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Ischemia-reperfusion injury:molecular mechanisms and therapeutic targets

Signal Transduction and Targeted Therapy 2024年第2期9卷 558-596页

作者： meng Zhang Qian Liu hui meng Hongxia Duan Xin Liu Jian Wu Fei Gao Shijun Wang Rubin tan Jinxiang Yuan The Collaborative Innovation Center Jining Medical UniversityJiningShandong 272067China Clinical Medical College Jining Medical UniversityJiningShandong 272067China Second Clinical Medical College Jining Medical UniversityJiningShandong 272067China Shanghai Institute of Cardiovascular Diseases Zhongshan Hospital and Institutes of Biomedical SciencesFudan UniversityShanghaiChina Institute of Zoology Chinese Academy of SciencesBeijingChina Department of Physiology Basic medical schoolXuzhou Medical UniversityXuzhou 221004China

Ischemia-reperfusion(I/R)injury paradoxically occurs during reperfusion following ischemia,exacerbating the initial tissue *** limited understanding of the intricate mechanisms underlying I/R injury hinders the development of effective therapeutic *** Wnt signaling pathway exhibits extensive crosstalk with various other pathways,forming a network system of signaling pathways involved in I/R *** review article elucidates the underlying mechanisms involved in Wnt signaling,as well as the complex interplay between Wnt and other pathways,including Notch,phosphatidylinositol 3-kinase/protein kinase B,transforming growth factor-β,nuclear factor kappa,bone morphogenetic protein,N-methyl-D-aspartic acid receptor-Ca2+-Activin A,Hippo-Yes-associated protein,toll-like receptor 4/toll-interleukine-1 receptor domain-containing adapter-inducing interferon-β,and hepatocyte growth factor/mesenchymal-epithelial transition *** particular,we delve into their respective contributions to key pathological processes,including apoptosis,the inflammatory response,oxidative stress,extracellular matrix remodeling,angiogenesis,cell hypertrophy,fibrosis,ferroptosis,neurogenesis,and blood-brain barrier damage during I/R *** comprehensive analysis of the mechanisms involved in Wnt signaling during I/R reveals that activation of the canonical Wnt pathway promotes organ recovery,while activation of the non-canonical Wnt pathways exacerbates ***,we explore novel therapeutic approaches based on these mechanistic findings,incorporating evidence from animal experiments,current standards,and clinical *** objective of this review is to provide deeper insights into the roles of Wnt and its crosstalk signaling pathways in I/R-mediated processes and organ dysfunction,to facilitate the development of innovative therapeutic agents for I/R injury.

关键词： therapeutic reperfusion damage

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Estimation of tunnel axial orientation in the interlayered rock mass using a comprehensive algorithm

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2579-2590页

作者： hui Li Weizhong Chen Xianjun tan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The axial selection of tunnels constructed in the interlayered soft-hard rock mass affects the stability and safety during *** optimization is primarily based on experience or comparison and selection of alternative values under specific geological *** this work,an intelligent optimization framework has been proposed by combining numerical analysis,machine learning(ML)and optimization *** automatic and intelligent numerical analysis process was proposed and coded to reduce redundant manual *** conventional optimization algorithm was developed from two aspects and applied to the hyperparameters estimation of the support vector machine(SVM)model and the axial orientation optimization of the ***,the comprehensive framework was applied to a numerical case study,and the results were compared with those of other *** results of this study indicate that the determination coefficients between the predicted and the numerical stability evaluation indices(STIs)on the training and testing datasets are 0.998 and 0.997,*** a given geological condition,the STI that changes with the axial orientation shows the trend of first decreasing and then increasing,and the optimal tunnel axial orientation is estimated to be 87.This method provides an alternative and quick approach to the overall design of the tunnels.

关键词： Tunnel Building information modeling Design optimization Particle swarm optimization Support vector machine(SVM)

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Higher-order expansions of powered extremes of logarithmic general error distribution

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 47-54页

作者： tan Xiao-feng LI Li-hui School of Mathematics and Statistics Southwest UniversityChongqing 400715China

In this paper,Let M_(n)denote the maximum of logarithmic general error distribution with parameter v≥***-order expansions for distributions of powered extremes M_(n)^(p)are derived under an optimal choice of normalizing *** is shown that M_(n)^(p),when v=1,converges to the Frechet extreme value distribution at the rate of 1/n,and if v>1 then M_(n)^(p)converges to the Gumbel extreme value distribution at the rate of(loglogn)^(2)=(log n)^(1-1/v).

关键词： logarithmic general error distribution convergence rate higher-order expansion powered ex-treme

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Intratumoural microbiota:a new frontier in cancer development and therapy

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Signal Transduction and Targeted Therapy 2024年第2期9卷 597-620页

作者： Yaqi Cao hui Xia Xueyun tan Chunwei Shi Yanling Ma Daquan meng mengmeng Zhou Zhilei Lv Sufei Wang Yang Jin Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesKey Laboratory of Respiratory Diseases of National Health CommissionState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Engineering Research Center for Tumour-Targeted Biochemotherapy MOE Key Laboratory of Biological Targeted TherapyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological *** studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to *** concept of intratumoural microbiota was subsequently *** could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour *** studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and *** more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under *** addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable ***,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field.

关键词： tumour invasion metabolism

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Clinical study on the relationship between liver cirrhosis,ascites,and hyponatremia

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 751-758页

作者： Xuan-Ji Li hui-hui meng Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430065Hubei ProvinceChina

BACKGROUND Cirrhosis is a common liver disease,and ascites is one of the common clinical ***,the clinical manifestations of ascites combined with hyponatremia as a high-risk condition and its relationship to patient prognosis have not been fully *** To explore the clinical manifestations,prognostic factors,and relationships of ascites with hyponatremia in patients with cirrhosis to provide better diagnostic and treatment *** In this study,we retrospectively analyzed the clinical data of 150 patients diagnosed with cirrhosis and ascites between 2017 and *** were divided into two groups:ascites combined with hyponatremia group and ascites *** compared the general characteristics,degree of hyponatremia,complications,treatment,and prognosis between the two *** In the study results,patients in the ascites combined with hyponatremia group showed an older average age(58.2±8.9 years),64.4%were male,and had a significantly longer hospitalization time(12.7±5.3 d).Hyponatremia was more severe in this group,with a mean serum sodium concentration of 128.5±4.3 mmol/L,which was significantly different from the ascites group of 137.6±2.1 mmol/*** with ascites and hyponatremia were more likely to develop hepatic encephalopathy(56.2%vs 39.0%),renal impairment(45.2%vs 28.6%)and infection(37.0%vs 23.4%).Regarding treatment,this group more frequently used diuretics(80.8%vs 62.3%)and salt supplements(60.3%vs 38.9%).Multiple logistic regression analysis identified older age[Odds ratio(OR)=1.06,P=0.025]and male gender(OR=1.72,P=0.020)as risk factors for hyponatremia combined with ***,patients with ascites and hyponatremia present a clear high-risk status,accompanied by severe complications and poor *** In patients with cirrhosis,ascites with hyponatremia is a high-risk condition that is often associated with severe complications.

关键词： Liver cirrhosis Ascites Hyponatremia Risk Complications

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Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： tan hui-qun HU Zhi-shui DONG Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

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Penile prosthesis implantation in a transsexual neophallus

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Asian Journal of Andrology 2000年第4期2卷 304-306页

作者： hui-meng tan Subang Jaya Medical Centre, Subang Jaya 47500, Malaysia Subang Jaya Medical Centre Subang Jaya 47500 Malaysia Subang Jaya Medical Centre No. 1 Jalan SS 12/1 A Subang Jaya 47500 Malaysia

Reconstruction surgery for a female to male transsexual usually involves mastectomy, hysterectomy and creating anaesthetically appealing neophallus. We have successfiflly inserted an inflatable prosthesis using the AMS CX prosthesisin a 45 year old transsexual, who had a large bulky neophallus constructed from the anterior abdominal subcutaneousfat, about 9 years ago. The single cylinder CX prosthesis was well anchored to the symphysis pubis using a dacronwindsock tubing, the activation pump was placed in the dependent pouch of the right labium and the reservior in theusual perivesical space. The patient subsequently had debulking procedure using liposuction to create a more aestheticand functional phallus. To date, the inflatable neophallus prosthesis is functioning well. (Asian J Androl 2000 Dec;2: 304-306)

关键词： transsexual neophallus penile prosthesis dacron graft

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Historical Changes and Multi-scenario Prediction of Land Use and Terrestrial Ecosystem Carbon Storage in China

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Chinese Geographical Science 2024年第3期34卷 487-503页

作者： AN Yue tan Xuelan REN hui LI Yinqi ZHOU Zhou College of Resources Hunan Agricultural UniversityChangsha 410128China School of Geographic Science Hunan Normal UniversityChangsha 410081China

Terrestrial carbon storage(CS)plays a crucial role in achieving carbon balance and mitigating global climate *** study employs the Shared Socioeconomic Pathways and Representative Concentration Pathways(SSPs-RCPs)published by the Intergovernmental Panel on Climate Change(IPCC)and incorporates the Policy Control Scenario(PCS)regulated by China’s land management *** Future Land Use Simulation(FLUS)model is employed to generate a 1 km resolution land use/cover change(LUCC)dataset for China in 2030 and *** on the carbon density dataset of China’s terrestrial ecosystems,the study analyses CS changes and their relationship with land use changes spanning from 1990 to *** findings indicate that the quantitative changes in land use in China from 1990 to 2020 are characterised by a reduction in the area proportion of cropland and grassland,along with an increase in the impervious surface and forest *** changing trend is projected to continue under the PCS from 2020 to *** the SSPs-RCPs scenario,the proportion of cropland and impervious surface predominantly increases,while the proportions of forest and grassland continuously *** loss in China’s carbon storage from 1990 to 2020 amounted to 0.53×10^(12)kg,primarily due to the reduced area of cropland and *** the SSPs-RCPs scenario,more significant carbon loss occurs,reaching a peak of8.07×10^(12)kg in the SSP4-RCP3.4 *** loss is mainly concentrated in the southeastern coastal area and the Beijing-TianjinHebei(BTH)region of China,with urbanisation and deforestation identified as the primary *** the future,it is advisable to enhance the protection of forests and grassland while stabilising cropland areas and improving the intensity of urban *** research findings offer valuable data support for China’s land management policy,land space optimisation,and the achievement of dual-carbon targets.

关键词： land use change Future Land Use Simulation(FLUS)model carbon storage carbon density dataset land use scenario China

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Simulation of urban expansion using geographical similarity transition rules and neighbourhood sizes

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Journal of Geographical Sciences 2024年第7期34卷 1394-1414页

作者： LI Yinqi AN Yue ZHOU Zhou REN hui tan Xuelan College of Resources Hunan Agricultural UniversityChangsha410128China College of Geographical Sciences Hunan Normal UniversityChangsha410081China

Most existing cellular automata(CA)models impose strict requirements on the number and spatial distribution of *** makes it a challenge to capture spatial heterogeneity in urban dynamics and meet the modeling needs of large and complex geographic *** paper presents a CA model based on geographically optimal similarity(GOS)transition rules and similarly sized neighborhoods(SSN).By comparing the similarity in geographical configuration between samples and predicted points,the model enables a comprehensive characterization of the driving mechanism behind urban expansion and its self-organizing *** helps to mitigate the impact of sample selection and assumptions about spatial stationarity on simulation *** performance of GOS-SSN-CA simulation was tested by taking the urban expansion in the Changsha-Zhuzhou-Xiangtan urban agglomeration in China as an *** results show that GOS can derive more accurate and reliable urban transition rules with fewer samples,thereby significantly reducing spatial prediction errors compared with logistic ***,SSN selects different neighborhood sizes to represent the difference between the local self-organizing range and surrounding cells,thus further improving the simulation accuracy and restricting urban expansion ***,GOS-SSN-CA effectively characterizes the geographical similarity of urban expansion,improves simulation accuracy while constraining the urban expansion form,and enhances the practical application value of CA.

关键词： urban growth cellular automata geographic similarity model optimization spatial nonstationarity

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The Asia Pacific Society for the Study of the Aging Male(APSSAM)

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Asian Journal of Andrology 2003年第2期 168-169页

作者： Dato hui meng tan APSSAM Secretary-General

The Asia Pacific Society for Study of the Aging Male was formed at the successful conclusion of the 1st Asian ISSAM Meeting in Kuala Lumpur in March 2001. Its inauguration was the result of the tremendous interest generated from this Asian Meeting and from the two precedent World Congresses on The Aging Male organized by the International Society for the Study of the Aging Male (ISSAM).

关键词： of for APSSAM The Asia Pacific Society for the Study of the Aging Male Asia

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