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Plant regeneration in the new era:from molecular mechanisms to biotechnology applications

Science China(Life Sciences) 2024年第7期67卷 1338-1367页

作者： Chunli Chen Yuxin Hu Momoko Ikeuchi Yuling Jiao Kalika Prasad Ying Hua Su Jun Xiao Lin Xu weibing Yang Zhong Zhao Wenkun Zhou Yun Zhou Jian Gao Jia-wei Wang National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China College of Life Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of Sciences(CAS)China National Botanical GardenBeijing 100093China Division of Biological Sciences Graduate School of Science and TechnologyNara Institute of Science and TechnologyNara 630-0192Japan State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Center for Quantitative BiologyAcademy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Indian Institute of Science Education and Research Pune 411008IndiaThiruvananthapuram 695551India State Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai’an 271018China Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology(IGDB)CASBeijing 100101China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) IGDBCASBeijing 100101China National Key Laboratory of Plant Molecular Genetics CEMPSInstitute of Plant Physiology and Ecology(SIPPE)CASShanghai 200032China CEPAMS SIPPECASShanghai 200032China Hefei National Laboratory for Physical Sciences at the Microscale CEMPSSchool of Life SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Botany and Plant Pathology and Center for Plant Biology Purdue UniversityWest Lafayette 47907USA School of Life Science and Technology Shang

Plants or tissues can be regenerated through various *** animal regeneration,cell totipotency and pluripotency are the molecular basis of plant *** systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant ***,plant hormones,cell division,epigenetic remodeling,and transcription factors play crucial roles in reprogramming somatic cells and reestablishing meristematic *** research on basal non-vascular plants and monocot crops has revealed that plant regeneration differs among species,with various plant species using distinct mechanisms and displaying significant differences in regenerative *** multi-omics studies at the single-cell level,tracking plant regeneration processes in real-time,and deciphering the natural variation in regenerative capacity will ultimately help understand the essence of plant regeneration,improve crop regeneration efficiency,and contribute to future crop design.

关键词： apical meristem model species regeneration phytohormone plant cell reprogramming somatic embryogenesis

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基于组合赋权—集对分析法的混凝土坝巡检综合评价

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水电能源科学 2024年第5期42卷 131-134,67页

作者：刘蕙徐世媚黄耀英方卫华三峡大学水利与环境学院湖北宜昌443002 广东粤电南水发电有限责任公司广东韶关512000 水利部南京水利水文自动化研究所江苏南京210000

鉴于模糊性巡视检查记录和指标权重赋值存在主观性的问题制约着水库大坝巡视检查信息综合评价的可靠性,首先针对巡视检查部位和内容,提出了较为全面的巡视检查状况评价体系;然后划分了巡视检查状况等级并设计了各评价指标的评分标准;进... 详细信息

鉴于模糊性巡视检查记录和指标权重赋值存在主观性的问题制约着水库大坝巡视检查信息综合评价的可靠性,首先针对巡视检查部位和内容,提出了较为全面的巡视检查状况评价体系;然后划分了巡视检查状况等级并设计了各评价指标的评分标准;进而提出采用组合赋权—集对分析法的巡视检查综合评价模型;最后将该综合评价模型应用于某混凝土坝巡视检查状况评价中。结果表明,模型计算得到的巡视检查状况与实际情况基本吻合,表明该评价模型合理、可行。

关键词：混凝土坝巡视检查评价体系评价模型组合赋权

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清代满语文的使用发展与满汉文化交融

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满语研究 2024年第1期 17-24页

作者：魏巧燕黑龙江大学满学研究院

满语在清代被称为“国语”“清语”,清朝统治者提出的“国语骑射”政策对满族具有重要意义。纵观有清一代，清代满语文的使用发展历经几次重大历史变革，从满文的创制到规范再到满语文使用的衰落，反映了满族在对待满语发展、运用，乃... 详细信息

满语在清代被称为“国语”“清语”,清朝统治者提出的“国语骑射”政策对满族具有重要意义。纵观有清一代，清代满语文的使用发展历经几次重大历史变革，从满文的创制到规范再到满语文使用的衰落，反映了满族在对待满语发展、运用，乃至满语语言体系的基本看法，而满语满文的濒危推动满族融入中华民族的进程。

关键词：清代满语文语言态度满汉文化

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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi Tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng Yu Tingting Ai wei Zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

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Chidamide plus prednisone,cyclophosphamide,and thalidomide for relapsed or refractory peripheral T-cell lymphoma:A multicenter phase II trial

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Chinese Medical Journal 2024年第13期137卷 1576-1582页

作者： Jinhua Liang Li Wang Xiaodong Wang Guohui Cui Jianfeng Zhou Tongyao Xing Kaixin Du Jingyan Xu Luqun Wang Rong Liang Biyun Chen Jian Cheng Haorui Shen Jianyong Li wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China Department of Hematology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of Medicine of University of Electronic Science and Technology of ChinaChengduSichuan 610000China Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Hematology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsu 210008China Department of Hematology Qilu Hospital of Shandong UniversityJinanShandong 250000China Department of Hematology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China Department of Hematology Fujian Provincial HospitalFuzhouFujian 350001China Department of Hematology Zhongda HospitalMedical School of Southeast UniversityNanjingJiangsu 210009China

Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfactory—particularly for relapsed or refractory(R/R)*** phase II trial was designed to explore the efficacy and safety of an all-oral regimen of chidamide plus prednisone,cyclophosphamide,and thalidomide(CPCT)for R/R PTCL patients who could not tolerate the standard chemotherapy for a variety of ***:We conducted a multicenter phase II clinical trial in which we combined chidamide(30 mg twice weekly)with prednisone(20 mg daily after breakfast),cyclophosphamide(50 mg daily after lunch),and thalidomide(100 mg daily at bedtime)(the CPCT regimen)for a total of fewer than 12 cycles as an induction-combined treatment period,and then applied chidamide as single-drug ***-five patients were ultimately enrolled from August 2016 to April 2021 with respect to Chinese patients at nine *** primary objective was to assess the overall response rate(ORR)after the treatment with ***:Of the 45 enrolled patients,the optimal ORR and complete response(CR)/CR unconfirmed(CRu)were 71.1%(32/45)and 28.9%(13/45),respectively,and after a median follow-up period of 56 months,the median progression-free survival(PFS)and overall survival(OS)were 8.5 months and 17.2 months,*** five-year PFS and OS rates were 21.2%(95%confidence interval[CI],7.9-34.5%)and 43.8%(95%CI,28.3-59.3%),*** most common adverse event was neutropenia(20/45,44.4%),but we observed no treatment-related ***:The all-oral CPCT regimen was an effective and safe regimen for R/R PTCL patients who could not tolerate standard chemotherapy for various *** Registration:***,NCT02879526.

关键词： Peripheral T-cell lymphoma Chidamide Prednisone Cyclophosphamide Thalidomide All-oral regimen

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考虑电动汽车和5G基站的电力-信息-交通耦合网络需求响应策略

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电力系统自动化 2024年第7期48卷 116-126页

作者：张巍祝童童苏瑾上海理工大学机械工程学院上海市200093

电动汽车(EV)是具有移动负荷和通信用户双重属性的主体,为充分挖掘其参与需求响应产生的可调度潜力并降低电网负荷波动,提出了电力-信息-交通网络耦合背景下EV和5G基站需求响应策略。首先,分析了EV和5G基站参与下的多网络耦合关系。其次... 详细信息

电动汽车(EV)是具有移动负荷和通信用户双重属性的主体,为充分挖掘其参与需求响应产生的可调度潜力并降低电网负荷波动,提出了电力-信息-交通网络耦合背景下EV和5G基站需求响应策略。首先,分析了EV和5G基站参与下的多网络耦合关系。其次,建立了EV集群和5G基站集群的灵活性模型。基于此模型,提出了两阶段需求响应优化调度策略:第1阶段以通信成本最小为目标,为EV提供充电导航和路径规划并优化基站用能模式;第2阶段以配电网负荷波动最小为目标,制定EV的充放电策略。最后,通过某城市交通模型的测试,分析了调度策略对基站运行、配电网负荷、潮流和用户的影响,验证了模型和方法的有效性。

关键词：电动汽车(EV) 5G基站充电站多网络耦合需求响应

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Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)Mo5}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-Lun Wu Jing Du Hai-Ying Zhang Ming-Jun Hou Qiao-Yue Li wei-Chao Chen Kui-Zhan Shao Bo Zhu Chao Qin Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)Mo5}motifs through optimizing the molar ratio of Mo/W,including[Gd_(2)Mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{Mo_(124)W_(14)},1),[Mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{Mo_(126)W_(14)}n,2),and[Mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{Mo_(124)W_(14)}n,3).Such important{(W)Mo5}structural motif brings new reactivity into gigantic Mo blue *** are different numbers and sites of{Mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via Mo-O-Mo covalent bonds driven by{Mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels Mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

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液体火箭发动机尾焰金属发射光谱仿真与实验研究

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推进技术 2024年第2期45卷 105-113页

作者：苏童雷庆春范玮西北工业大学动力与能源学院陕西西安710072

液体火箭发动机尾焰包含丰富的光谱信息,可以作为检测发动机运行状态与故障情况的重要依据。本文建立了高精度的液体火箭发动机尾焰金属发射光谱数值模拟方法,该方法以逐线法(Line-by-Line,LBL)为基础,考虑介质的光学厚度影响。利用该方... 详细信息

液体火箭发动机尾焰包含丰富的光谱信息,可以作为检测发动机运行状态与故障情况的重要依据。本文建立了高精度的液体火箭发动机尾焰金属发射光谱数值模拟方法,该方法以逐线法(Line-by-Line,LBL)为基础,考虑介质的光学厚度影响。利用该方法,对液体火箭发动机发生故障时,尾焰中可能存在的铁、镍、钾发射光谱进行了数值模拟,模拟结果与NASA光谱模拟程序所得结果相吻合。最后,在甲烷-氧气、乙烯-氧气预混火焰开展了铁、钾发射光谱的实验验证,结果表明,以光谱面积与特征峰强度为对比参数,光谱模拟结果和实验结果的相对误差在2.5%以下,利用实验数据,进一步讨论了光学薄和光学厚两种模型的适用性。

关键词：液体火箭发动机原子发射光谱数值模拟光学厚度逐线法

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A genetic variant in the immune-related gene ERAP1 affects colorectal cancer prognosis

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Chinese Medical Journal 2024年第4期137卷 431-440页

作者： Danyi Zou Yimin Cai Meng Jin Ming Zhang Yizhuo Liu Shuoni Chen Shuhui Yang Heng Zhang Xu Zhu Chaoqun Huang Ying Zhu Xiaoping Miao Yongchang wei Xiaojun Yang Jianbo Tian Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Epidemiology and Biostatistics School of Public HealthTaiKang Center for Life and Medical SciencesWuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubei 430071China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhanHubei 430071China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430071China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Sciences and TechnologyWuhanHubei 430030China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjingJiangsu 211166China

Background:Findings on the association of genetic factors and colorectal cancer(CRC)survival are limited and inconsistent,and revealing the mechanism underlying their prognostic roles is of great *** study aimed to explore the relationship between functional genetic variations and the prognosis of CRC and further reveal the possible ***:We first systematically performed expression quantitative trait locus(eQTL)analysis using The Cancer Genome Atlas(TCGA)***,the Kaplan-Meier analysis was used to filter out the survival-related eQTL target genes of CRC patients in two public datasets(TCGA and GSE39582 dataset from the Gene Expression Omnibus database).The seven most potentially functional eQTL single nucleotide polymorphisms(SNPs)associated with six survival-related eQTL target genes were genotyped in 907 Chinese CRC patients with clinical prognosis *** regulatory mechanism of the survival-related SNP was further confirmed by functional ***:The rs71630754 regulating the expression of endoplasmic reticulum aminopeptidase 1(ERAP1)was significantly associated with the prognosis of CRC(additive model,hazard ratio[HR]:1.43,95%confidence interval[CI]:1.08-1.88,P=0.012).The results of dual-luciferase reporter assay and electrophoretic mobility shift assay showed that the A allele of the rs71630754 could increase the binding of transcription factor 3(TCF3)and subsequently reduce the expression of *** results of bioinformatic analysis showed that lower expression of ERAP1 could affect the tumor immune microenvironment and was significantly associated with severe survival ***:The rs71630754 could influence the prognosis of CRC patients by regulating the expression of the immune-related gene *** Registration:***00454519(https://***/)

关键词： Colorectal cancer Prognosis Genetic variation Quantitative trait loci TCF3 rs71630754 Single nucleotide polymorphisms

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海洋自升式钻井平台加装推进系统适用性计算分析

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船海工程 2024年第4期53卷 113-117页

作者：冯明常双利黄聪聪韩伟吕会敏中海油田服务股份有限公司天津300450

分析对比适用于自升式平台推进系统的优缺点,并对3种不同船型的自升式平台进行水动力计算,设计推进系统布置方案。推进系统校核结果表明,各平台推进器布置方案均能满足给定海况条件下DP 1级动力定位要求,平台可实现短距离助航和辅助就... 详细信息

分析对比适用于自升式平台推进系统的优缺点,并对3种不同船型的自升式平台进行水动力计算,设计推进系统布置方案。推进系统校核结果表明,各平台推进器布置方案均能满足给定海况条件下DP 1级动力定位要求,平台可实现短距离助航和辅助就位。结合平台实际使用情况,设计推进器共享方案,以提高平台加装推进器的经济性。

关键词：钻井平台推进器水动力动力定位推进器共享

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