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Retinitis pigmentosa and stem cell therapy

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1363-1369页

作者： Xin-Ya Qi Chen-hui mi De-Rui Cao Xie-Qun Chen Peng Zhang School of Medicine Department of Life Sciences and MedicineNorthwest UniversityXi’an 710069Shaanxi ProvinceChina The Third Hospital of Xi’an Affiliated Hospital of Northwest UniversityXi’an 710021Shaanxi ProvinceChina

Retinitis pigmentosa(RP)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RPE)*** main clinical manifestations include night blindness and progressive loss of peripheral vision,making it a prevalent debilitating eye disease that significantly impacts patients’quality of *** exhibits significant phenotypic and genetic *** instance,numerous abnormal genes are implicated in RP,resulting in varying clinical presentations,disease progression rates,and pathological characteristics among different ***,gene therapy for RP poses challenges due to these ***,stem cells have garnered considerable attention in the field of RPE therapy since both RPE cells and photoreceptors can be derived from stem *** recent years,a large number of animal experiments and clinical trials based on stem cell transplantation attempts,especially cord blood mesenchymal stem cell(MSC)transplantation and bone marrow-derived MSC transplantation,have confirmed that stem cell therapy can effectively and safely improve the outer retinal function of the RP-affected ***,stem cell therapy also has certain limitations,such as the fact that RP patients may involve multiple types of retinal cytopathia,which brings great challenges to stem cell transplantation therapy,and further research is needed to solve various problems faced by this approach in the *** comprehensive analysis of the etiology and histopathological changes associated with RP,this study substantiates the efficacy and safety of stem cell therapy based on rigorous animal experimentation and clinical trials,while also highlighting the existing limitations that warrant further investigation.

关键词： retinitis pigmentosa photoreceptor stem cell therapy

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Ultracycles consisting of macrocycles

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Chinese Chemical Letters 2024年第5期35卷 183-188页

作者： Wen-hui mi Teng-Yu Huang Yu-Fei Ao Xu-Dong Wang Qi-Qiang Wang De-Xian Wang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Presented here is a one-pot strategy starting from rationally designed macrocyclic precursors for the diverse construction of sophisticated *** type and amount of the base were found to significantly influence the macrocyclization *** use of 4.0 *** resulted in ultracycles of both types A and B while the presence of CsF larger than 6.0 *** only type B *** of anion template increased the total yields and affected the distribution of the *** ultracycles can accommodate large organic dicarboxylates anions via multiple anion-πand hydrogen bonds,and show selectivity to the size-matched heptanedioate(C7^(2−)).Based on all possible species and relevant equilibrium constants as well as material and charge balances,a numerical iterative algorithm was developed and applied to fit the association constants of B2H with dicarboxylates from glutarate(C5^(2−))to octanedioate(C8^(2−)),which gave association constants up to 10^(3) L/mol.

关键词： Ultracycles Diversity-oriented synthesis Anion recognition Anion-πinteraction

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DYNAmiC VALUATION OF OPTIONS ON NON-TRADED ASSETS AND TRADING STRATEGIES

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Journal of Systems Science & Complexity 2013年第6期26卷 991-1001页

作者： mi hui ZHANG Shuguang School of Mathematical Sciences Nanjing Normal University Department of Statistics and Finance University of Science and Technology of China

This paper investigates the pricing of options written on non-traded assets and trading strategies for the stock and option in an exponential utility maximization *** the assumption that the option can be continuously traded without friction just as the stock,a dynamic relationship between their optimal positions is derived by using the stochastic dynamic programming *** dynamic option pricing equations are also *** particular,the properties of the associated solutions are discussed and their explicit representations are demonstrated via the Feynman-Kac *** paper further compares the dynamic option price to the existing price notions,such as the marginal price and indifference price.

关键词： Non-traded asset option pricing portfolio selection stochastic control.

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基于VOSviewer和CiteSpace对中药注射剂类过敏反应研究热点和趋势的可视化分析

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中草药 2024年第3期55卷 907-918页

作者：邓国艳米惠刘红宇欧阳林旗肖小河湖南中医药大学第一附属医院药学部湖南长沙410007 湖南中医药大学药学院湖南长沙410208 中国人民解放军总医院第五医学中心全军中医药研究所北京100039

目的分析中药注射剂(traditional Chinese medicine injections,TCmis)致类过敏反应(anaphylatiod reactions,ARs)相关研究文献,了解其研究脉络、热点和发展趋势。方法检索中国知网(CNKI)、维普(VIP)、万方(Wanfang)、Web of Science(WOS)、PubMed数据库中建库至2023年5月1日收录的TCmis相关ARs的中、英文文献,采用VOSviewer1.6.18绘制核心作者、机构合作及关键词共现网络,运用CiteSpace 5.7.R5进行关键词聚类及突现展示。结果共纳入中文文献190篇,英文文献48篇,文献发文量总体呈波浪式上升又缓慢下降趋势;发表机构以中国中医科学院中药研究所为主,发表文献高达41篇;形成了52位核心作者及梁爱华、易艳等代表性研究团队;研究机构间的合作以中医药大学及附属医院为主;关键词共现与聚类分析显示研究内容侧重于TCmis相关ARs的作用机制、模型建立、评价方法、检测指标、质量控制;关键词突现分析提示大分子物质、G蛋白偶联受体B2(Mas-related G protein-coupled receptor B2,MRGPRB2)、安全性评价是TCmis相关ARs未来研究领域的发展趋势。结论TCmis相关ARs研究热点主要围绕其作用机制、安全性评价展开,体现在TCmis致ARs成分的筛选、剂量选择及相关通路、受体分析,但此方面研究尚浅,需要借助新的技术手段进行系统挖掘,促进TCmis相关ARs研究领域的深入发展。

关键词：中药注射剂类过敏反应 CiteSpace VOSviewer 作用机制安全性评价可视化分析

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Dynamic Asset Allocation with Loss Aversion in a Jump-diffusion Model

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 557-566页

作者： hui mi Xiu-chun BI Shu-guang ZHANG School of Mathematical Sciences and Institute of Finance and Statistics Nanjing Normal University Department of Statistics and Finance University of Science and Technology of China

This paper investigates a dynamic asset allocation problem for loss-averse investors in a jumpdiffusion model where there are a riskless asset and N risky assets. Specifically, the prices of risky assets are governed by jump-diffusion processes driven by an m-dimensional Brownian motion and a（N- m）-dimensional Poisson process. After converting the dynamic optimal portfolio problem to a static optimization problem in the terminal wealth, the optimal terminal wealth is first solved. Then the optimal wealth process and investment strategy are derived by using the martingale representation approach. The closed-form solutions for them are finally given in a special example.

关键词： jump-diffusion process loss aversion asset allocation martingale

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Identification of potential diagnostic and prognostic biomarkers for breast cancer based on gene expression omnibus

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世界临床病例杂志 2023年第27期11卷 6344-6362页

作者： Xiong Zhang Zhi-hui mi Department of Pathology HuLunBuir Peoples’s HospitalHuLunBuir 010018Nei Monggol Autonomous RegionChina Department of Research and Marketing Inner Mongolia Di An Feng Xin Medical Technology Co.LTDHuhhot 010010Nei Monggol Autonomous RegionChina

BACKGROUND Breast cancer is regarded as a highly malignant neoplasm in the female population,posing a significant risk to women’s overall *** prevalence of breast cancer has been observed to rise in China,accompanied by an earlier age of onset when compared to Western *** cancer continues to be a prominent contributor to cancer-related mortality and morbidity among women,primarily due to its limited responsiveness to conventional treatment *** diagnostic process is challenging due to the presence of non-specific clinical manifestations and the suboptimal precision of conventional diagnostic *** is a prevailing uncertainty regarding the most effective screening method and target populations,as well as the specificities and execution of screening *** To identify diagnostic and prognostic biomarkers for breast *** Overlapping differentially expressed genes were screened based on Gene Expression Omnibus(GSE36765,GSE10810,and GSE20086)and The Cancer Genome Atlas datasets.A protein-protein interaction network was applied to excavate the hub genes among these differentially expressed *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses,as well as gene set enrichment analyses,were conducted to examine the functions of these genes and their potential mechanisms in the development of breast *** clarification of the diagnostic and prognostic roles of these genes,Kaplan–Mei-er and Cox proportional hazards analyses were *** This study demonstrated that calreticulin,heat shock protein family B member 1,insulin-like growth Factor 1,interleukin-1 receptor 1,Krüppel-like factor 4,suppressor of cytokine signaling 3,and triosephosphate isomerase 1 are potential diagnostic biomarkers of breast cancer as well as potential treatment targets with clinical *** The screening of biomarkers is of guiding significance for the diagnosis and prognosis of the disease

关键词： Breast cancer Diagnostic biomarker The Cancer Genome Atlas datasets Gene expression omnibus Enrichment analysis

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基于高频暂态的复杂接触网故障测距研究与仿真

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电工电气 2024年第8期 48-53页

作者：陈楚楚毛弥卉黎萱中铁上海设计院集团有限公司上海200070

接触网线路在发生故障时快速进行故障点清除对于保障高速列车的稳定运行至关重要。分析了传统的接触网故障测距方法以及测距方法中存在的问题,提出了一种适用于复杂线路的高频暂态故障测距方法,该方法在进行接触网故障测距时,采用接触... 详细信息

接触网线路在发生故障时快速进行故障点清除对于保障高速列车的稳定运行至关重要。分析了传统的接触网故障测距方法以及测距方法中存在的问题,提出了一种适用于复杂线路的高频暂态故障测距方法,该方法在进行接触网故障测距时,采用接触网线路参数模型确定波速度以及合适的数学方法查找波头,可实现主支线故障区分。选取上海铁路局某复杂自耦变压器(AT)供电线路进行仿真验证,仿真结果表明,基于高频暂态的复杂接触网故障测距方法具有良好的系统适应性,为复杂结构的供电线路故障测距提供了理论依据。

关键词：接触网故障测距复杂结构高频暂态 AT供电直供线路

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Pedestrian walking characteristics at stairs according to width change for application of piezoelectric energy harvesting

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Journal of Central South University 2012年第3期19卷 764-769页

作者： YI mi-hui NA Wook-jung HONG Won-hwa JEON Gyu-yeob School of Architecture and Civil Engineering Kyungpook National University Daegu 702-701 South Korea Department of Architecture Jeju National University Jeju 690-756 South Korea

This work aims at finding pedestrian walking characteristics at U-type stairs according to the width change of stairs and appropriate spot for installing piezoelectric energy *** number of pedestrian at two kinds of stairs(one is stairs with 1.5 m in width and the other is stairs with 3 m in width) was estimated by calculating the number of steps on the stairs by a zone which is divided into 30 cm×30 *** result shows high density in the middle in the case of narrow stairs but traffic is concentrated on stair inside(pillar side) in stairs with large *** conclusion,the location for installation of piezoelectric energy harvesting system should be considered differently on stairs width and the number of installation depends on total expected traffic and the expected traffic for a device.

关键词： piezoelectric energy harvesting pedestrian walking human power traffic distribution

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High Nitrogen Austenitic Stainless Steels Manufactured by Nitrogen Gas Alloying and Adding Nitrided Ferroalloys

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Journal of Iron and Steel Research International 2007年第3期14卷 63-68页

作者： LI Hua-bing JIANG Zhou-hua SHEN ming-hui YOU Xiang-mi School of Materials and Metalllargy Northeastern University Shenyang 110004 Liaoning China

A simple and feasible method for the production of high nitrogen austenitic stainless steels involves nitrogen gas alloying and adding nitrided ferroalloys under normal atmospheric conditions. Alloying by nitrogen gas bubbling in Fe-Cr-Mn-Mo series alloys was carried out in MoSi2 resistance furnace and air induction furnace under normal atmospheric conditions. The results showed that nitrogen alloying could be accelerated by increasing nitrogen gas flow rate, prolonging residence time of bubbles, increasing gas/molten steel interfaces, and decreasing the sulphur and oxygen contents in molten steel. Nitrogen content of 0.69% in 18Crl8Mn was obtained using air induction furnace by bubbling of nitrogen gas from porous plug. In addition, the nickel-free, high nitrogen austenitic stainless steels with sound and compact macrostructure had been produced in the laboratory using vacuum induction furnace and electroslag remelting furnace under nitrogen atmosphere by the addition of nitrided alloy with the maximum nitrogen content of 0.81%. Pores were observed in the ingots obtained by melting and casting in vacuum induction furnace with the addition of nitrided ferroalloys and under nitrogen atmosphere. After electroslag remelting of the cast ingots, they were all sound and were free of pores. The yield of nitrogen increased with the decrease of melting rate in the ESR process. Due to electroslag remelting under nitrogen atmosphere and the consequential addition of aluminum as deoxidizer to the slag, the loss of manganese decreased obviously. There existed mainly irregular Al2O3 inclusions and MnS inclusions in ESR ingots, and the size of most of the inclusions was less than 5 um. After homogenization of the hot rolled plate at 1 150℃ × 1 h followed by water quenching, the microstructure consisted of homogeneous austenite.

关键词： nitrogen gas alloying nitrided ferroalloy high nitrogen austenitic stainless steel vacuum induction melting electroslag remelting

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Reactive molecular dynamics insight into the thermal decomposition mechanism of 2,6-Bis(picrylamino)-3,5-dinitropyridine

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Defence Technology（防务技术） 2024年第3期33卷 134-146页

作者： Jianbo Fu hui Ren Xinzhou Wu Yongjin Chen mi Zhang Yazhi Cheng State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

2,6-bis(picrylamino)-3,5-dinitropyridine(PYX)has excellent thermostability,which makes its thermal decomposition mechanism receive much *** this paper,the mechanism of PYX thermal decomposition was investigated thoroughly by the ReaxFF-lg force field combined with DFT-B3LYP(6-311++G)*** detailed decomposition mechanism,small-molecule product evolution,and cluster evolution of PYX were mainly *** the initial stage of decomposition,the intramolecular hydrogen transfer reaction and the formation of dimerized clusters are earlier than the denitration *** the progress of the reaction,one side of the bitter amino group is removed from the pyridine ring,and then the pyridine ring is *** final products produced in the thermal decomposition process are CO_(2),H_(2)O,N_(2),and H_(2).Among them,H_(2)O has the earliest generation time,and the reaction rate constant(k_(3))is the *** clusters are formed during the decomposition of PYX,and the formation,aggregation,and decomposition of these clusters are strongly affected by *** low temperatures(2500 K-2750 K),many clusters are *** high temperatures(2750 K-3250 K),the clusters aggregate to form larger *** 3500 K,the large clusters decompose and become *** the late stage of the reaction,H and N in the clusters escaped almost entirely,but more O was trapped in the clusters,which affected the auto-oxidation process of ***'s initial decomposition activation energy(E_(a))was calculated to be 126.58 kJ/*** work contributes to a theoretical understanding of PYX's entire thermal decomposition process.

关键词： PYX Thermal decomposition ReaxFF-lg MD simulations Excellent thermostable explosives

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