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Progressive fragmentation of granular assemblies within rockslides: Insights from discrete-continuous numerical modeling

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Journal of Mountain Science 2024年第4期21卷 1174-1189页

作者： jiang hui ZHOU Yuande WANG Jinting DU Xiuli HUANG Hailong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China. Key Laboratory of the Hydrosphere Sciences of the Ministry of Water Resources Tsinghua UniversityBeijing 100084China China Three Gorges Construction Management Co. Ltd.Chengdu 610000China

Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during *** present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in *** rock granular assemblies are released along an inclined plane and flow onto a horizontal *** numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle *** evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is *** general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass *** process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing *** simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the *** propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock *** findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.

关键词： Rock fragmentation Rockslide Numerical modelling Discrete-continuous modelling Runout Cohesive zone model

Moderate Deviations for the Parameter Estimation in the Fractional Ornstein-Uhlenbeck Process with H∈(0,1/2)

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Acta Mathematicae Applicatae Sinica 2024年

作者： hui jiang Qing-shan YANG School of Mathematics Nanjing University of Aeronautics and Astronautics MOE Key Laboratory of Applied Statistics School of Mathematics and StatisticsNortheast Normal University

Abstract In this paper,we study the asymptotic properties for estimators of two parameters in the drift function in the ergodic fractional Ornstein-Uhlenbeck process with Hurst index H∈(0,1/2).The Cramér-type moderate deviations,as well as the moderation deviations with explicit rate function can be *** main methods consist of the deviation inequalities and Cramér-type moderate deviations for multiple WienerIt?integrals,as well as the asymptotic analysis techniques.

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Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2565-2573页

作者： Li-Ming Guo Zhi-hui jiang Hong-Zhen Liu Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina

BACKGROUND Pediatric appendicitis is a common cause of abdominal pain in children and is recognized as a significant surgical emergency.A prompt and accurate diagnosis is essential to prevent complications such as perforation and *** To investigate the predictive value of the systemic immune-inflammation index(SII)combined with the pediatric appendicitis score(PAS)for the assessment of disease severity and surgical outcomes in children aged 5 years and older with *** Clinical data of 104 children diagnosed with acute appendicitis were *** participants were categorized into the acute appendicitis group and chronic appendicitis group based on disease presentation and further stratified into the good prognosis group and poor prognosis group based on *** SII and PAS were measured,and a joint model using the combined SII and PAS was constructed to predict disease severity and surgical *** Significant differences were observed in the SII and PAS parameters between the acute appendicitis group and chronic appendicitis *** analysis showed associations among the SII,PAS,and disease severity,with the combined SII and PAS model demonstrating significant predictive value for assessing disease severity[aera under the curve(AUC)=0.914]and predicting surgical outcomes(AUC=0.857)in children aged 5 years and older with *** The study findings support the potential of integrating the SII with the PAS for assessing disease severity and predicting surgical outcomes in pediatric appendicitis,indicating the clinical utility of the combined SII and PAS model in guiding clinical decision-making and optimizing surgical management strategies for pediatric patients with appendicitis.

关键词： Systemic immune-inflammation index Pediatric appendicitis score Disease severity Surgical outcomes Risk factor Logistic regression Receiver operating characteristic analysis

Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-Yi Zhu Xiu-Hong Huang hui-Qing jiang Li Liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients with ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new prognostic model for patients with ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in *** The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all P<0.001).The consistency between actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score was excellent and superior to that of existing *** net benefit of MIMIC ACLF was greater than that achieved using existing scores within the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external *** We developed and validated a new prognostic model with satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores

The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He hui jiang Dong-Xu Liang Zhi-Sen jiang Huai-Na Yu Hua Wang Cheng-Wen Mao Jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL13U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 10 nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL13U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

Interface interaction between SiO_(2) and magnetite under high temperature:particle migration and inhibition mechanism

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Journal of Iron and Steel Research International 2024年第3期31卷 561-572页

作者： Yao-zu Wang Jian-liang Zhang Qiang Cheng hui-qing jiang Zheng-jian Liu Yu-bo Tan School of Intelligent Science and Technology University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Advanced Engineering University of Science and Technology BeijingBeijing 100083China

Silicon is one of the main gangue components in iron ore,usually in the form of quartz and *** studies have shown that SiO_(2) has a two-sided effect on the consolidation of pellets during high-temperature oxidation roasting of ***,it is very difficult to capture the structural evolution and migration mechanisms during high-tem-perature roasting process by existing experimental ***,the influence of SiO_(2) on the consolidation behavior of magnetite was studied through a series of roasting experiments and molecular dynamic *** results show that the consolidation index and particle growth index decrease with the increase in SiO_(2) content in the *** 1573 K,the liquid phase promotes the recrystallization growth of hematite at high *** dynamic study shows that it is difficult for quartz SiO_(2) to form sintering neck with Fe_(2)O_(3).When the calcination temperature is higher than 1400 K,the Fe_(2)O_(3)-Fe_(2)SiO_(4) system produces a considerable sintering neck structure after *** atomic migration ability of Fe_(2)SiO_(4) is much higher than that of Fe_(2)O_(3).The higher atomic migration ability of Fe_(2)SiO_(4) is the main reason for the formation of the sintering neck.

关键词： Sintering neck Crystal growth Consolidation Molecular dynamics SiO_(2)

Adeno-associated virus as a delivery vector for gene therapy of human diseases

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1808-1840页

作者： jiang-hui Wang Dominic J.Gessler Wei Zhan Thomas L.Gallagher Guangping Gao Horae Gene Therapy Center University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Microbiology and Physiological Systems University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVIC3002Australia Department of Neurological Surgery University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Department of Neurosurgery University of MinnesotaMinneapolisMN55455USA Department of Medicine University of Massachusetts Chan Medical SchoolWorcesterMA01605USA Li Weibo Institute for Rare Diseases Research University of Massachusetts Chan Medical SchoolWorcesterMA01605USA

Adeno-associated virus(AAV)has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different *** AAV(rAAV)has been engineered for enhanced specificity and developed as a tool for treating various ***,as rAAV is being more widely used as a therapy,the increased demand has created challenges for the existing manufacturing *** rAAV-based gene therapy products have received regulatory approval,but there continue to be concerns about safely using high-dose viral therapies in humans,including immune responses and adverse effects such as genotoxicity,hepatotoxicity,thrombotic microangiopathy,and *** this review,we explore AAV biology with an emphasis on current vector engineering strategies and manufacturing *** discuss how rAAVs are being employed in ongoing clinical trials for ocular,neurological,metabolic,hematological,neuromuscular,and cardiovascular diseases as well as *** outline immune responses triggered by rAAV,address associated side effects,and discuss strategies to mitigate these *** hope that discussing recent advancements and current challenges in the field will be a helpful guide for researchers and clinicians navigating the ever-evolving landscape of rAAV-based gene therapy.

关键词： diseases specificity approval

Qubit Mapping Based on Tabu Search

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Journal of Computer Science & Technology 2024年第2期39卷 421-433页

作者：蒋慧邓玉欣徐鸣 Shanghai Key Laboratory of Trustworthy Computing East China Normal UniversityShanghai 200062China

The goal of qubit mapping is to map a logical circuit to a physical device by introducing additional gates as few as possible in an acceptable amount of *** present an effective approach called Tabu Search Based Adjustment(TSA)algorithm to construct the *** consists of two key steps:one is making use of a combined subgraph isomorphism and completion to initialize some candidate mappings,and the other is dynamically modifying the mappings by *** experiments show that,compared with state-of-the-art methods,TSA can generate mappings with a smaller number of additional gates and have better scalability for large-scale circuits.

关键词： quantum computing qubit mapping initial mapping tabu search logical circuit

Engineered exosome hybrid copper nanoscale antibiotics facilitate simultaneous self-assembly imaging and elimination of intracellular multidrug-resistant superbugs

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Chinese Chemical Letters 2024年第7期35卷 319-324页

作者： Zengchao Guo Weiwei Liu Tengfei Liu Jinpeng Wang hui jiang Xiaohui Liu Yossi Weizmann Xuemei Wang State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

With the increasing emergence of bacterial infections,especially multidrug-resistant(MDR)bacteria,poses an urgent *** study demonstrated a novel multifunctional nanotheranostics platform developed by the strategic integration of both in-situ bio-assembly imaging and target bacteria *** the introduction of copper ions into bacteria,the Cu^(2+)could spontaneously bio-selfassembled into a multifunctional copper nanoclusters(NCs)which efficiently enhanced epigallocatechin gallate(EGCG)uptake into *** visualizing the bacteria,the developed theranostic nanoplatform exhibited highly efficient disinfection activities with negligible side effects as reflected by higher cell viability and insignificant hemolytic ***,the exosomal formulation of EGCG integrated with Cu^(2+)showed an increased intracellular antibacterial activity,which could eliminate most of the methicillin-resistant Staphylococcus aureus(MRSA)phagocytosed by macrophages,guide macrophages toward M2-like phenotype polarization and alleviate inflammation,without exhibiting obvious cytotoxicity on host *** regimen could be viewed as an effective strategy for the sterilization of intractable bacterial infections.

关键词： In situ self-assembled Exosome Antibacterial agents Bioimaging Intracellular infection