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Efficacy,Safety and Characteristics of the Amplatzer Vascular Plug II and IV Utilization for Various Percutaneous Occlusions in Children under 10 Years

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Congenital Heart Disease 2022年第4期17卷 421-436页

作者： hugues lucron Alban-Elouen Baruteau Caroline Ovaert Ali Houeijeh Mélanie Brard Patrice Guerin François Bourlon Claire Dauphin Saskia Tuttle Maha Tagorti Rishika Banydeen François Godart Antilles-Guyane M3C Paediatric Cardiology Center University Hospital of MartiniqueFort-de-FranceFrance L’institut du Thorax INSERMCNRSUNIV NantesCHU NantesNantesFrance Department of Paediatric Cardiology and Pediatric Cardiac Surgery University Hospital of NantesNantesFrance Department of Paediatric and Congenital Heart Disease University Hospital of MarseilleMarseilleFrance Department of Paediatric and Congenital Heart Disease University Hospital of Lille-Nord de FranceLilleFrance Department of Paediatric and Congenital Heart Disease Cardiothoracic Center of MonacoMonaco Department of Paediatric and Congenital Heart Disease University Hospital of Clermont-FerrandClermont-FerrandFrance Clinical Research Department CHU Martinique(University Hospital of Martinique)Fort-de-FranceFrance

Objectives:We aim to describe the efficacy,safety,and characteristics of the Amplatzer Vascular Plug(AVP)II and IV“off-label”use for multiple cardiovascular occlusions in children under 10 ***:Observational retrospective multicenter(2007–2020,6 centers)review of paediatric procedures using AVP II or ***:A total of 125 children(49.6%aged≤1 year,147 lesions)underwent 136 successive procedures(success rate:98.5%)using 169 devices(109 AVP IV,60 AVP II).The mean device diameter was 7.7±3.2 mm(4–20 mm).The median AVP size to vessel diameter ratio was 1.3(0–2).The median age and weight at implantation were 1.0 year(0.01–9.98)and 8.4 kg(1–69).Procedures were heterogeneous(55 patent ductus arteriosus(PDA),28 collaterals,18 sequestrations,22 arteriovenous/veinovenous/coronary fistulas,6 vertical veins,6 conduits,5 ventricular septal defects,7 miscellaneous).Day 1 and 6-month occlusion rates were respectively 94.8%and 98.5%.Major adverse events(MAE)occurred in 5.2%of cases(no procedure-related deaths),and more frequently in weight≤5 kg(p=0.01),younger patients(p=0.03)during PDA closure(p=0.02)of tubular types(p=0.02)using larger devices(p=0.03)and AVP II(p=0.003).Independent predictor of MAE risk was a higher AVP diameter to patient weight ratio(Odds-ratio:2.33,95%confidence interval 1.31–4.13,p=0.004,optimal cut off:1.45).Conclusions:Both AVPs are safe and effective for percutaneous occlusions in children under *** devices represent an alternative“off label”use for well selected paediatric patients.

关键词： Amplatzer vascular plug(AVP)II and IV cardiovascular occlusions off-label use children under 10 years efficacy safety

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Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

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Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas hugues Yu Luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

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Biohydrometallurgy applied to exploitation of black shale resources： Overview of Bioshale FP6 European project

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中国有色金属学会会刊：英文版 2008年第6期18卷 1485-1490页

作者： P. D＇hugues P. SPOLAORE Bioshale Consortium BRGM EPI/Eco 3 Avenue C. Guillemin 45060 Orleans Cedex 2 France

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属... 详细信息

Bioshale 工程，由欧洲委员会(FP6 计划) 共同资助，在 2004 年 10 月开始了并且在 2007 年 10 月完成了。这个工程的主要目的是为黑页岩矿石的 eco 有效的利用定义创新 biotechnological 过程。黑页岩矿石包含贱、宝贵、高技术的金属而且有机物的高内容由常规技术的那缺陷金属恢复。三世界级黑人页岩沉积物被选择为 R&D 行动的目标。这些包括在自然条件下面存在的一沉积物(Talvivaara，芬兰) ，一个当前在过程(Lubin，波兰) 并且在采矿以后的(Mansfeld，德国) 。工作计划的主要技术方面能如下被总结：忍受金属的部件的地质的资源和选择的评估；为金属恢复要测试的生物协会的选择；对 bioprocessing 的评价发送，包括为金属恢复处理的 hydrometallurgical；包括社会、环境的影响的新过程的 techno 经济的评估。13 欧洲人获得的主要结果的概述合伙(从 8 个国家) 在这个完成的研究计划包含了在这个工作被给。

关键词：生物技术生物浸取矿石处理黑页岩

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Perspectives in human brain plasticity sparked by glioma invasion:from intraoperative(re)mappings to neural reconfigurations

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Neural Regeneration Research 2024年第5期19卷 947-948页

作者： Sam Ng hugues Duffau Guillaume Herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of Functional Genomics University of MontpellierCNRSINSERMMontpellierFrance Praxiling Laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative *** term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences

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Hardware-programmable optical networks

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Science China(Information Sciences) 2016年第10期59卷 21-32页

作者： Shuangyi YAN Emilio hugues-SALAS Yanni OU Reza NEJABATI Dimitra SIMEONIDOU High Performance Networks Group University of Bristol

For future multi-dimensional optical networks, vast network resources provided by space division multiplexing and wavelength division multiplexing technologies, require new network architectures to scale up current network functions. The huge switch-granularity range requires a more dynamic way to deploy network resources. In this paper, we proposed a hardware-programmable optical network which deploys network resources according to incoming traffic requests. The proposed network supports node function programmability and node architecture adaptability, which are critical for dynamic function and resources deployments. Architecture-onDemand based node architecture adapts node architectures and also enables network function programmability by incorporating with several flexible node functions. Other enabling technologies, such as ubiquitous power monitoring and dynamic optical power management, assures the programmable optical node work *** on all these technologies, we established a hardware-programmable optical network testbed. Several use cases were demonstrated successfully, such as dynamic power equalization and optical debugging. These work verified the feasibility of hardware-programmable optical network, which dynamically allocate network resources for service provision. The proposed hardware programmable optical network will lead to a better hardware utilization and provide a possible solution for the future multi-dimensional optical network.

关键词： optical networks flexibility network function programmability

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Supramolecular gating of guest release from cucurbit[7]uril using de novo design

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npj Computational Materials 2022年第1期8卷 172-179页

作者： hugues Lambert Alvaro Castillo Bonillo Qiang Zhu Yong-Wei Zhang Tung-Chun Lee Institute of High Performance Computing A*STAR1 Fusionopolis WayConnexis Tower138632SingaporeSingapore Department of Chemistry Christopher Ingold BuildingUniversity College London(UCL)20 Gordon StreetLondonWC1H 0AJUK Institute for Materials Discovery University College London(UCL)LondonUK Institute of Materials Research and Engineering A*STAR2 Fusionopolis WayInnovis Tower138634SingaporeSingapore

Herein we computationally explore the modulation of the release kinetics of an encapsulated guest molecule from the cucurbit[7]uril(CB7)cavity by ligands binding to the host *** uncovered a correlation between the ligand-binding affinity with CB7 and the guest residence time,allowing us to rapidly predict the release kinetics through straightforward energy minimization *** high-throughput predictions in turn enable a Monte-Carlo Tree Search(MCTS)to de novo design a series of cap-shaped ligand molecules with large binding affinities and boosting guest residence times by up to 7 orders of ***,halogenated aromatic compounds emerge as top-ranking *** modeling suggests the presence of halogen-bonding between the ligands and the CB7 ***,the binding of top-ranked ligands is supported by^(1)H NMR and 2D *** findings open up possibilities in gating of molecular transport through a nanoscale cavity with potential applications in nanopore technology and controlled drug release.

关键词： release kinetics straight

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The mechanism of auxin transport in lateral root spacing

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Molecular Plant 2021年第5期14卷 708-710页

作者： Jian Chen hugues De Gernier Alaeddine Safi Tom Beeckman Steffen Vanneste Department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium Centerfor Plant Systems Biology VIB9052 GhentBelgium Lab of Plant Growth Analysis Ghent University Global CampusIncheon 21985Republic of Korea Department of Plants and Crops Ghent University9000 GhentBelgium

Transport of the plant hormone auxin(lndole-3-acetic acid;IAA)is crucial to ensure proper growth *** particular,the regular spacing of lateral roots(LRs)is governed by intricate auxin movements and an internal oscillator,called the“root clock”(Xuan et al.,2020).Multiple auxin influx and efflux carriers have been characterized in the broad context of root development.

关键词： development. spacing

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Acoustic Characteristics of Changning Shale Core in Sichuan,China

Acoustic Characteristics of Changning Shale Core in Sichuan,...

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作者： Ondongo Dona Dailla de hugues 中国石油大学(北京)

学位级别：硕士

在中国,下志留统地层页岩气的勘探和开发主要集中在四川盆地的长宁、威远和涪陵等区块。观察发现,长宁页岩岩心层理面发育较好。通过对川南五峰组岩心的单轴和三轴压缩实验,开展层理面对页岩力学性质的影响的研究。结果表明:页岩具有较... 详细信息

在中国,下志留统地层页岩气的勘探和开发主要集中在四川盆地的长宁、威远和涪陵等区块。观察发现,长宁页岩岩心层理面发育较好。通过对川南五峰组岩心的单轴和三轴压缩实验,开展层理面对页岩力学性质的影响的研究。结果表明:页岩具有较强的各向异性。由于层理面的存在,在受压条件下,页岩的弹性参数、强度特征和断裂方式都受围压效应影响。因此,这在理论基础上就提供了井筒稳定性,且影响页岩井筒稳定性的因素有:机械水化特性、孔隙压力和地应力。

关键词：声学特征长宁页岩气机械水化特性

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GPS Water Vapor and Its Comparison with Radiosonde and ERA-Interim Data in Algeria

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Advances in Atmospheric Sciences 2017年第5期34卷 623-634页

作者： Houaria NAMAOUI Salem KAHLOUCHE Ahmed Hafid BELBACHIR Roeland Van MALDEREN hugues BRENOT Eric POTTIAUX Faculte de Physique Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf USTO-MB BP 1505 El M'naouer 31000 Oran Algerie Departement de Geodesie Spatiale Centre des Techniques Spatiales 31200 Arzew Algerie Royal Meteorological Institute of Belgium 1180 Uccle Belgium Royal Belgian Institute for Space Aeronomy 1180 Uccle Belgium Royal Observatory of Belgium 1180 Uccle Belgium

Remote sensing of atmospheric water vapor using global positioning system（GPS） data has become an effective tool in meteorology,weather forecasting and climate research. This paper presents the estimation of precipitable water（PW）from GPS observations and meteorological data in Algeria,over three stations located at Algiers,Bechar and *** objective of this study is to analyze the sensitivity of the GPS PW estimates for the three sites to the weighted mean temperature（T;）,obtained separately from two types of T;–T;regression [one general,and one developed specifically for Algeria（T;stands for surface temperature）],and calculated directly from ERA-Interim data. The results show that the differences in T;are of the order of 18 K,producing differences of 2.01 mm in the final evaluation of PW. A good agreement is found between GPS-PW and PW calculated from radiosondes,with a small mean difference with Vaisala radiosondes.A comparison between GPS and ERA-Interim shows a large difference（4 mm） in the highlands region. This difference is possibly due to the topography. These first results are encouraging,in particular for meteorological applications in this region,with good hope to extend our dataset analysis to a more complete,nationwide coverage over Algeria.

关键词： GPS atmospheric water vapor radiosonde ERA-Interim

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United under stress:High-speed transport network emerging at bacterial living edge

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Fundamental Research 2024年第3期4卷 563-569页

作者： Xiaodong Wen Jingjing Feng Yuqian Sang Feng Ge hugues Chaté Yan He Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTshinghua UniversityBeijing 100084China Service de Physique de l'Etat Condensé CEACNRSUniversitéParis-SaclayCEA-SaclayGif-sur-Yvette 91191France Beijing Computational Science Research Center Beijing 100094China

Individuals tend to move freely when there is enough room but would act collectively for their survival under external *** the case of living cells,for instance,when a drop of low-density flagellated bacterial solution is transferred onto the agar surface,the initially disordered movement of individual bacteria would be replaced with coordinated cell swarming after a lag phase of a few ***,we study how such cooperation is established while overcoming the disorder at the onset of the lag phase with single nanoparticle *** the spreading of the droplet,the bacteria in the solution cluster and align near the almost immobilized contact line confining the drop,forming a narrow ring of *** individual cells move in and out of the ring continuously,certain flow patterns emerge in the inter-bacterial *** reveal high-speed long-distance unidirectional flows with definite chirality along the outside of the ring,along the inside of the ring and across the *** speculate that these flows enable the fast and efficient transport,facilitating the communication and unification of the bacterial community.

关键词： Bacterial droplet Environmental stress Single particle tracking Biological edge Flow transport network

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