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A Rare Cause of Hemiparesis: Intracranial Mycotic Aneurysm—A Case Report, and Review of the Literature

Open Journal of Modern Neurosurgery 2021年第3期11卷 171-179页

作者： Yao Christian hugues Dokponou Mehdi Hakkou Olivier Ouambi Nourou Dine Adeniran Bankole Abdessamad El Ouahabi Service de Neurochirurgie de l’Hô pital Des Spécialités Rabat Morocco Faculté de Médecine et de Pharmacie Université Mohammed V Rabat Rabat Morocco

Background: The intracranial mycotic aneurysm is known to be a rare complication of infective endocarditis and it is more clinically challenging to get this diagnosis right when it happened to be in a patient without a past medical history of heart diseases. We report a documented case of mycotic aneurysm revealed by isolated left hemiparesis and our management with the collaboration of the cardiology department. Case Description: A 48-year-old male patient with a history of teeth loss, a chronic smoker presented with sudden heaviness in the left upper and lower limbs. No fever. Physical examination revealed a left hemiparesis of 3/5 on the muscle tone scale without the stiffness of the neck. The CT-Scan and the MRI conclude of subarachnoid and cerebral hemorrhage with right temporal hematoma being most probably a vascular malformation. The cerebral arteriography concluded of a right Sylvian mycotic distal aneurysm in the M4 segment. Transesophageal echocardiography was performed and concluded of infectious endocarditis with mitral and aortic valvular disease grade II. Positive blood culture for staphylococcus coagulase-negative. The patient was managed with antibiotic therapy and clinically stable after 28 days. He was then transferred to the cardiology department for follow-up. Six (6) months later a CT-angiography was done for a check-up and shows no further changes in the aneurysm. The patient underwent surgery, two (2) months later, for clipping the aneurysm because the aneurysm did not regress in size. The aneurysm was then excluded with an eventless post-operative per

关键词： Mycotic Aneurysm Endocarditis Endovascular Case Report

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New Parameters of Cardiopulmonary Exercise Testing in Patients with Chronic Heart Failure: Practical Applications

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International Journal of Clinical Medicine 2012年第6期3卷 532-537页

作者： P. Gibelin A. Aldossari D. Bertora P. Moceri T. hugues Department of Cardiology CHU Pasteur Nice France Department of Cardiology Hospital Princesse Grace Monaco City Monaco

Cardiopulmonary exercise testing (CPX) has become the cornerstone of risk stratification for heart failure patients. Peak oxygen consumption (VO2) was the first CPX variable to demonstrate prognostic value and is still the most frequently analyzed variable in clinical practice. More recently, several investigations have shown that ventilatory efficiency, typically expressed as the minute ventilation/carbon dioxide production (VE/VCO2) slope, is a strong prognostic marker in patient with HF. The majority of studies report the VE/VCO2 slope to be prognostically superior to peak VO2 which underscore the clinical importance of assessing ventilatory efficiency in HF patients. Other expressions of ventilatory inefficiency like exercise oscillatory breathing (EOB), oxygen uptake efficiency slope (OUES), end-tidal carbon dioxide pressure (PET CO2) at rest, and haemodynamic responses such as heart rate recovery (HRR) are strong predictors of outcomes in patients with heart failure (HF). So there is a need for simplified approaches that integrate the additive prognostic information from cardiopulmonary exercise testing.

关键词： New Parameters Cardiopulmonary Exercise Testing Chronic Heart Failure

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Ypel5 regulates liver development and function in zebrafish

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Journal of Molecular Cell Biology 2023年第3期15卷 44-54页

作者： Yun Deng Xiao Han Huiqiao Chen Chaoxian Zhao Yi Chen Jun Zhou hugues de The Jun Zhu Hao Yuan Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuĳin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China CNRS-LIA Hematology and Cancer Sino-French Research Center for Life Sciences and GenomicsRuĳin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Hematology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310011China Universitéde Paris 7/INSERM/CNRS UMR 944/7212 Equipe Labellisée Ligue Nationale Contre le CancerHôpital St.LouisParis 75010France

YPEL5 is a member of the Yippee-like(YPEL)gene family that is evolutionarily conserved in eukaryotic *** date,the physiological function of YPEL5 has not been assessed due to a paucity of genetic animal ***,using CRISPR/Cas9-mediated genome editing,we generated a stable ypel5^(−/−)mutant zebrafish *** of ypel5 expression leads to liver enlargement associated with hepatic cell ***,hepatic metabolism and function are dysregulated in ypel5^(−/−)mutant zebrafish,as revealed by metabolomic and transcriptomic ***,Hnf4a is identified as a crucial downstream mediator that is positively regulated by *** hnf4a overexpression could largely rescue ypel5 deficiencyinduced hepatic ***,PPARαsignaling mediates the regulation of Hnf4a by Ypel5 through directly binding to the transcriptional enhancer of the Hnf4a ***,this work demonstrates an essential role of Ypel5 in hepatocyte proliferation and function and provides the first in vivo evidence for a physiological role of the ypel5 gene in vertebrates.

关键词： YPEL5 hepatomegaly hepatic function HNF4A PPARαsignaling

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Does Haptoglobin Phenotype Impact Infection Mortality?

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Advances in Biological Chemistry 2022年第5期12卷 143-150页

作者： Akissi Joelle Koffi hugues Thierno Ahiboh Philémond By Delphine Gabillard Roseline Affi Francisk Kouakou André Inwoley Département de Biochimie et Biologie Moléculaire UFR SPB Université Félix Houphouet Boigny Ivory Coast

Introduction: The physiological status of a subject and the pathophysiology in some diseases might be under the influence of haptoglobin phenotype. The objective of this work was to determine the relationship between mortality from HIV/AIDS infection and haptoglobin phenotype in a black population in Côte d’Ivoire. Methods: The study was conducted from a retrospective panel of 933 sera/plasma from the previous workup of the ANRS 12136 TEMPRANO trial at month 0 of patients in deferred-ART arms. For each subject, we determined the serum haptoglobin concentration, haptoglobin phenotype, and other variables from patient files from the TEMPRANO trial database. Statistical tests used were Chi-2, Fischer, and Kruskal-Wallis tests for non-gaussian distribution. We used the Kaplan-Meier method for survival analysis. Results: The distributions of the haptoglobin phenotypes were 32.3% for Hp 1-1, 39.5% for Hp 2-1 and 27.2% for Hp 2-2. The blood haptoglobin concentration seemed to be associated with haptoglobin phenotypes (p-value > 5%). The survival rate at M30 and for an extended follow-up up to 6 years was independent of haptoglobin phenotype (p-value > 5%). Besides, the haptoglobin phenotypes do not appear to be associated with CD4+ T-cell count and with hemoglobin concentration. Conclusion: Haptoglobin phenotype seems to not impact the mortality of HIV/AIDS infection. However, given the antioxidant and immunomodulatory properties of some haptoglobin phenotypes, it would be relevant to seek out possible confounding factors indirectly associated with haptoglobin phenotypes and clinical or biological infection variables.

关键词： HIV/AIDS Infection Phenotype of Haptoglobin CD4+ Cell Counts Hemoglobin Mortality

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Iron Status of a People Living with HIV in Sub-Saharan Africa Using a Multi-Criteria Approach Based on the Determination of Blood Ferritin, sTfR, CRP and sTfR-F Index

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Journal of Biosciences and Medicines 2023年第5期11卷 239-246页

作者： Joelle Akissi Koffi hugues Thierno Ahiboh Philémond By Delphine Gabillard Affi Roseline Francisk Kouakou Inwoley Andre Centre de Diagnostic et de Recherche sur le SIDA et Autres Maladies Infectieuses CHU de Treichville Abidjan C&ocircte d’Ivoire Département de Biochimie et Biologie Moléculaire UFR Sciences Pharmaceutiques et Biologiques Université Félix Houphouet Boigny C&ocircte d’Ivoire Laboratoire de Biochimie Pharmacodynamie UFR Bosciences Université Félix Houphouet Boigny C&ocircte d’Ivoire Programme PAC-CI site ANRS DE Cô te d’Ivoire Abidjan C&ocircte d’Ivoire University of Bordeaux National Institute for Health and Medical Research (INSERM) UMR 1219 Research Institute for Sustainable Development (IRD) EMR 271 Bordeaux Population Health Centre Bordeaux France

Background: The assessment of iron status using a single biomarker of iron metabolism is not enough sensitive and specific to reliably diagnose iron deficiency associated with multiple comorbidities. The objective of this study was to describe the iron status of people living with HIV in sub-Saharan Africa using a multi-criteria approach based on the determination of blood ferritin, sTfR, CRP and the calculation of sTfR-F index. Methods: This study was conducted using a retrospective panel of 933 sera/plasmas. We determined serum ferritin concentration, serum sTfR concentration, and C-reactive protein (CRP) by immunoturbidimetry for each subject. The sTfR-F index was determined by calculating the sTfR/log ferritin ratio. The statistical test used was Chi2. Results: Regardless of the inflammatory syndrome, we determined 3.80%, 30.29%, and 42.70% iron deficiency based on the separate interpretation of ferritin concentration, sTfR, and sTfR-F calculation, respectively. We used those biomarkers in addition to CRP in an algorithm for the diagnosis of iron deficiency. Subjects without inflammatory syndrome, had iron deficiency of 2.89% (n = 26). Taking into account the presence of an inflammatory syndrome, the frequency obtained was n = 88 (9.78%). Overall, iron deficiency was diagnosed in 114 (12.67%) patients when we used the diagnostic algorithm. Conclusion: The use of diagnostic algorithms combining several biomarkers of iron metabolism and taking into account the presence or absence of an inflammatory syndrome is a good approach to detect a large number of iron deficiencies in a population. Therefore, an assessment of the effectiveness of different diagnostic algorithms is necessary.

关键词： Iron Deficiency Iron Metabolism Biomarkers HIV Infection CRP

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Brain Stroke as a Post-Operative Lethal Complication of a Bilateral Chronic Subdural Hematoma: A Case Report

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Open Journal of Modern Neurosurgery 2021年第2期11卷 122-127页

作者： Fernand Nathan Imoumby Franck Kouakou Yao C. hugues Dokponou Abad Cherif El Asri Miloud Gazzaz Mohammed V Military Teaching Hospital Rabat Morocco Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Chronic subdural hematoma (CSDH) is a common neurosurgical condition that is frequently encountered in neurosurgery practice. Its etiologies are dominated by traumatic head injury, and clinical presentations are various. The prognosis is generally good, but complications can be seen. Some of these complications can lead to the death of the patient. We report the rare case of a 70-year-old man admitted to the emergency room for the management of bilateral CSDH revealed by severe headache, vomiting, and loss of consciousness. He underwent a successful evacuation of both hematomas but had a stroke in both posterior cerebral artery territories, which was lethal 72 hours after surgery. We present and try to find an explanation for this exceptional post-operative complication of CSDH.

关键词： Brain Stroke Complication Subdural Hematoma Case Report

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Severe Traumatic Brain Injury with Sphenopalatine Artery Ruptured: Case Report and Review of the Literature

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Open Journal of Modern Neurosurgery 2021年第3期11卷 204-209页

作者： Adil Belhachmi Yao Christian hugues Dokponou Fernand Nathan Imoumby Napoléon Imbunhe Sofia El Akroud Miloudi Gazzaz Mohammed V University Rabat Morocco Service de Neurochirurgie Hô pital Militaire d’Instruction Mohammed V Rabat Maroc

Emergency endovascular procedure for external carotid exclusion is required to save patients with life-threatening massive epistaxis from a ruptured sphenopalatine artery secondary to severe traumatic brain injury. We report a case of a 20-year-old pedestrian admitted with a severe traumatic brain injury (TBI) secondary to an automobile (a lorry) road accident at high velocity. He presented to the emergency room in a coma with a Glasgow coma scale of 6/15 and massive epistaxis. He underwent emergency stabilization by sedation and was intubated. Body CT-Scan shows fracture of the palatine and pterygoid plate and multiple fractures of the skull with intracranial right frontal lobe hematoma. CT-Angiography was done immediately and confirmed a rupture of the sphenopalatine artery. The patient died of massive epistaxis while waiting for the endovascular procedure. This is a rare clinical case that needs unusual emergency endovascular management. Arterial embolization in emergency settings should be thought in front of any patient with persistent post-traumatic nose bleeding and be carried out as soon as possible to save the patient’s life.

关键词： Traumatic Brain Injury Sphenopalatine Artery Endovascular

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Nonsurgical Management of the Brain’s Trauma in the University Hospital of Brazzaville

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Neuroscience & Medicine 2016年第4期7卷 157-162页

作者： hugues Brieux Ekouele Mbaki Marie Elombila Olivier Brice Ngackosso Brice Sinclair Kinata Léon Boukassa Gilbert Fabrice Otiobanda Department of Surgery University Hospital of Brazzaville Brazzaville Congo Department of Intensive Care University Hospital of Brazzaville Brazzaville Congo

The aim of this study was to evaluate the medical management of traumatic brain injury. We performed a retrospective and descriptive study during the period from 1st January 2014 to 31st December 2015 (24 months), into the surgical department of the University Hospital of Brazzaville. 167 cases of non-operated traumatized brain have been identified. The average age was 29.84 years. The sex ratio was 8.82. Accidents on public roads were responsible for injury in 88.2% of the cases. 46.71% of patients had a moderate traumatic brain injury while 10.18% had a severe traumatic brain injury. Radiological evaluation was highlighted for the brain contusion in 52.09% of the cases. Tracheal intubation and ventilation were completed only in 6 out of the 17 cases of severe traumatic brain injury. Prevention of post-traumatic seizure was performed with the use of phenobarbital or sodium valproate. Mannitol was used for its osmotic properties. The outcome was favorable in 55.68% of the cases. The most common complications were pulmonary infections, persistent neurological disorders, urinary infection and hyponatremia. Mortality was recorded at 13.77%. Nonsurgical management of traumatic brain injury involves an expansion of the ventilatory assistance indication at all severe traumatic brain injuries, the fight against infectious complications and ionic monitoring.

关键词： Nonsurgical Traumatic Brain Injury Morbidity Brazzaville

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病毒:人的可怕敌手

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科学对社会的影响 1989年第2期38卷 2-9页

作者： hugues de Thé 张绍宗巴斯德研究所

病毒可以呈多种形式,可以采取不同的再生方式和‘生命样式’,它们影响人的健康、家畜和谷物,在这篇介绍性文章中。

关键词：病毒人体病毒

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Functional Constipation in the General Population in Cotonou:Prevalence and Associated Socio-Demographic Factors

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Open Journal of Gastroenterology 2018年第9期8卷 306-316页

作者： Jean Sehonou Aboudou Raimi Kpossou Comlan N’dehougbea Martin Sokpon hugues Cataria Colette Azandjeme Koffi Rodolph Vignon Department of Gastroenterology and Hepatology National University Hospital Center-Hubert Koutoukou Maga(CNHU-HKM)CotonouBenin Regional Institute of Public Health(IRSP) OuidahBenin

Background: Constipation is considered rare in sub-Saharan Africa because of the high fiber content of the local diet. However, certain factors could intervene in this pathology. The purpose of this study was to assess the prevalence of constipation in the general population in Cotonou and to determine the associated socio-demographic factors. Methods: This was a cross-sectional descriptive and analytical study conducted from July to August 2017 in 7 districts of the township of Cotonou, according to a cluster sampling. We included anyone over the age of 15 living in the city of Cotonou for at least 6 months. Constipation was either self-reported or functional (meeting the Rome IV criteria). Results: A total of 1058 participants were included: 574 men (sex ratio of 1.2), mean age of 29 years [range 15 - 92]. Self-reported constipation was noted in 512 patients (48.5%). It was functional in 256 cases (24.2%). In the latter category, there was a predominance of women (138, 53.9%), of secondary education (46.5%), of self-employed professionals (50.4%), from the Ouémé-Plateau (41.8%). Were associated with the occurrence of functional constipation (univariate analysis), age ≥ 60 years (p = 0.049), female gender (p = 0.003), and subjects living alone (166, 64.8%) vs. those living in a relationship (90, 35.2%, p = 0.001). Conclusion: Constipation was not as rare in Cotonou. It was more common in women, subjects over 60 years old or living alone.

关键词： Constipation General Population Prevalence Associated Factors Cotonou

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