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肢端肥大症患者合并恶性肿瘤风险及相关危险因素研究进展

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中华内科杂志 2022年第4期61卷 433-437页

作者：肖童心段炼朱惠娟潘慧中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室疑难重症及罕见病国家重点实验室北京100730 北京协和医学院北京100730

肢端肥大症患者恶性肿瘤的发生风险与死亡风险可能升高,但不同临床研究结论尚不一致。甲状腺癌和结直肠癌为研究热点。研究发现患者年龄和肿瘤家族史与升高的恶性肿瘤风险显著相关。尚未证实生长激素和病程等其他肢端肥大症相关因素与... 详细信息

肢端肥大症患者恶性肿瘤的发生风险与死亡风险可能升高,但不同临床研究结论尚不一致。甲状腺癌和结直肠癌为研究热点。研究发现患者年龄和肿瘤家族史与升高的恶性肿瘤风险显著相关。尚未证实生长激素和病程等其他肢端肥大症相关因素与恶性肿瘤风险的关联。为提高临床医生对肢端肥大症患者恶性肿瘤发生风险的关注,对肢端肥大症患者恶性肿瘤发生风险与相关危险因素的最新研究进展进行综述。

关键词：肢端肥大症肿瘤生长激素危险因素

Cobalt-embedded 3D conductive honeycomb architecture to enable high-sulphur-loading Li-S batteries under lean electrolyte conditions

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Nano Research 2022年第9期15卷 8091-8100页

作者： Hui Pan Zhibin Cheng Jan Fransaer Jiangshui Luo Michael Wübbenhorst Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU LeuvenLeuven 3001Belgium Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007China Department of Materials Engineering KU LeuvenLeuven 3001Belgium Lab of Electrolytes and Phase Change Materials College of Materials Science and EngineeringSichuan UniversityChengdu 610065China

High sulphur loading and lean electrolyte conditions are important to achieve the high theoretical energy density of lithiumsulphur(Li-S)batteries.However,serious problems such as low sulphur utilization and fast capacity fade are typically experienced under low electrolyte/sulphur(E/S)ratios and high sulphur loading conditions.To address these issues,a cobaltcontaining three-dimensional conductive honeycomb(Co@N-HPC)is proposed in this work as a material for sulphur cathodes.The good electrical conductivity and high density of catalytic sites of(Co@N-HPC)allow fast redox kinetics of lithium polysulfide(LiPS)in high-sulphur-loading electrodes.In addition,the hierarchical structure and good wettability by the electrolyte of Co@NHPC facilitates electrolyte penetration and LiPS conversion,leading to a high utilization of sulphur under lean electrolyte conditions.Therefore,at a current density of 0.2 C,a volumetric capacity of 1,410 mAh·cm^(−3)was attained with a sulphur loading of 5.1 mg·cm^(−2)and an E/S ratio of 5μL·mg^(−1).This work provides ideas for the development of lean electrolyte Li-S batteries with a high sulphur loading.

关键词： honeycomb architecture cobalt nanoparticles high sulphur loading lean electrolyte lithium-sulphur battery

One-step nanoarchitectonics of a multiple functional hydrogel based on cellulose nanocrystals for effective tumor therapy

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Nano Research 2022年第9期15卷 8636-8647页

作者： Tianxing Chen Tengteng Yao Hui Pan hui Peng AndrewKWhittaker Yao Li Shenmin Zhu Zhaoyang Wang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology Shanghai Tenth People’s HospitalTongji UniversityShanghai 200092China Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology The University of QueenslandBrisbaneQLD 4072Australia

Hypoxia is a huge barrier for the development of photodynamic therapy(PDT).Chemodynamic therapy(CDT)could provide a possible solution to this dilemma.In this work,a controlled Schiff-base reaction was conducted between amido groups on the surface of carbon dots(CDs)and aldehyde groups on aldehyde-modified cellulose nanocrystals(mCNCs)as well as aldehydemCNCs decorated with Fe_(3)O_(4)nanoparticles.In this process,the mCNCs not only prevent the agglomeration of Fe_(3)O_(4)but also form hydrogels with CDs.The CDs act as both photothermal agent and photosensitizer.The hypoxia could be effectively relieved through the Fenton reaction due to the addition of Fe_(3)O_(4),and the·OH produced in the reaction further induces CDT and enhances tumor therapy efficiency.The therapy performance was further verified through in vitro cell experiments and in vivo animal experiments.This convenient method provides inspirations for the design and preparation of advanced biomaterials with multiple functions for cancer therapy.

关键词： injectable hydrogel tumor therapy carbon dots cellulose nanocrystals magnetic nanoparticles

A dynamic control structure of liquid-only transfer stream distillation column

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中国化学工程学报:英文版 2023年第7期59卷 135-145页

作者： Borui Liu Tao Zhang Yi Zheng Kailong Li Hui Pan Hao Ling State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power College of Environmental and Chemical EngineeringShanghai University of Electric PowerShanghai 200090China

The intention of this fundamental work is to explore the manipulation of a mixture of benzene,toluene and o-xylene separated from liquid-only transfer divided-wall column(LTS-DWC).First,two control structures are clearly proposed,including seven component control loops(CS1)and seven temperature control loops(CS2).However,two control structures can handle ±10% feed disturbances rather than larger feed disturbances.Subsequently,an equivalent four-column model by introducing withdraw ratio is developed to discuss the effect of two liquid-only side-stream on the overall reboiler duty.It is indicated that the second liquid-only side-stream withdraw ratio strongly affects the overall energy consumption.Hence,six-component control loops within the fixed second liquid-only side-stream withdraw ratio(CS3)is proposed and the purity of products returns to set value even as facing ±20% feed disturbances.Finally,based on the above results,it is established a temperature control structure(CS4)for controlling fixed second liquid-only side-stream withdraw ratio,which can cope with ±15% disturbances.Inspired by these findings,an insight into the dynamic control of LTS-DWC promotes the industrial implementation of DWC through new liquid-only side-stream configurations.

关键词： Separation Divided-wall column Liquid-only transfer stream Optimal design Dynamic modeling

How water molecules occupying the active site of a single-atom catalyst affect the electrochemical reduction of carbon dioxide

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Nano Research 2023年第7期16卷 9091-9098页

作者： Jia Zhao Di Liu Fenfei Wei Weng Fai Ip Hui Pan Sen Lin State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350002China Institute of Applied Physics and Materials Engineering University of MacaoTaipa 999078MacaoChina Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoTaipa 999078MacaoChina

In single-atom catalysts(SACs),the single atoms are often exposed as protrusions above the substrate.The solvent molecules in the electrocatalytic environment can interact or even bind to these coordination-unsaturated single atoms and thus influence the reaction process,but this has not been studied in depth.In this work,we systematically investigate the thermodynamics of CO_(2)reduction reaction(CO_(2)RR)to CO over MoS_(2)-supported single metal atom catalysts(TM@MoS_(2),TM=transition metal)under vacuum and explicit solvent environments using density functional theory.In addition,the ab initio molecular dynamics results show that explicit H_(2)O molecules can coordinate to the TM site and undergo competitive adsorption with the CO_(2)RR intermediates,which significantly affects the energy and conformation of the CO_(2)RR pathway.Electronic structure analysis reveals that the occupying H_(2)O molecules change the electronic state of single atom and further influence the adsorption strength of different CO_(2)RR intermediates.Our work shows that water molecules can not only act as ligands to influence the electronic state of TM,but also affect the energy and conformation of CO_(2)RR intermediates,which highlights the important role of occupying H_(2)O molecules at the single-atom sites in CO_(2)RR and provides useful insights for the design of SACs for efficient CO_(2)RR.

关键词： electrocatalytic CO_(2)reduction solvent effect single-atom catalysis density functional theory ab initio molecular dynamics

REEP1 Preserves Motor Function in SOD1^(G93A) Mice by Improving Mitochondrial Function via Interaction with NDUFA4

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Neuroscience Bulletin 2023年第6期39卷 929-946页

作者： Siyue Qin pan You hui Yu Bo Su Department of Cell Biology Shandong Provincial Key Laboratory of Mental DisordersSchool of Basic Medical SciencesShandong UniversityJinan250012China

A decline in the activities of oxidative phosphorylation(OXPHOS)complexes has been consistently reported in amyotrophic lateral sclerosis(ALS)patients and animal models of ALS,although the underlying molecular mechanisms are still elusive.Here,we report that receptor expression enhancing protein 1(REEP1)acts as an important regulator of complex IV assembly,which is pivotal to preserving motor neurons in SOD1^(G93A) mice.We found the expression of REEP1 was greatly reduced in transgenic SOD1^(G93A) mice with ALS.Moreover,forced expression of REEP1 in the spinal cord extended the lifespan,decelerated symptom progression,and improved the motor performance of SOD1^(G93A) mice.The neuromuscular synaptic loss,gliosis,and even motor neuron loss in SOD1^(G93A) mice were alleviated by increased REEP1 through augmentation of mitochondrial function.Mechanistically,REEP1 associates with NDUFA4,and plays an important role in preserving the integrity of mitochondrial complex IV.Our findings offer insights into the pathogenic mechanism of REEP1 deficiency in neurodegenerative diseases and suggest a new therapeutic target for ALS.

关键词： REEP1 Amyotrophic lateral sclerosis Mitochondria Complex IV assembly NDUFA4

Research progress of precise structural regulation of single atom catalyst for accelerating electrocatalytic oxygen reduction reaction

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Journal of Energy Chemistry 2022年第9期31卷 56-72,I0003页

作者： Minmin Wang hui Zhang Yunqi Liu Yuan pan State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580ShandongChin

The development and utilization of renewable clean energy can effectively solve the two major problems of energy and environment. As an efficient power generation device that converts hydrogen energy into electric energy, fuel cell has attracted more and more attention. For fuel cells, the oxygen reduction reaction(ORR) at the cathode is the core reaction, and the design and development of high-performance ORR catalysts remain quite challenging. Since the microenvironment of the active center of single atom catalysts(SACs) has an important influence on its catalytic performance, it has been a research focus to improve the ORR activity and stability of electrocatalysts by adjusting the structure of the active center through reasonable structural regulation methods. In this review, we reviewed the preparation and structure–activity relationship of SACs for ORR. Then, the structural precision regulation methods for improving the activity and stability of ORR electrocatalysts are discussed. And the advanced in-situ characterization techniques for revealing the changes of active sites in the electrocatalytic ORR process are summarized. Finally, the challenges and future design directions of SACs for ORR are discussed. This work will provide important reference value for the design and synthesis of SACs with high activity and stability for ORR.

关键词： Electrocatalyst Oxygen reduction reaction Structure regulation Single atom catalysts In-situ characterization technique

Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair

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Neural Regeneration Research 2023年第4期18卷 832-839页

作者： Ya-Jie Xiong Shahid Hussain Soomro Zhong-Hai Huang pan-pan Yu Jie Ping hui Fu Department of Anatomy School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education Joint International Research Laboratory of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Pharmacology School of Basic Medical SciencesWuhan UniversityWuhanHubei ProvinceChina

The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain.In many cases,the microenvironment surrounding demyelination lesions contains inhibitory molecules,which lead to repair failure.Accordingly,blocking the activity of these inhibitory factors in the extracellular matrix should lead to more successful remyelination.In the central nervous system,oligodendrocytes form the myelin sheath.We performed primary cell culture and found that a natural increase in fibronectin promoted the proliferation of oligodendrocyte progenitors during the initial stage of remyelination while inhibiting oligodendrocyte differentiation.Poly-L-ornithine blocked these inhibitory effects without compromising fibronectin’s pro-proliferation function.Experiments showed that poly-L-ornithine activated the Erk1/2 signaling pathway that is necessary in the early stages of differentiation,as well as PI3K signaling pathways that are needed in the mid-late stages.When poly-L-ornithine was tested in a lysolecithin-induced animal model of focal demyelination,it enhanced myelin regeneration and promoted motor function recovery.These findings suggest that poly-L-ornithine has the potential to be a treatment option for clinical myelin sheath injury.

关键词： differentiation Erk1/2 extracellular matrix fibronectin lysolecithin-induced demyelination oligodendrocyte PI3K poly-L-ornithine proliferation remyelination

Characteristics and reference values of the atherogenic index of plasma in an adult population in China

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Chinese Medical Journal 2022年第24期135卷 3013-3015页

作者： Yuelun Zhang Yunying Feng Shi Chen Hanze Du huijuan Zhu Hui Pan Guangliang Shan Medical Research Center Peking Union Medical College HospitalBeijing 100730China Eight-year Program of Clinical Medicine Peking Union Medical CollegeBeijing 100730China Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Endocrinology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100730China

To the Editor:The atherogenic index of plasma(AIP)is derived from the logarithmic conversion of the ratio of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C).It comprehensively reflects plasma lipid homeostasis.AIP has been reported to be related to cardiovascular disease(CVD)in population-based studies,^([1])and is regarded as a potential independent predictor for CVD risk in clinical practice.Currently,there are limited data on the characteristics of AIP values in China.We examined the differences in AIP values among ethnic groups based on multiethnic Chinese population data.The reference values of AIP in Chinese adults were established,and their variation tendencies according to age were identified.

关键词： homeostasis cholesterol cardiovascular