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阿司匹林与氯吡格雷对急性脑梗死患者NIHSS评分及ADL的影响

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黔南民族医专学报 2024年第3期37卷 259-262页

作者：王富鑫孙辉胡祖畅祝孔辉信阳市中心医院河南信阳464000

目的:对阿司匹林联合氯呲格雷治疗急性脑梗死(ACI)的疗效进行评价。方法:将100例ACI患者依据随机数字表法分组。对照组(n=50例)行阿司匹林治疗,观察组(n=50例)行阿司匹林+氯呲格雷治疗。观察治疗患者的总有效率;在应用前后,对患者行神... 详细信息

目的:对阿司匹林联合氯呲格雷治疗急性脑梗死(ACI)的疗效进行评价。方法:将100例ACI患者依据随机数字表法分组。对照组(n=50例)行阿司匹林治疗,观察组(n=50例)行阿司匹林+氯呲格雷治疗。观察治疗患者的总有效率;在应用前后,对患者行神经功能缺损(NIHSS)、自理能力(ADL)评分;在应用药物1 d及7 d后,行二磷酸腺苷(ADP)、花生四烯酸(AA)血小板抑制率检测,以观察血小板抑制率的变化,判断是否达标(ADP抑制率≥30%为药物有效,AA抑制率≥50%为药物有效)。结果:观察组患者治疗总有效率(96.00%)高于对照组(80.00%);治疗前,两组ADL、NIHSS评分无统计学意义(P>0.05);治疗1 d后,两组血小板抑制达标率组间相较无统计学意义,治疗7 d后,观察组的血小板抑制达标率高于对照组,ADL评分较治疗前呈现明显增高趋势,NIHSS评分有所降低,观察组优于对照组,两组数据相较具有统计学意义(P<0.05)。结论:阿司匹林联合氯呲格雷能提高ACI的治疗效果,能修复患者的神经功能缺损程度,提高自理能力,对抗血小板聚集,可阻止ACI进展。

关键词：阿司匹林氯呲格雷急性脑梗死神经缺损自理能力

Roles of Chinese medicine bioactive ingredients in the regulation of cellular function of endothelial progenitor cells

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Chinese Journal of Natural Medicines 2014年第7期12卷 481-487页

作者： ZHAO Qi-Tao LI Bao-Feng kong hui School of Basic Medicine Shandong University of Traditional Chinese Medicine Affiliated Hospital of Shandong University of Shandong Traditional Chinese Medicine School of Pharmaceutical Sciences Shandong University of Traditional Chinese Medicine

To improve the function of endothelial progenitor cells(EPCs) is one of the goals in Chinese traditional therapy to treat various cardio-celebrovascular diseases. In the past decades, scholars in the field of traditional Chinese medicine(TCM) have found fifteen active compounds to regulate the function of EPC. These metabolites are extracted from thirteen, plant-based Chinese medicine, with majority of them as potent reductive or oxidative hydrophilic molecules containing phenyl groups. These active compounds either enhance the mobilization of EPC, or inhibit their apoptosis through different signaling pathways. In this review, the molecular structure, biophysical properties, and the plant sources of these active ingredients and their regulatory effects on the function of EPC are summarized, aiming to reveal the modern basis of Chinese medicine for promoting blood circulation and removing blood stasis at the progenitor cell level.

关键词： Chinese medicine bioactive ingredients Endothelial progenitor cells Cardio-cerebrovascular protection Mobiliza-tion Apoptosis Oxidative stress

Leaching process of phosphorus and iron from steelmaking slag into malic acid solution

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Journal of Iron and Steel Research International 2022年第6期29卷 951-960页

作者： Ning-ning Lv Chang Su hui kong Hai-chuan Wang Yuan-chi Dong Key Laboratory of Metallurgical Emission Reduction and Resources Recycling Ministry of EducationAnhui University of TechnologyMa’anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

In order to remove phosphorus element from steelmaking slag and decrease iron loss,malic acid was selected as the leaching agent to dissolve steelmaking ***,the influences of different factors,such as malic acid concentration,slag particle size,temperature,liquid/solid ratio and stirring speed,on the leaching ratios of phosphorus and iron were ***,the kinetics for the leaching process of phosphorus was *** results showed that the leaching ratios of phosphorus and iron increase significantly with increasing the malic acid solution concentration and liquid/solid *** the concentration of malic acid solution increases up to 0.01492 mol/L,about 80%phosphorus can be dissolved,and iron leaching ratio is less than 17%.In addition,decreasing slag particle size can obviously increase the leaching ratio of ***,temperature and stirring speed have no significant effect on the dissolution of phosphorus and *** leaching kinetics of phosphorus follows the unreacted shrinking core *** through product layer is the rate-limiting step of the leaching process,and the corresponding apparent activation energy is determined to be 3.32 kJ/***,a semi-empirical kinetic equation was established.

关键词： Leaching process Steelmaking slag Phosphorus Iron Malic acid solution

Government subsidies, dual-credit policy, and enterprise performance: Empirical evidence from Chinese listed new energy vehicle companies

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Chinese Journal of Population,Resources and Environment 2023年第2期21卷 71-81页

作者： Lingling Pei hui kong Yiyin Xu School of Business Administration Zhejiang University of Finance&EconomicsHangzhou 310018China Business School Chengdu UniversityChengdu 611130China

The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon *** better guide future strategies,this study investigates the dual impact of subsidy and dual-integral policies on the performance of new energy vehicle *** study first theorizes the influential mechanism according to the institutional-based approach and technical innovation theory,and then collects data from listed companies in the new energy vehicle industry from 2016 to *** hypotheses are examined using a two-way fixed-effects *** findings show that:(1)subsidy policies are can still improve enterprise performance,but not through green technology innovation;(2)the dual-credit policy can improve enterprise performance through green technology innovation;and(3)under current policy conditions,with subsidies declining annually,the interaction effects between the subsidy and dual-integral policies will also ***,this study suggests that non-monetary industrial policy,represented by the dual credit policy is a more effective alternative to government subsidies.

关键词： New energy vehicles Enterprise performance Dual-credit policy Government subsidy policy Green technology innovation

从刘渡舟“古今接轨论”谈小柴胡汤在发热疾病中的应用

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现代中医药 2024年第3期44卷 17-22页

作者：邢洪霞董利洋李长香孔慧赵琰曲阜市中医院山东曲阜273100 北京中医药大学北京100029

小柴胡汤出自《伤寒杂病论》,具有调和枢机、祛邪透热的功效,仲景用其治疗少阳发热、三阳合病发热、妇人经期发热等多种外感热病。经过后代医家的临床拓展,该方也可以治疗当今常见的发热疾病,如癌性发热、术后发热、不明原因高热等。“... 详细信息

小柴胡汤出自《伤寒杂病论》,具有调和枢机、祛邪透热的功效,仲景用其治疗少阳发热、三阳合病发热、妇人经期发热等多种外感热病。经过后代医家的临床拓展,该方也可以治疗当今常见的发热疾病,如癌性发热、术后发热、不明原因高热等。“古今接轨论”是经方大家刘渡舟首先提出的,是将经方与时方合用的一种理论,文章以小柴胡汤为桥梁,对古今发热疾病进行联系接轨,这不仅丰富了“古今接轨论”的内涵,也拓宽了经方的现代应用。

关键词：小柴胡汤发热疾病古今接轨机制研究

保留生育功能的宫颈癌患者生育忧虑体验的质性研究

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中华现代护理杂志 2024年第17期30卷 2273-2279页

作者：王彬江子芳孔慧王丽芬浙江省肿瘤医院手术室杭州310022 浙江省肿瘤医院护理部杭州310022

目的通过挖掘保留生育功能宫颈癌患者生育忧虑的真实体验,为制订针对性护理措施提供依据。方法本研究为描述性现象学质性研究。采用目的抽样方法,选取2018年6月—2021年6月于浙江省肿瘤医院行腹式根治性宫颈切除术或微创腹腔镜下根治性... 详细信息

目的通过挖掘保留生育功能宫颈癌患者生育忧虑的真实体验,为制订针对性护理措施提供依据。方法本研究为描述性现象学质性研究。采用目的抽样方法,选取2018年6月—2021年6月于浙江省肿瘤医院行腹式根治性宫颈切除术或微创腹腔镜下根治性宫颈切除术的17例年轻宫颈癌患者为研究对象,对其进行面对面半结构式访谈,采用Colaizzi7步分析法对资料进行分析和提炼主题。结果共提炼出4个主题,分别为生育忧虑引起的多重表现、因疾病及生育问题导致的负罪感、需要更多的健康支持、积极应对生育忧虑引起心理问题的策略。结论保留生育功能的宫颈癌患者普遍存在生育忧虑,对获得健康支持有迫切需求,需要医护人员、家庭以及社会各方面的支持,医护人员应重视该类患者的生育忧虑问题,尽早提供个性化心理干预,降低患者生育忧虑水平。

关键词：宫颈癌生育功能生育忧虑质性研究

Safety Verification of Semi-Algebraic Dynamical Systems via Inductive Invariant

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Tsinghua Science and Technology 2014年第2期19卷 211-222页

作者： hui kong Fei He Xiaoyu Song Ming Gu Hongyan Tan Jiaguang Sun the School of Software Tsinghua University the Department of ECE Portland State University the Institute of Acoustics Chinese Academy of Sciences

To verify the safety of nonlinear dynamical systems based on inductive invariants, key issues include defining the most complete inductive condition and discovering an inductive invariant that satisfies the specified inductive condition. In this paper, to lay a solid foundation for future research into the safety verification of semi- algebraic dynamical systems, we first establish a formal framework for evaluating the quality of continuous inductive conditions. In addition, we propose a new complete and computable inductive condition for verifying the safety of semi-algebraic dynamical systems. Compared with the existing complete and computable inductive condition, this new inductive condition can be easily adapted to achieve a set of sufficient inductive conditions with different level of conservativeness and computational complexity, which provides us with a means to trade off between the verification power and complexity. These inductive conditions can be solved by quantifier elimination and SMT solvers.

关键词： inductive invariant semi-algebraic dynamical system safety verification hybrid system nonlinearsystem

A novel plant defensin from Chinese mistletoe,Viscum coloratum (Kom.) Nakai

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Chinese Chemical Letters 2007年第1期18卷 55-58页

作者： Shi Lei Liu Xiu Bao Du Jing Lin kong hui Jiang Research Institute of Chemical Defense Beijing 102205 China

A novel polypeptide named as defensin CM was isolated from Chinese mistletoe, Viscum coloratura （Kom.） Nakai. The amino acid sequence was determined by the combination of Edman degradation, endoproteinase Lys-C digestion, and MALDI-TOF mass spectrometry. The primary structure was ATCSAPSGRF KGACFSSNTC SNICKTLEGL KDGHCTGLAC YCSRNC.

关键词： Viscum coloratura Mistletoe Primary structure Plant defensin Polypeptide

The structure and dielectric properties of ionic compounds with flexible ammonium moiety

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Chinese Chemical Letters 2015年第3期26卷 382-386页

作者： hui-Ting Wang Li-hui kong Ping-Ping Shi Qiang Li Qiong Ye Da-Wei Fu Ordered Matter Science Research Center Southeast University

The 3-morpholin-4-yl-propyl-ammine tetrafluoroborate（MPA^＋）（BF4^-）（1） and the 3-morpholin-4-ylpropyl-ammine perchlorate（MPA^＋）（ClO4^-）（2） were synthesized and separated as colorless block ***（MPA^＋）（BF4^-） undergoes a reversible phase transition at ca.347.3 K with a hysteresis of16.1 *** measurement also can confirm the *** crystal structure determined at300 K（monoclinic,P21/c,a = 9.978（2）A,b = 7.5206（15）A,c = 15.058（3）A,b = 96.99（3）8,v = 1121.6（4）A^3,z = 4） and 373 K（triclinic,P-1,a = 10.021（7）A,b = 7.662（3）A,c = 7.920（4）A,a = 95.012（14）8,b = 101.67（4）8,g = 91.48（3）8,v = 592.7（6）A^3,z = 2） reveal that this compound has two *** most distinct is the BF4^- anion is disorder at 373 K,which is probably the driving force of the phase *** measurement,dielectric measurement and the crystal structure of the compound 2 did not change at 300 K and 100 K.

关键词： moiety ionic dielectric triclinic reversible monoclinic propyl ammonium anion cyclohexane