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MoS2 synaptic transistor with one-step manufacture

Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： Yihao GUO yang WANG Wenjie DENG Yi WU Jingtao LI Kexin LI Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG hui yan Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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噻吩酰亚胺衍生物二阶非线性光学性质的DFT研究

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原子与分子物理学报 2025年第1期42卷 20-28页

作者：蔺彬彬闫慧君哈尔滨学院食品工程学院化学系哈尔滨150086

采用密度泛函理论(DFT)CAM-B3LYP方法,计算研究了12个设计的噻吩酰亚胺衍生物的电子光谱和二阶非线性光学性质.结果表明,此类化合物有较大的第一超极化率β_(tot)值和β_(vec)值,且β_(tot)值和β_(vec)值随引入氰基数目的增加而显著增... 详细信息

采用密度泛函理论(DFT)CAM-B3LYP方法,计算研究了12个设计的噻吩酰亚胺衍生物的电子光谱和二阶非线性光学性质.结果表明,此类化合物有较大的第一超极化率β_(tot)值和β_(vec)值,且β_(tot)值和β_(vec)值随引入氰基数目的增加而显著增大.给/吸电子基团引起的电荷转移变化对体系β_(tot)值和β_(vec)值的影响大于分子六元杂环中N杂原子位置变化对其影响.

关键词：噻吩酰亚胺衍生物密度泛函理论二阶非线性光学性质电子光谱

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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li hui-yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Asteroseismology of the DBV star CBS 114

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Research in Astronomy and Astrophysics 2016年第8期16卷 17-24页

作者： yan-hui Chen Institute of Astrophysics Chuxiong Normal University School of Physics and Electronical Science Chuxiong Normal University Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences

Asteroseismology is a unique and powerful tool to investigate the internal structure of stars. CBS 114 is the sixth known pulsating DBV star. It was observed by Handler, Metcalfe, ＆ Wood at the South African Astronomical Observatory over three weeks in 2001. Then, it was observed by Metcalfe et al. for seven nights （2004 Feb. 19-25） on the 1.8 m telescope at the Bohyunsan Optical Astronomy Observatory and seven nights （2004 Feb. 21-27） on the 2.1 m telescope at the McDonald Observatory. Totally two triplets, four doublets, and five singlets were identified. The frequency splitting values are very different, from 5.2 *** to 11.9 ~tHz, which may reflect differential rotations. We evolve grids of white dwarf models by MESA. Cores, added with He/C envelopes, of those white dwarf models are inserted into WDEC to evolve grids of DBV star models. With those DBV star models, we calculate eigenperiods. Those calculated periods are used to fit observed periods. A best-fitting model is selected. The parameters are T^ff ----- 25 000 K, M, = 0.740 MG and log（MHe/M,） = -4.5. With the relatively large stellar mass, the effective temperature is close to the previous spectroscopic result. In addition, kinetic energy distributions are calculated for the best-fitting model. We find that the observed modes with large frequency splitting values are fitted by the calculated modes with a large amount of kinetic energy distributed in the C/O core. After preliminary analysis, we suggest that the C/O core may rotate at least two times faster than the helium layer for CBS 114.

关键词： stars: oscillations (including pulsations) -- stars: individual (CBS 114) -- white dwarfs

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Asteroseismology of DAV white dwarf stars and G29–38

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Research in Astronomy and Astrophysics 2013年第12期13卷 1438-1444页

作者： yan-hui Chen yan Li Yunnan Astronomical Observatory Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences

Asteroseismology is a powerful tool used for detecting the inner structure of stars, which is also widely used to study white dwarfs. We discuss the asteroseismology of DAV stars. The period-to-period fitting method is discussed in detail, including its reliability in detecting the inner structure of DAV stars. If we assume that all observed modes of some DAV stars are the l = I cases, the errors associated with model fitting will be always large. If we assume that the observed modes are com- posed of I = 1 and 2 modes, the errors associated with model fitting in this case will be small. However, there will be modes identified as l = 2 that do not have ob- served quintuplets. G29-38 has been observed spectroscopically and photometrically for many years. Thompson et al. made 1 modes identifications in the star through the limb darkening effect. With 11 known I modes, we also study the asteroseismology of G29-38, which reduces the blind l fittings and is a fair choice. Unfortunately, our two best-fitting models are not in line with the previous atmospheric results. Based on factors like only a few observed modes, stability and identification of eigenmodes, identification of spherical degrees, construction of physical and realistic models and so on, detecting the inner structure of DAV stars by asteroseismology needs further development.

关键词： stars: oscillations (including pulsations) - stars: individual (G29-38)- white dwarfs

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Imazaquin degradation and metabolism in a sandy loam soil amended with farm litters

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Journal of Environmental Sciences 2007年第9期19卷 1108-1113页

作者： WANG hui-li LI yan-yan WEI Guo-hui WANG Xue-dong Key Laboratory of Pesticide and Chemical Biology of Ministry of Education Central China Normal University Wuhan 430079 China

Irnazaquin applied in legume crops has a long residual time in soil, which often impacts safety of the susceptible crops. To increase safety of imazaquin application, two composted litters, bovine manure （BM） and chicken manure （CM）, were used to determine their effects on imazaquin environmental behavior by incorporating each kind of manure into the tested sandy loam soil at 10% （w/w）. The degradation of imazaquin in BM- and CM-amended soil was about 2.4 and 1.5 times, respectively, faster than that in unamended soil. The half-lives of imazaquin in BM-amended soil varied between 6.7 and 15.4 d over the temperature range of 20 to 40℃, and the degradation rate constant （k） increased by a factor of about 1.5 for every 10℃ change. Higher mix ratio did not significantly increase the degradation, and the optimal active degradation of imazaquin was observed approximately at the mix ratio of 10：1 of soil to BM. The different moisture levels had negligible effect on imazaquin degradation. In both unamended and BM-amended treatments, two metabolites were observed at 5, 10 and 30 d after treatment. One metabolite at retention time （RT） of 8.4 rain was identified as 2-（4- hydroxyl-5-oxo-2-imidazolin-2-yl） quinoline acid, originating from the loss of isopropyl group and hydroxylation at the 4-position of imidazolinone ring. The other at RT of 12.9 rain was identified as quinoline-2,3-dicarboxylic anhydride, resulting from detachment of imidazolinone ring and the forming of dicarboxylic anhydride. This finding suggested that the addition of farm litters into soil might be a good management option since it can not only increase soil fertility but also contribute to increase safety of imazaquin application to the following susceptible crops.

关键词： imazaquin farm litter enhanced degradation metabolite

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Investigation on the automatic parameters extraction of pulse signals based on wavelet transform

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1283-1289页

作者： WANG hui-yan ZHANG Pei-yong College of Computer Science ＆ Information Engineering Zhejiang Gongshang University Hangzhou 310018 China Institute of VLSI Design Zhejiang University Hangzhou 310027 China

This paper analyses a key problem in the quantification of pulse diagnosis. Due to the subjectivity and fuzziness of pulse diagnosis,quantitative methods are needed. To extract the parameters of pulse signals,the prerequisite is to detect the corners of pulse signals correctly. Up to now,the pulse parameters are mostly acquired by marking the pulse corners manually,which is an obstacle to modernize pulse diagnosis. Therefore,a new automatic parameters extraction approach for pulse signals using wavelet transform is presented. The results testified that the method we proposed is feasible and effective and can detect corners of pulse signals accurately,which can be expected to facilitate the modernization of pulse diagnosis.

关键词： Pulse signal Feature extraction Complex wavelet transform Quantitative diagnosis

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Characteristics of SEN clogging and adhesive behavior of oxide inclusion during continuous casting of Ti-stabilized ultra-pure ferritic stainless steels

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Journal of Iron and Steel Research International 2023年第10期30卷 1939-1951页

作者： Xue-feng Bai yan-hui Sun hui-bin Wu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China

Submerged entry nozzle(SEN)clogging during continuous casting of Ti-stabilized ultra-pure ferritic stainless(Ti-UPFS)steels was systematically investigated via cross-sectional analysis and acid dissolution *** SEN deposit profile was characterized as occurring in three major layers:(1)an eroded refractory layer;(2)an initial adhesive layer comprised an Al_(2)O_(3)-ZrO_(2) composite sub-layer and a dense Al_(2)O_(3)-based deposit sub-layer;and(3)a porous multiphase deposit layer mainly consisting of MgO·Al_(2)O_(3),CaO-Al_(2)O_(3),and *** MgO·Al_(2)O_(3)-rich inclusions did not adhere directly to the eroded refractory but were entrapped during the deposit *** of inclusion characterization in the tundish revealed that the MgO·Al2O3-rich particles present in the tundish served as the primary source of clogging ***,a novel cavity-induced adhesion model by circular approximation was established to explain the effects of complex inclusion characteristics and refractory material type on adhesion force.A high number of small MgO·Al_(2)O_(3) inclusions were expected to accelerate the buildup of clogging *** the modification of MgO·Al_(2)O_(3)-rich inclusions in the size range of 2-4μm by Ca treatment was crucial to minimizing the risk of SEN clogging during the continuous casting of Ti-UPFS steels.

关键词： Ti-stabilized ultra-pure ferritic stainless steel Submerged entry nozzle clogging MgO·Al_(2)O_(3)-rich inclusion Adhesion Continuous casting

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Commentary review on peripapillary morphological characteristics in high myopia eyes with glaucoma:diagnostic challenges and strategies

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 600-605页

作者： yan-hui Chen Rui-Hua Wei yan-Nian hui Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science Tianjin 300070China Eye Institute and School of Optometry Tianjin Medical University Eye HospitalTianjin 300384China Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710023Shaanxi ProvinceChina

The incidences of open angle glaucoma(OAG)and high myopia are increasing *** the aging population and concurrent rapid increase in the number of individuals with myopia,the risk of visual defects caused by highly myopic OAG is likely to increase dramatically over the next few ***,precise screening and diagnosis of OAG is challenging because of the tilt and rotation of the optic disc,as well as extensiveβ-zone parapapillary atrophy in highly myopic *** advances in optical coherence tomography(OCT)and OCT angiography(OCTA)technologies imply that both modalities are promising tools for the detection of highly myopic ***,the diagnosis of OAG remains to be determined with the longitudinal changes of functional damages(*** field defect,visual electrophysiological changes).We herein describe some aspects of microvascular and microstructural pathology in patients with highly myopic OAG and proposes a framework for the development of novel diagnostic and therapeutic strategies.

关键词： high myopia open angle glaucoma parapapillary atrophy parapapillary microvasculature optic disc lamina cribrosa optical coherence tomography

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A model for automatic identification of human pulse signals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1382-1389页

作者： hui-yan WANG Pei-yong ZHANG College of Computer Science and Information Engineering Zhejiang Gongshang University Hangzhou 310018 China Institute of VLSI Design Zhejiang University Hangzhou 310027 China

This paper presents a quantitative method for automatic identification of human pulse signals. The idea is to start with the extraction of characteristic parameters and then to construct the recognition model based on Bayesian networks. To identify depth, frequency and rhythm, several parameters are proposed. To distinguish the strength and shape, which cannot be represented by one or several parameters and are hard to recognize, the main time-domain feature parameters are computed based on the feature points of the pulse signal. Then the extracted parameters are taken as the input and five models for automatic pulse signal identification are constructed based on Bayesian networks. Experimental results demonstrate that the method is feasible and effective in recognizing depth, frequency, rhythm, strength and shape of pulse signals, which can be expected to facilitate the modernization of pulse diagnosis.

关键词： Pulse signal identification Feature extraction Bayesian network Quantitative diagnosis Wavelet transform

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