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Biomedical and Environmental Sciences 2024年第1期37卷 117-121页

作者： WEN Si hui LI Lu Bei HUANG hui dan XIE Ying LUO Lei Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina Department of Occupational Health Changsha Centre for Disease Control and PreventionChangsha 410004HunanChina The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Hunan Normal University School of MedicineChangsha 410013HunanChina

The pervasive utilization of industrial substances has escalated human exposure to cadmium(Cd),a metal associated with long-term negative health outcomes such as renal dysfunction,neurological disorders,and various cancers^([1]).Once ingested by humans,Cd interacts with cysteine-rich metallothioneins(MTs)which have metal-binding and antioxidant properties and is subsequently transported to the kidney^([2]).

关键词： Renal kidney cadmium

Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm

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Chinese Journal of Integrative Medicine 2024年第11期30卷 993-1000页

作者： XU Yu-ying LI Qiu-yan YI dan-hui CHEN Yue ZHAI Jia-wei ZHANG Tong SUN Ling-yun YANG Yu-fei Department of Oncology Xiyuan Hospital China Academy of Chinese Medical Sciences School of Statistics Renmin University of China Graduate School Beijing University of Chinese Medicine

Objective: To establish the dynamic treatment strategy of Chinese medicine(CM) for metastatic colorectal cancer(m CRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment strategies for m CRC. Methods: From the outpatient cases of m CRC in the Department of Oncology at Xiyuan Hospital, China Academy of Chinese Medical Sciences, 197 cases that met the inclusion criteria were screened. According to different CM intervention strategies, the patients were divided into 3 groups: CM treatment alone, equal emphasis on Chinese and Western medicine treatment(CM combined with local treatment of tumors, oral chemotherapy, or targeted drugs), and CM assisted Western medicine treatment(CM combined with intravenous regimen of Western medicine). The survival time of patients undergoing CM intervention was taken as the final evaluation index. Factors affecting the choice of CM intervention scheme were screened as decision variables. The dynamic CM intervention and treatment strategy for m CRC was explored based on the cost-sensitive classification learning algorithm for survival(CSCLSurv). Patients' survival was estimated using the Kaplan-Meier method, and the survival time of patients who received the model-recommended treatment plan were compared with those who received actual treatment plan. Results: Using the survival time of patients undergoing CM intervention as the evaluation index, a dynamic CM intervention therapy strategy for m CRC was established based on *** CM intervention strategies for m CRC can be selected according to dynamic decision variables, such as gender, age, Eastern Cooperative Oncology Group score, tumor site, metastatic site, genotyping, and the stage of Western medicine treatment at the patient's first visit. The median survival time of patients who received the modelrecommended treatment plan was 35 months, while those who receive the actual treatment plan was 26.0 months(P=0.06). Conclusions:

关键词： Chinese medicine cost sensitive classification learning for survival dynamic treatment strategy metastatic colorectal cancer

Predictive performance of the variation rate of the driving pressure on the outcome of invasive mechanical ventilation in patients with acute respiratory distress syndrome

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Chinese Journal of Traumatology 2024年第2期27卷 107-113页

作者： hui-dan Jing Jun-Ying Tian Wei Li Bing-Ling He Hong-Chao Li Fu-Xia Jian Cui Shang Feng Shen Department of Intensive Care Unit The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Intensive Care Unit Army Medical Center of PLAChongqing400042China College of Foreign Languges Chongqing Medical UniversityChongqing400016China

Purpose:To assess the value of the driving pressure variation rate(ΔP%)in predicting the outcome of weaning from invasive mechanical ventilation in patients with acute respiratory distress ***:In this case-control study,a total of 35 patients with moderate-severe acute respiratory distress syndrome were admitted to the intensive care unit between January 2022 and December 2022 and received invasive mechanical ventilation for at least 48 h were *** were divided into successful weaning group and failed weaning group depending on whether they could be removed from ventilator support within 14 *** measures including driving pressure,PaO2:FiO2,and positive end-expiratory pressure,*** assessed every 24 h from day 0 to day 14 until successful weaning was *** measurement data of non-normal distribution were presented as median(Q1,Q3),and the differences between groups were compared by Wilcoxon rank sum *** categorical data use the Chi-square test or Fisher's exact test to *** predictive value ofΔP%in predicting the outcome of weaning from the ventilator was analyzed using receiver operating characteristic ***:Of the total 35 patients included in the study,17 were successful vs.18 failed in weaning from a ventilator after 14 days of mechanical *** cut-off values of the medianΔP%measured by Operator 1 *** 2 in the first 4 days were≥4.17%and 4.55%,respectively(p<0.001),with the area under curve of 0.804(sensitivity of 88.2%,specificity of 64.7%)and 0.770(sensitivity of 88.2%,specificity of 64.7%),*** was a significant difference in mechanical ventilation duration between the successful weaning group and the failure weaning group(8(6,13)vs.12(7.5,17.3),p=0.043).The incidence of ventilator-associated pneumonia in the successful weaning group was significantly lower than in the failed weaning group(0.2‰vs.2.3‰,p=0.001).There was a significant difference noted between these

关键词： Driving pressure Driving pressure variation rate Acute respiratory distress syndrome Mechanical ventilation

One-year results for myopia control of orthokeratology with different back optic zone diameters: a randomized trial using a novel multispectral-based topographer

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 324-330页

作者： Wen-Ting Tang Xiang-Ning Luo Wen-Jing Zhao Jia Liao Xin-Yue Xu hui-dan Zhang Li Zhang Department of Ophthalmology the First Affiliated Hospital of Chengdu Medical CollegeChengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

AIM:To present the 1-year results of a prospective cohort study investigating the efficacy,potential mechanism,and safety of orthokeratology(ortho-k)with different back optic zone diameters(BOZD)for myopia control in ***:This randomized clinical study was performed between Dec.2020 and *** were randomly assigned to three groups wearing ortho-k:5 mm BOZD(5-MM group),5.5 mm BOZD(5.5-MM group),and 6 mm BOZD(6-MM group).The 1-year data were recorded,including axial length,relative peripheral refraction(RPR,measured by multispectral refractive topography,MRT),and visual *** contrast sensitivity(CS)was evaluated by CSV-1000 instrument with spatial frequencies of 3,6,12,and 18 cycles/degree(c/d);the corneal higher-order aberrations(HOAs)were measured by iTrace aberration *** one-way ANOVA was performed to assess the differences between the three *** correlation between the change in AL and RPR was calculated by Pearson’s correlation ***:The 1-year results of 20,21,and 21 subjects in the 5-MM,5.5-MM,and 6-MM groups,respectively,were *** were no statistical differences in baseline age,sex,or ocular parameters between the three groups(all P>0.05).At the 1-year visit,the 5-MM group had lower axial elongation than the 6-MM group(0.07±0.09 vs 0.18±0.11 mm,P=0.001).The 5-MM group had more myopic total RPR(TRPR,P=0.014),with RPR in the 15°–30°(RPR 15–30,P=0.015),30°–45°(RPR 30–45,P=0.011),temporal(RPR-T,P=0.008),and nasal area(RPR-N,P<0.001)than the 6-MM *** 15–30 in the 5.5-MM group was more myopic than that in the 6-MM group(P=0.002),and RPR-N in the 5-MM group was more myopic than that in the 5.5-MM group(P<0.001).There were positive correlations between the axial elongation and the change in TRPR(r=0.756,P<0.001),RPR 15–30(r=0.364,P=0.004),RPR 30–45(r=0.306,P=0.016),and RPR-N(r=0.253,P=0.047).The CS decreased at 3 c/d(P<0.001),and the corneal HOAs increased in the 5-MM group(P=0.030).CONCL

关键词： relative peripheral refraction orthokeratology myopia back optic zone diameter axial length multispectral refractive topography

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新疆达坂城风区顺风向脉动风功率谱

科学技术与工程 2024年第3期24卷 1161-1169页

作者：王逸豪赵锐淡丹辉奉泽华冯磊新疆大学建筑工程学院乌鲁木齐830017 新疆建筑结构与抗震重点实验室乌鲁木齐830017 同济大学桥梁工程系上海200092 中建铁路投资建设集团有限公司东莞523000 中建新疆建工集团第一建筑工程有限公司乌鲁木齐830017

为研究新疆乌鲁木齐所处达坂城风区的复杂脉动风环境,基于实测风场风速数据分析并拟合了该风区的顺风向脉动风功率谱。结果表明:以反比例函数拟合山区峡谷地形平均风速与湍流强度的关系误差较小;山区峡谷地形湍流积分尺度分布较离散,但... 详细信息

为研究新疆乌鲁木齐所处达坂城风区的复杂脉动风环境,基于实测风场风速数据分析并拟合了该风区的顺风向脉动风功率谱。结果表明:以反比例函数拟合山区峡谷地形平均风速与湍流强度的关系误差较小;山区峡谷地形湍流积分尺度分布较离散,但整体随平均风速的增大而增大;考虑地形系数的Kaimal修正谱在含能区和惯性子区间能较好地表征实测谱,在耗能区选用三参数拟合描述实测谱效果良好;选用过渡函数来描述惯性子区间与耗能区接触区域的功率谱,拟合效果较为理想。可见达坂城风区具有特殊顺风向脉动风特性,以修正谱和拟合谱分段构成的函数模型可用于表征该风区顺风向脉动风功率谱。

关键词：顺风向脉动风湍流强度湍流积分尺度风功率谱密度风谱拟合

Co-YPO_(4)双功能催化剂促进乙醇高值转化制丁二烯

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Chinese Journal of Catalysis 2024年第1期56卷 166-175页

作者：周百川李文翠王嘉孙丹卉向诗煜高新芊陆安慧大连理工大学化工学院辽宁省低碳资源高值化利用重点实验室精细化工国家重点实验室辽宁大连116024

丁二烯是重要的化工原料,主要用于生产树脂、合成橡胶、丁二醇和己二腈等大宗化学品,还可以用于制备蒽醌、四氢苯酐等精细化学品.目前,工业上制备丁二烯的方法主要是乙烯副产抽提法.近年来,随着生物乙醇技术大力发展,催化乙醇制丁二烯... 详细信息

丁二烯是重要的化工原料,主要用于生产树脂、合成橡胶、丁二醇和己二腈等大宗化学品,还可以用于制备蒽醌、四氢苯酐等精细化学品.目前,工业上制备丁二烯的方法主要是乙烯副产抽提法.近年来,随着生物乙醇技术大力发展,催化乙醇制丁二烯成为很有吸引力的生产丁二烯的路线之一.目前催化乙醇制丁二烯的催化剂种类较多,合理设计具有活性位点结构和功能的催化新材料是提升催化剂活性的关键.稀土金属元素如Y,La和Ce等具有独特的电子层结构,并且具有中等强度的Lewis酸性,本文尝试将稀土磷酸盐与具有乙醇脱氢活性的过渡金属位点结合起来,设计过渡金属改性的稀土磷酸盐催化剂并用于乙醇转化制丁二烯.本文开发了Co-YPO_(4)双功能催化剂,应用于乙醇转化制丁二烯反应,所制材料表现出较高的催化活性与稳定性.在YPO4催化剂上,乙醇主要发生脱水反应,生成大量的乙烯和乙醚,且丁二烯选择性不超过5%;而在Co-YPO_(4)催化剂上,乙醇转化产物分布出现明显改变,丁二烯选择性增加.在乙醇重时空速和反应温度分别为1.0 gC2H5OH×gCat.‒1×h^(‒1)和350℃的条件下,乙醇转化率为78.2%,丁二烯选择性为68.5%.原位紫外-可见漫反射光谱、X射线光电子能谱以及H_(2)^(-)程序升温还原表征结果表明,Co2+中心与PO_(4)^(3‒)基团存在强的配位相互作用,形成稳定且高度分散的[Co-O-P]物种.通过NH_(3)^(-)程序升温脱附(TPD)和吡啶探针分子吸附红外对YPO4和Co-YPO4进行酸性表征,结果表明,YPO_(4)和Co-YPO4表面均是典型的Lewis酸性位点;结合CO_(2)-TPD表征发现,Co^(2+)与YPO4表面部分Y3+位点发生置换,即引入适量的Co会减弱酸性同时增强表面碱性.进一步通过停留时间、乙醇程序升温表面反应和原位乙醇吸附反应漫反射红外光谱测试对反应机理进行详细研究.结果表明,乙醇首先在Co^(2+)位发生脱氢生成乙醛和H_(2),随后乙醛迁移至Y^(3+)位点吸附活化,两分子乙醛依次发生C‒C偶联、加氢以及脱水反应生成丁二烯.动力学测试结果表明,乙醇脱氢是整个反应过程的关键步骤,整体反应路径如下:乙醇→乙醛→丁烯醛→丁烯醇→丁二烯.综上所述,以乙醇作为平台分子合成丁二烯能够丰富可持续发展的新能源结构体系.本文揭示了磷酸根基团通过配位作用稳定Co^(2+)物种,Co^(2+)和Y^(3+)位点协同催化乙醇选择性生成丁二烯,为乙醇高值转化催化剂设计提供了新思路.

关键词：乙醇丁二烯脱氢碳碳偶联磷酸盐

福建省农村义务教育学生营养改善计划地区学生贫血状况及影响因素分析

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现代预防医学 2024年第2期51卷 238-244页

作者：黄峥阳丽君吴慧丹福建省疾病预防控制中心卫生检验检测所

目的了解2021—2022年福建省营养改善计划地区学生贫血状况，分析其影响因素。方法采用多阶段分层随机整群抽样的方法，共抽取8 895名学生纳入研究。依据WHO贫血诊断标准，分析不同特征学生的Hb水平和贫血率，采用logistic回归模型分... 详细信息

目的了解2021—2022年福建省营养改善计划地区学生贫血状况，分析其影响因素。方法采用多阶段分层随机整群抽样的方法，共抽取8 895名学生纳入研究。依据WHO贫血诊断标准，分析不同特征学生的Hb水平和贫血率，采用logistic回归模型分析贫血的可能影响因素。结果 2021—2022年福建省农村营养改善计划地区学生Hb均值为134.44 g/L,贫血率为7.21%。多因素logistic回归分析显示，女生(OR=1.51,95%CI:1.28～1.78)、位于乡镇或者村里的学校(OR=1.50,95%CI:1.71～1.91)、教育局统一提供食谱的学校(OR=3.80,95%CI:1.62～8.92)、没有开展过健康宣传教育的学校(OR=1.54,95%CI:0.09～0.62)和不知道如何预防缺铁性贫血的学生(OR=1.29,95%CI:1.03～1.63)是学生贫血的危险因素；每周午餐提供肉类次数≥3次的学校食堂(OR=0.74,95%CI:0.56～0.99)、每周摄入肉类量>14个乒乓球的学生(OR=0.78,95%CI:0.62～0.98)、每天摄入蔬菜种类≥3种(OR=0.53,95%CI:0.32～0.89)是学生贫血的保护因素。结论福建省农村义务教育学生营养改善计划地区学生贫血率低于全国实施学生营养改善计划的平均水平，但是显著高于全国6～17岁儿童的贫血率，学生贫血状况还有很大的改善空间，需要在今后的工作中开展有针对性的干预来改善学生的贫血状况。

关键词：贫血血红蛋白学生回归分析

POLYMER COLLOIDS FORMED BY POLYELECTROLYTE COMPLEXATION OF VINYL POLYMERS AND POLYSACCHARIDES IN AQUEOUS SOLUTION

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Chinese Journal of Polymer Science 2013年第1期31卷 39-49页

作者： hui-dan Liu Takahiro Sato Department of Macromolecular Science Osaka University

The polyelectrolyte complex formed from the polyanion and polycation was studied by turbidimetry, static and electrophoretic light scattering, and elementary analysis. Sodium salts of polyacrylate （PA） and heparin （Hep） were chosen as the polyanion, and hydrochloric salts of poly（vinyl amine）（PVA） and chitosan （Chts） as the polycation. Although these vinyl polymers and polysaccharides have remarkably different backbone chemical structures and linear charge densities, all the four combinations PA-PVA, PA-Chts, Hep-PVA, and Hep-Chts provide almost stoichiometric polyelectrolyte complexes which are slightly charged owing to the adsorption of the excess polyelectrolyte component onto the neutral complex. The charges stabilize the complex colloids in aqueous solution of a non-stoichiometric mixture, and the aggregation number of the complex colloids increases with approaching to the stoichiometric mixing ratio. The mixing ratio dependence of the aggregation number for the four complexes is explained by the model proposed in the previous study.

关键词： Polyelectrolyte complex Colloidal dispersion Polyacrylate Poly(vinyl amine) Heparin Chitosan Lightscattering.

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我国关键产业链供应链安全评估及提升措施

经济学家 2024年第6期 86-94页

作者：孙天阳张其仔杨丹辉中国社会科学院工业经济研究所

在全球经济不确定性增加背景下,维护产业链供应链安全的意义凸显。本文从依赖程度、可控韧性、自主能力三个维度,综合构建了评估关键产业链供应链安全水平的指标体系,选取集成电路、大容量电池两个当前大国博弈的焦点领域,对产业链供应... 详细信息

在全球经济不确定性增加背景下,维护产业链供应链安全的意义凸显。本文从依赖程度、可控韧性、自主能力三个维度,综合构建了评估关键产业链供应链安全水平的指标体系,选取集成电路、大容量电池两个当前大国博弈的焦点领域,对产业链供应链的安全水平做出了评估。测算结果显示,在依赖程度方面,我国集成电路产业与发达国家之间存在非对称依赖关系,发达国家对我国大容量电池产业的依赖程度较高;可控韧性方面,发达国家在集成电路产业上游有较强的垄断优势,我国大容量电池产业链供应链韧性整体表现良好;自主能力方面,我国集成电路产业上游大部分领域比较优势相对较弱,大容量电池产业链各环节的专利申请处于领先地位,但部分核心产品比较优势不够突出。应增强重点领域技术自主性,加大对链主企业的扶持力度,降低产业链供应链路径依赖,全面提高我国关键产业链供应链安全水平。

关键词：产业链供应链安全评估集成电路大容量电池

Dilation theory and analytic model theory for doubly commuting sequences of C._(0)-contractions

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Science China Mathematics 2023年第2期66卷 303-340页

作者： hui dan Kunyu Guo College of Mathematics Sichuan UniversityChengdu 610065China School of Mathematical Sciences Fudan UniversityShanghai 200433China

It is known that every C·_(0)-contraction has a dilation to a Hardy *** leads to an elegant analytic functional model for C·_(0)-contractions,and has motivated lots of further works on the model theory and generalizations to commuting tuples of C·_(0)-*** this paper,we focus on doubly commuting sequences of C·_(0)-contractions,and establish the dilation theory and the analytic model theory for these sequences of *** results are applied to generalize the Beurling-Lax theorem and Jordan blocks in the multivariable operator theory to the operator theory in the infinite-variable setting.

关键词： doubly commuting sequence dilation theory analytic functional model Beurling-Lax theorem Jordan block