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The synergistic effect of 3D-printed microscale roughness surface and nanoscale feature on enhancing osteogenic differentiation and rapid osseointegration

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Journal of Materials Science & Technology 2021年第4期63卷 18-26页

作者： hui Wang Jiaqiang Liu Chengtao Wang steve Guofang Shen Xudong Wang Kaili Lin Department of Oral and Cranio-maxillofacial Surgery Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China School&Hospital of Stomatology Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghai200072China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China Shanghai University of Medicine&Health Sciences Shanghai201318China

Personalized precision therapy and rapid osseointegration are the main development directions of dental implants.3 D printing is a vital advanced manufacturing technology for personalized precision ***,the osteogenesis of the 3 D printed Ti6 Al4 V implants is *** the bionic perspective,the hierarchical micro/nano-topography can mimic the microenvironment of the multilevel structure of natural bone tissue and may endow the implant surface with superior *** the present study,the hierarchical micro/nano-topography was successfully fabricated by construction the nanoscale feature on 3 D printed microscale roughness surface of 3 D-printed Ti6 Al4 V implants by alkali-heat treatment and hydrothermal *** the cell biological responses in vitro and osseointegration performance in vivo were systematically *** hierarchical micro/nano-topography evidently increased the roughness,improved the hydrophilicity and accelerated the hydroxyapatite deposition and mineralization,which significantly enhanced the adhesion,differentiation and extracellular matrix mineralization of bone marrow derived mesenchymal stromal cells(BMSCs).Most importantly,the hierarchical micro/nano-topography on 3 D-printed implants facilitated the new bone formation and rapid osseointegration in *** study suggested that 3 D-printed implant with micro/nano-topography may be a promising candidate to be applied in orthopedic field to meet the need of customized therapy and rapid osseointegration.

关键词： rapid roughness topography

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断裂方式对氧化铝基复合陶瓷耐磨性的影响

无机材料学报 2007年第3期22卷 493-498页

作者：张福成罗海辉 Roberts steve-G Todd Richard-I 燕山大学亚稳材料制备技术与科学国家重点实验室秦皇岛066004 Department of Materials University of OxfordParks RoadOxford OX1 3PHUK.

通过磨粒磨损试验测定了氧化铝陶瓷、氧化铝／碳化硅复合陶瓷和氧化铝／莫来石复合陶瓷的耐磨性．利用透射电子显微镜(TEM)观察了样品的微观结构,采用扫描电子显微镜(SEM)分析了样品的断口形貌和磨损表面的剥落情况．研究了断裂方式对... 详细信息

通过磨粒磨损试验测定了氧化铝陶瓷、氧化铝／碳化硅复合陶瓷和氧化铝／莫来石复合陶瓷的耐磨性．利用透射电子显微镜(TEM)观察了样品的微观结构,采用扫描电子显微镜(SEM)分析了样品的断口形貌和磨损表面的剥落情况．研究了断裂方式对磨损表面剥落和耐磨性的影响．结果表明:氧化铝陶瓷的磨损主要由断裂磨损机制控制,氧化铝／碳化硅复合陶瓷的磨损主要由塑性磨损机制控制,氧化铝／莫来石复合陶瓷受这两种磨损机制共同作用．相对于氧化铝陶瓷,氧化铝／碳化硅复合陶瓷和氧化铝／莫来石复合陶瓷的耐磨性提高2-4倍,这主要是由于其断裂方式转变为以穿晶断裂为主,减少了磨损面的脆性剥落．

关键词：氧化铝复合陶瓷耐磨性断裂方式

Outcomes of a single-step endoscopic ultrasound-guided drainage of pancreatic-fluid collections using an electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent with and without fluoroscopy

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Gastroenterology Report 2020年第6期8卷 425-430,I0001页

作者： Babatunde Olaiya Parit Mekaroonkamol Bai-Wen Li Julia Massaad Cicily TVachaparambil Jennifer Xu Vladamir Lamm hui Luo Shan-Shan Shen hui-Min Chen steve Keilin Field FWillingham Qiang Cai Department of Internal Medicine Marshfield ClinicMarshfieldWIUSA Division of Digestive Diseases Emory University School of MedicineAtlantaGAUSA Division of Gastroenterology King Chulalongkorn Memorial HospitalChulalongkorn University and Thai Red CrossBangkokThailand Department of Gastroenterology Shanghai General HospitalShanghai Jiaotong UniversityShanghaiP.R.China Department of Gastroenterology Xijing HospitalXi’anShaanxiP.R.China Department of Gastroenterology Nanjing Drum Tower HospitalNanjingJiangshuP.R.China Department of Gastroenterology Renji HospitalShanghai Jiaotong UniversityShanghaiP.R.China

Background:Fluoroscopy is often used during the endoscopic drainage of pancreatic-fluid collections(PFCs).An electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS)facilitates a single-step procedure and may avoid the need for *** study compares the treatment outcomes using ELAMS with and without ***:Patients with PFCs who had cystogastrostomy from January 2014 to February 2017 were *** groups were studied based on fluoroscopy *** success was defined as uneventful insertion of ELAMS at time of *** success was defined as(i)clinical resolution of symptoms after the procedure and(ii)>75%reduction in cyst size on computed tomography 8 weeks after stent *** events including bleeding,stent migration,and infection were ***:A total of 21 patients(13 males)had PFCs drainage with ELAMS in the study *** mean age was 51.6614.2 *** patients had walled-off necrosis while eight had a pancreatic *** mean size of the PFCs was 11.363.3 *** was used in seven cases(33%)and was associated with a longer procedure time compared to non-fluoroscopy(43.1610.4 vs 33.3610.5 min,P=0.025).This association was independent of the size,location,or type of *** had no effect on the technical success *** fluoroless procedures,the clinical resolution was 91%as compared to 71%in fluoroscopy procedures(P=0.52)and the radiologic resolution was 57%as compared to 71%in fluoroscopy procedures(P=0.65).Three cases of stent migration/displacement occurred in the fluoroless ***:ELAMS may avoid the need for fluoroscopy during *** without fluoroscopy were significantly shorter and fluoroscopy use had no impact on the technical or clinical success rates.

关键词： pancreatic-fluid collections electrocautery-enhanced coaxial lumen-apposing,self-expanding metal stent(ELAMS) fluoroscopy endoscopic ultrasound

Correlating Bladder Cancer Risk Genes with Their Targeting MicroRNAs Using MMiRNA-Tar

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Genomics, Proteomics & Bioinformatics 2015年第3期13卷 177-182页

作者： Yang Liu steve Baker hui Jiang Gary Stuart Yongsheng Bai Department of Electrical and Computer Engineering Rose-Hulman Institute of Technology Department of Math and Computer Science Indiana State University Department of Biostatistics University of Michigan Department of Biology Indiana State University The Center for Genomic Advocacy Indiana State University

The Cancer Genome Arias （TCGA）（http：//***） is a valuable data resource focused on an increasing number of well-characterized cancer genomes. In part, TCGA provides detailed information about cancer-dependent gene expression changes, including changes in the expression of transcription-regulating microRNAs. We developed a web interface tool MMiRNA-Tar （http：f/***-Tar） that can calculate and plot the correlation of expression for mRNA-microRNA pairs across samples or over a time course for a list of pairs under different prediction confidence cutoff criteria. Prediction confidence was estab- lished by requiring that the proposed mRNA-microRNA pair appears in at least one of three target prediction databases： TargetProfiler, TargetScan, or miRanda. We have tested our MMiRNA-Tar tool through analyzing 53 tumor and 11 normal samples of bladder urothelial carcinoma （BLCA） datasets obtained from TCGA and identified 204 microRNAs. These microRNAs were correlated with the mRNAs of five previously-reported bladder cancer risk genes and these selected pairs exhib- ited correlations in opposite direction between the tumor and normal samples based on the cus- tomized cutoff criterion of prediction. Furthermore, we have identified additional 496 genes （830 pairs） potentially targeted by 79 significant microRNAs out of 204 using three cutoff criteria, i.e.,false discovery rate （FDR）〈 0.1, opposite correlation coefficient between the tumor and normal samples, and predicted by at least one of three target prediction databases. Therefore, MMiRNA- Tar provides researchers a convenient tool to visualize the co-relationship between microRNAs and mRNAs and to predict their targeting relationship. We believe that correlating expression profiles for microRNAs and mRNAs offers a complementary approach for elucidating their interactions.

关键词： The Cancer Genome Atlas Bladder cancer MicroRNA mRNA Correlation Target prediction

China’s Bigger Role in Globalization

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China Today 2018年第1期67卷 32-34页

作者： zhang hui 不详

steve Howard,secretary general of the Australia-based non-profit organization Global Foundation,advocates"cooperative globalization"and believes China will play a bigger role in globalization in the new era.

关键词： AIIB

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约束态SMA混凝土梁的裂缝监测及自修复

建筑材料学报 2010年第2期13卷 237-242页

作者：狄生奎花尉攀汲生伟李慧 steve Zou 兰州理工大学土木工程学院甘肃兰州730050 Department of Civil and Resource Engineering Dalhousie University

利用形状记忆合金(shape memory alloy,SMA)丝超弹性和激励回复产生较大驱动力的特性,将不同预拉长度及根数的Ni-Ti SMA丝预埋入混凝土模型梁中,研究了混凝土梁加载过程中Ni-Ti SMA丝电阻变化率与混凝土梁裂缝宽度的关系以及Ni-Ti SMA... 详细信息

利用形状记忆合金(shape memory alloy,SMA)丝超弹性和激励回复产生较大驱动力的特性,将不同预拉长度及根数的Ni-Ti SMA丝预埋入混凝土模型梁中,研究了混凝土梁加载过程中Ni-Ti SMA丝电阻变化率与混凝土梁裂缝宽度的关系以及Ni-Ti SMA通电激励过程中混凝土梁裂缝恢复的变化规律.试验中考虑了SMA滑移的影响,并通过理论计算对其进行验证,计算时考虑了锚具造成的附加电阻的影响.结果表明:SMA显著提高了混凝土梁的变形能力和抗裂能力;在通电激励后,混凝土梁在Ni-Ti SMA激励回复效应驱动下,挠度迅速恢复,裂缝闭合;增加Ni-TiSMA总截面面积可提高合金对混凝土梁的驱动效果;在裂缝宽度小于1.5 mm时,Ni-Ti SMA电阻变化率和混凝土梁的裂缝宽度呈明显的线性关系;钢筋塑性变形的存在,对混凝土模型梁的变形回复起阻碍作用.

关键词：形状记忆合金(SMA) 混凝土梁裂缝变形自修复

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SMA混凝土梁的裂缝监测及自修复

建筑材料学报 2009年第1期12卷 27-31页

作者：狄生奎李慧杜永峰 steve Zou 韩全治兰州理工大学土木工程学院甘肃兰州730050 Department of Civil and Resource Engineering Dalhousie UniversityHalifax B3J 1Z1Canada

试验研究了混凝土梁加载过程中Ni-Ti形状记忆合金(shape memory alloy,简称SMA)丝电阻变化率与混凝土梁裂缝宽度的关系和SMA丝通电激励过程中混凝土梁裂缝恢复的变化规律.结果表明:SMA丝电阻变化率随混凝土梁裂缝宽度的增加呈现出规律... 详细信息

试验研究了混凝土梁加载过程中Ni-Ti形状记忆合金(shape memory alloy,简称SMA)丝电阻变化率与混凝土梁裂缝宽度的关系和SMA丝通电激励过程中混凝土梁裂缝恢复的变化规律.结果表明:SMA丝电阻变化率随混凝土梁裂缝宽度的增加呈现出规律性的变化,尤其是当混凝土裂缝在0.3 mm范围内变化时其电阻变化率对梁裂缝变化更为敏感;SMA丝通电激励后的恢复特性能使SMA混凝土梁的裂缝很好愈合.利用SMA丝电阻变化率对裂缝变化的敏感性和其相位恢复特性可实现对混凝土梁裂缝的自监测和自修复.

关键词：形状记忆合金(SMA) 混凝土梁自修复电阻变化率裂缝

Opportunities to search for extraterrestrial intelligence with the FAST

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Research in Astronomy and Astrophysics 2020年第5期20卷 193-204页

作者： Di Li Vishal Gajjar Pei Wang Andrew Siemion Zhi-Song zhang Hai-Yan zhang You-Ling Yue Yan Zhu Cheng-Jin Jin Shi-Yu Li Sabrina Berger Bryan Brzycki Jeff Cobb steve Croft Daniel Czech David DeBoer Julia DeMarines Jamie Drew J.Emilio Enriquez Nectaria Gizani Eric J.Korpela Howard Isaacson Matthew Lebofsky Brian Lacki David H.E.MacMahon Morgan Nanez Chen-hui Niu Xin Pei Danny C.Price Dan Werthimer Pete Worden Yunfan Gerry zhang Tong-Jie zhang FAST Collaboration CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy University of California BerkeleyBerkeley CA 94720USA SETI Institute Mountain ViewCA 94043USA Department of Astrophysics/IMAPP Radboud UniversityNijmegenNetherlands University of Malta Institute of Space Sciences and AstronomyMalta Space Sciences Laboratory University of CaliforniaBerkeleyBerkeley CA 94720USA Breakthrough Initiatives NASA Research ParkMoffett Field CA 94043USA Hellenic Open University School of Science&TechnologyParodos AristotelousPerivola PatronGreece University of Southern Queensland QLD 4350Australia Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Centre for Astrophysics&Supercomputing Swinburne University of TechnologyHawthornVIC 3122Australia Department of Astronomy Beijing Normal UniversityBeijing 100875China Institute of Astronomical Science Dezhou UniversityDezhou 253023China

The discovery of ubiquitous habitable extrasolar planets,combined with revolutionary advances in instrumentation and observational capabilities,has ushered in a renaissance in the search for extraterrestrial intelligence(SETI).Large scale SETI activities are now underway at numerous international *** Five-hundred-meter Aperture Spherical radio Telescope(FAST)is the largest single-aperture radio telescope in the world,and is well positioned to conduct sensitive searches for radio emission indicative of *** is one of the five key science goals specified in the original FAST project plan.A collaboration with the Breakthrough Listen Initiative was initiated in 2016 with a joint statement signed both by *** Yan,the then director of National Astronomical Observatories,Chinese Academy of Sciences(NAOC),and *** Worden,Chairman of the Breakthrough Prize *** this paper,we highlight some of the unique features of FAST that will allow for novel SETI *** identify and describe three different signal types indicative of a technological source,namely,narrow band,wide-band artificially dispersed and modulated ***,we propose observations with FAST to achieve sensitivities never before *** nearby exoplanets,such as TESS targets,FAST will be sensitive to an EIRP of 1.9×1011 W,well within the reach of current human *** the Andromeda Galaxy,FAST will be able to detect any Kardashev type II or more advanced civilization there.

关键词： Search for Extraterrestrial Intelligence Five-hundred-meter Aperture Spherical radio Telescope

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云联云是中国云计算的最好切入点

程序员 2010年第4期 12-13页

作者： steve hui Power-All Networks

自2006年开始，云计算在美国市场爆发，201O年云计算成为全球的热点和主流。当今云计算炒作成分甚高，学术界对此态度较冷，而商业界相对热情。纵观目前市场的发展趋势，我个人认为，2010-2011年可以说是云联云的快速发展之年。在这场... 详细信息

自2006年开始，云计算在美国市场爆发，201O年云计算成为全球的热点和主流。当今云计算炒作成分甚高，学术界对此态度较冷，而商业界相对热情。纵观目前市场的发展趋势，我个人认为，2010-2011年可以说是云联云的快速发展之年。在这场云计算的战争中，中国若想成为后起之秀，就必须目标明确，方能实现事半功倍。

关键词：计算中国美国市场发展趋势学术界