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A deep kernel method for lithofacies identification using conventional well logs

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Petroleum Science 2023年第3期20卷 1411-1428页

作者： Shao-Qun Dong Zhao-hui Zhong Xue-hui cui Lian-Bo Zeng Xu Yang Jian-jun Liu Yan-Ming Sun jing-Ru Hao State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China Collge of Science China University of PetroleumBeijing102249China College of Geoscience China University of PetroleumBeijing102249China

How to fit a properly nonlinear classification model from conventional well logs to lithofacies is a key problem for machine learning *** methods(e.g.,KFD,SVM,MSVM)are effective attempts to solve this issue due to abilities of handling nonlinear features by kernel *** mining of log features indicating lithofacies still needs to be improved for kernel ***,this work employs deep neural networks to enhance the kernel principal component analysis(KPCA)method and proposes a deep kernel method(DKM)for lithofacies identification using well *** includes a feature extractor and a *** feature extractor consists of a series of KPCA models arranged according to residual network structure.A gradient-free optimization method is introduced to automatically optimize parameters and structure in DKM,which can avoid complex tuning of parameters in *** test the validation of the proposed DKM for lithofacies identification,an open-sourced dataset with seven con-ventional logs(GR,CAL,AC,DEN,CNL,LLD,and LLS)and lithofacies labels from the Daniudi Gas Field in China is *** are eight lithofacies,namely clastic rocks(pebbly,coarse,medium,and fine sand-stone,siltstone,mudstone),coal,and carbonate *** comparisons between DKM and three commonly used kernel methods(KFD,SVM,MSVM)show that(1)DKM(85.7%)outperforms SVM(77%),KFD(79.5%),and MSVM(82.8%)in accuracy of lithofacies identification;(2)DKM is about twice faster than the multi-kernel method(MSVM)with good *** blind well test in Well D13 indicates that compared with the other three methods DKM improves about 24%in accuracy,35%in precision,41%in recall,and 40%in F1 score,*** general,DKM is an effective method for complex lithofacies *** work also discussed the optimal structure and classifier for *** re-sults show that(m_(1),m_(2),O)is the optimal model structure and linear svM is the optimal classifier.(m_(1),m_(2),O)means there

关键词： Lithofacies identification Deepkernel method Well logs Residual unit Kernel principal component analysis Gradient-free optimization

PhoPepMass： A database and search tool assisting human phosphorylation peptide identification from mass spectrometry data

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Journal of Genetics and Genomics 2018年第7期45卷 381-388页

作者： Menghuan Zhang hui cui Lanming Chen Ying Yu Michael O. Glocker Lu Xie School of Life Science and Technology Shanghai Tech University Shanghai 201210 China Shanghai Center for Bioinformation Technology Shanghai Academy of Science and Technology Shanghai 201203 China Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Shanghai 200031 China College of Food Science and Technology Shanghai Ocean University Shanghai 201306 China Department of Pharmacology School of Basic Medical Sciences Tianjin Medical University Tianjin 30007 China Proteome Center Rostock University of Rostock Rostoek 18055 Germany

Protein phosphorylation, one of the most important protein post-translational modifications, is involved in various biological processes, and the identification of phosphorylation peptides （phosphopeptides） and their corresponding phosphorylation sites （phosphosites） will facilitate the understanding of the molecular mechanism and function of phosphorylation. Mass spectrometry （MS） provides a high- throughput technology that enables the identification of large numbers of phosphosites. PhoPepMass is designed to assist human phosphopeptide identification from MS data based on a specific database of phophopeptide masses and a multivariate hypergeometric matching algorithm. It contains 244,915 phosphosites from several public sources. Moreover, the accurate masses of peptides and fragments with phosphosites were calculated. It is the first database that provides a systematic resource for the query of phosphosites on peptides and their corresponding masses. This allows researchers to search certain proteins of which phosphosites have been reported, to browse detailed phosphopeptide and fragment information, to match masses from MS analyses with defined threshold to the corresponding phos- phopeptide, and to compare proprietary phosphopeptide discovery results with results from previous studies. Additionally, a database search software is created and a ＂two-stage search strategy＂ is suggested to identify phosphopeptides from tandem mass spectra of proteomics data. We expect PhoPepMass to be a useful tool and a source of reference for proteomics researchers.

关键词： Phosphosite Phosphopeptide Phosphopeptide mass

Severe pneumonia and acute myocardial infarction complicated with pericarditis after percutaneous coronary intervention:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3222-3231页

作者： Wei-Chao Liu Shun-Bao Li Chen-Feng Zhang Xiang-hui cui The Third Ward of the Department of Cardiology Baoding No.1 Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Cases of severe pneumonia complicated with acute myocardial infarction(AMI)with good prognosis after percutaneous coronary intervention(PCI)are rare,especially those with postoperative pericarditis and intestinal *** SUMMARY A 53-year-old male patient was admitted to the emergency department of our hospital because of paroxysmal chest tightness for 4 d,aggravated with chest pain for 12 *** symptoms,electrocardiography,biochemical parameters,echocardiography and chest computed tomography confirmed the diagnosis of severe pneumonia complicated with *** patient was treated with antiplatelet aggregation,anticoagulation,lipid regulation,vasodilation,anti-infective agents and direct *** patient was discharged after 3 wk of ***-up showed that the patient was asymptomatic without *** For patients with severe pneumonia complicated with AMI,PCI and antibiotic therapy is a life-saving strategy.

关键词： Severe pneumonia Acute myocardial infarction Percutaneous coronary intervention Pericarditis Intestinal obstruction Case report

Development of Surface Plasmon Resonance-Based Biosensor Immunoassay for Sulfamethoxazole

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稀有金属材料与工程 2006年第A3期35卷 91-94页

作者： hui Li Dafu cui Yujie Wang Hao-yuan Cai Junbo Wang Zipan Zheng State Key Lab. of Transducer Tech. Inst. of Electronics Chinese Academy of Sciences Beijing 100080 China

The illegal use of veterinary drugs has led to the occurrence of residues in food of animal *** is a hazard to people's *** this paper,a sensitive and fast assay was developed to determine sulfamethoxazole (SMOZ) in PBS with a homemade surface plasmon resonance (SPR)-based biosensor which had a single flow channel and two *** derivative of SMOZ was covalently immobilized to a carboxymethyldextran modified gold film.A recently developed monoclonal antibody against sulfamethoxazole was used to develop an inhibitive immunobiosensor assay in which the antibody was mixed with SMOZ of different concentrations prepared with PBS to construct a standard curve with a low limit of detection(LOD).The effect of matrix in milk was also *** of the apparent concentration showed the cross-reactivity with other sulfonamides.

关键词： SPR immunobiosensor sulfamethoxazole

Aerodynamic Characteristics,Power Requirements and Camber Effects of the Pitching-Down Flapping Hovering

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Journal of Bionic Engineering 2009年第2期6卷 120-134页

作者： Peng Bai,Er-jie cui,hui-ling ZhanChina Academy of Aerospace Aerodynamics,Beijing 100074,P.R.China [a]China Academy of Aerospace Aerodynamics Beijing 100074 P. R. China

The pitching-down flapping is a new type of bionic flapping,which was invented by the author based on previous studies on the aerodynamic mechanisms of fruit fly(pitching-up)*** motivation of this invention is to improve the aerodynamic characteristics of flapping Micro Air Vehicles(MAVs).In this paper the pitching-down flapping is briefly *** major works include:(1)Computing the power requirements of pitching-down flapping in three modes(advanced,symmetrical, delayed),which were compared with those of pitching-up flapping;(2)Investigating the effects of translational acceleration time,Δτ_t,and rotational time,Δτ_r,at the end of a stroke,and the angle of attack,α,in the middle of a stroke on the aerodynamic characteristics in symmetrical mode;(3)Investigating the effect of camber on pitching-down *** the above works, conclusions can be drawn that:(1)Compared with the pitching-up flapping,the pitching-down flapping can greatly reduce the time-averaged power requirements;(2)The increase in Δτt and the decrease in Δτ_r can increase both the lift and drag coefficients, but the time-averaged ratio of lift to drag changes a *** α has significant effect on the aerodynamic characteristics of the pitching-down flapping;(3)The positive camber can effectively increase the lift coefficient and the ratio of lift to drag.

关键词： aerodynamic characteristics flapping wing power requirements camber effect pitching-down-flapping MAVs

基于专思创融合的“课堂革命”典型案例设计与实践——以“用户测试与产品开发”为例

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教育教学论坛 2024年第1期 117-120页

作者：杨利洁崔慧通陈菊宋文娟广州卫生职业技术学院护理学院广东广州510180 广州卫生职业技术学院药学院广东广州510180

“专思创”融合的创新创业教育体系对于推动经济高质量发展、提升人才培养质量和推动高等职业院校转型发展、提升社会服务的能力具有重要意义。基于专思创融合背景,探讨“课堂革命”视角下“大学生创新创业基础”课程的教学改革与实践... 详细信息

“专思创”融合的创新创业教育体系对于推动经济高质量发展、提升人才培养质量和推动高等职业院校转型发展、提升社会服务的能力具有重要意义。基于专思创融合背景,探讨“课堂革命”视角下“大学生创新创业基础”课程的教学改革与实践。以“用户测试与产品开发”为例,通过对高职学生学情进行分析调研,发现课程教学中存在的主要问题,并从问题解决思路、实施过程与做法、实施效果、反思与改进等方面进行了分析和总结,以期为高职院校“课堂革命”提供借鉴。

关键词：专创融合课程思政专思创融合创新创业典型案例

Pore-scale investigation of residual oil displacement in surfactant–polymer flooding using nuclear magnetic resonance experiments

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Petroleum Science 2016年第1期13卷 91-99页

作者： Zhe-Yu Liu Yi-Qiang Li Ming-hui cui Fu-Yong Wang A.G.Prasiddhianti EOR Research Institute China University of Petroleum

Research on the Gangxi III area in the Dagang Oilfield shows that there was still a significant amount of oil remaining in oil reservoirs after many years of polymer *** is a potential target for enhanced oil recovery（EOR）.Surfactant–polymer（SP） flooding is an effective chemical EOR method for mobilizing residual oil and improving displacement efficiency macroscopically,but the microscopic oil displacement efficiency in pores of different sizes is *** magnetic resonance（NMR） is an efficient method for quantifying oil saturation in the rock matrix and analyzing pore *** this paper,the threshold values of different pore sizes were established from the relationship between mercury injection curves and NMR T2 *** distribution and migration of residual oil in different flooding processes was evaluated by quantitatively analyzing the change of the relaxation *** oil displaced from pores of different sizes after the water flood,polymer flood,and the SP flood was calculated,*** results indicate that（1） the residual oil in medium pores contributed the most to the incremental oil recovery for the SP flood,ranging from 40 % to 49 %,and small pores usually contributed ／30 %;（2） the residual oil after the SP flood was mainly distributed in small and medium pores;the residual oil in medium pores accounted for 47.3 %–54.7 %,while that trapped in small pores was 25.7 %–42.5 %.The residual oil in small and medium pores was the main target for EOR after the SP flood in oilfields.

关键词： flooding pores reservoirs surfactant migration remaining quantitatively rock relaxation sizes

Effects of bortezomib in sensitizing human prostate ：ancer cell lines to NK-mediated cytotoxicity

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Asian Journal of Andrology 2012年第5期14卷 695-702页

作者： Wei Hu Rui-Rui Zheng hui-Xia cui Dan Yue Yong Wang You-Hong Jiang Cancer Research Institute First Affiliated HospitalChina Medical UniversityShenyang 110001China Department of Laboratory Medicine Tianjin Medical University Tianjin 300192China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300192China

The proteasome inhibitor, bortezomib, has been demonstrated to sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand （TRAIL）-mediated apoptosis. Natural killer （NK） cells represent potent antitumor effector cells. They also express TRAIL. Therefore, we investigated whether bortezomib could sensitize tumor cells to NK cell-mediated killing, and have the same effect in human prostate cancer cell lines （LNCaP and DU145）. We found that bortezomib strongly inhibits proliferation in both cell lines. Furthermore, compared with LNCaP cells, DU145 cells are more sensitive to bortezomib-induced apoptosis. However, bortezomib is unable to sensitize these two cell lines to NK cell-mediated killing in short-term assays. In long-term assays, we found that killing mediated by activated NK cells following bortezomib treatment leads to greater antitumor effects than either treatment alone. In addition, treatment with bortezomib causes these cells to upregulate apoptosis-related mRNA as well as death receptors and downregulate the major histocompatibility class （MHC）-I molecule on the cell surface of DU145 cells. In contrast, LNCaP cells are not sensitized by this treatment. Death receptors and the MHC-I molecule did not change in this cell line. These data suggest that bortezomib can be used to sensitize prostate cancer cells to NK cell-mediated killing and improve current cancer therapies. This theral）eutic stratelzv may be more effective in I）atients with androeen-insensitive orostate cancer.

关键词： bortezomib DU145 cells human prostate cancer LNCaP ceils NK cells

Delivery of CatSper2 siRNA into Rat Sperms by Electroporation Repressed Ca^(2+) Influx During Sperm Hyperactivation

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Agricultural Sciences in China 2011年第12期10卷 1958-1967页

作者： ZHANG Zhen ZHOU Xuan LI hui-xia cui Qun-wei YU Jing WANG Gen-lin College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 PR.China

CatSper is a unique Ca2＋ channel-like protein family exclusively expressed in the testis and sperm, and plays important roles in sperm motility, capacitation, acrosome reaction and sperm-egg interactions. Here we studied the mechanism of regulation of CatSper2-dependent Ca〉 influx, extracellular and intracellular Ca2＋on sperm hyperactivated motility. The siRNA duplexes were transfected into the sperm cells by electroporation （EP） to silence the expression of CatSper2. The results for targeted disruption of CatSper2 showed the highest silence efficiency 77.7% （P〈0.05）, the hyperactivated sperm rate calculated by computer-assisted semen analysis （CASA） analysis of interferenced sperm was significantly lower 11.1% than the control 99.2%. Flow cytometry （FCM） detection of the intracellular Ca2＋ concentration of interferenced sperm was 50 nmol L-t higher than the normal. It was remarkably lower than hyperactivated sperm with 200-1 000 nmol L-1 （P〈0.05）. It was not sufficient to evoke hyperactivation. To trigger hyperactivation, the sperm were incubated in 50 pmol L-t thimerosal or 5 mmol L-1 procaine, it sharply increased the intracellular Ca2＋ via two different channels. CASA and FCM detection indicated that intracellular Ca〉 is required for initiating hyperactivation while extracellular Ca2＋ is essential to maintain the process. We concluded that to mediate sperm hyperactivation, it is essential to inhibit Ca〉peak present with targeted disruption of CatSper2 expression. This provides important prospective for further exploration of signal channel of sperm hyperactivated motility, potential factors for male infertility and provide further reference to the exploration of male contraceptive drug targets of male reproduction.

关键词： sperm hyperactivation motility CatSper2 Ca2+ channel RNAi electroporation (EP)