检索结果-南通市图书馆

General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin Hang Yan-Chang Yang Yu-Han Hu Fu-Quan Fang Lang Wang Xing-Hua Qian Patrick M.McQuillan hui xiong Jian-Hang Leng Zhi-Yong Hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial cells.Oligodendrocytes perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity regulation.They are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and apoptosis.Neurologists are increasingly interested in the effects of general anesthetic agents on oligodendrocytes.These agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and function.In this review,we summarize the effects of general anesthetic agents on oligodendrocytes.We anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Evaluating combined bevacizumab and XELOX in advanced colorectal cancer: Serum markers carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199 analysis

引用

World Journal of Clinical Cases 2024年第1期12卷 15-23页

作者： Dong-Bing Zhou Jun Cheng xiong-hui Zhang Department of Gastroenterology The Second People's Hospital of Jingzhou HubeiJingzhou 434000Hubei ProvinceChina Department of Gastrointestinal Surgery Qianjiang Central HospitalQianjing 433100Hubei ProvinceChina Department of Gastroenterology Xiantao First People's Hosepital Affiliated to Yangtze UniversityXiantao 433000Hubei ProvinceChina

BACKGROUND Colorectal cancer ranks third and second among common and fatal cancers.The treatment of metastatic colorectal cancer(mCRC)is generally based on XELOX in clinical practice,which includes capecitabine(CAP)and oxaliplatin.Serum tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen(CA)125 and CA199 are prognostic factors for various tumors.AIM To investigate evaluating combined bevacizumab(BEV)and XELOX in advanced colorectal cancer:Serum markers CEA,CA125,CA199 analysis.METHODS In this retrospective study,a total of 94 elderly patients diagnosed with mCRC were recruited and subsequently categorized into two groups based on the distinct treatment modalities they received.The control group was treated with XELOX plus CAP(n=47),while the observation group was treated with XELOX plus CAP and BEV(n=47).Several indexes were assessed in both groups,including disease control rate(DCR),incidence of adverse effects,serum marker levels(CEA,CA125,and CA19)and progression-free survival(PFS).RESULTS After 9 wk of treatment,the serum levels of CEA,CA199 and CA125 in the observation group were significantly lower than those in the control group(P0.05).CONCLUSION On the basis of XELOX treatment,the combination of BEV and CAP can reduce serum tumor marker levels and prolong PFS in patients with mCRC.

关键词： Metastatic colorectal cancer Bevacizumab Capecitabine XELOX Tumor markers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

引用

Journal of Iron and Steel Research(International) 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He Xin-hui Chen hui Li Kai-hua Shi hui-wen xiong Xin Xiang Li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide particles.The effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in detail.The results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy composites.Cast tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten carbide.When 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,respectively.The main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Simultaneously enhanced electrochemical performance and air stability of Ni-rich cathode with a modified washing process

引用

Rare Metals 2024年第1期43卷 87-97页

作者： Ben-Rui Hu Ying-Yi Yuan Yu-Cheng Wang Xun-hui xiong School of Environment and Energy Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640China

Water washing has been regarded as one of the most effective strategies to remove surface residual lithium of nickel-rich layered oxides for lithium-ion batteries(LIBs).However,the loss of lattice lithium during the water washing process deteriorates the electrochemical performances and air stability.Herein,washing the LiNi_(0.90)Co_(0.05)Al_(0.02)O_(2)(NCA) with ammonium dihydrogen phosphate(NH_(4)H_(2)PO_(4)) solution has been proposed to simultaneously enhance electrochemical performances and air stability,in which in-situ generated Li_(3)PO_(4) coating layer on surface of NCA can suppress the loss of lattice lithium.Besides,as a fast ionic conductor,Li_(3)PO_(4) coating layer on NCA can prevent the direct contact with electrolyte/air.As a result,the NH_(4)H_(2)PO_(4) solution washed NCA cathode can deliver a high capacity of131.9 mAh·g^(-1) at 10.0C rate as well as impressive cycle stability with a capacity retention of 83.1% after 100 cycles at 1.0C,much higher than those of water washed NCA(WS-NCA) electrode.After exposed in air for 7 days,the NH_(4)H_(2)PO_(4) solution washed NCA electrode can more effectively maintain the structural integrity as well as the electrochemical performances than water-washed NCA.This work provides a simple and effective approach to enhance the cycle stability and air stability of Nickel-rich cathode materials.

关键词： Layered Ni-rich cathode Residual lithium Li_(3)PO_(4)coating Rate performance Air stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theoretical understanding of correlation between magnetic phase transition and the superconducting dome in high-Tc cuprates

引用

Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 167-173页

作者： Chen Zhang Cai-Xin Zhang Su-Huai Wei Haiqing Lin hui-xiong Deng State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Computational Science Research Center Beijing 100193China

Many issues concerning the origin of high-temperature superconductivity(HTS)are still under debate.For example,how the magnetic order varies with doping and its relationship with the superconducting temperature(Tc);and why Tcalways peaks near the quantum critical point.In this paper,taking hole-doped La_(2)CuO_(4)as a classical example,we employ the first-principles band structure and total energy calculations with Monte Carlo simulations to explore how the symmetry-breaking magnetic ground state evolves with hole doping and the origin of a dome-shaped superconductivity region in the phase diagram.We demonstrate that the local antiferromagnetic order and doping play key roles in determining the electron-phonon coupling,thus Tc.Initially,the La_(2)CuO_(4)possesses a checkerboard local antiferromagnetic ground state.As the hole doping increases,Tcincreases with the enhanced electron-phonon coupling strength.But as the doping increases further,the strength of the antiferromagnetic interaction weakens and spin fluctuation increases.At the critical doping level,a magnetic phase transition occurs that reduces the local antiferromagnetism-assisted electron-phonon coupling,thus diminishing the Tc.The superconductivity disappears in the heavily overdoped region when the ferromagnetic order dominates.These observations could account for why cuprates have a dome-shaped superconductivity region in the phase diagram.Our study,thus,contributes to a fundamental understanding of the correlation between doping,local magnetic order,and superconductivity of HTS.

关键词： high-temperature superconductivity antiferromagnetic order electron-phonon coupling doping effect cuprates

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitigation of Deane and Hamill phenomenon in gallium nitride high-voltage power supply for electric propulsion system application

引用

High Voltage 2024年第1期9卷 252-265页

作者： Minghai Dong hui Li Shan Yin Kye Yak See Yingzhe Wu xiong Xin School of Aeronautics&Astronautics University of Electronic Science and Technology of ChinaChengduChina School of Electrical&Electronic Engineering Nanyang Technological UniversitySingaporeSingapore School of Automation Engineering University of Electronic Science and Technology of ChinaChengduChina Innoscience(Shenzhen)Semiconductor Co.Ltd. ShenzhenChina

The step-up resonant converters are widely adopted to provide high voltage in kV-level for electric propulsion system due to their high efficiency,low mass,modularisation,and high-power density.The bipolar Cockcroft-Walton voltage multiplier(BiCWVM)is a major circuit that steps up the voltage in the resonant converter.However,the diode nonlinearity in BiCWVM can introduce self-sustained quasi-periodic oscillations in the voltage and current waveforms,which is commonly known as the Deane and Hamill(DH)phenomenon.The oscillation can lead to higher magnetic loss and control failure,and it is more likely to present in the gallium nitride-based converter due to the highfrequency operation.The authors aim to investigate and mitigate the DH phenomenon systematically so that proper mitigation can be implemented.To facilitate the investigation,the circuit before the BiCWVM in the converter is derived and modelled as a voltage source v_(m)and a series inductor L_(sy).Also,the reverse recovery process of the diode in the BiCWVM can be represented by a piecewise-linear(PWL)model,with the simplified circuit and PWL model,the relationship between voltage and current under different operating conditions can be determined with ease.The relationship allows to understand the mechanism of diode reverse recovery in BiCWVM that leads to DH phenomenon.Finally,a hybrid-/full-silicon carbide(SiC)design is proposed to mitigate the DH phenomenon,which is verified experimentally for a 300-kHz,5-W,20-V/1.5-kV GaN-based step-up resonant converter.

关键词： power resonant high

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates

引用

Opto-Electronic Advances 2024年第1期7卷 36-46页

作者： Yuncheng Liu Ke Xu Xuhao Fan Xinger Wang Xuan Yu Wei xiong hui Gao Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Interactive holography offers unmatched levels of immersion and user engagement in the field of future display.Despite of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate limitations.In this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates.To our knowledge,this is the first reported practical dynamic interactive metasurface holographic system.We spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed sub-pattern.The switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame rate.Our approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational platform.According to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram creation.Our technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems.

关键词： interactive display meta-holography bitwise operation ultra-high frame rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A survey on model-based reinforcement learning

引用

Science China(Information Sciences) 2024年第2期67卷 59-84页

作者： Fan-Ming LUO Tian XU Hang LAI xiong-hui CHEN Weinan ZHANG Yang YU National Key Laboratory for Novel Software Technology Nanjing University Polixir. ai Department of Computer Science and Engineering Shanghai Jiao Tong University

Reinforcement learning(RL) interacts with the environment to solve sequential decision-making problems via a trial-and-error approach. Errors are always undesirable in real-world applications, even though RL excels at playing complex video games that permit several trial-and-error attempts. To improve sample efficiency and thus reduce errors, model-based reinforcement learning(MBRL) is believed to be a promising direction, as it constructs environment models in which trial-and-errors can occur without incurring actual costs. In this survey, we investigate MBRL with a particular focus on the recent advancements in deep RL. There is a generalization error between the learned model of a non-tabular environment and the actual environment. Consequently, it is crucial to analyze the disparity between policy training in the environment model and that in the actual environment, guiding algorithm design for improved model learning, model utilization, and policy training. In addition, we discuss the recent developments of model-based techniques in other forms of RL, such as offline RL, goal-conditioned RL, multi-agent RL, and meta-RL. Furthermore,we discuss the applicability and benefits of MBRL for real-world tasks. Finally, this survey concludes with a discussion of the promising future development prospects for MBRL. We believe that MBRL has great unrealized potential and benefits in real-world applications, and we hope this survey will encourage additional research on MBRL.

关键词： reinforcement learning model-based reinforcement learning planning model learning model learning with reduced error model usage

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Influence of powder oxidation on powder properties and formability in H13 hot-work steels processed by electron beam melting

引用

Journal of Iron and Steel Research(International) 2024年第4期31卷 924-932页

作者： Wei Liu Yan Wang Li-xiong Han Ying-kang Wei hui-ping Tang Shi-feng Liu School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina School of Engineering Zhejiang University City CollegeHangzhou 310015ZhejiangChina

The oxygen content of metal powder is decisive for the recyclability of powder.The research on the effect of oxygen content on powder properties and material formability has practical significance for economical production with additive manufacturing while preventing the waste of resources.Here,we deliberately oxidized the powder by baking at high temperature to increase the oxygen content in the powder and gave the calculation method of the oxygen content in the powder oxidation film.The majority of oxygen element was found in the oxide particles in the powder and the oxide flm on the powder surface,which did affect the flowability of the powder.It is worth noting that the increase in the oxygen content does not change the phase of H13 steel,but it can promote the molten pool flow and obtain a smoother surface.The increase in the oxygen content in the powder is not the decisive factor for the formability and defects of the printed samples.It is the combined effect of the powder deformation,the increase in the oxygen content,and the impurity pollution after repeated use,which leads to the limitation of repeated utilization of the powder.

关键词： Additive manufacturing Electron beam melting H13 steel powder-Powder oxidation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Respiratory Viruses and Mycoplasma Pneumoniae Surveillance Among Hospitalized Children with Acute Respiratory Infections—Wuhan City,Hubei Province,China,September-November 2023

引用

China CDC weekly 2024年第8期6卷 139-142页

作者： Ying Li Yi Yan Jiaming Huang Yue Shi hui Du Chao xiong Kai Chen Di Liu Xiaoxia Lu Computational Virology Group Center for Bacteria and Viruses Resources and BioinformationWuhan Institute of VirologyChinese Academy of SciencesWuhan CityHubei ProvinceChina Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei ProvinceChina Pediatric Respiratory Disease Laboratory Institute of Maternal and Child HealthWuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei ProvinceChina University of Chinese Academy of Sciences BeijingChina CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan CityHubei ProvinceChina Data Center Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei ProvinceChina

Summary What is already known about this topic?Acute respiratory infections(ARIs)are a significant contributor to illness and death in children.There has been a notable rise in the occurrence of ARIs and the associated pathogens in China,which has garnered worldwide attention.What is added by this report?This study conducted a retrospective analysis of the clinical characteristics of children with ARIs in Wuhan City from September to November 2023.

关键词： November Wuhan Hubei

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：