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Bioinformatics analysis of key genes associated with the prognosis of breast cancer

Journal of Nutritional Oncology 2023年第4期8卷 176-182页

作者： Kun Zhou Dao-Lai Huang hui-chao ruan Xiang-Hua Wu Department of Gastrointestinal Gland Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina

Objective:We sought to identify potential therapeutic targets for breast cancer patients by employing a bioinformatics analysis to screen for genes linked with an unfavorable ***:The Gene Expression Omnibus(GEO)database was utilized to obtain three gene expression profile datasets,namely GSE42568,GSE86374,and *** identify differentially expressed genes(DEGs),the GEO2R online tool was ***,a func-tional enrichment analysis was ***,a protein-protein interaction network was established using STRING,and DEGs were subjected to module analysis via Cytoscape software to identify pivotal ***,the selected pivotal genes underwent further ex-amination and validation utilizing three databases:GEPIA,UALCAN,and Kaplan-Meier ***:A total of 121 DEGs were detected,comprising 74 genes with increased expression and 47 genes with decreased *** key genes were identified:HMMR,RRM2,CDK1,TOP2A,AURKA,CCNB1,MAD2L1,KIF2C,BUB1B,*** in the GEPIA database revealed high expression levels for all key genes except CDK1.A survival analysis conducted using the Kaplan-Meier Plotter database revealed noteworthy associations between nine crucial genes and the overall survival(OS)of individuals diagnosed with breast ***,these nine key genes exhibited significantly increased expression across different molecular subtypes of breast cancer according to the UALCAN data ***:We identified nine crucial genes significantly linked to the onset,progression,and unfavorable prognosis of breast cancer,providing potential targets for novel treatment options and biomarkers to predict patient outcomes.

关键词： Breast cancer Bioinformatics Differentially expressed gene Key gene Survival analysis Prognosis

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The Role of the PNI and NLR in Nutritional Risk Screening and Assessment of Gastric Cancer Patients

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Journal of Nutritional Oncology 2022年第4期7卷 192-198页

作者： hui chao ruan Xiang Hua Wu Dao Lai Huang Xiao Bin Fu chao Zhang Kun Zhou Guan Yu Zhu Dang Liu Jin Tao Cai Ming Hao Tan Guangxi Medical University NanningGuangxi 530021China Guangxi Key Laboratory Of Enhanced Recovery After Surgery For Gastrointestinal Cancer NanningGuangxi 530021China Department of Gastrointestinal Gland Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China

Background The use of nutritional risk screening and assessment is becoming increasingly common in cancer *** Nutritional Risk Screening 2002(NRS 2002)is a nutritional risk screening programe with good *** patient generated-subjective global assessment(PG-SGA)is a method used to assess the nutritional status of cancer *** prognostic nutritional index(PNI)and neutrophil to lymphocyte ratio(NLR)are considered to be predictors of the prognosis following treatment for patients with a variety of ***,the relationship between the PNI and NLR in the nutritional screening and assessment in patients with gastric cancer is *** A retrospective analysis was performed on 378 patients with gastric cancer who underwent surgery at the First Affiliated Hospital of Guangxi Medical University from August 2019 to December *** 2002 and PG-SGA were performed within 24 hours of admission,and indicators such as the serum albumin level,body mass index(BMI),PNI and NLR were *** In the grouping based on the NRS2002,patients in the positive group(NRS 2002≥3)had a higher platelet value,a higher median NLR,and a lower PNI than those in the negative group(NRS 2002<3)(295.50±118.49×10^(9)/L vs.269.36±93.52×10^(9)/L,2.38 vs.1.77,42.36±5.96 vs.46.64±4.29).Based on the PG-SGA grouping,the serum albumin level and lymphocyte count were highest in the mild group(PG-SGA:score 2-3),(36.94±3.51 g/L and 1.91±0.7610^(9)/L)and lowest within the severe group(PG SGA score≥9)(34.09±4.18 g/L and 1.51±0.6410^(9)/L).The BMI was highest in the mild group(23.35±3.00 kg/m^(2))and lowest in the severe group(20.63±2.97 kg/m^(2)),and the PNI was also highest in the mild group(46.50±5.17)and lowest in the severe group(41.64±5.53).However,the NLR was lowest in the mild group(median 1.91)and highest in the severe group(median 2.44).Conclusion The PNI and NLR in gastric cancer patients are closely related to the results of the nutritional risk screening and a

关键词： Nutritional risk screening 2002 Patient-Generated Subjective Global Assessment Gastric cancer Prognostic nutritional index Neutrophil-to-lymphocyte ratio

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差示扫描量热法在聚烯烃纤维定性鉴别中的应用

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纺织科技进展 2017年第3期 35-38页

作者：谷小辉阮超明李娟曹月婵国家纺织品服装服饰产品质量监督检验中心广东广州511447

采用拉伸实验、燃烧鉴别法、显微镜观察法、化学溶解法、红外吸收光谱法和差示扫描量热法(DSC)对常见的聚烯烃类纤维乙纶、丙纶、聚乙烯/聚丙烯复合纤维和聚烯烃弹性纤维进行了测试分析。结果表明这4种纤维属于同类纤维,其物理、化学特... 详细信息

采用拉伸实验、燃烧鉴别法、显微镜观察法、化学溶解法、红外吸收光谱法和差示扫描量热法(DSC)对常见的聚烯烃类纤维乙纶、丙纶、聚乙烯/聚丙烯复合纤维和聚烯烃弹性纤维进行了测试分析。结果表明这4种纤维属于同类纤维,其物理、化学特征比较接近,用单一的传统鉴别方法对其准确定性鉴别比较困难,需要多种方法结合进行系统鉴别。差示扫描量热分析法能有效、直观地表征纤维的热性能,是一种准确、可靠的鉴别方法。

关键词：差示扫描量热法聚烯烃纤维定性分析系统鉴别

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-hui Zheng Bo Shao chao-Min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Bibliometric Analysis of Global Research Progress on Coastal Flooding 1995–2016

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Chinese Geographical Science 2018年第6期28卷 998-1008页

作者： GAO chao ruan Tian Department of Geography & Spatial Information Techniques Ningbo University College of Territorial Resources and Tourism Anhui Normal University

Global research progress on coastal flooding was studied using a bibliometric evaluation of publications listed in the Web of Science extended scientific citation index. There was substantial growth in coastal flooding research output, with increasing publications, a higher collaboration index, and more references during the 1995–2016 period. The USA has taken a dominant position in coastal flooding research, with the US Geological Survey leading the publications ranking. Research collaborations at institutional scales have become more important than those at global scales. International collaborative publications consistently drew more citations than those from a single country. Furthermore, coastal flooding research included combinations of multi-disciplinary categories, including ‘Geology' and ‘Environmental Sciences & Ecology'. The most important coastal flooding research sites were wetlands and estuaries. While numerical modeling and 3 S(Remote sensing, RS; Geography information systems, GIS; Global positioning systems, GPS) technology were the most commonly used methods for studying coastal flooding, Lidar gained in popularity. The vulnerability and adaptation of coastal environments, their resilience after flooding, and ecosystem services function showed increases in interest.

关键词： coastal flood scientific outputs bibliometric analysis research trends Web of Science

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Floor positioning method indoors with smartphone’s barometer

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Geo-Spatial Information Science 2019年第2期22卷 138-148,I0006页

作者： Min Yu Feng Xue chao ruan Hang Guo College of Computer Information and Engineering Jiangxi Normal UniversityNanchangChina Institute of Space Science and Technology Nanchang UniversityNanchangChina

This paper presents an indoor floor positioning method with the smartphone’s barometer for the purpose of solving the problem of low availability and high environmental dependence of the traditional floor positioning ***,an initial floor position algorithm with the“entering”detection algorithm has been ***,the user’s going upstairs or downstairs activities are identified by the characteristics of the air pressure ***,the moving distance in the vertical direction and the floor change during going upstairs or downstairs are estimated to obtain the accurate floor *** order to solve the problem of the floor misjudgment from different mobile phone’s barometers,this paper calculates the pressure data from the different cell phones,and effectively reduce the errors of the air pressure estimating the elevation which is caused by the heterogeneity of the mobile *** experiment results show that the average correct rate of the floor identification is more than 85%for three types of the cell phones while reducing environmental dependence and improving ***,this paper compares and analyzes the three common floor location methods–the WLAN Floor Location(WFL)method based on the fingerprint,the Neural Network Floor Location(NFL)methods,and the Magnetic Floor Location(MFL)method with our *** experiment results achieve 94.2%correct rate of the floor identification with Huawei mate10 Pro mobile phone.

关键词： Floor positioning smartphone’s barometer sensor calibration indoor location service

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Energy and Laplacian of fractal interpolation functions

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Applied Mathematics(A Journal of Chinese Universities) 2017年第2期32卷 201-210页

作者： LI Xiao-hui ruan Huo-jun School of Mathematical Science Zhejiang UniversityHangzhou 310027China.

Abstract. In this paper, we first characterize the finiteness of fractal interpolation functions （FIFs） on post critical finite self-similar sets. Then we study the Laplacian of FIFs with uniform vertical scaling factors on the Sierpinski gasket （SG）. As an application, we prove that the solution of the following Dirichlet problem on SG is a FIF with uniform vertical scaling factor 1/5 ：△=0 on SG ／ {q1, q2, q3}, and u（qi）=ai, i = 1, 2, 3, where qi, i=1, 2, 3, are boundary points of SG.

关键词： Dirichlet problem fractal interpolation function Sierpinski gasket energy Laplacian.

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Movement History of the Microcontinents from the Tibetan Plateau Based on Paleomagnetic Results with Sufficient Sampling Units

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Journal of Earth Science 2022年第5期33卷 1072-1080页

作者： Yiming Ma Weimin ruan chao Niu Tianshui Yang School of Earth Sciences China University of GeosciencesWuhan 430074China College of Earth Sciences Guilin University of TechnologyGuilin 541004China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China

Paleomagnetic results cannot be applied in global and regional tectonic reconstructions unless the paleosecular variation has been adequately ***,how many sampling sites and samples are enough to calculate a reliable paleopole remains *** on the relation among the sampling sites N,the precision parameter k,the virtual geomagnetic pole scatter s,and the confidence limit A_(95) of the paleopole,we find that 20 sites(samples)or more are required to yield a paleopole with an A_(95)≈5°based on a review of available paleomagnetic results from the Lhasa,Qiangtang and Tethyan *** samplings of Jurassic virtual geomagnetic poles from the Sangri area show that the Fisher mean pole with neglectable angle deviation can be obtained when sampling sites increase to ***-quality paleomagnetic results,with sites/samples number N/n≥~20–30,show that the Qiangtang,Lhasa,and Tethyan Himalaya moved northward in the Late Permian–Middle Triassic,Jurassic,and Cretaceous,respectively,and then accreted to Asia in the Late Triassic,Late Jurassic–Early Cretaceous and Paleocene–Early Eocene,respectively.

关键词： paleolatitude evolution Fisher mean random sampling sampling sites and samples continental collision tectonics

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Triple plasmon-induced transparency and outstanding slow-light in quasi-continuous monolayer graphene structure

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Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 61-71页

作者： CuiXiu Xiong hui Xu MingZhuo Zhao Baihui Zhang chao Liu Biao Zeng Kuan Wu BanXian ruan Min Li HongJian Li School of Physics and Electronics Central South UniversityChangsha410083China All-solid-state Energy Storage Materials and Devices Key Laboratory of Hunan Province College of Information and Electronic EngineeringHunan City UniversityYiyang413000China School of Mathematics and Statistics Hunan University of Technology and BusinessChangsha410205China

We propose a simple quasi-continuous monolayer graphene structure and achieve a dynamically tunable triple plasmon-induced transparency(PIT)effect in the proposed *** analyses indicate that the proposed structure contains a selfconstructed bright-dark-dark mode system.A uniform theoretical model is introduced to investigate the spectral response characteristics and slow light-effects in the proposed system,and the theoretical and the simulated results exhibit high *** addition,the influences of the Fermi level and the carrier mobility of graphene on transmission spectra are *** is found that each PIT window exhibits an independent dynamical adjustability owing to the quasi-continuity of the proposed ***,the slow-light effects are investigated based on the calculation of the group refractive index and phase *** is found that the structure displays excellent slow-light effects near the PIT windows with high-group indices,and the maximum group index of each PIT window exceeds 1000 when the carrier mobility of graphene increases to 3.5 m^2 V^-1s^-*** proposed structure has potential to be used in multichannel filters,optical switches,modulators,and slow-light ***,the established theoretical model lays a theoretical basis for research on multimode coupling effects.

关键词： monolayer graphene structure plasmon-induced transparency slow light

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Simulation Study on Hydrogen-Heating-Power Poly-Generation System based on Solar Driven Supercritical Water Biomass Gasification with Compressed Gas Products as an Energy Storage System

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Journal of Thermal Science 2020年第2期29卷 365-377页

作者： JIN hui WANG Cui FAN chao State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong UniversityXi'an 710049China

Supercritical water gasification driven by solar energy is a promising way for clean utilization of biomass with high moisture content, but direct discharge of liquid residual causes energy waste and decreases energy efficiency. To reduce energy waste, a poly-generation system for hydrogen-rich gas production coupling heat supply and power generation based on supercritical water gasification of biomass driven by concentrated solar energy was established in this paper, which also provided a novel energy storage method to overcome the shortcomings of solar discontinuity. Thermodynamic model of the system was proposed and life cycle assessment(LCA) of the system was conducted. Influence of different parameters(temperature of 600℃ to 800℃, outlet temperature of heat exchanger of 42℃ to 56℃, biomass slurry concentration of 5% to 6.5%) on the gasification performance, energy and exergy efficiency, energy distribution and global warming potential(GWP) was discussed. The results indicated that hydrogen yield increased as gasification temperature increased since free radical reaction was enhanced which gas production reaction was classified into. Molar fraction of hydrogen increased as gasification temperature increased and reached 65.6% at 750℃. Energy and exergy efficiency of the system reached 74.84% and 34.87% at 700℃ and 600℃ respectively and that of gas production was 18.15% at 650℃, which was the highest. Increasing reaction temperature and decreasing biomass slurry concentration were effective ways to decrease GWP. Optimal operating parameter was reaction temperature of 650℃, outlet temperature of heat exchanger of 50℃ and biomass concentration of 5%.

关键词： biomass supercritical water gasification poly-generation system thermodynamics analysis energy storage life cycle assessment

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