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Single-cell transcriptomes provide insights into expansion of glial cells in Bombyx mori

Insect Science 2024年第4期31卷 1041-1054页

作者： Xiaojing Liu Zhongjie Zhang Bo Hu Kai Chen Ye Yu hui Xiang Anjiang tan Jiangsu Key Laboratory of Sericultural Biology and Biotechnology School of BiotechnologyJiangsu University of Science and TechnologyZhenjiangJiangsu ProvinceChina Key Laboratory of Silkworm and Mulberry Genetic Improvement Ministry of Agriculture and Rural AffairsThe Sericultural Research InstituteChinese Academy of Agricultural SciencesZhenjiangJiangsu ProvinceChina Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and Technology and School of Life SciencesSouth China Normal UniversityGuangzhouChina

The diversity of cell types in the brain and how these change during different developmental stages,remains largely *** life cycle of insects is short and goes through 4 distinct stages including embryonic,larval,pupal,and adult *** postembryonic life,the larval brain transforms into a mature adult version after *** silkworm,Bombyx mori,is a lepidopteran model ***,we characterized the brain cell repertoire of larval and adult *** by obtaining 50708 single-cell *** and 12 cell clusters from larval and adult brains were assigned based on marker genes,*** cell types include Kenyon cells,optic lobe cells,monoaminergic neurons,surface glia,and astrocyte *** further assessed the cell type compositions of larval and adult *** found that the transition from larva to adult resulted in great expansion of glial *** glial cell accounted for 49.8%of adult midbrain *** to flies and ants,the mushroom body kenyon cell is insufficient in ***,which accounts for 5.4%and 3.6%in larval and adult brains,*** of neuropeptide expression showed that the abundance and specificity of expression varied among individual ***,we found that ion transport peptide was specifically expressed in glial cells of larval and adult *** cell atlas dataset provides an important resource to explore cell diversity,neural circuits and genetic profiles.

关键词： brain neuropeptide silkworm single-cell transcriptome

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Physiotherapy for patients with depression:Recent research progress

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World Journal of Psychiatry 2024年第5期14卷 635-643页

作者： hui-Ling Liu Jing Sun Shi-Feng meng Ning Sun Department of Mental Health First Clinical Medical College of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Rehabilitation First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Mental Health First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

Depression,a common mental illness,seriously affects the health of individuals and has deleterious effects on *** prevention and treatment of depression has drawn the attention of many researchers and has become an important social *** treatment strategies for depression include drugs,psychotherapy,and *** therapy is ineffective in some patients and psychotherapy has treatment *** a reliable adjuvant therapy,physiotherapy compensates for the shortcomings of drug and psychotherapy and effectively reduces the disease recurrence *** is more scientific and rigorous,its methods are diverse,and to a certain extent,provides more choices for the treatment of *** can relieve symptoms in many ways,such as by improving the levels of neurobiochemical molecules,inhibiting the inflammatory response,regulating the neuroendocrine system,and increasing *** has biological effects similar to those of antidepressants and may produce a superimposed impact when combined with other *** article summarizes the findings on the use of physiotherapy to treat patients with depression over the past five *** also discusses several methods of physiotherapy for treating depression from the aspects of clinical effect,mechanism of action,and disadvantages,thereby serving as a reference for the in-depth development of physiotherapy research.

关键词： Depression Physiotherapy Non-pharmacological Rehabilitation therapy Recent advances

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Optimal Reinsurance Strategy Based on the Lundberg Exponent

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Journal of Systems Science & Complexity 2024年

作者： WANG Yeshunying meng hui LIAO Pu School of Insurance Central University of Finance and Economics Beijing 100081 China China Institute for Actuarial Science Central University of Finance and Economics

In this paper, the authors investigate the optimal per-claim reinsurance problem under the continuous-time framework to minimize the insurer’s ruin probability based on the Lundberg exponent. Considering reinsurance participants’ diversified risk preferences, the authors assume that the reinsurance premium is calculated by a combined premium principle, including the expected value premium principle and upper moment premium principle. Then, the authors derive the insurer’s optimal reinsurance strategy satisfying the principle of indemnity and the incentive compatibility condition in an infinite reinsurance space based on the point-wise optimization approach. Besides, the proposed work emphasizes the optimality and admissibility of the combination of the excess of loss reinsurance and its dual form when a piecewise reinsurance premium principle is considered. As a special case, the optimal reinsurance strategy under the expected value premium principle reduces to the classic ***, the numerical analyses are provided to illustrate the effects of the main parameters on the maximal Lundberg exponent and the optimal reinsurance strategy.

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UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG Xiao-hui QIN Yuan-yuan WANG Ya-hui tan Jin-hua SU Lian-lin YAN Shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

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Global analysis of basic leucine zipper transcription factors in trifoliate orange and the function identification of PtbZIP49 in salt tolerance

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Horticultural Plant Journal 2024年第1期10卷 115-130页

作者： Yuanyuan Xu Qiuling hui meng Li Hongxian Peng Yizhong He Changpin Chun Liangzhi Peng Xingzheng Fu National Citrus Engineering Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China

As one of the most widely distributed and highly conserved transcription factors in eukaryotes,basic leucine zipper proteins(bZIPs)are involved in a variety of biological processes in plants,but they are largely unknown in *** this study,56 bZIP family members were identified genome-wide from an important citrus rootstock,namely trifoliate orange(Poncirus trifoliata ***.),and these putative bZIPs were named PtbZIP1—*** PtbZIPs were classified into 13 subgroups by phylogenetic comparison with Arabidopsis thaliana bZIPs(AtbZIPs),and they were randomly distributed on nine known(50 genes)chromosomes and one unknown(6 genes)*** analysis revealed the detailed characteristics of PtPZIPs,including their amino acid length,isoelectric point(pI),molecular weight(MW),predicted subcellular localization,gene structure,and conserved *** of promoter elements suggested the presence of drought,low-temperature,wound,and defense and stress responsive elements,as well as multiple hormone-responsive cis-acting *** expression analysis showed the transcriptional patterns of PtbZIPs in different tissues and under dehydration,high salt,ABA,and IAA *** addition,21 PtbZIPs were predicted to have direct or indirect protein—protein *** these,PtbZIP49 was experimentally proven to interact with PtbZIP1 or PtbZIP11 by using a yeast two-hybrid assay and bimolecular fluorescence complementation(BiFC).Subcellular localization analysis further revealed that PtbZIP1,PtbZIP11,and PtbZIP49 were localized in the ***,PtbZIP49 was functionally identified as having an important role in salt stress via ectopic expression in *** and silenced in trifoliate orange using virus-induced gene silencing(VIGS).This study provided comprehensive information on PtbZIP transcription factors in citrus and highlights their potential functions in abiotic stress.

关键词： bZIP Citrus Trifoliate orange Abiotic stress Expression pattern

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Sea-level change in coastal areas of China:Status in 2021

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Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： Wen-Shan LI hui WANG Wen-Xi XIANG Ai-Mei WANG Wei-Qing XU Yu-Xi JIANG Xin-hui WU meng-Yuan QUAN National Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒Shanghai Jiao Tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress

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Clinical relevance of distolingual roots and periodontal status in mandibular first molars: a cross-sectional study employing CBCT analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 244-253页

作者： Feifei MAO meng WANG Shuai ZHOU Yan ZHAO Jiaping HUANG Fengying YIN Haiping YANG Pei-hui DING Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310016China

Objectives:Distolingual root of the permanent mandibular first molar(PMFM-DLR)has been frequently reported,which may complicate the treatment of *** study aimed to assess the morphological features of PMFM-DLR and investigate the correlation between the morphological features of PMFM-DLR and periodontal status in patients with Eastern Chinese ethnic *** and methods:A total of 836 cone beam computed tomography(CBCT)images with 1497 mandibular first molars were analyzed to observe the prevalence of PMFM-DLR at the patients and tooth levels in Eastern *** them,complete periodontal charts were available for 69 Chinese patients with 103 *** and regression analyses were used to evaluate the correlation between the morphological features of DLR,bone loss,and periodontal clinical parameters,including clinical attachment loss(CAL),probing pocket depth(PPD),gingival recession(GR),and furcation involvement(FI).Results:The patient-level prevalence and tooth-level prevalence of DLR in mandibular first molars were 29.4%and 26.3%,*** linear regression analysis suggested that bone loss at the lingual site and CAL were negatively affected by the angle of separation between distolingual and mesial roots in the transverse section,while they were significantly influenced by age and the angle of separation between distobuccal and mesial roots in the coronal ***:The prevalence of PMFM-DLR in Eastern China was relatively high in our *** morphological features of DLR were correlated with the periodontal status of mandibular first *** study provides critical information on the morphological features of DLR for improved diagnosis and treatment options of mandibular molars with DLR.

关键词： Distolingual root Mandibular first molar Periodontal clinical parameter Clinical attachment loss Cone beam computed tomography(CBCT)

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Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases:Recent advancements and prospects

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World Journal of Stem Cells 2024年第2期16卷 70-88页

作者： Min meng Wei-Wei Zhang Shuang-Feng Chen Da-Rui Wang Chang-hui Zhou Department of Central Laboratory Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Clinical Laboratory Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues *** diverse disease con-ditions,the currently available approaches are focused on alleviating clinical symptoms and delaying disease progression but have not shown significant therapeutic effects in patients with lung *** umbilical cord-derived mesenchymal stem cells(UC-MSCs)isolated from the human UC have the capacity for self-renewal and multilineage ***,in recent years,these cells have been demonstrated to have unique advantages in the treatment of lung *** searched the Public Clinical Trial Database and found 55 clinical trials involving UC-MSC therapy for pulmonary diseases,including coronavirus disease 2019,acute respiratory distress syndrome,bron-chopulmonary dysplasia,chronic obstructive pulmonary disease,and pulmonary *** this review,we summarize the characteristics of these registered clinical trials and relevant published results and explore in depth the challenges and opportunitiesfaced in clinical ***,the underlying mole-cular mechanisms involved in UC-MSC-based therapy for pulmonary diseases are also analyzed in *** brief,this comprehensive review and detailed analysis of these clinical trials can be expected to provide a scientific reference for future large-scale clinical application.

关键词： Pulmonary diseases Mesenchymal stem cells Human umbilical cord Cell therapy Clinical trials

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Highly Stretchable and Tunable Thermo-fluorochromic Polymer Elastomer through Eu^(3+)Dynamic Coordination Cross-linking

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Chinese Journal of Polymer Science 2024年第10期42卷 1449-1458,I0008页

作者： Qiu-Li tan Kai Gou Jing-Zhi tang Ming-hui Wei Chong Wang Yi-Jing Nie Geng-Sheng Weng School of Materials Science and Chemical Engineering State Key Laboratory Base of Novel Functional Materials and Preparation ScienceNingbo UniversityNingbo315211China Institute of Polymer Materials School of Materials Science and EngineeringJiangsu UniversityZhenjiang212013China

Thermochromic polymers with tunable thermochromism,high stretchability and mechanical strength are of interests for optical information storage and *** this work,we demonstrate a new design of thermo-fluorochromic carboxylated nitrile butadiene rubber(XNBR)elastomer cross-linked by Eu^(3+)-COOH dynamic coordination with deprotonated imidazole(DPIm)as the ancillary *** presence of DPIm not only improves the mechanical strength and stretchability,but also dramatically intensifies the fluorescence emission and lifetime of the Eu-containing *** elastomer behaves reversible thermo-fluorochromism with easily tunable transition temperature and emission intensity by the simple change of the deprotonation degree of *** facile tunable thermo-fluorochromism,exceptional mechanical strength,and high stretchability(up to about 5000%)enable the Eu-containing XNBR elastomer with potential applications in soft electronics where optical information storage and encryption are required.

关键词： Dynamic coordination Thermochromism Highly stretchable Elastomer Europium

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Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis

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BIOCELL 2024年第4期48卷 591-599页

作者： SAIFEI XIE hui XIE JINCAI GUO JIN tan YULIN YU MINYI ZHANG SHANG WEN Department of Periodontal Mucosa Hunan University of Chinese MedicineChangshaChina Department of Periodontal Mucosa Changsha Stomatology HospitalChangshaChina Department of Pharmacy Changsha Stomatology HospitalChangshaChina Department of Stomatology The First Hospital of Hunan University of Chinese MedicineChangshaChina

Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antiﬁbrotic *** work aimed at exploring the function of Pue in oral submucousﬁbrosis(OSF)***:Human oral mucosaﬁbroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with *** ofﬁbrosis-related markers were analyzed by Western blot and IF *** viability was characterized by the CCK-8 *** of miR-30 family members were quantiﬁed by *** correlation betweenﬁbroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefﬁ*** prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and *** speciﬁc mechanism of Pue on OSF was explored through the promotion or inhibition of ***:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most signiﬁ*** intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family *** prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP ***,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedﬁbrosis *** intervention signiﬁcantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p ***:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF.

关键词： Puerarin miR-30b-5p FAP Oral submucous fibrosis

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