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Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high-and low-incidence areas

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cancer Biology & Medicine 2017年第1期14卷 60-65页

作者： lian-Qun Zhang Xin Song Xue-Ke Zhao jia Huang Peng Zhang Lu-Wen Wang hui Meng jian-Wei Ku guo-Qiang Kong Tao jiang Xin-Min li Xiao-Long lv Teng Ma guo Yuan Min-Jie wu Shou-jia Hu Shuang lv tang-juan Zhang ling-Fen Ji Zong-Min Fan Neng-Chao Wang yao-Wen Zhang Fu-you zhou li-Dong Wang Henan Key Laboratory for Esophageal cancer Research of the First Affiliated Hospital Zhengzhou UniversityZhengzhou 450052China Anyang Tumor Hospital Anyang 455000China cancer Research Center Xinxiang Medical UniversityXinxiang 453003China

Objective: This study aimed to determine if gastric cardia adenocarcinoma(GCA) risk was associated with the lys(A or *2) allele at the rs671(glu504lys) polymorphism within the aldehyde dehydrogenase 2(ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma(ESCC).Methods: We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and lowincidence areas for both GCA and ESCC in China. Taq Man allele discrimination assay was used to genotype the rs671 polymorphism. χ~2 test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA,and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different ***: Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population(P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in highincidence areas for both GCA and ESCC was lower than that in low-incidence areas(Plity in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.

关键词： Gastric cardia adenocarcinoma rs671 ALDH2

作用于秋水仙碱位点的微管蛋白抑制剂的结合模式研究与结构模型的构建

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化学学报 2008年第14期66卷 1735-1739页

作者：李耀武周有骏朱驹郑灿辉陈军盛春泉吕加国唐辉栗亚男张珏第二军医大学药学院药物化学教研室上海200433

采用对接的方法建立了秋水仙碱位点抑制剂与微管蛋白的结合模式,并构建了其结构模型.结果表明:抑制剂主要借助于与口袋I和II的疏水作用,以及同α-Thr178,α-Val181和β-Cys241之间的氢键来实现与微管蛋白的结合.根据抑制剂的结合构象,... 详细信息

采用对接的方法建立了秋水仙碱位点抑制剂与微管蛋白的结合模式,并构建了其结构模型.结果表明:抑制剂主要借助于与口袋I和II的疏水作用,以及同α-Thr178,α-Val181和β-Cys241之间的氢键来实现与微管蛋白的结合.根据抑制剂的结合构象,将抑制剂的结构分为A,B以及AB间的桥连三个部分,从而建立了由A部分中的疏水中心H1、氢键受体A1,B部分中的疏水中心H2、疏水基团H3和极性原子P以及桥连结构中的氢键受体A2组成的结构模型.并指出H1与H2对活性的影响因素分别为疏水基团的体积和平面特征,而桥连部分则应以刚性的形式保证AB处于桥连的同侧(即顺式构象).还提出在A2与loop区之间存在一个的潜在氢键受体A3.研究结果为设计新型小分子微管蛋白抑制剂提供指导.

关键词：微管蛋白秋水仙碱对接结合模式结构模型

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da tang Yong-Hao chen Jing-Yu tang Rui-Rui Fan Qiang li Gong li Dong liu zheng-yao Jin Xing-zhu Cui Tian-Xiang chen Yi-Wei Yang Rong liu Han Yi Yang li Zhen Yang Qi An Hao-Fan Bai jiang-Bo Bai Jie Bao Ping Cao Qi-Ping chen Zhen chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han guo-zhu He Yong-cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Wei-Hua jia Hao-yu jiang Wei jiang Zhi-jie jiang ling Kang Bo li Chao li jia-Wen li Xiao li Jie liu Shu-Bin liu Guang-Yuan Luan Chang-jun Ning Bin-Bin Qi Jie Ren Zhi-zhou Ren Xi-Chao Ruan Zhao-hui Song Kang Sun Zhi-Xin Tan li-jiao Wang Peng-cheng Wang Zhao-hui Wang Zhong-Wei Wen Xiao-Guang wu Xuan wu li-Kun Xie Yong-Ji Yu guo-hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping zhou Zhi-Hao zhou Ke-jun zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑jiao Wang Xiang‑Biao Qiu Jing‑Wen li Wei Xu Tao li Ze‑Bin lin Chang‑jun Ning Yong‑Hao chen Rui‑Rui Fan Kang Sun Jing‑Yu tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping chen Zhen chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han guo‑zhu He Yong‑cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua jia Hao‑Yu jiang Wei jiang Zhi‑Jie jiang zheng‑yao Jin ling Kang Bo li Chao li Gong li jia‑Wen li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑zhou Ren Xi‑Chao Ruan Zhao‑hui Song Zhi‑Xin Tan Sheng‑Da tang Peng‑cheng Wang Zhao‑hui Wang Zhong‑Wei Wen Xiao‑Guang wu Xuan wu li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu guo‑hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping zhou Zhi‑Hao zhou Ke‑jun zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-Wei liu Yi-Peng Jing Gang Wang Hao-Tong Zhang jian-Rong Shi Xiang-Qun Cui yao-Quan Chu guo-Ping li Zhong-Rui Bai Yue wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan chen jian-jun chen Kun-Xin chen li chen Xue-Lei chen Xiao-Yan chen Ying chen Norbert Christlieb jia-Ru Chu chen-zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-hui Hou Wen Hou Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei jia Fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong Xu Kong Ya-juan Lei Ai-Hua li Chang-Hua li Guang-Wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li Yin-Bi li Ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-jun Ni Zhao-Xiang Qi Yong-jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-jun Su zheng-Hong tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang guo-Min Wang Hai Wang Hong-Chi Wang jian Wang jia-Ning Wang jian-ling Wang jian-Ping Wang jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang you Wang Yue-Fei Wang you-Fen Wang Peng Wei Ming-Zhi Wei Hong wu Ke-Fei wu Xue-Bing wu Yu-Zhong wu Xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang hui-Qin Yang Ming Yang zheng-Qiu yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang jian-Nan Zhang li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang zheng-Chao Zhang Ming Zhao Fang zhou Xu zhou Jie zhu Yong-Tian zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in june 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in june 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun liu Dan-Dan li Wei Dong Yu-Qi liu Yang wu Da-Xuan tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He jun li Bai Du Ting-Hai Du lin-lin Niu Xue-jun jiang Bo Cui jiang-Bin chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin liu li-Qin Duan Ming-jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua li Ying Xiao you-Zhi Hu Xiao-Yu Huang Kun Xing Xin jiang Chao-Feng liu Jing An Feng-Chun li Tao Tao Jin-Fa jiang Ying Yang yao-Rong Dong Lei Zhang Guang Fu Ying li Shu-Wei Huang li-Ping Dou Lan-jun Sun Ying-Qiang Zhao Jie li Yun Xia jun liu Fan liu Wen-Jin He Ying li jian-Cong Tan Yang lin Ya-Bin zhou jian-Fei Yang guo-Qing Ma hui-jun chen He-Ping liu Zong-wu liu jian-Xiong liu Xiao-jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing li Fei Teng Wang-Min Qiao Xiao-Long zhu Bing-Wei chen Qi-Guang chen Chun-Ti Shen Yong-Yan Wang Yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Progress of Jinping Underground laboratory for Nuclear Astrophysics(junA)

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Science China(Physics,Mechanics & Astronomy) 2016年第4期59卷 1-7页

作者： WeiPing liu ZhiHong li jiangjun He XiaoDong tang Gang lian zhu An jianjun Chang Han chen QingHao chen Xiongjun chen Zhijun chen BaoQun Cui XianChao Du ChangBo Fu lin Gan Bing guo guozhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu jia liYang jiang Shigeru Kubono jianMin li KuoAng li Tao li Yunju li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen jun Su liangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang youBao Wang Qi wu ShiWei Xu ShengQuan Yan liTao Yang yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang hui Zhang liYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao zhou Department of Nuclear Physics China Institute of Atomic Energy Beijing 102413 China Institute of Modern Physics Lanzhou 730000 China College of Nuclear Science and Engineering Sichuan University Chengdu 610065 China Department of Engineering Physics Tsinghua University Beijing 100084 China Department of Physics and Astronomy Shanghai Jiaotong University Shanghai 200240 China School of Physics and Astronomy Monash University Melbourne Victoria 3800 Australia Center for Nuclear Study University of Tokyo Wako Saitama 351-0198 Japan Konkoly Observatory of the Hungarian Academy of Sciences 1121 Budapest Konkoly-Thege Miklos u. 13-17 Hungary Department of Physics University of South Dakota Vermillion SD 57069 United States School of Physics and Astronomy University of Minnesota Minneapolis MN 55455 United States Department of Physics University of Notre Dame Notre Dame IN 46556 Unites States Research Center for Nuclear Physics Osaka University Suita Osaka 565-0871 Japan School of Space Science and Physics Shandong University Weihai Campus Weihai 264209 China

Jinping Underground laboratory for Nuclear Astrophysics(junA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, junA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of junA will be given.

关键词： direct measurement underground laboratory (25)Mg(p γ)(26)Al (19)F(p α)(16)O (13)C(α n)(16)O and (12)C(α γ)(16)O reactions Gamow window junA

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui guo-Ping li yao-Quan Chu jian-Rong Shi Gang Wang jian-Nan Zhang Zhong-Rui Bai Xiao-Yan chen Feng-Fei Wang Yan-Xin guo jian-jun chen Bing Du Xiao Kong Ya-juan Lei Yin-Bi li Yi-Han Song Yue wu Yan-Xia Zhang Xin-lin zhou Fang Zuo Peng Du lin He Wen Hou Yi-Qiao Dong jian li Guang-Wei li Shuang li Jing Song Yuan Tian Meng-Xin Wang Yong-hui Hou Zhi-Ying Huo Hong-zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei jia Fang-Hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-Hua li Qi li Yin-Dun Mao zheng-Hong tang Qing-Sheng Tao liang-Ping Tu Da-Qing Wang Dan Wang jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang you Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang zheng-Qiu yao Yong Yu hui Yuan Chao Zhai En-Peng Zhang Jing Zhang li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang zhou Yong-Tian zhu Jie zhu Si-cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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Biomarkers of aging

Science China(life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao jiani Cao Mengting chen Min chen Wei chen Xiao chen Yanhao chen Yu chen Yutian chen Zhiyang chen Jagadish K Chhetri Yingjie Ding junlin Feng jun guo Mengmeng guo Chuting He Yujuan jia Haiping jiang Ying Jing Dingfeng li jiaming li Jingyi li Qinhao liang Rui liang Feng liu Xiaoqian liu Zuojun liu Oscar junhong Luo jianwei lv Jingyi Ma Kehang Mao jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang tang jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo wu Kai Xia Fu-hui Xiao lingyan Xu Yingying Xu Haoteng Yan liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang zhuo Zhang Min zhou Rui zhou Qingchen zhu zhengmao zhu Feng Cao Zhongwei Cao Piu Chan Chang chen guobing chen Hou-Zao chen jun chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu ju Qing-Peng Kong Ji li jian li Xin li Baohua liu Feng liu lin liu Qiang liu Qiang liu Xingguo liu Yong liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang liang Zhang Weiqi Zhang Yong Zhang Yun-wu Zhang zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai zhu Weiguo Zou Gang Pei Guang-hui liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock