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Vasculopathy in dermatomyositis

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Chinese Medical Journal 2024年第2期137卷 247-249页

作者： hui Xu Jie qian Department of Rheumatology Affiliated Hospital of Nantong UniversityNantongJiangsu 226001China

To the Editor:Dermatomyositis(DM)is a rare autoimmune disease characterized by specific cutaneous manifestations and proximal muscle weakness,in which abnormalities of nailfold capillary(NFC)and serum levels of vascular biomarkers are *** changes in vascular lesions play an important role in the occurrence and development of DM and reflect the disease activity and treatment *** to the diversity of clinical manifestations in DM patients,vascular involvement is often under-evaluated,causing the treatment of refractory vascular damage *** review aims to explore the mechanisms,clinical manifestations,and treatment options of vasculopathy in DM to achieve early recognition and improve prognosis.

关键词： involvement clinical myositis

Submerged fermentation improves bioactivity of mulberry fruits and leaves

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Chinese Herbal Medicines 2021年第4期13卷 565-572页

作者： hui qian Chuah Pei Ling Tang Ni Jing Ang hui Yin Tan Department of Bioscience Faculty of Applied SciencesTunku Abdul Rahman University CollegeSetapak 53300Kuala LumpurMalaysia

Objective:Mulberry(Morus spp.)fruits and leaves have been proven to possess nutraceutical *** to its fast and easy growing characteristics,mulberry fruits(MF)and leaves(ML)potentially emerge as a great source of functional *** study aims to enhance bioactivities(antioxidant,antiinflammation,and hypoglycemic activity)of MF and ML via submerged fermentation using bacteria(Lactobacillus plantarum TAR 4),yeast(Baker’s yeast and red yeast)and fungi(Tempeh and Tapai starter).Methods:In this study,25%(mass to volume ratio)of MF and ML were fermented(48 h)with 1%(mass to volume ratio)of different microbial cultures,*** of different fermentations on MF and ML were determined based on the changes of total phenolics(TPC),flavonoids(TFC),anthocyanins,total sugar,DPPH activity,ferric reducing antioxidant power(FRAP),albumin denaturation inhibition activity(ADI),anti-lipoxygenase activity and a-amylase inhibition activity(AI).Results:Generally,ML had higher AI than ***,MF exhibited higher DPPH,FRAP and antilipoxygenase activity than *** all forms of fermentation,DPPH and AI activity of MF and ML were increased significantly(P<0.05).However,the effects of fermentation on TPC,FRAP,ADI and antilipoxygenase activity of MF were in contrast with ***,FRAP and anti-lipoxygenase activity of ML were enhanced,but reduced in MF after *** the effects exerted by different microorganisms in MF and ML fermentation were different,the bioactivities of MF and ML were generally improved after *** by Tempeh starter enhanced TPC(by 2-fold),FRAP(by 2.3-fold),AI(at 10%increment)and anti-lipoxygenase activity(by 5-fold)of ML,whereas Tapai fermentation effectively enhanced the DPPH(at 17%increment)and ADI(by 2-fold)activity of ***:Findings of this study provide an insight into the future process design of MF and ML processing into novel functional foods.

关键词： anti-inflammation activity antioxidant activity fermentation hypoglycemic activity mulberry fruits mulberry leaves

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动态校深在水力喷砂射孔中的应用

内蒙古石油化工 2024年第8期50卷 103-106页

作者：田树波张倩慧罗举杜东元徐子元胜利油田康贝石油工程装备有限公司石油工程技术研究院中石化石油工程地球物理有限公司华东分公司

传统水力喷砂射孔施工时，由于校深和射孔时管柱处于不同状态，容易导致射孔偏差。为改善这一现状，开展了动态校深技术理论分析和实践，并详细阐述了动态校深具体的实施步骤和计算公式，通过总结、分析6口井施工数据，对比静态、动态... 详细信息

传统水力喷砂射孔施工时，由于校深和射孔时管柱处于不同状态，容易导致射孔偏差。为改善这一现状，开展了动态校深技术理论分析和实践，并详细阐述了动态校深具体的实施步骤和计算公式，通过总结、分析6口井施工数据，对比静态、动态校深结果可以看出，在相同管柱组合(4-1/2"套管+2-7/8"平式油管)下，射孔管柱轴向的平均伸长量为7.4cm/km,并对施工数据进行归纳拟合，建立了基于动态校深法的射孔管柱轴向形变量数学模型。案例中通过MIC40+MDC43联合测井，进一步验证了动态校深的精确性。研究结论对于进一步提高水力喷砂射孔精度具有一定的指导意义。

关键词：水力喷砂射孔动态校深轴向形变

成年近视患者眼轴长度与眼部生物学特征的相关性研究

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临床医学研究与实践 2024年第23期9卷 25-28页

作者：钱会薛劲松纪玉珂蒋沁陈楠南京医科大学附属眼科医院江苏南京210029

目的对比不同眼轴长度(AL)成年近视患者的眼部生物学测量结果,探讨AL与其他眼部生物学参数之间的相关性。方法收集2021年1月至12月在我院就诊的413例(826眼)成年近视患者的病例资料,根据AL分为四组:A组(102眼)AL<24 mm,B组(181眼)AL 24~... 详细信息

目的对比不同眼轴长度(AL)成年近视患者的眼部生物学测量结果,探讨AL与其他眼部生物学参数之间的相关性。方法收集2021年1月至12月在我院就诊的413例(826眼)成年近视患者的病例资料,根据AL分为四组:A组(102眼)AL<24 mm,B组(181眼)AL 24~<25 mm,C组(288眼)AL 25~<26 mm,D组(255眼)AL≥26 mm。测量所有患者的AL、平均角膜曲率(Km)、角膜曲率半径(CR)、前房深度(ACD)、中央角膜厚度(CCT),计算AL/CR。比较不同AL近视患者眼部生物学测量结果的差异;并采用Pearson相关或Spearman秩相关分析AL与其他眼部生物学参数的相关性。结果四组患者的Km、AL/CR、ACD、SE及CCT比较,差异具有统计学意义(P<0.001)。Pearson相关性分析结果显示,AL与AL/CR、ACD呈正相关(r=0.607、0.359,P<0.001);AL与Km呈负相关(r=-0.658,P<0.001)。Spearman相关分析结果显示,AL与SE呈负相关(r=-0.656,P<0.001);AL与CCT呈正相关(r=0.145,P<0.001)。结论AL与近视患者眼部生物学参数相关,随着AL的增长,Km降低,AL/CR增加,ACD变深,SE降低,CCT增厚。

关键词：近视眼轴长度眼轴长度与角膜曲率半径比值眼部生物学参数

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Prevalence, diagnosis, and treatment of primary hepatic gastrointestinal stromal tumors

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World Journal of Gastroenterology 2020年第40期26卷 6195-6206页

作者： Xiao-hui qian Ying-Cai Yan Bing-qiang Gao Wei-Lin Wang Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310009Zhejiang ProvinceChina Research Center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of Zhejiang Province Hangzhou 310009Zhejiang ProvinceChina Clinical Medicine Innovation Center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of Zhejiang University Hangzhou 310009Zhejiang ProvinceChina Clinical Research Center of Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou 310009Zhejiang ProvinceChina

Gastrointestinal stromal tumors(GIST), which is the most common mesenchymal tumor of the digestive tract, account for 1%-3% of gastrointestinal tumors. Primary stromal tumors outside the gastrointestinal tract are collectively referred to as extra GISTs, and stromal tumors in different regions often have different prognoses. A primary hepatic GIST is a rare tumor with an unknown origin, which may be related to interstitial Cajal-like cells. Although primary hepatic GIST has certain characteristics on imaging, it lacks specific symptoms and signs;thus, the final diagnosis depends on pathological and genetic evidence. This review summarizes all cases of primary hepatic GIST described in the literature and comprehensively analyzes the detailed clinical data of all patients. In terms of treatment, local resection alone or with adjuvant therapy was the prioritized choice to obtain better disease-free survival and longer survival time. For advanced unresectable cases, imatinib mesylate was applied as the first-line chemotherapy agent. Moreover, transcatheter arterial chemoembolization,/by-nc/4.0/Manuscript source: Unsolicited manuscript radiofrequency ablation, and microwave ablation were shown to improve overall survival for selected patients. Liver transplantation was a final treatment option after resistance to chemotherapy developed.

关键词： Extra gastrointestinal stromal tumor Treatment Liver transplant Review

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顶空气相色谱法测定包书皮中有机溶剂残留

中国检验检测 2024年第2期32卷 73-76,95页

作者：王爱霞高丽钱辉陈松辉花露王林萍泰州市产品质量监督检验院/国家精细化学品质量检验检测中心泰州225300

建立了一种用于包书皮中常见有机溶剂残留量的顶空气相色谱检测方法。采用DB-624色谱柱(30m×320μm×1.8μm)分离,氢火焰离子化检测器(FID)检测,顶空进样器平衡时间为35min,平衡温度为90℃;初始温度35℃保持6min,以10℃/min的速度升至6... 详细信息

建立了一种用于包书皮中常见有机溶剂残留量的顶空气相色谱检测方法。采用DB-624色谱柱(30m×320μm×1.8μm)分离,氢火焰离子化检测器(FID)检测,顶空进样器平衡时间为35min,平衡温度为90℃;初始温度35℃保持6min,以10℃/min的速度升至60℃,保持5min,再以20℃/min的速度升至220℃,保持3min;检测器温度:250℃;进样口温度:220℃;载气:氮气;流速:1.0mL/min;外标法定量。结果表明:有机溶剂残留量在0.125~2.5mg/m^(2)范围内峰面积与质量浓度呈线性,线性相关系数(R2)均大于0.999,目标物的定量限(LOQ,S/N=10)为0.009~0.031mg/m^(2)。加标平均回收率为78.30%~111.99%;相对标准偏差(RSD)为0.57%~9.47%。该方法操作具有方便快捷、灵敏度高、稳定性好及回收率高等特点,适用于包书皮中有机溶剂残留的检测,具有实际应用价值。

关键词：顶空气相色谱有机溶剂残留量包书皮

济南济泺路穿黄隧道典型粉质黏土HSS模型参数获取及适用性

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科学技术与工程 2024年第17期24卷 7260-7268页

作者：杨州孙文昊张亮亮李亚楠傅金阳孙前辉中南大学土木工程学院长沙410075 中铁第四勘察设计院集团有限公司武汉430063 黄河勘测规划设计研究院有限公司郑州450003

盾构施工过程中土体大部分区域处于小应变状态,与常用的本构模型的土体性质有所不同。因此,为研究济南济泺路穿黄隧道区域内典型粉质黏土的的静动力行为特性及工程适用性,通过室内基础土工试验、侧限固结试验、标准三轴固结试验以及动... 详细信息

盾构施工过程中土体大部分区域处于小应变状态,与常用的本构模型的土体性质有所不同。因此,为研究济南济泺路穿黄隧道区域内典型粉质黏土的的静动力行为特性及工程适用性,通过室内基础土工试验、侧限固结试验、标准三轴固结试验以及动三轴试验,确定了粉质黏土基本物理性质参数以及切线刚度E_(oed)^(ref)、割线模量E_(50)^(ref)、卸载/重加载参考刚度E_(ur)^(ref),并将所得参数应用于济南济泺路穿黄隧道工程下穿北岸大堤沉降分析中,同时通过对比应用硬化土小应变硬化(hardening soil model with small strain stiffness,HSS)本构模型、摩尔库伦(M-C)本构模型的模拟结果与现场实测结果,验证了HSS本构模型在该地区变形分析中的准确性。结果表明:围压一定时,该地区粉质黏土试样竖向应变以塑性应变为主,且随动应力的增加,土体达到稳定所需时间越长;循环荷载一定时,增大土体围压可提高土体的稳定性;基于室内试验获取的HSS本构模型参数模拟的济南济泺路穿黄隧道下穿大堤工程地层变形结果与现场实测值吻合良好,验证了基于所提出的室内试验获取岩土小应变相关参数方法的适用性。研究成果可以丰富济南黄河地区粉质黏土地层参数研究,并为该地区岩土工程数值模拟分析的本构模型与地层参数选取提供参考。

关键词：粉质黏土 HSS模型室内试验适用性

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高温雷达吸波涂层研究进展

航空发动机 2024年第3期50卷 17-32页

作者：高雨毅李千慧韩擎之肖杰何雯婷郭洪波北京航空航天大学材料科学与工程学院北京100191 高温结构材料与涂层技术工业和信息化部重点实验室北京100191

在现代信息化战争中,探测和制导技术迅猛发展。在众多探测信号中,雷达探测占比高达60%,因此武器装备雷达隐身能力尤其重要。随着新一代装备性能的提升,热端部件的服役温度不断升高,对高温雷达吸波涂层提出了更加严苛的要求。在高温服役... 详细信息

在现代信息化战争中,探测和制导技术迅猛发展。在众多探测信号中,雷达探测占比高达60%,因此武器装备雷达隐身能力尤其重要。随着新一代装备性能的提升,热端部件的服役温度不断升高,对高温雷达吸波涂层提出了更加严苛的要求。在高温服役环境下,部分雷达吸波材料存在氧化、居里温度低而失去吸波性能的问题。高温雷达吸波材料主要依靠介电损耗和电导损耗机制实现对电磁波的损耗吸收。基于此,综述了以碳化物、硼化物、氧化物、金属材料、MAX相材料为吸波剂的高温雷达吸波涂层研究情况,分析了各材料的优势及存在的问题,其中氧化物吸波剂高温稳定性好,易于制备,成本低,其吸波性能可通过掺杂改性调控,是面向未来更加严苛服役环境下更具应用潜力的吸波材料。此外,还从梯度结构和超材料设计2个角度分析了涂层结构设计在拓宽涂层吸波频带,降低涂层厚度方面的作用。结合当前研究进展提出了新材料研发、新结构设计和与材料结构相适应的制备工艺研究是未来高温雷达吸波涂层的发展方向。

关键词：雷达吸波高温涂层吸波机制结构设计吸波剂高温隐身材料

Adaptive sampling approach based on Jensen-Shannon divergence for efficient reliability analysis

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Journal of Central South University 2021年第8期28卷 2407-2422页

作者： CHEN Liang-jun HONG Yu Sujith MANGALATHU GOU Hong-ye PU qian-hui Department of Bridge Engineering School of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China National Engineering Laboratory for Technology of Geological Disaster Prevention in Land Transportation Southwest Jiaotong UniversityChengdu 611756China Research Scientist Equifax IncA lpharetta 30309USA

Extensive studies have been carried out for reliability studies on the basis of the surrogate model,which has the advantage of guaranteeing evaluation accuracy while minimizing the need of calling the real yet complicated performance ***,one novel adaptive sampling approach is developed for efficiently estimating the failure ***,one innovative active learning function integrating with Jensen-Shannon divergence(JSD)is derived to update the Kriging model by selecting the most suitable sampling *** improving the efficient property,one trust-region method receives the development for reducing computational burden about the evaluation of active learning function without compromising the ***,a termination criterion based on uncertainty function is introduced to achieve better robustness in different situations of failure *** developed approach shows two main merits:the newly selected sampling points approach to the area of limit state boundary,and these sampling points have large ***,three case analyses receive the conduction for demonstrating the developed approach s feasibility and *** with Monte Carlo simulation or other active learning functions,the developed approach has advantages in terms of efficiency,convergence,and accurate when dealing with complex problems.

关键词： reliability Monte Carlo Kriging model Jensen-Shannon divergence trust-region