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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng hui gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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A Novel Green Supplier Selection Method Based on the Interval Type-2 Fuzzy Prioritized Choquet Bonferroni Means

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IEEE/CAA Journal of Automatica Sinica 2021年第9期8卷 1549-1566页

作者： Peide Liu hui gao School of Management Science and Engineering Shandong University of Finance and EconomicsJinan 250014China School of Business Heze UniversityHeze 274015China

In view of the environment competencies,selecting the optimal green supplier is one of the crucial issues for enterprises,and multi-criteria decision-making(MCDM)methodologies can more easily solve this green supplier selection(GSS)*** addition,prioritized aggregation(PA)operator can focus on the prioritization relationship over the criteria,Choquet integral(CI)operator can fully take account of the importance of criteria and the interactions among them,and Bonferroni mean(BM)operator can capture the interrelationships of ***,most existing researches cannot simultaneously consider the interactions,interrelationships and prioritizations over the criteria,which are involved in the GSS ***,the interval type-2 fuzzy set(IT2FS)is a more effective tool to represent the ***,based on the advantages of PA,CI,BM and IT2FS,in this paper,the interval type-2 fuzzy prioritized Choquet normalized weighted BM operators with fuzzy measure and generalized prioritized measure are proposed,and some properties are ***,a novel MCDM approach for GSS based upon the presented operators is developed,and detailed decision steps are ***,the applicability and practicability of the proposed methodology are demonstrated by its application in the shared-bike GSS and by comparisons with other *** advantages of the proposed method are that it can consider interactions,interrelationships and prioritizations over the criteria simultaneously.

关键词： Bonferroni mean operator Choquet integral operator Green supplier selection(GSS) interval type-2 fuzzy set(IT2FS) prioritized aggregation operator

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Influence of the Northeast Cold Vortex on Flooding in Northeast China in Summer 2013

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Journal of Meteorological Research 2018年第2期32卷 172-180页

作者： Jing gao hui gao Inner Mongolia Climate Center Hohhot 010051 National Climate Center China Meteorological Administration Beijing 100081

Severe flooding occurred in Northeast China（NEC） in summer 2013. Compared with the rainfall climatology of the region, the rainy season began earlier in 2013 and two main rainy periods occurred from late June to early July and from mid July to early August, respectively. During the summer season of 2013, the western Pacific subtropical high（WPSH） was located farther westward, which strengthened the southerly winds on its west side in the lower troposphere. Under this circulation pattern, more water vapor was transported to North China and NEC. Another moisture transport pathway to NEC was traced to the cross-equatorial flow over the Bay of Bengal. In mid–high latitudes in summer 2013, the Northeast Cold Vortex（NECV） was much stronger and remained stable over NEC. Thus, the cold air flow from its northwest side frequently met with the warm and wet air from the south to form stronger moisture convergence at lower levels in the troposphere, resulting in increased precipitation over the region. Correlation analysis indicated that the NECV played a more direct role than the WPSH. Synoptic analyses of the two heaviest flood cases on 2 and 16 July confirmed this conclusion. The four wettest summers in NEC before 2000 were also analyzed and the results were consistent with the conclusion that both the WPSH and the NECV led to the intense rainfall in NEC, but the NECV had a more direct role.

关键词： flood Northeast China Northeast Cold Vortex westem Pacific subtropical high

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Real-time Feed-forward Force Compensation for Active Magnetic Bearings System Based on H∞ Controller

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Chinese Journal of Mechanical Engineering 2011年第1期24卷 58-66页

作者： gao hui XU Longxiang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

There are two kinds of unbalance vibrations—force vibration and displacement vibration due to the existence of unbalance excitation in active magnetic bearings（AMB） system. And two unbalance compensation methods—closed-loop feedback and open loop feed-forward are presented to reduce the force vibration. The transfer function order of the control system directly influencing the system stability will be increased when the closed-loop method is adopted, which makes the real-time compensation not easily achieved. While the open loop method would not increase the primary transfer function order, it provides conditions for real-time compensation. But the real-time compensation signals are not easy to be obtained in the open loop method. To implement real-time force compensation, a new method is proposed to reduce the force vibration caused by the rotor unbalance on the basis of AMB active control. The method realizes real-time and on-line force auto-compensation based on H∞ controller and one novel feed-forward compensation controller, which makes the rotor rotate around its inertia axis. The time-variable feed-forward compensatory signal is provided by a modified adaptive variable step-size least mean square（VSLMS） algorithm. And the relevant least mean square（LMS） algorithm parameters are used to solve the H∞ controller weighting functions. The simulation of the new method to compensate some frequency-variable and sinusoidal signals is completed by MATLAB programming, and real-time compensation is implemented in the actual AMB experimental system. The simulation and experiment results show that the compensation scheme can improve the robust stability and the anti-interference ability of the whole AMB system by using H∞ controller to achieve close-loop control, and then real-time force unbalance compensation is implemented. The proposed research provides a new control strategy containing real-time algorithm and H∞ controller for the force compensation of AMB system. And

关键词： active magnetic bearings H∞ robust controller sensitivity and complementary sensitivity VSLMS algorithm feed-forward compensation

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The Record-Breaking Extreme Drought in Yunnan Province, Southwest China during Spring-Early Summer of 2019 and Possible Causes

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Journal of Meteorological Research 2020年第5期34卷 997-1012页

作者： Ting DING hui gao National Climate Center China Meteorological AdministrationBeijing 100081

In spring and early summer of 2019, Yunnan Province experienced the most severe seasonal drought on record,with days of extreme drought area exceeding 10^5 km^2 far more than normal. Consistently, the precipitation in each month from February to June is over 30% less than normal, and about 50% less in the most severe drought period(April–June). The rainy season in Southwest China(SWC) started on the third pentad in June 2019, which is the second latest in history. The rainy season in Yunnan started on 24 June, which is the latest(29 days later than normal). On the contrary, the onset of the South China Sea summer monsoon(SCSSM) is abnormally early. The lag time between the start of the rainy season in SWC and the onset of the SCSSM in 2019 is 7 pentads, which is the largest since 1961, much longer than the climate mean(less than 1 pentad). The present study analyzes the possible reasons why the rainy season came extremely late and the drought disaster persisted and intensified after a much early SCSSM, at both seasonal and subseasonal timescales. The abnormally late onset of the rainy season and the second greatest potential evapotranspiration(PET) since 1981 are the direct reasons for the persistent drought. Statistical results show that the water vapor from southwest of Yunnan in April–June contributes more than that from the east at the seasonal scale. In April–June 2019, however, the southern branch trough(SBT) was abnormally weak, the large and strong anticyclonic wind anomaly prevailed over the Bay of the Bengal(BOB), and the meridional water vapor transport to Yunnan was weak. At the subseasonal scale, the weaker SBT lasted the longest, and the strong convection over the BOB came up late despite of an early onset of the SCSSM, which resulted in reduced low-level moisture convergence in Yunnan and development of drought prior to the SCSSM onset. From the onset of SCSSM to the start of rainy season in SWC, the SBT and meridional water vapor transport from the B

关键词： Yunnan Province extreme drought South China Sea summer monsoon(SCSSM) rainy season in Southwest China(SWC) southern branch trough(SBT)

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Impacts of grazing and mowing on reproductive behaviors of Stipa grandis and Stipa krylovii in a semi-arid area

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Journal of Arid Land 2014年第1期6卷 97-104页

作者： hui gao YuBao gao XingDong HE College of Life Sciences Nankai University

Disturbance can affect biomass allocation of plants,but can it influence plant reproductive behavior?To address this issue,we performed field plant community investigations and explored the reproductive behaviors of Stipa grandis and Stipa krylovii in response to grazing and mowing treatments at Maodeng pasture of Xilinguole League of Inner Mongolia,China during 2007–*** results showed that,with a similar niche width for the two plant species under mowing and grazing treatments,mowing significantly increased the ratio of ramet to genet number of *** and the carbon to nitrogen ratio of ***,and grazing significantly decreased the ratio of vegetative to reproductive tiller biomass of *** and increased the ratio of vegetative to reproductive tiller number of *** analysis showed that the significantly positive effect of root to shoot biomass ratio was stronger on the ratio of vegetative to reproductive tiller number of *** than on that of *** results indicated that grazing and mowing influenced the reproductive manner and the process of sexual reproduction of *** and ***.

关键词： Stipa grandis Stipa krylovii disturbance Maodeng pasture reproductive strategy

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The Right Gorenstein Subcategory rg(l,D)

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Acta Mathematica Sinica,English Series 2023年第2期39卷 339-362页

作者： Zeng hui gao Wan WU College of Applied Mathematics Chengdu University of Information TechnologyChengdu610225China

In this paper,we generalize the idea of Song,Zhao and Huang[***.J.,70,483±504(2020)]and introduce the notion of right(left)Gorenstein subcategory rg(l,∂)(lg(l,D)),relative to two additive full subcategoriesφand∂of an abelian category *** the assumption thatφ⊆∂,we prove that the right Gorenstein subcategory rg(l,D)possesses many nice properties that it is closed under extensions,kernels of epimorphisms and direct ***φ⊆Dandφ⊥D,we show that the right Gorenstein subcategory rg(l,D)admits some kind of *** we discuss a resolution dimension for an object in A,called rg(l,D)-projective ***,we prove that if(U,V)is a hereditary cotorsion pair with kernelφhas enough injectives,such that U⊆Dand U⊥∂,then(rg(l,D),φφ)is a weak Auslander±Buchweitz context,whereφis the subcategory of A consisting of objects with finiteφ-projective dimension.

关键词： Right Gorenstein subcategory rg(l,D)-projective dimension cotorsion pair weak Auslander-Buchweitz context

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Radiation-induced defects in different silicon (111) wafers by 400 keV electron irradiation

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Rare Metals 2012年第3期31卷 290-295页

作者： gao, hui Wang, Heyi Yuan, Yonggang Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Mianyang 621900 China

The energy deposition for low-energy electron beam on Si-SiO2 models was calculated by Monte-Carlo method. Making use of electron paramagnetic resonance (EPR) technique, an investigation of the effect of dopant type and concentration on EPR signal variations was carried out by using p-type and n-type silicon(111) wafers with concentration of 1×1015 cm 3 and 1×1017 cm 3, and the changes of intensity of defect paramagnetic centers before and after irradiation of electrons were compared. The chemical states of Si-SiO2 structure were determined by X-ray photoelectrons spectroscopy(XPS). The results clearly indicate that the effects of dopant variations (type and concentration) are of obvious difference. Compared with p-type silicon, n-type silicon, especially with higher dopant concentration, tends to produce defect at the interface under low-energy electron irradiation with certain flux, which arises from the hole trapped on a nonbridging oxygen atom bonded to P. It is represented in the form of distinct changes of POHC intensity and P2P spectrum. According to the theoretical and experimental data, the relationship among electron energy deposition, chemical states of element Si at SiO2 -Si(111) interface, and radiation effect were analyzed and discussed.

关键词： SiO2-Si(111) interface low-energy electron energy deposition XPS spectrum EPR spectrum radiation effect

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Unbalance Vibratory Displacement Compensation for Active Magnetic Bearings

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Chinese Journal of Mechanical Engineering 2013年第1期26卷 95-103页

作者： gao hui XU Longxiang ZHU Yili College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

As the dynamic stiffness of radial magnetic bearings is not big enough, when the rotor spins at high speed, unbalance displacement vibration phenomenon will be produced. The most effective way for reducing the displacement vibration is to enhance the radial magnetic bearing stiffness through increasing the control currents, but the suitable control currents are not easy to be provided, especially, to be provided in real time. To implement real time unbalance displacement vibration compensation, through analyzing active magnetic bearings （AMB） mathematical model, the existence of radial displacement runout is demonstrated. To restrain the runout, a new control scheme-adaptive iterative learning control （A1LC） is proposed in view of rotor frequency periodic uncertainties during the startup process. The previous error signal is added into AILC learning law to enhance the convergence speed, and an impacting factor/3 influenced by the rotor rotating frequency is introduced as learning output coefficient to improve the rotor control effects, As a feed-forward compensation controller, AILC can provide one tmknown and perfect compensatory signal to make the rotor rotate around its geometric axis through power amplifier and radial magnetic bearings. To improve AMB closed-loop control system robust stability, one kind of incomplete differential PID feedback controller is adopted. The correctness of the AILC algorithm is validated by the simulation of AMB mathematical model adding AILC compensation algorithm through MATLAB soft. And the compensation for fixed rotational frequency is implemented in the actual AMB system. The simulation and experiment results show that the compensation scheme based on AILC algorithm as feed-forward compensation and PID algorithm as close-loop control can realize AMB system displacement minimum compensation at one fixed frequency, and improve the stability of the control system. The proposed research provides a new adaptive iterative/earning cont

关键词： active magnetic bearings unbalance displacement compensation mathematical model adaptive iterative learning control

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The day after the 7th day of the Creation:Breakthrough of human embryo in vitro culture

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Science China(Life Sciences) 2017年第6期60卷 665-667页

作者： hui gao Wei Li State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China

Since the creation of intelligent creatures,we are no longer the puppets of the *** thousands of years,people have been thinking about the nature and the future of ourselves,and reconstruction of the process of life has become the ultimate dream for *** 1951,William Harvey,a British scientist,elaborated the theory of the structure and function of embryos for the first time in his book'the reproduction of animals',which established the foundation for people to explore the process and the mechanism of embryonic development.

关键词： embryo ultimate thinking Harvey intelligent Creation creation reproduction oocyte dream

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