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Rare Metals 2007年第1期26卷 39-44页

作者： LIU Hongyu kong hui JIANG Dongmei SHI Wangzhou MA Xueming ZHANG huining Department of Physics East China Normal University Shanghai 200062 China College of Science Wuhan University of Science and Technology Wuhan 430081 China Shanghai Research Institute of Petrochemical Technology Shanghai 201208 China

The microstructure, electrical properties, and density of Dy2O3-doped ZnO-based varistor ceramics, prepared using high-energy ball milling （HEBM） and sintered at 800℃, were investigated by increasing the cooling rate in the order of H （slow cooling in furnace） → L （cooling in furnace） → K （cooling in air）. With the increase in cooling rate, the grain size and density decreased, the breakdown voltage （VImA/mm） increased, and the nonlinear coefficient （α） and leakage current （IL） exhibited extremum. The sample with the cooling type L showed the best properties with the breakdown voltage of 2650 V/ram, o：of 20.3, IL of 5.2 laA, and density of 5.42 g/cm^3. The barrier height （ФB）, donor concentration （Nd）, density of the interface states （Nd）, and barrier width （ω） all exhibited extremum during the alteration in cooling rate. The different relative amount of Bi-rich phase and its distribution as well as the characteristic parameters of grain boundary, resulting from the alteration of cooling rate, led to the changes in the properties of varistor ceramics.

关键词： varistor ZnO Dy2O3 microstructure electrical properties high-energy ball milling low-temperature sintering

紫杉醇联合卡铂同步放化疗在食管癌患者中的应用效果研究

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医药论坛杂志 2024年第3期45卷 293-296页

作者：张博亚张琳孔慧芳张羲茜魏梦霞郑州大学第一附属医院放疗科郑州450000

目的研究食管癌患者应用紫杉醇联合卡铂同步放化疗的临床效果。方法选取2020年1月—2022年1月郑州大学第一附属医院放疗科接受治疗的食管癌患者120例,随机分为对照组和实验组各60例,对照组应用卡铂注射液开展同步放化疗治疗,实验组在... 详细信息

目的研究食管癌患者应用紫杉醇联合卡铂同步放化疗的临床效果。方法选取2020年1月—2022年1月郑州大学第一附属医院放疗科接受治疗的食管癌患者120例,随机分为对照组和实验组各60例,对照组应用卡铂注射液开展同步放化疗治疗,实验组在对照组基础上联合应用紫杉醇注射液治疗,治疗2个周期后,以疾病整体治疗效果、血清肿瘤标志物、1年内生存、复发情况以及不良反应情况作为观察指标,对比组间治疗效果。结果治疗后实验组和对照组治疗有效率分别为75.00%、56.67%,实验组有效率更高,差异有统计学意义(P0.05),治疗后均显著下降,且实验组CEA、CA19-9水平分别为(4.01±0.18)μg/L及(35.88±0.65)μ/mL,均低于对照组,差异有统计学意义(P0.05)。结论食管癌采用紫杉醇与卡铂联合开展同步放化疗疗效显著,可有效降低患者血清肿瘤标志物水平,降低复发风险,提升患者临床生存率,且未明显增加不良反应,整体疗效良好,值得临床推广应用。

关键词：食管癌紫杉醇卡铂同步放化疗治疗效果

Analysis of Topographic Heterogeneity in the Sanjiangyuan

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Asian Agricultural Research 2021年第6期13卷 40-41,63页

作者： Dan WU hui kong Shaanxi Provincial Land Engineering Construction Group Co. Ltd.Xi'an 710075China Institute of Land Engineering and Technology Shaanxi Provincial Land Engineering Construction Group Co.Ltd.Xi'an 710075China Key Laboratory of Degraded and Unused Land Consolidation Engineering Ministry of Natural ResourcesXi'an 710075China Shaanxi Provincial Land Consolidation Engineering Technology Research Center Xi'an 710075China

Based on the DEM raster image data with a resolution of 60 m×60 m in the Sanjiangyuan region,the topographic heterogeneity in the Sanjiangyuan region was analyzed by calculating and processing the topographic relief,elevation standard deviation,terrain heterogeneity and surface roughness *** results show that the overall terrain elevation of the Sanjiangyuan area is high,and the surface undulations are *** southern and southeastern parts of the region are the places with the most dramatic terrain *** absolute values of terrain undulations,elevation standard deviation and surface roughness are *** the central and western regions,the terrain change is small,the relief degree is small,the elevation standard deviation and the surface roughness are small.

关键词： Topographic heterogeneity Relief of topography Surface roughness

Immune infiltration-associated serum amyloid A1 predicts favorable prognosis for hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第35期26卷 5287-5301页

作者： Wei Zhang hui-Fang kong Xu-Dong Gao Zheng Dong Ying Lu Jia-Gan Huang Hong Li Yong-Ping Yang Center for Diagnosis and Research of Liver Tumor Fifth Medical Center of People's Liberation Army General HospitalBeijing 100191China Department of Infectious Diseases the Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

BACKGROUND Serum amyloid A1(SAA1)is an acute-phase protein involved in acute or chronic *** function is still *** addition,the effect of the expression of SAA1 and its molecular function on the progression in hepatocellular carcinoma(HCC)is still *** To demonstrate the expression of SAA1 and its effect on the prognosis in HCC and explain further the correlation of SAA1 and immunity *** SAA1 expression in HCC was conducted with The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC)in GEPIA tool,and the survival analysis based on the SAA1 expression level was achieved in the Kaplan-Meier *** high or low expression group was then drawn based on the median level of SAA1 *** correlation of SAA1 and the clinical features were conducted in the UALCAN web-based portal with TCGA-LIHC,including tumor grade,patient disease stage,and the TP53 *** correlation analysis between SAA1 expression and TP53 mutation was subjected to the TCGA *** tumor purity score and the immune score were analyzed with *** correlation of SAA1 expression and tumor-infiltrating lymphocytes was achieved in TISIDB web-based integrated repository portal for tumor-immune system ***125336 dataset was used to test the SAA1 expression in the responsive or resistant group with anti-PD1 *** set enrichment analysis was applied to evaluate the gene enrichment signaling pathway in *** similar genes of SAA1 in HCC were identified in GEPIA,and the proteinprotein interaction of SAA1 was conducted in the Metascape *** expression of C-X-C motif chemokine ligand 2,C-C motif chemokine ligand 23,and complement C5a receptor 1 was studied and overall survival analysis in HCC was conducted in GEPIA and Kaplan-Meier portal,*** SAA1 expression was decreased in HCC,and lower SAA1 expression predicted poorer overall survival,progression-free survival,and disease-specific ***

关键词： Serum amyloid A1 Hepatocellular carcinoma Low expression Prognosis Hepatitis Immune pathways

Endow activated carbon with the ability to activate peroxymonosulfate for the treatment of refractory organics

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Green Chemical Engineering 2022年第4期3卷 374-384页

作者： Pei-Lin Yi Wen-Jie Zhang Ling-hui kong Rong-Fang Shen Xiao-Jing Guo Xi Yan Yan Chen Wan-Zhong Lang The Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional MaterialsDepartment of Chemistry and Chemical EngineeringShanghai Normal University200234China Division of Nuclear Materials Science and Engineering Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800China

Herein,we demonstrated that various activated carbons could be endowed with high ability activating peroxymonosulfate(PMS)just through pyrolysis for the degradation of various organic *** ofloxacin(OFX)was proved to be degraded rather than adsorbed in the advanced oxidation *** catalyst showed good stability and could be recovered by simple pyrolysis showing the initial *** defects were identified as active sites of the catalyst,andπ-π^(*)shake up was related to the catalyst *** electron transfer was verified to be responsible for the degradation of *** inhibition effect of furfuryl alcohol(FFA)on the degradation of contaminant was proved to be insufficient to verify^(1)O_(2).The main OFX degradation intermediates were identified by LC-MS,and possible degradation pathways were *** study provided a simple way for the development of low-cost,metal-free,and high-efficient carbonaceous materials to activate PMS in advanced oxidation processes,and proposed new insights for the exploration of PMS activation mechanism.

关键词： Activated carbon Advanced oxidation processes Peroxymonosulfate Electron transfer pathway

AAV-mediated gene therapies by miniature gene editing tools

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Science China Life Sciences 2024年

作者： Xiangfeng kong Tong Li hui Yang Shanghai Institute of Materia Medica Chinese Academy of Sciences Institute of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences huidaGene Therapeutics Co. Ltd. Shanghai Center for Brain Science and Brain-Inspired Technology

The advent of CRISPR-Cas has revolutionized precise gene editing. While pioneering CRISPR nucleases like Cas9 and Cas12 generate targeted DNA double-strand breaks(DSB) for knockout or homology-directed repair, next generation CRISPR technologies enable gene editing without DNA DSB. Base editors directly convert bases, prime editors make diverse alterations, and dead Cas-regulator fusions allow nuanced control of gene expression, avoiding potentially risks like translocations. Meanwhile, the discovery of diminutive Cas12 orthologs and Obligate Mobile Element-Guided Activity(OMEGA) nucleases has overcome cargo limitations of adeno-associated viral vectors, expanding prospects for in vivo therapeutic delivery. Here, we review the ever-evolving landscape of cutting-edge gene editing tools, focusing on miniature Cas12 orthologs and OMEGA effectors amenable to single AAV packaging. We also summarize CRISPR therapies delivered using AAV vectors, discuss challenges such as efficiency and specificity, and look to the future of this transformative field of in vivo gene editing enabled by AAV vectors delivery.

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Serum IL-1β and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients

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The Journal of Biomedical Research 2015年第5期29卷 426-428页

作者： Yanli Wang Chunmei Hu Zailiang Wang hui kong Weiping Xie Hong Wang Department of Respiratory Medicine The First Affiliated Hospital of Nanjing Medical University

Dear Editor： The emergence of multidrug-resistant tuberculosis （MDR-TB） is bringing new challenges. MDR-TB is caused by Mycobacterium tuberculosis （M. tuberculosis） that is resistant to isoniazid and rifampicin, with or with- out resistance to other anti-tuberculosis drugs. Approximately 450,000 people developed MDR-TB worldwide in 2012 and an estimated 170,000 people died from the disease. Bacterial burden is not strictly corre- lated with disease progression, and several hallmarks of severe tuberculosis suggest that insufficiently controlled inflammation plays an important role in pathogenesis.

关键词： ESR TB CRP and IL-18 correlate with ESR and CRP in multidrug-resistant tuberculosis patients Serum IL-1 IL MDR

Diagnosis of a Chinese man with 45,X/46,X,i（Y）（q10）/47,X,i（Y）（q10） ×2 mosaic Turner syndrome

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Asian Journal of Andrology 2018年第2期20卷 205-207页

作者： Yan-Wei Sha Lu Ding Zhi-Yong Ji Yun-Sheng Ge hui kong Qing Zhang Yu-Lin Zhou Ping Li Department of Reproductive Medicine Maternal and Child Health Hospital of Xiamen Xiamen 361005 China Genetics Laboratory Maternal and Child Health Hospital of Xiamen Xiamen 361005 China

Turner syndrome （TS）, characterized by the complete or partial absence of an X chromosome, is the only known viable chromosomal monosomy. It is one of the most common sex chromosome abnormalities in women, but it ca...

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基于CASIA2评价白内障术后3种非球面人工晶状体囊袋内倾斜和偏心的研究

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山东大学耳鼻喉眼学报 2024年第4期38卷 76-85页

作者：马继玲王晓明李琰穆延潇靳琳孔慧杨乃甫党光福山东中医药大学眼科与视光医学院济南明水眼科医院白内障科山东第一医科大学第一附属医院眼科

目的应用新型眼前节扫频光相干断层扫描仪CASIA2比较白内障术后3种不同非球面人工晶状体(intraocular lens, IOL)倾斜和偏心。方法回顾2020年10月至2021年3月于山东省千佛山医院行白内障超声乳化摘除联合IOL植入术的患者资料，其中包... 详细信息

目的应用新型眼前节扫频光相干断层扫描仪CASIA2比较白内障术后3种不同非球面人工晶状体(intraocular lens, IOL)倾斜和偏心。方法回顾2020年10月至2021年3月于山东省千佛山医院行白内障超声乳化摘除联合IOL植入术的患者资料，其中包括患者的年龄、性别、术前及术后1 d最佳矫正视力(best corrected visual acuity, BCVA)、眼轴长度(axial length, AL)、IOL类型及度数等资料，并分别于术后1 d、7 d、30 d应用CASIA2测量IOL在2D图像中水平和垂直方向的倾斜度和偏心量以及3D图像中的倾斜度、偏心量及其方向。结果患者134例(157眼),其中男52例，女82例，年龄45～86岁，平均(67.86±8.26)岁。分为A(HOYA250)组56眼(右眼31只，左眼25只)、B(RS60A)组63眼(右眼34只，左眼29只)、C(ZCB00)组38眼(右眼15只，左眼23只)。右眼结果显示，术后7 d在2D图像中A组水平倾斜度大于B组IOL的水平倾斜度；术后1 d、7 d, A组的水平偏心量均小于B组IOL的水平偏心量。术后1 d和7 d, A组的垂直倾斜度均大于C组IOL的垂直倾斜度，以上差异均有统计学意义。在3D图像中术后1 d、7 d, A组的倾斜方向与C组IOL的倾斜方向差异均有统计学意义。A组术后7 d的倾斜度大于术后30 d的倾斜度，差异有统计学意义。术后1 d、7 d和30 d, A组的偏心量均分别小于B组IOL的偏心量，差异均有统计学意义。A组和C组术后1 d的偏心量均分别小于术后30 d,差异均有统计学意义。左眼结果显示：在3D图像中，术后7 d、30 d, A组的偏心量均小于B组IOL的偏心量，差异均有统计学意义。C组术后1 d的倾斜度小于术后30 d的倾斜度，差异有统计学意义。术后1 d、7 d和30 d, IOL均出现向颞侧和颞下倾斜趋势，偏心未表现出有偏向的趋势。结论 3种IOL在囊袋内存在不同程度的倾斜和偏心，均出现向颞侧和颞下倾斜趋势，偏心未表现出有偏向的趋势。

关键词：白内障非球面人工晶体扫频源光学相干层析成像倾斜偏心

dECM restores macrophage immune homeostasis and alleviates iron overload to promote DTPI healing

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Regenerative Biomaterials 2024年第2期3卷 100-113页

作者： Ju Zhang Ruijuan Si Yu Gao hui Shan Qi Su Zujian Feng Pingsheng Huang Deling kong Weiwei Wang Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical EngineeringChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China School of Nursing Qingdao UniversityNingde RoadShinan DistrictQingdaoShandong266071China Cancer Hospital of Tianjin Medical University North Huanhu West RoadTianjinChina The Affliated Hospital of Qingdao University 16 Jjiangsu RoadShinan DistrictQingdaoChina 5NankaiUniver aniin300071.China

Due to its highly insidious and rapid progression,deep tissue pressure injury(DTPI)is a clinical *** previous study found that DTPI may be a skeletal muscle injury dominated by macrophage immune dysfunction due to excessive iron *** extracellular matrix(dECM)hydrogel promotes skeletal muscle injury ***,its role in po-larizing macrophages and regulating iron metabolism in DTPI remains ***,porcine dECM hydrogel was prepared,and its therapeutic function and mechanism in repairing DTPI were *** stimulus of dECM hydrogel toward RAW264.7 cells resulted in a significantly higher percentage of CD2o6+macrophages and notably decreased intracellular divalent iron *** mice DTPI model,dECM hydrogel treatment promoted M1 to M2 macrophage conversion,improved iron metabolism and reduced oxidative stress in the early stage of *** the remodeling phase,the dECM hydrogel remarkably enhanced revascularization and accelerated skeletal muscle ***,the immunomodulation of dEcM hydrogels in vivo was mainly involved in the P13k/Akt signaling pathway,as revealed by GO and KEGG pathway analysis,which may ameliorate the iron deposition and promote the healing of *** findings indicate that dECM hydrogel is promising in skeletal muscle repair,inflammation resolution and tissue injury healing by effectively restoring macrophage immune homeostasis and normalizing iron metabolism.

关键词： Deep tissue pressure injury hydrogel immunomodulation tissue repair