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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-hui jiang hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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三峡水库微塑料与悬沙的聚集特性及作用机制

湖泊科学 2025年第1期37卷 149-158页

作者：刘洁张智超李霞朱丽帆蒋晖重庆交通大学国家内河航道工程技术研究中心重庆400074 重庆交通大学河海学院重庆400074

本文依据三峡库区悬沙矿物组成和泥沙级配为依据配置沙样,选择长江上游典型微塑料PMMA和PS,在自制大型水箱中开展水流剪切作用下微塑料和泥沙异质聚集实验,分析微泥絮团的形态特征和聚集机制。结果表明在水流紊动剪切作用下,相比泥沙同... 详细信息

本文依据三峡库区悬沙矿物组成和泥沙级配为依据配置沙样,选择长江上游典型微塑料PMMA和PS,在自制大型水箱中开展水流剪切作用下微塑料和泥沙异质聚集实验,分析微泥絮团的形态特征和聚集机制。结果表明在水流紊动剪切作用下,相比泥沙同质聚集的絮团粒径,微泥异质聚集的絮团粒径更大,且每毫升样品中微泥絮团上的微塑料吸附数量随水流剪切率增大而迅速增加。扫描电镜和能谱分析结果表明,在水动力条件下泥沙与PMMA、PS微球发生异质聚集,聚集过程中存在电子转移和化学态的转变,并产生不饱和键(C C)。由于PMMA官能团的结合能变化比PS大,此过程失电子更多、表面电荷更大,更容易与泥沙发生聚集。

关键词：微塑料悬沙微泥絮团形貌聚集机制三峡水库

Large and moderate Ornstein-Uhlenbeck deviations in testing process with linear drift

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Frontiers of Mathematics in China 2016年第2期11卷 291-307页

作者： hui jiang Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016 China

This paper studies hypothesis testing in the Ornstein-Ulenbeck process with linear drift. With the help of large and moderate deviations for the log-likelihood ratio process, the decision regions and the corresponding... 详细信息

关键词： Hypothesis testing large deviations log-likelihood ratio process,moderate deviations Ornstein-Uhleneck (O-U) process

Filling up complex spectral regions through non-Hermitian disordered chains

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Chinese Physics B 2022年第5期31卷 1-9页

作者： hui jiang Ching Hua Lee Department of Physics National University of SingaporeSingapore 117551Republic of Singapore

Eigenspectra that fill regions in the complex plane have been intriguing to many,inspiring research from random matrix theory to esoteric semi-infinite bounded non-Hermitian *** this work,we propose a simple and robust ansatz for constructing models whose eigenspectra fill up generic prescribed *** approach utilizes specially designed non-Hermitian random couplings that allow the co-existence of eigenstates with a continuum of localization lengths,mathematically emulating the effects of semi-infinite *** some of these couplings are necessarily long-ranged,they are still far more local than what is possible with known random matrix *** ansatz can be feasibly implemented in physical platforms such as classical and quantum circuits,and harbors very high tolerance to imperfections due to its stochastic nature.

关键词： non-Hermitian skin effect disordered chain disorder localization non-Hermitian spectra

Expression of cell cycle regulator p57^(kip2), cyclinE protein and proliferating cell nuclear antigen in human pancreatic cancer: An immunohistochemical study

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World Journal of Gastroenterology 2005年第32期11卷 5057-5060页

作者： hui Yue hui-Yong jiang Institute for Digestive Medicine Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China Department of Pathology Nanfang Hospital Southern Medical University Guangzhou 510515 Guangdong Province China

AIM： To investigate the effects of p57^kip2, cyclinE protein and proliferating cell nuclear antigen （PCNA） on occurrence and progression of human pancreatic cancer. METHODS： The expression of p57^kip2, cyclinE protein and PCNA in tumor tissues and adjacent tissues from 32 patients with pancreatic cancer was detected by SP immunohistochemical technique. RESULTS： The positive expression rate of p57^kip2 protein in tumor tissues was 46.9%, which was lower than that in adjacent pancreatic tissues （χ^2 = 5.317, P〈0.05）. p57^kip2 protein positive expression remarkably correlated with tumor cell differentiation （P〈0.05）, but not with lymph node metastasis （P〉0.05）. The positive expression rate of cyclinE protein in tumor tissues was 68.8%, which was higher than that in adjacent pancreatic tissues （χ^2 = 4.063, P〈0.05）. CyclinE protein positive expression significantly correlated with tumor cell differentiation and lymph node metastasis （P〈0.05）. The positive expression rate of PCNA in the tumor tissues was 71.9%, which was higher than that in adjacent pancreatic tissues （χ^2 = 5.189, P〈0.05）. PCNA positive expression remarkably correlated with tumor cell differentiation and lymph node metastasis （P〈0.05）. CONCLUSION： The decreased expression of p57^kip2 and/or overexpression of cyclinE protein and PCNA may contribute to the occurrence and progression of pancreatic cancer. p57^kip2, cyclinE protein, and PCNA play an important role in occurrence and progression of pancreatic cancer.

关键词： p57^kip2 CyclinE PCNA Human pancreatic cancer

ANALYSIS ON AGRICULTRUAL INFORMATION DEMAND——Case of Jilin Province

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Chinese Geographical Science 2005年第3期15卷 281-287页

作者： ZHANG hui-min jiang hui-ming Northeast Institute of Geography and Agricultural Ecology Chinese Academy of Sciences Changchun 130012 P. R. China Managerial College Jilin Agricultural University Changchun 130118 P. R. China

With the rapid development of agricultural informalization in the world, the demand of agricultural information has been a focus in the international agriculture and information fields. Based on the investigation, this paper presented the four characteristics of the demand of agricultural information in China, includingregionality, seasonality, great potential demand and variation in kind and level. The factors infuencing the demand of agricultural information were analyzed by the Optimized Less Square （OLS） method. The result shows that, of all factors influcing agricultural information demand, the most important one is economy, the second is facility of information pass, and knowledge and education of user, credit of agricultural information service system and production situation follow. Taking Jilin Province as an example, this article also elaborated the agricultural information demand status, and deduced the regression model of agricultural information demand and verified it by the survey in rural Jilin.

关键词： agricultural information demand agricultural information service system Jilin Province

Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-hui jiang Wei-Dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

Deviation inequalities for quadratic Wiener functionals and moderate deviations for parameter estimators

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Science China Mathematics 2017年第7期60卷 1181-1196页

作者： GAO FuQing jiang hui School of Mathematics and Statistics Wuhan University Wuhan 430072 China Hubei Key Laboratory of Computational Science Wuhan University Wuhan 430072 China Department of Mathematics Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

We study deviation inequalities for some quadratic Wiener functionals and moderate deviations for parameter estimators in a linear stochastic differential equation ***,we give some estimates for Laplace integrals of the quadratic Wiener functionals by calculating the eigenvalues of the associated HilbertSchmidt *** applying the estimates,we establish deviation inequalities for the quadratic functionals and moderate deviation principles for the parameter estimators.

关键词： quadratic Winer functional Laplace integral moderate deviations parameter estimator

Design of dual metal ions/dual amino acids integrated photoluminescent logic gate by high-molecular weight protein-localized Au nanoclusters

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Nano Research 2018年第1期11卷 311-322页

作者： Liu Liu hui jiang Xuemei Wang State Key Laboratory of Bioelectronics School of BiologicaI Science and Medical Engineering Southeast University Nanjing 210096 China

Proteins are excellent templates and stabilizers for Au nanoclusters （NCs） because of their abundant thiol groups and unique internal environments. However, high-molecular weight （MW） proteins with special quaternary structures are rarely reported as such templates. Considering that proteins may afford different spatial configurations as templates for Au NCs, we focused on alkaline phosphatase, catalase, and fibrinogen （MW range from 150 to 340 kDa） as direct templates for synthesizing Au NCs. We demonstrated that both Cu2~ and Hg2~ could induce photoluminescence （PL） quenching of these Au NCs, while their binding mech- anisms were different. Therefore, significant PL recovery by amino acids, e.g., histidine and cysteine, was observed for Cu2＋-treated Au NCs, but not Hg2＋-treated Au NCs, allowing for selective detection of Hg2＋ by using histidine as a masking agent. The detection ranges were 0.06-2.0 DM for Hg2＋ and 0.04-5.0 DM for Cu2＋, with low limits of detection of 0.02 and 0.01μM, respectively. The PL change showed opposite tendency for histidine and cysteine at higher concentrations, resulting in different PL outputs. Using dual metal ion and dual amino acid combinations, an integrated PL logic gate was fabricated. This work improves the understanding of the PL mechanisms of complicated protein-localized Au NCs.

关键词： gold nanoclusters proteins logic gate metal ions amino acids