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Quasi-in vivo corrosion behavior of AZ31B Mg alloy with hybrid MWCNTs-PEO/PCL based coatings

Journal of Magnesium and Alloys 2022年第11期10卷 3217-3233页

作者： Morteza Daavari Masoud Atapour Marta Mohedano hugo mora sánchez Juan Rodríguez-Hernández Endzhe Matykina Raul Arrabal Aboozar Taherizadeh Department of Materials Engineering Isfahan University of Technology84156-83111 IsfahanIran Departamento de Ingeniería Química y de Materiales Facultad de Ciencias QuímicasUniversidad Complutense28040 MadridSpain Institute of Polymer science and Technology(CsIC) Polymer Functionalization GroupMadrid 28006Spain

This study investigated the effects of multi-walled carbon nanotubes(MWCNTs) and polycaprolactone(PCL) on the quasi-in vivo corrosion behavior of AZ31B Mg alloy treated by plasma electrolytic oxidation(PEO). Thin(~2 μm, PCTPCL4) and thick(~60 μm, PCTPCL6) PCL layers were applied only onto the MWCNTs-PEO coating(PCT) as it showed better corrosion performance. Findings reveal that incorporation of MWCNTs induced several structural and functional modifications in the PEO coating, such as increased roughness, a thicker inner barrier layer, and reduced hydrophilicity.Quasi-in vivo corrosion testing was carried out under controlled temperature, p H, and fluid flow in simulated body fluid(sBF) by electrochemical impedance spectroscopy(EIs) and hydrogen evolution experiments. EIs results revealed that, after 48 h immersion, a diffusion process controlled hydration of the ceramic coatings. Comparison of the collected hydrogen after 15 days of immersion in the quasi-in vivo environment revealed that the PEO and PCT ceramic coatings decreased hydrogen generation by up to 74% and 91%, respectively, compared to non-coated alloy.PCTPCL6 coating exhibited the lowest amount of collected hydrogen(0.2 m L/cm^(2)). The thick PCL layer delayed the onset of substrate corrosion for at least 120 h, reducing the corrosion rate by 85% compared with the PCT.

关键词： AZ31B Mg alloy Plasma electrolyte oxidation(PEO) Multi-walled carbon nanotubes(MWCNTs) Quasi-in vivo condition Polycaprolactone(PCL)

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Pharmacokinetics of sildenafil in children with pulmonary arterial hypertension

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World Journal of Pediatrics 2017年第6期13卷 588-592页

作者： hugo Juárez Olguín Hector Osnaya Martínez Carmen Flores Pérez Blanca Ramírez Mendiola Liliana Rivera Espinosa Juan Luis Chávez Pacheco Janett Flores Pérez Ignacio mora Maga(n)a Laboratory of Pharmacology National Institute of PediatricsMexico CityMexico Department of Pharmacology Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico service of Cardiology National Institute of PediatricsMexico CityMexico Laboratory of Pharmacology National Institute of PediatricsMexico CityMexico subdirection of Teaching and Educational Programming National Institute of PediatricsMexico CityMexico

Background:Recently,sildenafil was introduced to treat pulmonary arterial hypertension (PAH);however,there are currently few studies on the pharmacokinetics of sildenalfil in children.Therefore,we aimed to carry out a pharmacokinetic study of sildenafil in children with PAH using a single dose.Methods:Twelve children diagnosed with PAH,consisting of with ten males and two females,were recruited for the study after obtaining written consent from their parents or guardians.Blood samples were obtained predose and at 0.25,0.5,1,2,4,8 and 12 hours after the oral administration of 1 mg/kg of sildenafil using an extemporal pediatric formulation developed in our laboratory.The samples were analyzed using a previously validated high performance liquid chromatography method.Results:A pharmacokinetic analysis using the WinNonlin 3.1 program that considered the Akaike information criterion (AIC) for sdecting a more adjustable model was performed.The following pharmacokinetic parameters were obtained:maximal concentration (Cmax):366+179 ng/mL,time to maximal concentration:0.92±0.30 hours,elimination half-life (t1/2):2.41±1.18 hours,total clearance (CLto/F):5.85±2.81 L/hour,volume of distribution (Vd/F):20.13±14.5 L,absorption rate constants (Ka):0.343 hour-1,elimination rate (Ke):0.35 hour-1,area under curve from zero to infinity:2061±618 ng/mL/hour.The data of all patients adjusted to the model of one compartment were corroborated using AIC.Conclusions:The parameters Ka,Ke and t1/2 were found to be similar to those reported in adults;however,the values of Cmax and Vd/F were significantly higher.Based on these findings,we propose that treatment regimen of sildenafil be adjusted in children with PAH.

关键词： pharmacokinetics pulmonary arterial hypertension sildenafil

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