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A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie tang Xiao-Li Ma Xiang-ling He Wei-Hua Pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu hui-Zhong Niu Chun-Mei Wang Li-Rong Sun hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

基于UPLC-Q-TOF MS鉴定复方香薷水化学成分

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分析测试学报 2024年第4期43卷 541-554页

作者：林结玲周熙赵昕遆慧慧广东药科大学药学院广东广州510006 广东省科学院测试分析研究所(中国广州分析测试中心) 广东省化学测量与应急检测技术重点实验室广东省中药质量安全工程技术研究中心广东广州510070

采用超高效液相色谱-四极杆串联飞行时间质谱(UPLC-Q-TOF MS)技术对中药复方香薷水的化学成分进行快速分析鉴定。通过色谱峰响应程度和分离效果优化复方香薷水的前处理方法和仪器条件;采用Agi⁃lent Phe Hex(150 mm×2.1 mm,1.9µm)色谱... 详细信息

采用超高效液相色谱-四极杆串联飞行时间质谱(UPLC-Q-TOF MS)技术对中药复方香薷水的化学成分进行快速分析鉴定。通过色谱峰响应程度和分离效果优化复方香薷水的前处理方法和仪器条件;采用Agi⁃lent Phe Hex(150 mm×2.1 mm,1.9µm)色谱柱进行分离,以0.1%甲酸水溶液-乙腈为流动相进行梯度洗脱,柱温35℃,流速0.3 mL/min;通过正、负两种离子模式采集复方香薷水的质谱数据,得到精确质量数和二级碎片,结合对照品、Pubchem、安捷伦中药化合物质谱数据库和文献报道等信息对其化合物进行分析鉴定。鉴定出复方香薷水的112个成分,其中黄酮类22个,苯丙素类20个、有机酸18个、萜类14个、生物碱11个、氨基酸5个以及其他类型化合物22个。该研究全面阐述了复方香薷水的化学物质基础,为其质量控制和药效物质研究提供了理论依据。

关键词：超高效液相色谱-四极杆串联飞行时间质谱(UPLC-Q-TOF MS) 复方香薷水成分分析黄酮类

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Polarization control of above-threshold ionization spectrum in elliptically polarized two-color laser fields

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Chinese Physics B 2024年第4期33卷 136-144页

作者：金发成杨慧慧宋晓红李飞杜玲玲薛红杰魏丽敏白悦刘浩翔王兵兵杨玮枫 Faculty of Science Xi'an Aeronautical InstituteXi'an 710077China School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570288China Center for Theoretical Physics Hainan UniversityHaikou 570288China Laboratory of Optical Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China College of Science Shantou UniversityShantou 515063China University of Chinese Academy of Sciences Beijing 100049China

We study the above-threshold ionization(ATI)process of atoms exposed to fundamental and high-frequency lasers with arbitrary ellipticity by applying the frequency-domain *** is found that the angular-resolved ATI spectrum is sensitive to ellipticities of two lasers and emitted angles of the *** for the photon energy of the highfrequency laser more than atomic ionization potential,the width of plateau tends to a constant with increasing ellipticity of fundamental field,the dip structure disappears with increasing ellipticity of the high-frequency *** the help of the quantum channel analysis,it is shown that the angular distribution depends mainly on the ellipticity of high-frequency field in the case that its frequency is ***,one can see that the maximal and minimal energies in quantum numerical results are in good agreement with the classical *** investigation may provide theoretical support for experimental research on polarization control of ionization in elliptically polarized two-color laser fields.

关键词： above-threshold ionization two-color laser polarization control

Information-motivation-behavioral guided nursing for stroke patients with pulmonary dysfunction:A randomized controlled trial

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World Journal of Clinical Cases 2024年第24期12卷 5549-5557页

作者： Xia Peng hui-Qin Ni Yong-Mei Liu Jin-ling Zhu Yu-Ting Bai Department of Respiratory and Critical Care Medicine Yancheng First Hospital Affiliated to Nanjing University School of MedicineYancheng 224006Jiangsu ProvinceChina Department of Neurology Yancheng First Hospital Affiliated to Nanjing University School of MedicineYancheng 224006Jiangsu ProvinceChina Department of Nursing Yancheng First Hospital Affiliated to Nanjing University School of MedicineYancheng 224006Jiangsu ProvinceChina

BACKGROUND Patients with stroke frequently experience pulmonary *** To explore the effects of information-motivation-behavioral(IMB)skills modelbased nursing care on pulmonary function,blood gas indices,complication rates,and quality of life(QoL)in stroke patients with pulmonary *** We conducted a controlled study involving 120 stroke patients with pulmonary *** control group received routine care,whereas the intervention group received IMB-model-based nursing *** parameters including pulmonary function,blood gas indices,complication rates,and QoL were assessed before and after the *** Baseline data of the control and intervention groups were ***-intervention,the IMB model-based care group showed significant improvements in pulmonary function indicators,forced expiratory volume in 1 sec,forced vital capacity,and peak expiratory flow compared with the control *** gas indices,such as arterial oxygen pressure and arterial oxygen saturation,increased significantly,and arterial carbon dioxide *** decreased significantly in the IMB model-based care group compared with the control *** intervention group also had a lower complication rate(6.67%vs 23.33%)and higher QoL scores across all domains than the control *** IMB model-based nursing care significantly enhanced pulmonary function,improved blood gas indices,reduced complication rates,and improved the QoL of stroke patients with pulmonary *** research is needed to validate these results and to assess the long-term efficacy and broader applicability of the model.

关键词： Cerebrovascular accident rehabilitation Respiratory function tests Nursing methodology research Behavioral medicine Quality of life

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论党的组织法规制度法典化

南通大学学报（社会科学版） 2024年第2期40卷 97-109页

作者：祝捷金玲慧武汉大学法学院武汉大学党内法规研究中心

党的组织法规制度法典化是成文法规的必然趋势,也是立法手段在政党规范领域的全新尝试。当前,官方已有明确导向而学界尚未形成规模研究,亟须对党的组织法规法典化展开“全景式”的研究讨论,以减轻或避免其在现实中缺乏实践性的可能。概... 详细信息

党的组织法规制度法典化是成文法规的必然趋势,也是立法手段在政党规范领域的全新尝试。当前,官方已有明确导向而学界尚未形成规模研究,亟须对党的组织法规法典化展开“全景式”的研究讨论,以减轻或避免其在现实中缺乏实践性的可能。概念主体的解构分析、必要性可行性及可见困境的探讨、实践路径的初步拟定等是系统阐释党的组织法规制度法典化不可或缺的部分。以上述内容为引导,可形成“理解党的组织法规制度法典化”到“认可党的组织法规制度法典化”再到“探索党的组织法规制度法典化”的逻辑路径,实现对党的组织法规制度法典化的理性认知,最终为推动党的组织法规制度法典化打造理论基石。

关键词：党内法规党的组织法规制度党的组织法规制度法典化法典化

共生理论视域下的职业本科教育高质量发展:结构、样态与路向

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成人教育 2024年第6期44卷 76-84页

作者：蒙玲蒋士会广西医科大学第一临床医学院南宁530021 广西师范大学教育学部广西桂林541004

职业教育的跨界属性使得职业本科教育呈现多元共生的形态。在共生理论视域下,围绕共生单元、共生模式、共生环境“三要素”,析理职业本科教育的共生结构,审思职业本科教育的现实共生样态:人才培养目标定位失准、培养主体功能失调、培养... 详细信息

职业教育的跨界属性使得职业本科教育呈现多元共生的形态。在共生理论视域下,围绕共生单元、共生模式、共生环境“三要素”,析理职业本科教育的共生结构,审思职业本科教育的现实共生样态:人才培养目标定位失准、培养主体功能失调、培养体系规制失范使得共生系统动力缺失、平衡受损、价值损耗。职业本科教育的各利益主体之间尚未形成共建共生的和谐关系。职业本科教育要回应人才培养的需求,实现价值旨归,亟待在聚焦培养目标定位中走向共容,在深化跨界合作中走向共融,在共塑教育形象中走向共荣,在强化实践智慧中走向共涌,推动职业本科教育人才培养实现跨界共生与协同共治,从而促进职业本科教育实现高质量发展。

关键词：职业本科教育高质量发展人才培养共生理论跨界融合

Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu ling CAO Wei Hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

Isoscaling properties for neutron-rich fragments in highly asymmetric heavy ion collision systems

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Chinese Physics C 2024年第6期48卷 136-144页

作者：彭丹马春旺乔春源刘星泉魏慧玲 Institute of Particle and Nuclear Physics College of PhysicsHenan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of SciencesZhengzhou 450046China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Sichuan UniversityChengdu 610064China

Traditionally,isoscaling has been interpreted and applied within the framework of the grand canonical ensemble,based on the assumption that fragment production occurs following the attainment of a statistical equilibrium ***,the influence of the symmetry energy can lead to differences in the neutron and density distribution in neutron-rich *** in turn may impact the iso scaling parameters(usually denoted byαandβ).We examine the isoscaling properties for neutron-rich fragments produced in highly asymmetric systems on inverse kinematics,namely^(40,48)Ca and ^(58,64)Ni+^(9)Be at 140 MeV per *** evaluate α and β values and sort them as a function of the neutron excess I≡*** significant differences in a extracted from fragments within different ranges of I emphasize the importance of understanding the dependence of isoscaling parameters on fragments generated in various collision ***,the|β(N)|/α(Z)value for a specific fragment in small size and highly iso spin asymmetry systems can serve as a probe to detect the variations in neutron density and proton density in different regions of the nucleus and indicate the limitations of theoretical models in investigating these issues.

关键词： isoscaling symmetry energy nuclear density neutron-rich fragment heavy ion collision

剖宫产瘢痕子宫对辅助生殖技术助孕结局影响的研究进展

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中华生殖与避孕杂志 2024年第8期44卷 847-852页

作者：王嘉怡季慧凌秀凤南京医科大学附属妇产医院(南京市妇幼保健院)生殖中心南京210004

由于剖宫产率的增加, 继发性不孕的人数增多, 从而使剖宫产术后接受辅助生殖技术(assisted reproductive technology, ART)助孕治疗的患者也逐渐增加, 但目前关于剖宫产术对ART妊娠结局的影响尚存争议。研究显示剖宫产切口瘢痕可能通过... 详细信息

由于剖宫产率的增加, 继发性不孕的人数增多, 从而使剖宫产术后接受辅助生殖技术(assisted reproductive technology, ART)助孕治疗的患者也逐渐增加, 但目前关于剖宫产术对ART妊娠结局的影响尚存争议。研究显示剖宫产切口瘢痕可能通过改变子宫解剖结构、降低子宫内膜容受性、破坏宫腔微生态环境等影响胚胎着床, 从而增加反复种植失败、复发性流产及异位妊娠等风险。瘢痕修补术是改善此类患者助孕结局的有效手段, 近年来宫腔灌注、抑制异常宫缩、抗生素治疗等也成为改善宫腔环境的新思路。本文基于剖宫产瘢痕子宫与后续生育力的关系, 围绕其影响ART妊娠结局的可能机制及处理方案展开综述, 为临床工作提供参考。

关键词：剖宫产术瘢痕生殖技术,辅助妊娠结局继发不孕