检索结果-南通市图书馆

Tumor microenvironment reprogramming by nanomedicine to enhance the effect of tumor immunotherapy

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 1-37页

作者： Yu Huang hui fan huihui Ti School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Province Precise Medicine Big Date of Traditional Chinese Medicine Engineering Technology Research Center Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

With the rapid development of the fields of tumor biology and immunology, tumor immunotherapy has been used in clinical practice and has demonstrated significant therapeutic potential, particularly for treating tumors that do not respond to standard treatment options. Despite its advances, immunotherapy still has limitations, such as poor clinical response rates and differences in individual patient responses, largely because tumor tissues have strong immunosuppressive microenvironments. Many tumors have a tumor microenvironment (TME) that is characterized by hypoxia, low pH, and substantial numbers of immunosuppressive cells, and these are the main factors limiting the efficacy of antitumor immunotherapy. The TME is crucial to the occurrence, growth, and metastasis of tumors. Therefore, numerous studies have been devoted to improving the effects of immunotherapy by remodeling the TME. Effective regulation of the TME and reversal of immunosuppressive conditions are effective strategies for improving tumor immunotherapy. The use of multidrug combinations to improve the TME is an efficient way to enhance antitumor immune efficacy. However, the inability to effectively target drugs decreases therapeutic effects and causes toxic side effects. Nanodrug delivery carriers have the advantageous ability to enhance drug bioavailability and improve drug targeting. Importantly, they can also regulate the TME and deliver large or small therapeutic molecules to decrease the inhibitory effect of the TME on immune cells. Therefore, nanomedicine has great potential for reprogramming immunosuppressive microenvironments and represents a new immunotherapeutic strategy. Therefore, this article reviews strategies for improving the TME and summarizes research on synergistic nanomedicine approaches that enhance the efficacy of tumor immunotherapy.

关键词： Tumor immunotherapy Tumor micr oenvir onment Nanomedicine Tumor repr ogramming

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spectral Fittings of Warm Coronal Radiation with High Seed Photon Temperature:Apparent Low-temperature and Flat Soft Excess in AGNs

引用

Research in Astronomy and Astrophysics 2024年第7期24卷 135-144页

作者： Ze-Yuan Tang Jun-Jie Feng Jun-hui fan School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China

A warm corona has been widely proposed to explain the soft excess(SE)in X-ray above the 2-10 ke V power law extrapolation in Active Galactic Nuclei(AGNs).In actual spectral fittings,the warm coronal seed photon temperature(T_s)is usually assumed to be far away from the soft X-ray,but kT_scan reach close to 0.1 ke V in the standard accretion disk *** this study,we used Monte Carlo simulations to obtain radiation spectra from a slab-like warm corona and fitted the spectra using the spherical-geometry-based routine THCOMP or a thermal *** findings reveal tha high T_scan influence the fitting results.A moderately high kT_s(around 0.03 ke V)can result in an apparent low-temperature and flat SE,while an extremely high kT_s(around 0.07 ke V)can even produce an unobserved blackbody-like *** conclusions indicate that,for spectral fittings of the warm coronal radiation(SE in AGNs),kT_sshould be treated as a free parameter with an upper limit,and an accurate coronal geometry is necessary when kT_s>0.01 ke V.

关键词： galaxies active-accretion-accretion disks-black hole physics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-area Frequency-constrained Unit Commitment for Power Systems with High Penetration of Renewable Energy Sources and Induction Machine Load

引用

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 754-766页

作者： Leibao Wang hui fan Jifeng Liang Longxun Xu Tiecheng Li Peng Luo Bo Hu Kaigui Xie the State Grid Hebei Electric Power Research Institute Shijiazhuang 050021China State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqing 400044China

The increasing penetration of renewable energy sources(RESs)brings great challenges to the frequency security of power *** traditional frequency-constrained unit commitment(FCUC)analyzes frequency by simplifying the average system frequency and ignoring numerous induction machines(IMs)in load,which may underestimate the risk and increase the operational *** this paper,we consider a multiarea frequency response(MAFR)model to capture the frequency dynamics in the unit scheduling problem,in which regional frequency security and the inertia of IM load are modeled with high-dimension differential algebraic equations.A multi-area FCUC(MFCUC)is formulated as mixed-integer nonlinear programming(MINLP)on the basis of the MAFR ***,we develop a multi-direction decomposition algorithm to solve the MFCUC *** original MINLP is decomposed into a master problem and *** subproblems check the nonlinear frequency dynamics and generate linear optimization cuts for the master problem to improve the frequency security in its optimal *** studies on the modified IEEE 39-bus system and IEEE 118-bus system show a great reduction in operational ***,simulation results verify the ability of the proposed MAFR model to reflect regional frequency security and the available inertia of IMs in unit scheduling.

关键词： Decomposition algorithm frequency response frequency-constrained unit commitment induction machine multi-area mixed-integer nonlinear programming(MINLP)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prediction of suitable water content in granulation of sintering mixture based on Litster's model

引用

Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： fang-lei Dai Xiao-hui fan Xiao-xian Huang Xu-ling Chen Min Gan Zhi-yun Ji Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of Litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

引用

Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu Lin Shen hui-fan Liu Xiang-hui Zou Juan Zhao Yu Huang Yu-fan Zhu Zhao-Yu Li Chao Xu Li-Hua Luo Zhi-Qiang Luo Min-Hao Wu Lin Cai Xiao-Kun Li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 ***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

引用

Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： Min Gan Hao-xiang Zheng Xiao-hui fan Zhi-yun Ji Qiang Li Ming Wu Yi-fan Wang Xiao-long Wang Yu-feng Wu Xu-ling Chen Zeng-qing Sun Xiao-xian Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Optical Variability Properties of TeV Blazars

引用

Research in Astronomy and Astrophysics 2024年第9期24卷 66-75页

作者： Zi-An Su Wen-Xin Yang Xiang-Tao Zeng Le-Jian Ou Ze-Lin Li Jiang-He Yang Jun-hui fan Department of Physics School of Physics and ElectronicsHunan Normal UniversityChangsha 410081China Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Greater Bay Brand Center of the National Astronomical Data Center Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China College of Microelectronics Feicuihu Campus of Hefei University of TechnologyHefei 230601China College of Mathematics and Physics Science Hunan University of Arts and ScienceChangde 415000China

Variability is one of the typical observational properties of blazars and the spectral changes are usually associated with variability,although this kind of association is unclear *** this work,we used data from the Steward Observatory blazar monitoring program to investigate the optical variability properties including the short-term timescale,the brightness-dependent spectral property,the correlation between the the brightness variation and the polarization,and then estimate the Doppler factors based on the obtained short timescale to study the polarization property for a sample of 20 TeV *** analyses arrive at the following results:(1)The largest variation amplitude in R-band,ΔR_(M),covers a range from ΔR_(M)=0.29 mag(1ES 2344+514)to ΔR_(M)=4.66 mag(3C 279).(2)Intra-day variability was found from five sources with timescales from 0.14 day for S50716+714 to 0.98 day for PKS *** sources show spectra that are bluer when they become brighter,suggesting a common bluer-when-brighter property.(3)The plot of the polarization versus estimated Doppler factor is consistent with the Doppler factor dependent formula of polarization.(4)The largest polarization is correlated with the largest optical variation,suggesting that the high polarization and high amplitude variation are both the indicator of beaming effect.

关键词： galaxies:active galaxies:jets radiation mechanisms:non-thermal

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Detachable string magnetically controlled capsule endoscopy for the noninvasive diagnosis of esophageal diseases:A prospective,blind clinical study

引用

World Journal of Gastroenterology 2024年第9期30卷 1121-1131页

作者： Yan-Ling Yang Huang-Wen Qin Zhao-Yu Chen hui-Ning fan Yi Yu Wei Da Jin-Shui Zhu Jing Zhang Department of Gastroenterology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200233China

BACKGROUND Traditional esophagogastroduodenoscopy(EGD),an invasive examination method,can cause discomfort and pain in *** contrast,magnetically controlled capsule endoscopy(MCE),a noninvasive method,is being applied for the detection of stomach and small intestinal diseases,but its application in treating esophageal diseases is not *** To evaluate the safety and efficacy of detachable string MCE(ds-MCE)for the diagnosis of esophageal *** Fifty patients who had been diagnosed with esophageal diseases were pros-pectively recruited for this clinical study and underwent ds-MCE and conven-tional *** primary endpoints included the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for patients with esophageal *** secondary endpoints consisted of visualizing the esophageal and dentate lines,as well as the subjects'tolerance of the *** Using EGD as the gold standard,the sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy of ds-MCE for esophageal disease detection were 85.71%,86.21%,81.82%,89.29%,and 86%,***-MCE was more comfortable and convenient than EGD was,with 80%of patients feeling that ds-MCE examination was very comfortable or comfortable and 50%of patients believing that detachable string v examination was very *** This study revealed that ds-MCE has the same diagnostic effects as traditional EGD for esophageal diseases and is more comfortable and convenient than EGD,providing a novel noninvasive method for treating esophageal diseases.

关键词： Clinical trial Detachable string magnetically controlled capsule endoscopy Esophagogastroduodenoscopy Noninvasive diagnosis Esophageal diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential distribution of fibrovascular proliferative membranes in 25-gauge vitrectomy for proliferative diabetic retinopathy

引用

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1462-1468页

作者： Nan Lu Shi-Lin Yang Shuo Guo Dong-Ni Yang Li Liu Chun-hui fan Ying Guo Jian Liu Wei Zhao Department of Ophthalmology the First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004Hebei ProvinceChina

AIM:To analyze the distribution of fibrovascular proliferative membranes(FVPMs)in proliferative diabetic retinopathy(PDR)patients that treated with pars plana vitrectomy(PPV),and to evaluate the outcomes ***:This was a retrospective and cross-sectional *** 25-gauge(25-G)PPV cases operated for PDR from May 2018 to April *** to the FVPMs images outlined after operations,subjects were assigned into three groups:arcade type group,juxtapapillary type group,and central type *** patients were followed up for over one *** characteristics,operation-related variables,postoperative parameters and complications were ***:Among 103 eyes recruited,the FVPMs distribution of nasotemporal and inferiosuperioral was significantly different(both P<0.01),with 95(92.23%)FVPMs located in the nasal quadrants,and 74(71.84%)in the *** eyes with a central FVPM required the longest operation time,with silicon oil used in most patients,generally combined with tractional retinal detachment(RD)and rhegmatogenous RD,the worst postoperative bestcorrected visual acuity(BCVA)and the highest rates of recurrent RD(all P<0.05).FVPM type,age of onset diabetes mellitus,preoperative BCVA,and combined with tractional RD and rhegmatogenous RD were significantly associated with BCVA improvement(all P<0.05).Compared with the central type group,the arcade type group had higher rates of BCVA ***:FVPMs are more commonly found in the nasal and inferior mid-peripheral retina in addition to the area of arcade *** 25-G PPV for treating PDR eyes with central FVPM have relatively worse prognosis.

关键词： proliferative diabetic retinopathy fibrovascular proliferative membrane 25-gauge pars plana vitrectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Probing the Gamma-Ray Emission Region of Five TeV Flat Spectrum Radio Quasars

引用

Research in Astronomy and Astrophysics 2024年第6期24卷 156-169页

作者： Hu-Bing Xiao Hai-Tao Cao Rui Xue Jin-Ting Cai Ge-Ge Wang Marina Manganaro Shao-Hua Zhang Zhi-Hao Ouyang Li-Ping Fu Jun-hui fan Shanghai Key Lab for Astrophysics Shanghai Normal UniversityShanghai 200234China School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou 511483China Department of Physics Zhejiang Normal UniversityJinhua 321004China College of Mathematics and Physics Guangxi Minzu UniversityNanning 530006China Key Laboratory of Cosmology and Astrophysics(Liaoning) College of SciencesNortheastern UniversityShenyang 110819China Department of Physics University of RijekaRijeka 51000Croatia Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Key Laboratory for Astronomical Observation and Technology of Guangzhou Guangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of Education of Guangdong Province Guangzhou 510006China

The location ofγ-ray emission of blazars remains a contested topic,inspiring the development of numerous investigative techniques to address this *** this work,we analyzed Fermiγ-ray light curves in the GeV and MeV bands,employing the discrete cross-correlation function method to discern time lags between the two *** 4C+21.35,Ton 599,B21420+32,and PKS 1510-089,we identified a time lag spanning several days,while for PKS 1441+25,the time lag was not statistically *** results imply that the soft photons necessary for inverse Compton scattering predominantly originate from the dusty torus in the first four sources,whereas for PKS1441+25,they seem to be sourced mainly from the broad-line *** analysis of the opacity(τγγ)and the GeV spectra study supports the conclusion that the location of the dissipation region must be beyond the BLR to avoid significant ***,for PKS 1441+25,the emission region is also posited to lie outside yet proximate to the *** parameters of describing the emission region were obtained by fitting broadband spectral energy distribution with contemporaneous observation *** findings suggest that for the five TeV FSRQs,during Te V flaring events,the jet appears to maintain an equilibrium between the energy density of the magnetic field and that of the particles for all investigated sources,with the exceptions of 4C+21.35 and PKS1441+*** terms of the overall jet power,particle energy is the dominant contributor,and the observed blazar radiation cannot be solely attributed to the magnetic field,except in the case of 4C+***,magnetic reconnection is unlikely to be the primary mechanism behind particle acceleration in these systems.

关键词： galaxies:active gamma-rays:galaxies galaxies:jets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：