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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-hui tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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耳穴压豆联合磁刺激治疗产后压力性尿失禁临床观察

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中国中医药现代远程教育 2025年第2期23卷 108-110页

作者：何艳唐慧潜江市中心医院产科湖北潜江433199

目的探究耳穴压豆联合磁刺激治疗产后压力性尿失禁的效果。方法选取潜江市中心医院2021年1月—2022年6月收治的产后压力性尿失禁患者60例作为研究对象,按照治疗方式的不同分为对照组、研究组,各30例。对照组予耳穴压豆治疗,研究组予耳... 详细信息

目的探究耳穴压豆联合磁刺激治疗产后压力性尿失禁的效果。方法选取潜江市中心医院2021年1月—2022年6月收治的产后压力性尿失禁患者60例作为研究对象,按照治疗方式的不同分为对照组、研究组,各30例。对照组予耳穴压豆治疗,研究组予耳穴压豆联合磁刺激治疗。比较两组临床疗效及治疗后盆底肌力、60 min漏尿量、3 d漏尿次数、生活质量评分。结果研究组治疗总有效率为96.67%(29/30),高于对照组的80.00%(24/30)(P<0.05)。治疗后,研究组盆底肌肌力、生活质量评分均高于对照组,60 min漏尿量、3 d漏尿次数均低于对照组(P<0.05)。结论耳穴压豆联合磁刺激治疗产后压力性尿失禁的临床效果显著,不仅能够缓解盆底肌肌力、降低漏尿量及漏尿次数,还能促进产妇生活质量提高,缓解焦虑、降低压力,值得临床推广使用。

关键词：产后压力性尿失禁耳穴压豆疗法磁刺激疗法

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Revisiting the Model of Servicing Machines with Repairable Service Facility-A New Analyzing Idea and Some New Results

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 557-566页

作者： Ying-hui tang School of Fundamental Education Sichuan Normal UniversityChengdu 610066China School of Mathematics and Software Science Sichuan Normal UniversityChengdu 610066China

In this paper the model of servicing machines with repairable facility is further *** standard conditioning decomposition argument,two reliability indices-the probability that the service facility fails at time t and the expected number of failure occurring during（0,t] are *** important relations of them are ***,some new reliability problems are presented and discussed as follows：1） The numbers of the service facility failures during the generalized service time and the generalized busy period;2） The asymptotic expansion of the expected failure number of the service facility during（0,t].A series of new reliability results of the service facility are obtained.

关键词： Repairable service facility reliability index failure number breakdown

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Nanoscale Reorganization of Glutamate Receptors Underlies Synaptic Plasticity and Pathology

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Neuroscience Bulletin 2024年第6期40卷 840-844页

作者： Jia-hui Chen Ai-hui tang Hefei National Laboratory for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseNeurodegenerative Disorder Research Center and Biomedical Sciences and Health Laboratory of Anhui ProvinceUniversity of Science and Technology of ChinaHefei230027China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei230088China

Excitatory synapses serve as the primary sites for information transmission between neurons in the *** work over the past decades has identified and revealed multiple compositions and functions of the synaptic proteome in the postsynaptic density(PSD),including receptors,scaffold proteins,and signaling molecules,which work together to ensure stable and effective synaptic transmission.

关键词： Receptor scale Glutamate

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Deep reinforcement learning in fluid mechanics:A promising method for both active flow control and shape optimization

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Journal of Hydrodynamics 2020年第2期32卷 234-246页

作者： Jean Rabault Feng Ren Wei Zhang hui tang hui Xu Department of Mathematics University of OsloOsloNorway Research Center of Fluid Structure Interactions Department of Mechanical Engineering Hong Kong Polytechnical UniversityHong KongChina Science and Technology on Water Jet Propulsion Laboratory Marine Design and Research Institute of ChinaShanghai200011China School of Aeronautic and Astronautic Shanghai Jiao Tong UniversityShanghai200011China Department of Aeronautics Imperial College LondonLondonUK

In recent years,artificial neural networks(ANNs)and deep learning have become increasingly popular across a wide range of scientific and technical fields,including fluid *** it will take time to fully grasp the potentialities as well as the limitations of these methods,evidence is starting to accumulate that point to their potential in helping solve problems for which no theoretically optimal solution method is *** is particularly true in fluid mechanics,where problems involving optimal control and optimal design are ***,such problems are famously difficult to solve effectively with traditional methods due to the combination of non linearity,non convexity,and high dimensionality they *** contrast,deep reinforcement learning(DRL),a method of optimization based on teaching empirical strategies to an ANN through trial and error,is well adapted to solving such *** this short review,we offer an insight into the current state of the art of the use of DRL within fluid mechanics,focusing on control and optimal design problems.

关键词： Machine learning deep reinforcement learning(DRL) flow control

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Active flow control using machine learning:A brief review

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Journal of Hydrodynamics 2020年第2期32卷 247-253页

作者： Feng Ren Hai-bao Hu hui tang Research Center for Fluid-Structure Interactions Department of Mechanical EngineeringThe Hong Kong Polytechnic UniversityHong KongChina School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an710072China

Nowadays the rapidly developing artificial intelligence has become a key solution for problems of diverse disciplines,especially those involving big *** in these areas also attract researchers from the community of fluid mechanics,especially in the field of active flow control(AFC).This article surveys recent successful applications of machine learning in AFC,highlights general ideas,and aims at offering a basic outline for those who are interested in this specific *** this short review,we focus on two methodologies,i.e.,genetic programming(GP)and deep reinforcement learning(DRL),both having been proven effective,efficient,and robust in certain AFC problems,and outline some future prospects that might shed some light for relevant studies.

关键词： Active flow control(AFC) machine learning genetic programming(GP) deep reinforcement learning(DRL)

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Differences between lower extremity joint running kinetics captured by marker-based and markerless systems were speed dependent

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Journal of Sport and Health Science 2024年第4期13卷 569-578页

作者： hui tang Barry Munkasy Li Li Department of Health Sciences and Kinesiology Georgia Southern UniversityStatesboroGA 30458USA Department of Kinesiology and Health Education University of Texas at AustinAustinTX 78712USA

Background:The development of computer vision technology has enabled the use of markerless movement tracking for biomechanical *** research has reported the feasibility of markerless systems in motion analysis but has yet to fully explore their utility for capturing faster movements,such as *** studies using markerless systems in clinical and sports settings are still ***,the present study compared running biomechanics estimated by marker-based and markerless *** running speed not only affects sports performance but is also associated with clinical injury prevention,diagnosis,and rehabilitation,we aimed to investigate the effects of speed on the comparison of estimated lower extremity joint moments and powers between markerless and marker-based technologies during treadmill running as a concurrent validating ***:Kinematic data from marker-based/markerless technologies were collected,along with ground reaction force data,from 16 young adults running on an instrumented treadmill at 3 speeds:2.24 m/s,2.91 m/s,and 3.58 m/s(5.0 miles/h,6.5 miles/h,and 8.0 miles/h).Sagittal plane moments and powers of the hip,knee,and ankle were calculated by inverse dynamic *** series analysis and statistical parametric mapping were used to determine system ***:Compared to the marker-based system,the markerless system estimated increased lower extremity joint kinetics with faster speed during the swing phase in most ***:Despite the promising application of markerless technology in clinical settings,systematic markerless overestimation requires focused *** on segment pose estimations,the centers of mass estimated by markerless technologies were farther away from the relevant distal joint centers,which led to greater joint moments and powers estimates by markerless ***-based *** differences were amplified by running speed.

关键词： Biomechanics Motion capture Gait Statistical parametric mapping

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Precipitation and stability of reversed austenite in 9Ni steel

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International Journal of Minerals,Metallurgy and Materials 2010年第5期17卷 587-595页

作者： Yue-hui Yang Qing-wu Cai Di tang hui-bin Wu Research Institute of Metallurgical Engineering University of Science and Technology Beijing Beijing 100083 China

A new method was used to analyze the factors affecting the precipitation of reversed austenite during tempering. The samples were kept at various tempering temperatures for 10 min and their length changes were recorded. Then, the precipitation of reversed austenite which led to the length reduction was shown by thermal expansion curves. The results show that the effects of process parameters on the precipitation of reversed austenite can be determined more accurately by this method than by X-ray diffraction. When the quenching and tempering process is adopted, both the lower quenching temperature and higher tempering temperature can promote the precipitation of reversed austenite during tempering; and when the quenching, lamellarizing, and tempering process is used, intercritical quenching is considered beneficial to the precipitation of reversed austenite in the subsequent tempering because of Ni segregation during holding at the intercritical temperature.

关键词： cryogenic equipment low carbon steel reversed austenite precipitation stability thermal expansion measurement

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The Recursive Solution for Geom/G/1(E,SV) Queue with Feedback and Single Server Vacation

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Acta Mathematicae Applicatae Sinica 2011年第1期27卷 155-166页

作者： Chuan-yi Lu Ying-hui tang School of Economic Mathematics Southwestern University of Finance and Economics Chengdu 610074 China School of Mathematics and Software Science Sichuan Normal University Chengdu 610066 China

Using recursive method, this paper studies the queue size properties at any epoch n＋ in Geom/G/ I（E, SV） queueing model with feedback under LASDA （late arrival system with delayed access） setup. Some new results about the recursive expressions of queue size distribution at different epoch （n＋, n, n-） are obtained. Furthermore the important relations between stationary queue size distribution at different epochs are discovered. The results are different from the relations given in M/G/1 queueing system. The model discussed in this paper can be widely applied in many kinds of communications and computer network.

关键词： Discrete time queue feedback single server vacation recursive expression

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Bridge detection method for HSRRSIs based on YOLOv5 with a decoupled head

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International Journal of Digital Earth 2023年第1期16卷 113-129页

作者： Mulan Qiua Liang Huang Bo-hui tang Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunmingPeople’s Republic of China Key Laboratory of Plateau Remote Sensing Yunnan Provincial Department of EducationKunmingPeople’s Republic of China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijingPeople’s Republic of China

The different imaging conditions of high spatial resolution remote sensing images(HSRRSIs)tend to cause large differences in the background information of bridges from the images,including problems of difficult detection of multiscale bridges,leakage of small bridges and insufficient detection accuracy for their *** address these problems,a YOLOv5 network with a decoupled head for the automatic detection of bridges in HSRRIs is proposed in this ***,the problem of inconsistent scale of information fusion of each feature in the feature pyramid network is solved using a weighted bi-directional feature pyramid network(BiFPN).Then,the convolutional block attention module(CBAM)is fused into the three effective feature layers after feature pyramid network *** bridge feature information is effectively extracted from the channel and spatial ***,the decoupled head is fused in the YOLO Head to separate the classifier and regressor to speed up the network convergence and improve the network detection accuracy ***,the practical effect is evaluated by calculating the average precision(AP).According to the experimental results,the AP of the proposed method is 98.1%,which is improved by 4.1%∼23.5%compared with other models.

关键词： HSRRIs bridge detection BiFPN CBAM feature fusion decoupled head

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