词： Historical disturbance Legacy effects Secondary forests Overstory species Functional groups

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