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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

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Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-Yuan Qu Ying Lei Qi Chen Yu-Xiu Chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-xia Fu Yuan Kong Yue-Ying Li Qian-Fei Wang xiao-Jun Huang xiao-hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

废弃铅锌冶炼场地土壤和地下水重金属迁移及预测

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Journal of Central South University 2024年第4期31卷 1136-1148页

作者：张云霞郭朝晖谢慧民肖细元徐锐 School of Metallurgy and Environment Central South UniversityChangsha 410083China

长期的金属冶炼活动会导致重金属在场地土壤和地下水中的富集和扩散。基于机器学习模型研究了某废弃铅锌冶炼场地土壤中重金属向地下水的迁移规律并进行了含量预测。结果表明,场地土壤重金属主要累积在杂填土和素填土层,并存在垂向迁移... 详细信息

长期的金属冶炼活动会导致重金属在场地土壤和地下水中的富集和扩散。基于机器学习模型研究了某废弃铅锌冶炼场地土壤中重金属向地下水的迁移规律并进行了含量预测。结果表明,场地土壤重金属主要累积在杂填土和素填土层,并存在垂向迁移到地下水的现象。场地土壤中As、Cd和Pb含量平均值均明显超过场地土壤风险筛选值。地下水中Zn、Cd、Pb和As的平均浓度均超过了相应的地下水Ⅵ类限值。土壤重金属污染主要集中在火法冶炼区、湿法冶炼区和原料堆存区。土壤中Cd以活性态为主,Pb以还原态为主。当冶炼场地地下水位低于5 m且土壤Cd含量超过344 mg/kg时,或土壤中活性Pb含量超过5425 mg/kg时,需要对场地土壤和地下水进行协同修复。

关键词：铅锌冶炼场地迁移转化机器学习重金属预测

Influence of the position relationship between the cathode and magnetic separatrix on the discharge process of a Hall thruster

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Plasma Science and Technology 2024年第1期26卷 74-81页

作者：曹希峰麻洪宁夏国俊刘辉赵方舟王宇航陈巨辉 School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150001People’s Republic of China Shanghai Institute of Satellite Engineering Shanghai 20040People’s Republic of China Lab of Plasma Propulsion Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Previous studies have shown that there is an obvious coupling relationship between the installation location of the external cathode and the magnetic separatrix in the plume region of a Hall *** this paper,the particle-in-cell simulation method is used to compare the thruster discharge process under the conditions of different position relationships between the cathode and the magnetic *** comparing the distribution of electron conduction,potential,plasma density and other microscopic parameters,we try to explain the formation mechanism of the discharge *** simulation results show that the cathode inside and outside the magnetic separatrix has a significant effect on the distribution of potential and plasma *** the cathode is located on the outer side of the magnetic separatrix,the potential above the plume region is relatively low,and there is a strong potential gradient above the plume *** potential gradient is more conducive to the radial diffusion of ions above the plume,which is the main reason for the strong divergence of the *** distribution of ion density is also consistent with the distribution of *** the cathode is located on the outer side of the magnetic separatrix,the radial diffusion of ions in the plume region is ***,by comparing the results of electron conduction,it is found that the traiectories of electrons emitted from the cathode are significantly different between the inner and outer sides of the magnetic *** is mainly because the electrons are affected by the magnetic mirror effect of the magnetic tip,which makes it difficult for the electrons to move across the magnetic *** is the main reason for the difference in potential *** this paper,the simulation results of macroscopic parameters under several conditions are also compared,and they are consistent with the experimental *** cathode is located on the inner side of the ma

关键词： Hall thruster cathode magnetic separatrix

芬戈莫德增效多粘菌素B抗铜绿假单胞菌活性的发现

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中国药理学通报 2024年第1期40卷 195-196页

作者：吴夏丽黄维典灵辉广东医科大学药学院广东东莞523000 深圳市人民医院检验科暨南大学附属第二临床医学院南方科技大学第一附属医院广东深圳518020

耐碳青霉烯类铜绿假单胞菌(Carbapenem resistant Pseudomonas aeruginosa,CRPA)已被世界卫生组织列为迫切需要开发新抗生素的最优先级关键性病原体之一[1]。多粘菌素B(PolymyxinB,PB)对包括CRPA在内的耐药革兰阴性菌具有良好的抗菌效果... 详细信息

耐碳青霉烯类铜绿假单胞菌(Carbapenem resistant Pseudomonas aeruginosa,CRPA)已被世界卫生组织列为迫切需要开发新抗生素的最优先级关键性病原体之一[1]。多粘菌素B(PolymyxinB,PB)对包括CRPA在内的耐药革兰阴性菌具有良好的抗菌效果,被认为是治疗其感染的“最后一道防线”[1]。然而,PB的毒性及临床上出现的多粘菌素耐药是阻碍其临床应用的两个重要因素[2]。开发新的替代PB的抗生素是解决上述问题最有效的方式,但周期较长且成功率极低,而开发其增效剂则是一种很好的替代方案[3]。本研究通过对已知靶点化合物库的筛选发现芬戈莫德可增强PB的抗PA活性,具有与PB形成联合用药方案的潜能。芬戈莫德(Fingolimod)的中文化学名称:2-氨基-2-[2-(4-辛烷基苯基)乙基]-1,3-丙二醇,分子式为C19H33NO2,分子量为307.5[4]。

关键词：铜绿假单胞菌多粘菌素B 芬戈莫德 pmrB 点突变

酸性矿井水环境中矸石胶结充填体的强度演化及劣化规律

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Journal of Central South University 2024年第5期31卷 1560-1573页

作者：赵永辉郭育霞冯国瑞 College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi Province Research Centre of Green Mining Engineering Technology Taiyuan 030024China Shanxi Province Coal-based Resources Green and High-efficiency Development Engineering Center Taiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030024China

矸石胶结充填开采是一种重要的充填开采方法,然而,酸性矿井水会严重影响矸石胶结充填体的强度。在本研究中,将矸石胶结充填体试件分别置于不同环境(空气、水、硫酸溶液、硫酸与荷载耦合)中,测试了不同龄期试件的抗压强度、电阻率及超声... 详细信息

矸石胶结充填开采是一种重要的充填开采方法,然而,酸性矿井水会严重影响矸石胶结充填体的强度。在本研究中,将矸石胶结充填体试件分别置于不同环境(空气、水、硫酸溶液、硫酸与荷载耦合)中,测试了不同龄期试件的抗压强度、电阻率及超声波波速,监测了加载过程中试件的声发射能量数值,同时结合扫描电镜和X衍射分析不同龄期充填体的微观结构。结果表明,1)空气中与水中养护的充填体抗压强度的增长趋势随龄期的增加而逐渐减缓。硫酸溶液中的充填体强度在前90天大于空气及水中养护的充填体强度。硫酸溶液与荷载耦合作用下充填体的强度随龄期的下降速率比单一硫酸溶液作用的较为缓慢;2)不同龄期矸石胶结充填体电阻率与超声波波速与强度有较好的对应关系。受侵蚀后矸石胶结充填体的破坏形式较为多样,且在加载不同阶段表现出不同的声发射能量特征,可以将声发射能量激增作为充填体的破坏前兆;3)侵蚀产物前期填充充填体内部孔隙,提高了其强度,后期会导致充填体膨胀开裂,强度降低。施加40%应力强度比的荷载会抵抗硫酸溶液的侵蚀。本文研究结果可以为充填体的耐侵蚀设计提供参考。

关键词：酸性矿井水矸石胶结充填体劣化规律电阻率超声波波速声发射能量微观结构

Assessing Coarctation of the Aorta With Fetal Heart Quantification Technology

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Maternal-Fetal Medicine 2024年第3期6卷 147-155页

作者： Jiaojiao Yang Fang tan Yuqin Shen Yuan Zhao Yan xia Sihan Fan Xueqin Ji Department of Obstetrics and Gynecology Center General Hospital of Ningxia Medical UniversityYinchuanNingxia 750003China Ultrasound Medicine Department Xian Yang Central HospitalXianyangShaanxi 712099China Ultrasound Medicine Department Peking University First Hospital Ningxia Women’s and Children's Hospital(Ningxia Hui Autonomous Region Maternal and Child Health Hospital)YinchuanNingxia 750002China Ningxia Medical University YinchuanNingxia 750004China

Objective:To use fetal heart quantification(fetal HQ)technology to compare the coarctation of the aorta(CoA)and normal fetal heart structure and systolic function and to assess whether there are abnormalities in the fetal heart structure and systolic function associated with ***:This prospective cohort study was conducted from May 2020 to December 2022 and involved 18–40-week-old singleton pregnancies and 30 fetuses diagnosed with CoA using fetal echocardiography at the General Hospital of Ningxia Medical University and Peking University First Hospital Ningxia Women’s andChildren’s Hospital,*** control group contained 60 normal *** following parameters were recorded and analyzed statistically:four-chamber view(4CV)end-diastolic long diameter,4CV epicardial–contralateral epicardial transverse maximum diameter,4CV global sphericity index(GSI),left ventricular(LV)and right ventricular(RV)24-segment end-diastolic diameter(EDD),24-segment sphericity index(SI),LV-fractional area change(LV-FAC),LV-longitudinal strain(LV-LS),RV-fractional area change(RV-FAC),RV-longitudinal strain(RV-LS),and LV and RV 24-segment transverse fractional shortening(FS).Measurement data were compared between the two groups using an independent sample t test,with P0.9,indicating high consistency,and a coefficient of variable of<1%,indicating low *** analysis revealed no obvious correlation between gestational age and GSI,LV-FAC,LV-LS,RV-FAC,and RV-LS.A comparison of the fourchamber morphological structural parameters of the hearts in the two groups revealed that when compared with the control group,the 4CV end-diastolic long diameter was shortened in

关键词： Fetal heart Quantitative analysis technology Fetal HQ software Coarctation of the aorta Spherical index Systolic function

外源CO和H_(2)S对NaCl胁迫下加工番茄幼苗光合及叶绿素荧光动力学的影响

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植物营养与肥料学报 2024年第3期30卷 538-549页

作者：骆霞滕元旭崔辉梅石河子大学农学院/特色果蔬栽培生理与种质资源利用兵团重点实验室新疆石河子832003

[目的]研究一氧化碳(CO)和硫化氢(H_(2)S)调控作物幼苗抗盐能力的机理,为缓解盐渍土中NaCl对作物的胁迫提供理论和技术。[方法]以加工番茄品系KT-7为试验材料,采用无土栽培方法进行CO和H_(2)S叶面喷施试验。CO供体为氯化血红素溶液(hemi... 详细信息

[目的]研究一氧化碳(CO)和硫化氢(H_(2)S)调控作物幼苗抗盐能力的机理,为缓解盐渍土中NaCl对作物的胁迫提供理论和技术。[方法]以加工番茄品系KT-7为试验材料,采用无土栽培方法进行CO和H_(2)S叶面喷施试验。CO供体为氯化血红素溶液(hemin 15μmol/L),H_(2)S供体为硫氢化钠溶液(NaHS,50μmol/L),并因处理需要使用了H_(2)S清除剂次牛磺酸溶液(HT,100μmol/L)和血红素加氧酶抑制剂锌原卟啉溶液(ZnPPⅨ,25μmol/L)。试验共设6个处理,除对照根部浇灌营养液,叶面喷施清水外(CK_(0)),其余5个处理均根部浇灌200 mmol/L NaCl溶液,叶面分别喷施清水(CK_(1))、CO、H_(2)S、CO+HT、H_(2)S+ZnPPⅨ。幼苗长至四叶一心时,连续6天进行NaCl浇灌和叶面喷施处理,然后测定幼苗形态学指标,用Li-6800便携式光合测定仪测定光合参数,用Imaging-PAM荧光成像系统测定叶绿素荧光系数,植物效率仪测定叶绿素荧光动力学曲线(OJIP曲线)。[结果]胁迫6天后,加工番茄幼苗的各项形态学参数、净光合速率(P_(n))、实际光化学效率[Y(Ⅱ)]和光系统Ⅱ(PSⅡ)性能指标[PI_(ABS)和PI_((CSM))]显著下降,OJIP曲线产生形变,并出现K点。CO和H_(2)S处理均有效提高了加工番茄幼苗的光合色素含量、光合参数、PSⅡ的综合性能和受体侧的电子传递效率;提升了OJIP曲线中的J点、I点、P点,降低了ΔK,从而缓解了OJIP曲线的形变;CO处理的P_(n)、表观CO^(2)利用率(CUEapp)、Y(Ⅱ)和电子传递速率(ETR)分别较CK_(1)上升了75.63%、100%、60.00%和57.72%,H_(2)S处理分别上升了65.95%、100%、55.00%和52.68%,CO和H_(2)S处理均降低了非光化学淬灭和热耗散的比例,减少了PSⅡ供体侧放氧复合体(OEC)的损伤。CO+HT处理缓解NaCl胁迫的效果和CO处理相似,而H_(2)S+ZnPPⅨ处理则不能缓解NaCl胁迫,其光合色素含量、P_(n)、F_(v)/F_(m)、Y(Ⅱ)、qL、ETR、PI_(ABS)和PI_((CSM))较H_(2)S处理显著下降,热耗散比率则较H_(2)S处理显著升高。[结论]外源施用CO和H_(2)S均可通过提高光合效率,优化PSⅡ能量分配比率,保护光合电子传递链免受盐害损伤,显著提高番茄幼苗的抗盐能力。CO的作用位点可能在H_(2)S下游,具有协同H_(2)S提高加工番茄耐盐性的作用。

关键词：一氧化碳硫化氢加工番茄 NaCl胁迫叶绿素荧光

向上社会流动的蜗牛模型:基于寒门学子论文致谢的叙事研究

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青海社会科学 2024年第2期 127-136页

作者：惠霞周爱保西北师范大学教育科学学院甘肃政法大学西北师范大学心理学院

寒门学子社会流动是近年来教育社会学领域的热点研究主题。尽管针对寒门学子通过教育实现社会流动的影响因素有较多研究,但诸多因素之间发挥合力的机制理路仍不明晰。以近几年走红于网络的寒门学子博士论文致谢为文本材料,通过教育生活... 详细信息

寒门学子社会流动是近年来教育社会学领域的热点研究主题。尽管针对寒门学子通过教育实现社会流动的影响因素有较多研究,但诸多因素之间发挥合力的机制理路仍不明晰。以近几年走红于网络的寒门学子博士论文致谢为文本材料,通过教育生活叙事的研究方法,对亲历者主体性建构文本中的结构、实践、情感、心理等要素进行综合分析,探索寒门学子实现社会流动的机制。研究发现,蜗牛模型可能会成为阐释寒门学子实现社会流动机制的有益尝试:螺旋形的外壳、可隐的软体以及“软硬”有机融合的整体结构能够表征寒门学子在成长过程中的具身体验与自我心理赋能。寒门学子在教育生活中的具身体验是其社会流动过程中进行自我心理赋能的实践源泉与基础,而自我心理赋能让特殊、曲折的成长经历的价值最大化,并为行动和实践提供动力;二者以“共存”的方式有机结合,形成“软硬”兼具的寒门学子向上社会流动的蜗牛模型。

关键词：蜗牛模型社会流动寒门学子具身体验自我心理赋能

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A Retrospective Investigation of a Case of Dual Infection by Avian-Origin Influenza A(H10N5)and Seasonal Influenza A(H3N2)Viruses-Anhui Province,China,December 2023-January 2024

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China CDC weekly 2024年第25期6卷 605-613页

作者： Jun He Lei Gong xiaolong Chen Deman Cheng Sai Hou Mengyao Kong Xun Wei Junling Yu Qian Zhu Weiwei Li Wanhang Lu Yujie Feng Hongya Gui Weixi Fang Peng Wang Yidan xia Yong Sun Wanrong Luo Yun Yang Guowei Shen hui Wang Jiabing Wu Anhui Provincial Center for Disease Control and Prevention Hefei CityAnhui ProvinceChina School of Public Health Bengbu Medical UniversityBengbu CityAnhui ProvinceChina Public Health Research Institute of Anhui Province Hefei CityAnhui ProvinceChina School of Public Health Anhui Medical UniversityHefei CityAnhui ProvinceChina Xuancheng City Center for Disease Control and Prevention Xuancheng CityAnhui ProvinceChina Guangde City Center for Disease Control and Prevention Guangde CityAnhui ProvinceChina

Summary What is known about this topic?H10 avian influenza viruses circulate in wild birds and can reassort with other subtypes.H10N8 and H10N3 have previously caused sporadic human infections in *** is added by this report?This report documents the first human case of coinfection with avian-origin H10N5 and seasonal H3N2 influenza *** investigations identified H10N5 in environmental samples linked to the patient,but no transmission to close contacts *** are the implications for public health practice?Enhanced surveillance of avian influenza in live poultry markets and poultry populations is crucial for thoroughly characterizing the epidemiology,transmission,and pathogenesis of H10N5 *** assessments of outbreak control measures is essential to guide effective management.

关键词： poultry Anhui thoroughly