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Spatial Distribution Feature Extraction Network for Open Set Recognition of Electromagnetic Signal

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 279-296页

作者： hui zhang Huaji Zhou Li Wang Feng Zhou The Ministry Key Laboratory of Electronic Information Countermeasure and Simulation Xidian UniversityXi’an710071China Science and Technology on Communication Information Security Control Laboratory Jiaxing314033China

This paper proposes a novel open set recognition method,the Spatial Distribution Feature Extraction Network(SDFEN),to address the problem of electromagnetic signal recognition in an open *** spatial distribution feature extraction layer in SDFEN replaces convolutional output neural networks with the spatial distribution features that focus more on inter-sample information by incorporating class center *** designed hybrid loss function considers both intra-class distance and inter-class distance,thereby enhancing the similarity among samples of the same class and increasing the dissimilarity between samples of different classes during ***,this method allows unknown classes to occupy a larger space in the feature *** reduces the possibility of overlap with known class samples and makes the boundaries between known and unknown samples more ***,the feature comparator threshold can be used to reject unknown *** signal open set recognition,seven methods,including the proposed method,are applied to two kinds of electromagnetic signal data:modulation signal and real-world *** experimental results demonstrate that the proposed method outperforms the other six methods overall in a simulated open ***,compared to the state-of-the-art Openmax method,the novel method achieves up to 8.87%and 5.25%higher micro-F-measures,respectively.

关键词： Electromagnetic signal recognition deep learning feature extraction open set recognition

Exceptional activity of amino-modified rGO-immobilized PdAu nanoclusters for visible light-promoted dehydrogenation of formic acid

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Chinese Chemical Letters 2024年第7期35卷 428-432页

作者： Yiyue Ding Qiuxiang zhang Lei zhang Qilu Yao Gang Feng zhang-hui Lu Key Laboratory of Energy Catalysis and Conversion of Nanchang College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renewability,wide availability,stability,and high volumetric capacity(53 g H_(2)/L).The development of highly efficient catalytic systems to achieve enhanced catalytic activity is attractive but still ***,ultrafine and highly dispersed PdAu nanoclusters(NCs)anchored on amino-modified reduced graphene oxide(ArGO)were successfully synthesized via a facile impregnation-reduction method and applied as a catalyst toward formic acid dehydrogenation(FAD).Benefiting from the promoting effect of amino groups,the strain and ligand effect in the alloy,and the Mott–Schottky effect between PdAu NCs and ArGO,the resultant PdAu/ArGO affords an ultrahigh activity under visible light irradiation with an exceptional turnover frequency value of 10,699.5 h^(-1)at 298 K without any additives,more than 2.6times improvement than that under dark,which is the highest among all reported catalysts under the same *** study provides a green and convenient strategy for developing more efficient and sustainable FAD catalysts and promotes the effective utilization of FA as a prospective renewable LOHC.

关键词： Visible-light-enhanced Hydrogen production Formic acid Pd-Au Heterogeneous catalyst

Research on intelligent search-and-secure technology in accelerator hazardous areas based on machine vision

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Nuclear Science and Techniques 2024年第4期35卷 96-107页

作者： Ying-Lin Ma Yao Wang Hong-Mei Shi hui-Jie zhang School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China School of Mechanical Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Prompt radiation emitted during accelerator operation poses a significant health risk,necessitating a thorough search and securing of hazardous areas prior to ***,manual sweep methods are ***,the limitations of manual sweeps have become increasingly evident with the implementation of large-scale *** leveraging advancements in machine vision technology,the automatic identification of stranded personnel in controlled areas through camera imagery presents a viable solution for efficient search and *** the criticality of personal safety for stranded individuals,search and security processes must be sufficiently *** ensure comprehensive coverage,180°camera groups were strategically positioned on both sides of the accelerator tunnel to eliminate blind spots within the monitoring *** YOLOV8 network model was modified to enable the detection of small targets,such as hands and feet,as well as larger targets formed by individuals near the ***,the system incorporates a pedestrian recognition model that detects human body parts,and an information fusion strategy is used to integrate the detected head,hands,and feet with the identified pedestrians as a cohesive *** strategy enhanced the capability of the model to identify pedestrians obstructed by equipment,resulting in a notable improvement in the recall ***,recall rates of 0.915 and 0.82were obtained for Datasets 1 and 2,*** there was a slight decrease in accuracy,it aligned with the intended purpose of the search-and-secure software *** tests conducted within an accelerator tunnel demonstrated the effectiveness of this approach in achieving reliable recognition outcomes.

关键词： Search and secure Machine vision Camera Human body parts recognition Particle accelerator Hazardous area

Alisol B 23-acetate promotes white adipose tissue browning to mitigate high-fat diet-induced obesity by regulating mTOR-SREBP1 signaling

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Journal of Integrative Medicine 2024年第1期22卷 83-92页

作者： Lu-lu Han Xin zhang hui zhang Ting Li Yi-chen Zhao Ming-hui Tian Feng-lei Sun Bo Feng Department of Neurology Three The Fifth People’s Hospital of JinanJinan 250013Shandong ProvinceChina Department of Gastroenterology Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina The First Clinical Medical College Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Geriatrics the First Affiliated Hospital of Shandong First Medical University(Shandong Provincial Qianfoshan Hospital)Jinan 250014Shandong ProvinceChina Chinese Medicine Culture and Literature Research Institute Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of General Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Traditional Chinese Medicine the Second People’s Hospital of Haibei PrefectureZangzu Autonomous Prefecture of Haibei810300Qinghai ProvinceChina

Objective Obesity is a global health concern with management strategies encompassing bariatric surgery and anti-obesity drugs;however,concerns regarding complexities and side effects persist,driving research for more effective,low-risk *** promotion of white adipose tissue(WAT)browning has emerged as a promising ***,alisol B 23-acetate(AB23A)has demonstrated efficacy in addressing metabolic disorders,suggesting its potential as a therapeutic agent in obesity ***,in this study,we aimed to investigate the therapeutic potential of AB23A for mitigating obesity by regulating metabolic phenotypes and lipid distribution in mice fed a high-fat diet(HFD).Methods An obesity mouse model was established by administration of an *** and insulin metabolism were assessed via glucose and insulin tolerance *** size was determined using hematoxylin and eosin *** expression of browning markers in WAT was evaluated using Western blotting and quantitative real-time polymerase chain *** cage monitoring involved the assessment of various parameters,including food and water intake,energy metabolism,respiratory exchange rates,and physical ***,oil red O staining was used to evaluate intracellular lipid accumulation.A bioinformatic analysis tool for identifying the molecular mechanisms of traditional Chinese medicine was used to examine AB23A targets and associated signaling *** AB23A administration significantly reduced the weight of obese mice,decreased the mass of inguinal WAT,epididymal WAT,and perirenal adipose tissue,improved glucose and insulin metabolism,and reduced adipocyte ***,treatment with AB23A promoted the expression of browning markers in WAT,enhanced overall energy metabolism in mice,and had no discernible effect on food intake,water consumption,or physical *** 3T3-L1 cells,AB23A inhibited lipid accumulation,and both AB23A and rapamycin inhibited t

关键词： Obesity Alisol B 23-acetate Adipose tissue mTOR-SREBP1 High-fat diet

Magnetic resonance imaging combined with serum endolipin and galactagoglobin-3 to diagnose cerebral infarction in the elderly with diabetes mellitus

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World Journal of Diabetes 2024年第7期15卷 1509-1517页

作者： Yan-hui zhang Dong Liang Magnetic Resonance Imaging Room Tianjin Huanhu HospitalTianjin 300350China Department of Endocrinology Tianjin First Central HospitalTianjin 300190China

BACKGROUND Magnetic resonance imaging(MRI)combined with serum endothelin and galactagoglobin-3(Gal-3)can improve the clinical diagnosis of diabetes mellitus complicated with cerebral *** To analyze the clinical value of MRI combined with serum endolipin and Gal-3 for the diagnosis of cerebral infarction in the elderly with diabetes *** One hundred and fifty patients with acute cerebral infarction hospitalized between January 2021 and December 2023 were divided into two groups according to comorbid diabetes mellitus,including 62 and 88 cases in the diabetic and nondiabetic cerebral infarction *** samples were collected to detect the expression of serum endolipoxins,and Gal-3,and cranial MRI was performed at *** between the two groups were compared to analyze the diagnostic value of these *** Serum endolipin and Gal-3 expression were higher in the diabetic cerebral infarction group(P<0.05).The arterial wall area,vessel area,normalized wall index,and lumen stenosis rate were higher in the diabetic cerebral infarction group,while the rate of arterial lumen moderate and severe stenosis was 48.39% higher(36.36%,P<0.05).The percentage of large(29.03%)and multiple infarcts(33.87%)in the diabetic cerebral infarction group was higher(13.64% and 20.45%),and the incidence rate of lacunar infarcts was lower(37.10%vs 65.91%)(P<0.05).The total incidence of arterial plaque in patients in the diabetic cerebral infarction group was 96.77% higher(69.32%),while the incidence of necrotic lipid core plaque was 58.06%higher(26.14%)(P<0.05).Receiver operating characteristic curve analysis was performed to assess the diagnosis utility of these *** in combination with serum endoglin and Gal-3 had the highest area under the curve,the Yoden index,sensitivity and specificity(P<0.05).CONCLUSION The expression of serum endolipin and Gal-3 in elderly patients with diabetes mellitus with cerebral infarction showed an eleva

关键词： Endolipin Galectin-3 Magnetic resonance imaging Elderly Diabetes mellitus Cerebral infarction

Modeling human gastric cancers in immunocompetent mice

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Cancer Biology & Medicine 2024年第7期21卷 553-570页

作者： Weihong zhang Shilong Wang hui zhang Yan Meng Shi Jiao Liwei An Zhaocai Zhou Department of Stomatology Department of Medical UltrasoundShanghai Tenth People's HospitalTongji University Cancer CenterTongji University School of MedicineShanghai 200072China State Key Laboratory of Genetic Engineering School of Life SciencesZhongshan HospitalFudan UniversityShanghai 200032China Collaborative Innovation Center for Cancer Personalized Medicine School of Public HealthNanjing Medical UniversityNanjing 211166China

Gastric cancer(GC)is a major cause of cancer-related mortality *** is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high heterogeneity,with different cellular origins and diverse histological and molecular *** heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient *** the past decade,great progress has been made in the study of GC,particularly in molecular subtyping,investigation of the immune microenvironment,and defining the evolutionary path and *** mouse models,particularly immunocompetent models that mimic the cellular and molecular features of human GC,in combination with organoid culture and clinical studies,have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion,and the development of novel therapeutic ***,we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models,emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies.

关键词： Gastric cancer heterogeneity mouse model GEMM immunocompetent

Variations and future projections of glacial discharge of Urumqi River Headwaters,eastern Tien Shan(1980s-2017)

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Advances in Climate Change Research 2024年第3期15卷 537-546页

作者： hui zhang Fei-Teng WANG Ping ZHOU Yi-Da XIE State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

To address data scarcity on long-term glacial discharge and inadequacies in simulating and predicting hydrological processes in the Tien Shan,this study analysed the observed discharge at multiple timescales over 1980se2017 and projected changes within a representative glacierized high-mountain region:eastern Tien Shan,Central *** processes were simulated to predict changes under four future scenarios(SSP1,SSP2,SSP3,and SSP5)using a classical hydrological model coupled with a glacier dynamics *** rates at annual,monthly(June,July,August)and daily timescales were obtained from two hydrological gauges:Urumqi Glacier No.1 hydrological station(UGH)and Zongkong station(ZK).Overall,annual and summer discharge increased significantly(p<0.05)at both stations over the study *** intra-annual variations mainly resulted from differences in their recharge *** simulations show that a tipping point in annual discharge at UGH may occur between 2018 and 2024 under the four SSPs *** discharge is predicted to cease earlier at ZK than at *** relates to glacier type and size,suggesting basins with heavily developed small glaciers will reach peak discharge sooner,resulting in an earlier freshwater supply *** findings serve as a reference for research into glacial runoff in Central Asia and provide a decision-making basis for planning local water-resource projects.

关键词： Observed glacial discharge Temporal variations Urumqi River Headwaters Eastern Tien Shan Simulation and projection

Screening for Bioactive Compounds from Mulberry Leaves Combining Bio-Affinity Ultrafiltration with α-Glucosidase and Pancreatic Lipase

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Journal of Analysis and Testing 2024年第3期8卷 315-326页

作者： hui zhang Guilin Chen Yongli zhang Felix Wambua Muema Jun Ding Mingquan Guo CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical Garden Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Ningbo Cixi Institute of Biomedical Engineering

With the growing prevalence of diabetes and obesity worldwide, the role of α-glucosidase and lipase inhibitors has gained increasing concentration. Mulberry, a functional medicinal and edible plant, has been reported extensively in alleviating both diabetes and obesity. However, there is still a lack of refined research on its active ingredients and mechanisms. In our study, the inhibitory activities of mulberry leaf against α-glucosidase and pancreatic lipase reached 191.37 ± 14.46 and 775 ± 68.60 μg/mL, respectively. Meanwhile, it also promoted glucose consumption in the HepG2 cells model. Subsequently,four α-glucosidase ligands and four pancreatic lipase ligands were identified through bio-affinity ultrafiltration combined with liquid-chromatography-mass spectrometry(UF-HPLC–MS/MS). In vitro inhibition assays confirmed the inhibitory potential of these representative ligands. Molecular docking suggested that these possible ligands could be inserted into the active pocket of the target enzyme through multiple intermolecular forces. Our findings indicated that the polyphenols in mulberry leaves may contribute significantly to their hypoglycemic and hypolipidemic properties. Furthermore, our study provides valuable insights for the screening of active ingredients in other medicinal and edible plants, which could help in the development of new therapies for diabetes and obesity.

关键词： Bio-affinity ultrafiltration Diabetes Mulberry leaves Obesity

A hybrid nickel/iron-pyromellitic acid electrocatalyst for oxygen evolution reaction

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Nano Research 2024年第4期17卷 2481-2491页

作者： Guoqi Li Lin Li Wenlong Li Fusheng Li Chunze Yuan Nian zhang hui zhang Tsu-Chien Weng School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China State Key Lab of Fine Chemicals Institute of Artificial PhotosynthesisDUT-KTH Joint Education and Research Center on Molecular DevicesDalian University of Technology(DUT)Dalian 116024China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

The migration of protons during the oxygen evolution reaction(OER)is a key factor that affects the performance of OER *** enhance proton transportation,we designed a catalyst based on nickel/iron-pyromellitic acid(NiFe-PMA)prepared by the electrochemical deposition *** catalyst exhibited a low overpotential of 188 mV at a current density of 10 mA·cm^(-2),a Tafel slope of 28.2 mV·dec^(-1),and long-term stability for 30 days with a current of 50 mA·cm^(-2).We characterized the NiFe-PMA catalyst using various techniques,including Fourier transform infrared(FTIR)spectroscopy,Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),X-ray absorption spectroscopy(XAS),transmission electron microscopy(TEM),scanning electron microscopy(SEM),and inductively coupled plasma-optical emission spectrometry(ICP-OES).Our results showed that NiFe-PMA contains nickel,iron atoms,and both coordinated and uncoordinated carboxylate ***,XPS data confirmed that carboxylate ligands could adjust the outer electronic structure of metal ions,resulting in the high valence state of Ni in *** result of XAS indicated that the nickel atoms present in the catalyst might be easier to maintain a higher chemical *** investigations using kinetic isotope effects(KIEs)and proton inventory revealed that the uncoordinated carboxylic protons played a crucial role in receiving protons during the OER,which promoted the proton transfer of the rate-determining step of the *** novel electrocatalysts provide a new strategy for designing more active and cost-effective catalysts for the OER.

关键词： nickel/iron-pyromellitic acid oxygen evolution reaction kinetic isotope effects