检索结果-南通市图书馆

Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhipeng Zhang Binyan Wang Yu Wang Xiangyi Kong Yong Sun Aimin Li Yimin Cui Yan Zhang Jianping Li Yong Huo hui huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quorum Sensing:An Emerging Role for Vibrio Infection and Host Defense

引用

Infectious Microbes & Diseases 2024年第2期6卷 47-55页

作者： Hao-Nan Lin Xian-hui huang Xin-Jun Miao Wei-Lin Hu Yong-Liang Lou Dan-Li Xie The School of Laboratory Medicine&Life Sciences Wenzhou Medical UniversityWenzhouChina Key Laboratory of Laboratory Medicine Ministry of Education of ChinaWenzhouChina Wenzhou Key Laboratory of Sanitary Microbiology WenzhouChina Department of Emergency Wenzhou Central HospitalWenzhouZhejiangChina Department of Microbiology School of MedicineZhejiang UniversityHangzhouChina Zhuji Institute of Biomedical Research School of PharmacyWenzhou Medical UniversityZhujiChina

Quorum sensing(QS)is a mechanism that allows bacteria to regulate various physiological and biochemical functions by secreting,sensing and responding to signaling molecules called autoinducers(AIs).In Vibrio species,QS plays a crucial role in modulating different biological *** can influence the formation of biofilms,which are communities of bacteria encased in a protective *** also controls flagella formation and motility,ensuring that Vibrio *** move efficiently in response to environmental ***ally,QS in Vibrio *** the production of different virulence factors based on cell *** enables the bacteria to adjust their virulence strategies accordingly,enhancing *** also influences the interaction between Vibrio *** their ***ing infection by Vibrio spp.,QS can affect the host immune response and colonization *** the role of QS in these interactions is crucial for unraveling the complex dynamics between Vibrio *** the *** summary,research on QS in Vibrio *** revealed its significance in regulating various biological phenotypes,controlling virulence factor production and affecting host de*** provides valuable insights into the intricate mechanisms underlying microbial behavior,host adaptation and Vibrio ***.

关键词： quorum sensing Vibrio species biological phenotype bacterial virulence host defense

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

环境工程技术的未来——颠覆性创新视角（英文）

引用

Engineering 2024年第10期41卷 153-160页

作者： hui huang Junjie Lu Lili Jin Hongqiang Ren State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University

Scientific and technological revolutions and industrial transformations have accelerated the rate of innovation in environmental engineering ***,few researchers have evaluated the current status and future trends of *** paper summarizes the current research status in eight major subfields of environmental engineering-water treatment,air pollution control,soil/solid waste management,environmental biotechnology,environmental engineering equipment,emerging contaminants,synergistic reduction of pollution and carbon emissions,and environmental risk and intelligent management-based on bibliometric analysis and future trends in greenization,low carbonization,and *** technologies are further identified based on discontinuous transformation,and ten such technologies are proposed,covering general and specific fields,technical links,and value ***,the background and key innovations in disruptive technologies are elucidated in *** study not only provides a scientific basis for strategic decision-making,planning,and implementation in the environmental engineering field but also offers methodological guidance for the research and determination of breakthrough technologies in other areas.

关键词： Environmental engineering technology Disruptive innovation Bibliometric analysis Discontinuous transformation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Convenient room-temperature synthesis of sulfur and nitrogen co-doped NiCo-LDH coupled with CNTs on NiCo foam as battery-type electrode for high performance hybrid supercapacitor

引用

Rare Metals 2024年第9期43卷 4286-4301页

作者： Li Song Xiao-Hong Zhong Fang-Lin Wang Zhi-hui huang Zhe Hong Yun-Fang Gao Hai-Dong Wang Jian-Wei Ren Sheng-Jie Peng Lei Li College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Research and Development Department Jiangxi Ganfeng LiEnergy Technology Co.Ltd.Xinyu 338000China Department of Mechanical Engineering Science University of JohannesburgAuckland ParkJohannesburg 2092South Africa

The convenient synthesis of the composite electrode with high supercapacitance performance plays an important role in practical application but is ***,the carbon nanotubes(CNTs)coupled with lowcrystalline sulfur and nitrogen co-doped Ni Co-LDH(denoted as SN-Ni Co-LDH)nanosheets array are grown on Ni Co foam(NCF)substrate by two convenient steps of metal induced self-assembly and corrosion engineering,which present the advantages of operating at roomtemperature and low preparation *** from the S–N co-doping and low-crystallinity of Ni Co-LDH,the prepared SN-Ni Co-LDH@CNTs@NCF electrode presents a topping charge capacity of 2470 C·g^(-1)(4.94 C·cm^(-2))at 5 m A·cm^(-2).Furthermore,the fabricated asymmetry supercapacitor(ASC)achieves an extraordinary energy density of 77 Wh·kg^(-1)(0.617 m Wh·cm^(-2))at a power density of 438 W·kg^(-1)(3.5 m W·cm^(-2))and outstanding stability(91%capacity retention after 5000 cycles at20 m A·cm^(-2)).Impressively,the structure evolution of Ni Co-LDH during the charge/discharge processes has been thoroughly elucidated by in-situ Raman ***,this work verifies a powerful strategy and practical value for preparing composite electrodes with high supercapacitance performance,and also provides guidance for the rational design of the smart electrodes.

关键词： Supercapacitor NiCo-LDH Carbon nanotubes Sulfur and nitrogen co-doped Convenient synthesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sulfonated carbon dots modified IrO_(2)nanosheet as durable and high-efficient electrocatalyst for boosting acidic oxygen evolution reaction

引用

Nano Research 2024年第9期17卷 8017-8024页

作者： Mengjie Ma Wenxiang Zhu Fan Liao Kui Yin hui huang Kun Feng Dongdong Gao Jinxin Chen Zenan Li Jun Zhong Lai Xu Yang Liu Mingwang Shao Zhenhui Kang Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering(MIMSE) Macao University of Science and TechnologyTaipaMacao 999078China

Oxygen evolution reaction(OER)plays a crucial role in developing energy conversion and adjusting electronic structure of the electrocatalysts can effectively improve the catalytic activity and ***,it is a challenge to adjust the electronic structure on two-dimensional iridium dioxide nanosheets(IrO_(2)NS),which have the advantages of high atom ***,we regulate the surface properties of IrO_(2)NS through sulfonated carbon dots(SCDs)to promote the OER catalytic *** catalyst IrO_(2)NS/SCDs-2 exhibited excellent catalytic activity with a lower overpotential of 180 mV than IrO_(2)NS(230 mV)at the current density of 10 mA·cm^(-2)in a 0.5 M H_(2)SO_(4) *** after 160 h of stability testing,the overpotential of IrO_(2)NS/SCDs-2 only decreased by 4 ***,transient potential scanning test can visually demonstrate that the addition of SCDs improves the conductivity of the catalyst and increases the electron transfer rate.

关键词： sulfonated carbon dots oxygen evolution reaction electrocatalysis transient potential scanning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

冲突法中的选法意外规制

引用

法商研究 2024年第3期41卷 152-166页

作者：黄晖重庆大学法学院

不确定性是冲突法作为间接调整方法的内在属性,选法意外则是不确定性的一种极端形态。立法的空白、不明晰以及司法裁量的存在是选法意外的现实基础。作为冲突法理性之治产生的非理性结果,选法意外合法但不合理。选法意外应被规制,因其... 详细信息

不确定性是冲突法作为间接调整方法的内在属性,选法意外则是不确定性的一种极端形态。立法的空白、不明晰以及司法裁量的存在是选法意外的现实基础。作为冲突法理性之治产生的非理性结果,选法意外合法但不合理。选法意外应被规制,因其挑战了选法的纯粹理性、违背了立法的规范理性、削减了司法的实践理性并减损了主体的期待理性。由于选法意外是合法的,因此现有针对违法性问题设置的制度安排无法对其进行有效矫正;也因其独特性,故现有针对合理性问题设计的制度安排无法对其进行有效救济。为否定极端选法,排除最不合理的选法结果,有必要构建选法意外的规制方案。选法意外与冲突法具有共生关系,无法完全切割,相对合理且现实的对策是从原则、制度与规则3个层面进行限制,综合构建选法意外的阻断安排,将冲突法的选法结果限定在最不坏的选项之中。

关键词：冲突法选法期待选法意外法律规制选法排除

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论《反不正当竞争法》对未注册商标的保护——兼论《反不正当竞争法》与《商标法》的体系协调

引用

法商研究 2024年第5期41卷 185-200页

作者：黄汇西南政法大学民商法学院

对未注册商标进行保护不仅必要而且具有可行性。虽然《中华人民共和国反不正当竞争法》第2条和第6条尚因制度缺陷无法为未注册商标提供有效保护,但是通过革新一般条款的适用理念,科学重构“不正当竞争”概念,采用“不正当竞争界定+重点... 详细信息

对未注册商标进行保护不仅必要而且具有可行性。虽然《中华人民共和国反不正当竞争法》第2条和第6条尚因制度缺陷无法为未注册商标提供有效保护,但是通过革新一般条款的适用理念,科学重构“不正当竞争”概念,采用“不正当竞争界定+重点示例”的开放立法,可以增强反不正当竞争法对未注册商标保护的制度涵摄。同时前置性地在商标法中植入未注册商标系当事人财产的观念,强化对抢注行为的规制,可以增强适用反不正当竞争法对未注册商标所有人进行损害赔偿救济的力度,从而提高抢注违法成本,形成对其打击和预防的双重治理效果。结合商标法注册取得制度,合理划定反不正当竞争保护的逻辑边界,在科学化解未注册商标保护与注册效力规则冲突的同时,给予前者以合比例的救济与尊重,从而实现对未注册商标保护的必要性与合理性、全面性与谦抑性、前瞻性与针对性的有机统一。

关键词：反不正当竞争法商标法未注册商标体系协调制度重塑

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fine 3D control of THz emission in air with dual femtosecond laser pre-pulses at tunnelling ionisation regime

引用

Light(Advanced Manufacturing) 2024年第3期5卷 62-74页

作者： Hsin-hui huang Takeshi Nagashima Kota Kumagai Yoshio Hayasaki Saulius Juodkazis Vladimir T.Tikhonchuk Koji Hatanaka Optical Sciences Centre ARC Training Centre in Surface Engineering for Advanced Materials(SEAM)School of ScienceSwinburne University of TechnologyHawthornVictoria 3122Australia Faculty of Science and Engineering Setsunan University17-8 Ikeda-NakamachiNeyagawaOsaka572-8508Japan Center for Optical Research and Education(CORE) Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan WRH Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaKanagawa 226-8503 Japan Laser Research Center Physics FacultyVilnius UniversitySauletekio Ave.1010223 VilniusLithuania Centre Lasers Intenses et Applications Universite de Bordeaux351Cours de la Liberation33405 Talence cedexFrance Extreme Light Infrastructure ERIC ELI Beamlines FacilityZa Radnicic 83525241 Dolni BřežanyCzech Republic Organization for Research Strategy and Development Okayama Univ.1-1-1 Tsushima-nakaKita-kuOkayama 700-8530Japan

Emission of THz radiation from air breakdown at focused ultra-short fs-laser pulses(800 nm/35 fs)was investigated for the 3D spatio-temporal control where two pre-pulses are used before the *** laser pulse induced air breakdown forms a~120μm-long focal volume generate shockwaves which deliver a denser air into the focal region of the main pulse for enhanced generation of THz radiation at 0.1-2.5 THz spectral *** intensity of 162 pre-and main-pulses was at the tunnelling ionisation intensities(1-3)×10 W/cm and corresponded to sub-critical(transparent)plasma formation in *** analysis of THz radiation revealed that orientation of the air density gradients generated by pre-pulses and their time-position locations defined the ellipticity of the generated THz electrical *** rotational component of electric current is the origin of THz radiation.

关键词： THz radiation Femtosecond laser induced breakdown Air breakdown spatio-temporal control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overexpression of TRPV1 activates autophagy in human lens epithelial cells under hyperosmotic stress through Ca^(2+)-dependent AMPK/mTOR pathway

引用

International Journal of Ophthalmology(English edition) 2024年第3期17卷 420-434页

作者： Liu-hui huang Jiao Lyu Sheng Chen Ting-Yi Liang Yu-Qing Rao Ping Fei Jing Li Hai-Ying Jin Pei-Quan Zhao Department of Ophthalmology Shanghai Xinhua Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology Shanghai Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China Centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Ophthalmology Department of SurgeryUniversity of MelbourneEast MelbourneVictoria 3002Australia Shenzhen Eye Hospital Shenzhen Key Laboratory of OphthalmologyAffiliated Shenzhen Eye Hospital of Jinan UniversityShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

●AIM:To explore whether autophagy functions as a cellular adaptation mechanism in lens epithelial cells(LECs)under hyperosmotic stress.●METHODS:LECs were treated with hyperosmotic stress at the concentration of 270,300,400,500,or 600 mOsm for 6,12,18,24h in *** chain reaction(PCR)was employed for the mRNA expression of autophagyrelated genes,while Western blotting detected the targeted protein *** transfection of stub-RFP-sens-GFPLC3 autophagy-related double fluorescence lentivirus was conducted to detect the level of autophagy *** electron microscopy was used to detect the existence of *** interfering RNA of autophagy-related gene(ATG)7,transient receptor potential vanilloid(TRPV)1 overexpression plasmid,related agonists and inhibitors were employed to their influence on autophagy related *** cytometry was employed to test the apoptosis and intracellular Ca^(2+)*** membrane potential was measured by JC-1 *** cell counting kit-8 assay was used to calculate the cellular *** wound healing assay was used to evaluate the wound closure *** 6.0 software was utilized to evaluate the data.●RESULTS:The hyperosmotic stress activated autophagy in a pressure-and time-dependent manner in *** 1 protein expression and conversion of LC3B II to LC3B I increased,whereas sequestosome-1(SQSTM1)protein expression *** Ca^(2+)influx was stimulated caused by hyperosmotic stress,levels of mammalian target of rapamycin(mTOR)phosphorylation decreased,and the level of AMP-activated protein kinase(AMPK)phosphorylation increased in the early *** on this evidence,autophagy activation through the Ca^(2+)-dependent AMPK/mTOR pathway might represent an adaptation process in LECs under hyperosmotic *** stress decreased cellular viability and accelerated apoptosis in LECs and cellular migration *** of autophagy by ATG7 knockdown had sim

关键词： cataract posterior capsular opacification lens epithelial cell hyperosmotic stress autophagy apoptosis transient receptor potential vanilloid 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultra-homogeneous dense Ag nano layer enables long lifespan solid-state lithium metal batteries

引用

Journal of Energy Chemistry 2024年第9期96卷 110-119页

作者： Yaning Liu Tianqi Yang Ruyi Fang Chengwei Lu Ruojian Ma Ke Yue Zhen Xiao Xiaozheng Zhou Wenkui Zhang Xinping He Yongping Gan Jun Zhang Xinhui Xia hui huang Xinyong Tao Yang Xia College of Materials Science and Engineering Zhejiang University of TechnologyHangzhou 310014ZhejiangChina Key Laboratory of Rare Earth Optoelectronic Materials and Devices of Zhejiang Province Institute of Optoelectronic Materials and DevicesChina Jiliang UniversityHangzhou 310018ZhejiangChina

The unstable electrolyte/lithium(Li)anode interface has been one of the key challenges in realizing high energy density solid-state lithium metal batteries(LMBs)***,a dense and uniform silver(Ag)nano interlayer with a thickness of∼35 nm is designed accurately by magnetron sputtering technology to optimize the electrolyte/Li anode *** Ag nano layer reacts with Li metal anode to in-situ form Li-Ag alloy,thus enhancing the physical interfacial contact,and further improving the interfacial wettability and *** particular,the Li-Ag alloy is inclined to form AgLi phase proved by cryo-TEM and DFT,effectively preventing SN from continuously“attacking”the Li metal anode due to the lower adsorption of succinonitrile(SN)molecules on AgLi than that of pure Li metal,thereby significantly reinforcing the interfacial ***,the enhanced physical and chemical stability of electrolyte/Li anode interface promotes the homogeneous deposition of Li^(+)and inhibits the dendrite *** Li-symmetric cell maintains stable operation for up to 1700 h and the cycling stability of LiFePO_(4)|SPE|Li full cell is remarkably improved at room temperature(capacity retention rate of 91.9%for 200 cycles).This work opens an effective way for accurate and controllable interface design of long lifespan solid-state LMBs.

关键词： Silvernano layer Poly(ethylene oxide) Solid polymer electrolyte Succinonitrile Lithium metal battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：