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Indecomposable Large Sets of Steiner Triple Systems with Indices 5, 6

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2169-2184页

作者： mei hui cheng Zi Hong TIAN Institute of Mathematics Hebei Normal University

A family （X, B1）,（X, B2）,..., （X, Bq） of q STS（v）s is a λ-fold large set of STS（v） and denoted by LSTSλ（v） if every 3-subset of X is contained in exactly A STS（v）s of the collection. It is indecomposable and denoted by IDLSTSx（v） if there does not exist an LSTSx, （v） contained in the collection for any λ 〈 λ. In this paper, we show that for λ = 5, 6, there is an IDLSTSλ（v） for v ≡ 1 or 3 （rood 6） with the exception IDLSTS6（7）.

关键词： Steiner triple system, large set, candelabra system indecomposable

Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications

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Bioactive Materials 2024年第2期32卷 222-241页

作者： Jia Min Loh Yun Jie Larissa Lim Jin Ting Tay hui mei cheng Hong Liang Tey Kun Liang A*STAR Skin Research Labs(A*SRL) Agency for ScienceTechnology and Research(A*STAR)Singapore National Skin Centre(NSC) Singapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore Yong Loo Ling School of Medicine National University of SingaporeSingapore Skin Research Institute of Singapore Singapore

Microneedles(MNs)is an emerging technology that employs needles ranging from 10 to 1000μm in height,as a minimally invasive technique for various procedures such as therapeutics,disease monitoring and *** commonly used method of fabrication,micromolding,has the advantage of scalability,however,micromolding is unable to achieve rapid customizability in dimensions,geometries and architectures,which are the pivotal factors determining the functionality and efficacy of the MNs.3D printing offers a promising alternative by enabling MN fabrication with high dimensional accuracy required for precise applications,leading to improved ***,enabled by its customizability and one-step process,there is propitious potential for growth for 3D-printed MNs especially in the field of personalized and on-demand medical *** review provides an overview of considerations for the key parameters in designing MNs,an introduction on the various 3D-printing techniques for fabricating this new generation of MNs,as well as highlighting the advancements in biomedical applications facilitated by 3D-printed ***,we offer some insights into the future prospects of 3D-printed MNs,specifically its progress towards translation and entry into market.

关键词： Microneedles 3D printing Drug delivery Extraction of biological specimen Biosensing

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan cheng hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen Li hui Ye Xue-Zhi Zhang Jian-Xiang Liu Hong cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Pancreatic stent improves the success rate of needle-knife papillotomy in patients with difficult biliary cannulation

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World Journal of Gastroenterology 2025年第1期31卷 58-67页

作者： Mu-Hsien Lee cheng-hui Lin Chi-Huan Wu Yung-Kuan Tsou Kai-Feng Sung Sheng-Fu Wang Nai-Jen Liu Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital and Chang Gung University College of MedicineTaoyuan 33305Taiwan School of Medicine Chang Gung UniversityTaoyuan 33305Taiwan

BACKGROUND Needle-knife precut papillotomy(NKP)is typically performed ***,it remains unclear whether pancreatic stent(PS)placement can improve the outcomes of *** To explore whether PS placement improves the success rate of NKP in patients with difficult biliary *** This single-center retrospective study included 190 patients who underwent NKP between January 2017 and December 2021 after failed conventional biliary *** cases with incidental pancreatic duct cannulation during conventional biliary cannulation,the decision for pre-NKP PS placement was made at the endoscopist's *** primary outcome was the difference in the NKP success rate between patients with and without PS placement;the secondary outcome was the adverse event *** Among the 190 participants,82 received pre-NKP PS(PS-NKP group)whereas 108 did not[freehand or freehand NKP(FH-NKP)group].Post-NKP selective biliary cannulation was successful in 167(87.9%)patients,and the PS-NKP had a significantly higher success rate than the FH-NKP group(93.9%vs 83.3%,P=0.027).The overall adverse event rates were 7.3%and 11.1%in the PS-NKP and FH-NKP groups,respectively(P=0.493).A periampullary diverticulum(PAD)and significant intraoperative bleeding during NKP were independently associated with NKP failure;however,a pre-NKP PS was the only predictor of NKP *** the 44 participants with PADs,the PS-NKP group had a non-significantly higher NKP success rate than the FH-NKP group(87.5%and 65%,respectively;P=0.076).CONCLUSION PS significantly improved the success rate of NKP in patients with difficult biliary cannulation.

关键词： Difficult biliary cannulation Endoscopic retrograde cholangiopancreatography Needle-knife papillotomy Pancreatic stent Selective biliary cannulation

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江西修水县辉煌地热地质特征及成因分析

地质灾害与环境保护 2013年第2期24卷 49-53页

作者：梅惠呈李忠社蔡亮江西省地质矿产勘查开发局九一五地质大队南昌330002

辉煌地下热水属低温地热资源中的温热水。埋藏浅,热储形态简单,平面分布为一个由构造破碎带组成的椭圆状。辉煌温泉的异常地热主要来源于九岭花岗闪长岩体深部余热与北东向活动性断裂带的深循环热有关。

关键词：地热地质特征成因辉煌

Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen Bo-cheng Li De-cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

江西浮梁葫芦尖锡矿地质特征及外围找矿前景分析

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资源调查与环境 2013年第1期34卷 44-52页

作者：刘九金黄韶春梅惠呈江西省地矿局九一五地质大队南昌330002

本文介绍了葫芦尖锡矿区区域地质背景、锡矿体的地质特征,系统阐述了地层、构造和岩浆岩地质特征。通过重点分析该矿区及外围地区的找矿前景,发现葫芦尖矿区构造蚀变岩带是重要的找矿标志,认为莲花山(潘村)——鄣公山地区成矿地质条件优... 详细信息

本文介绍了葫芦尖锡矿区区域地质背景、锡矿体的地质特征,系统阐述了地层、构造和岩浆岩地质特征。通过重点分析该矿区及外围地区的找矿前景,发现葫芦尖矿区构造蚀变岩带是重要的找矿标志,认为莲花山(潘村)——鄣公山地区成矿地质条件优越,锡多金属矿找矿潜力巨大,进一步在该地区进行锡多金属矿找矿、勘查工作都将对找矿突破产生积极的促进和指导作用。

关键词：鄣公山地质特征构造蚀变岩带找矿前景

基于ANSYS的缺口和裂纹对结构应力分布影响有限元研究

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力学季刊 2003年第3期24卷 407-410页

作者：郁大照陈跃良蒋荟段成美海军航空工程学院员旅山东烟台264001 西北工业大学西安710072 海军航空工程学院青岛分院山东青岛266041

缺口和裂纹都会对结构的应力分布产生影响,过去对这两个领域的研究一直平行发展,交叉领域的研究比较少。本文应用有限元软件ANSYS,分析了金属材料中缺口根部和裂纹尖端的应力分布。有限元计算结果与Taylor的理论分析一致,即在缺口和裂... 详细信息

缺口和裂纹都会对结构的应力分布产生影响,过去对这两个领域的研究一直平行发展,交叉领域的研究比较少。本文应用有限元软件ANSYS,分析了金属材料中缺口根部和裂纹尖端的应力分布。有限元计算结果与Taylor的理论分析一致,即在缺口和裂纹根部存在一临界距离,大于这一临界距离时,缺口和裂纹具有类似的应力值,并都易受尺寸因素的影响;临界距离内的应力与最大应力之比只同缺口半径有关,而与结构绝对尺寸无关。文中并对缺口和裂纹交叉领域以后的研究方向提出了看法。

关键词：缺口裂纹有限元应力分布 ANSYS