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Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way

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Journal of Molecular Cell Biology 2022年第6期14卷 68-71页

作者： Otávio Augusto Chaves Carolina Q.Sacramento Natalia Fintelman-Rodrigues Jairo Ramos Temerozo Filipe Pereira-Dutra Daniella M.Mizurini Robson Q.Monteiro Leonardo Vazquez Patricia T.Bozza hugo caire castro-faria-neto Thiago Moreno L.Souza Laboratory of Immunopharmacology Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil National Institute for Science and Technology on Innovation on Neglected Diseases(INCT/IDN) Center for Technological Development in Health(CDTS)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil National Institute for Science and Technology on Neuroimmunomodulation(INCT/NIM) Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil Laboratory on Thymus Research Oswaldo Cruz Institute(IOC)Oswaldo Cruz Foundation(Fiocruz)Rio de JaneiroRJ21040-900Brazil Institute of Medical Biochemistry Leopoldo de Meis Federal University of Rio de Janeiro(UFRJ)Rio de JaneiroRJ21941-590Brazil

Dear Editor,The severe coronavirus disease 2019(COVID-19)is associated with ***,such as low-molecular-weight heparin,warfarin,thrombin inhibitors,and factor Xa(FXa)inhibitors,are thus recommended by the American Society of Hematology and National Institutes of Health for COVID-19 patients(Wenzler et al.,2020;Adam et al.,2021).Clinical trials with anticoagulants have shown the increased survival of critically ill COVID-19 patients under non-invasive and invasive ventilatory assistance(Wenzler et al.,2020;Adam et al.,2021),along with decreased consumption of platelets and clotting factors and a reduced risk of hemorrhage(Adam et al.,2021).Among the anti-clotting agents,early use of orally available FXa and thrombin inhibitors(Chowdhury et al.,2020;Rentsch et al.,2021)prevented high levels of D-dimer,which is the final product from the clotting/fibrinolysis cascade and is directly implicated with severe COVID-19(Rentsch et al.,2021).

关键词： al. Clinical heparin

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Comparative study measuring the dilatory effect of a mydriatic device(Mydriasert~) versus topical drops

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 801-804页

作者： Manuel Saenz-de-Viteri Patricia Fernandez-Robredo Elisa de Nova Elvira Bonet-Farriol Alfonso L.Sabater Javier Zarranz-Ventura Josemaria caire Luis M.Sadaba Angel Salinas-Alaman Alfredo Garcia-Layana Department of Ophthalmology University of Navarra

AIM:To compare the mydriatic efficacy of an ophthalmic insert(Mydriasert,MY)versus phenylephrine and tropicamide(PT)eye ***:Two controlled,prospective,randomized,single-blind studies were *** the first study,a total of 80 eyes from 40 outpatient-clinic patients were *** drops were applied to the right eye,and a MY device was inserted in the left eye for *** until maximal pupil dilation for each eye was then *** the second study,80 eyes from 80 patients undergoing cataract surgery were *** dilation was achieved using either PT drops three-times for one hour prior to surgery(40 patients),or a MY device was inserted one hour prior to surgery(40 patients).RESULTS:In the first study,MY achieved superior mydriasis compared to PT eye drops at 90min(9.04±1.33mm vs 8.78±1.37mm,P=0.012).However MY took longer than PT drops to achieve maximal dilation,and mydriasis was inferior in eyes with MY compared to PT drops at 30min(7.21±1.73mm vs 8.22±1.43mm,P<0.001),the two groups only becoming similar by 60min(8.85±1.44mm vs 8.71±1.27mm,P=0.236).In the second study,both MY and PT achieved similar levels of mydriasis at the beginning of surgery(8.75±0.76mm with MY vs 8.77±0.63mm with PT),and also at the end of surgery(7.96±1.06mm with MY vs 8.32±0.72mm with PT),with no significant difference between groups(P=0.08).MY was well tolerated and cardiovascular effects were not influenced by dilation ***:MY could be a safe and efficacious alternative for *** mydriatic effect of MY is as good as conventional PT eye drops after 60min,and is superior after *** also maintains good pupil dilation during cataract surgery.

关键词： Mydriasert~ mydriasis pupil dilation cataract surgery device

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Neutralization of Omicron BA.1,BA.5.1.6,BQ.1.3 and XBB1.1 induced by heterologous vaccination Ad5-nCoV and mRNA-1273

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2085-2087页

作者： Jesús Hernández Freddy Dehesa-Canseco Alma B.Vázquez-López Mónica Reséndiz-Sandoval Graciela caire-Juvera Mario Solís-Hernández Olivia Valenzuela Bruno Gómez-Gil Verónica Mata-Haro Centro de Investigación en Alimentación y Desarrollo A.C.HermosilloSonora83304Mexico Comisión México-Estados Unidos para la Prevención de la Fiebre Aftosa y otras Enfermedades Exóticas de los Animales(CPA) SENASICASADERCiudad de México05010Mexico Departamento de Ciencias Químico Biológicas Universidad de SonoraHermosilloSonora83000Mexico

Dear Editor,The emergence of Omicron subvariants has required additional boosters to induce a highly neutralizing antibody response.1 However,the new Omicron subvariants BQ.1 and XBB,evade the humoral response induced by multiple mRNA vaccinations and infections.2,3 CansinoBio(Ad5-nCoV)is a single-dose adenovirus vector-based vaccine with high protection against severe disease4 but lower efficacy and antibody response than mRNA ***,hybrid immunity induced by infection plus vaccine or heterologous vaccines has produced a robust neutralizing antibody response.

关键词： vaccination vaccine immunity

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Understanding and Promoting Clinical Reasoning in Chronic and Multimorbid Conditions: A Call for GPs and Healthcare Professionals

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Health 2019年第10期11卷 1338-1346页

作者： Marie-Claude Audétat Julia Sader Sarah Cairo Notari Claire Ritz Nathalie caire Fon Hubert Maisonneuve Katherine Blondon Mathieu Nendaz UDREM (Unit of Development and Research in Medical Education) Faculty of Medicine University of Geneva Geneva Switzerland UIGP (Family Medicine Unit) Faculty of Medicine University of Geneva Geneva Switzerland Family and Emergency Medicine Department Faculty of Medicine Université de Montréal Montréal Canada CIS (Center of Interprofessional Simulation) Geneva Switzerland Department of Medicine Faculty of Medicine University of Geneva Geneva Switzerland.

Multimorbidity, defined as 2 or more chronic diseases, is of increasing importance for health professionals. Many factors are at play when it comes to multimorbidity, but we still know very little about how clinicians actually weigh up the different factors—medical, social, and psychological—to reach a particular course of action. Further research is therefore required to explore the ways in which clinical reasoning processes are involved in the follow up of patients suffering from multimorbidities, to highlight their potential risks of errors. A better understanding of these clinical processes will also enrich supervision of trainees and collaboration between healthcare professionals involved in primary care.

关键词： Clinical Reasoning Primary Care Multimorbidity Supervision

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Multimorbidity and clinical reasoning through the eyes of GPs:a qualitative study

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Family Medicine and Community Health 2021年第4期9卷 78-86,I0024-I0027页

作者： Claire Ritz Julia Sader Sarah Cairo Notari Cedric Lanier Nathalie caire Fon Mathieu Nendaz Marie-Claude Audétat Faculty of Medicine(IuMFE) University of GenevaGenevaSwitzerland Faculty of Medicine (UDREM)University of GenevaGenevaSwitzerland Faculty of Medicine Universitéde MontrealMontrealQuebecCanada

Objectives Despite the high prevalence of patients suffering from multimorbidity,the clinical reasoning processes involved during the longitudinal management are still *** study aimed to investigate what are the different characteristics of the clinical reasoning process clinicians use with patients suffering from multimorbidity,and to what extent this clinical reasoning differs from diagnostic *** Given the exploratory nature of this study and the difficulty general practitioners(GPs)have in expressing their reasoning,a qualitative methodology was therefore,*** Clinical reasoning Model described by Charlin et al was used as a framework to describe the multifaceted processes of the clinical *** Semistructured interviews were conducted with nine GPs working in an ambulatory setting in June to September 2018,in Geneva,*** Participants were GPs who came from public hospital or private *** interviews were transcribed verbatim and a thematic analysis was *** The results highlighted how some cognitive processes seem to be more specific to the management ***,the main goal is not to reach a diagnosis,but rather to consider several possibilities in order to maintain a balance between the evidence-based care options,patient’s priorities and maintaining quality of *** initial representation of the current problem seems to be more related to the importance of establishing links between the different pre-existing diseases,identifying opportunities for actions and trying to integrate the new elements from the patient’s context,rather than identifying the signs and symptoms that can lead to generating new clinical *** multiplicity of options to resolve problems is often perceived as difficult by ***,longitudinal management does not allow them to achieve a final resolution of problems and that requires continuous review and an ongoing prioritisation process.C

关键词： morbidity reasoning qualitative

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胰腺癌中新的肿瘤抑制基因

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医学研究与教育 1997年第1期24卷 46-46页

作者：张梅 caire o' Brien 河北职工医学院生物教研室

多数人认为,胰腺癌比乳腺癌或前列腺癌的危险性要小,其原因是患该病的人数不多,但事实上,胰腺癌具有更大的危险性;大多数胰腺癌患者在被确诊之前癌细胞就已经转移了。因此,大约500名患者中只有一人还可选择外科手术治疗,半数患者在被确... 详细信息

多数人认为,胰腺癌比乳腺癌或前列腺癌的危险性要小,其原因是患该病的人数不多,但事实上,胰腺癌具有更大的危险性;大多数胰腺癌患者在被确诊之前癌细胞就已经转移了。因此,大约500名患者中只有一人还可选择外科手术治疗,半数患者在被确诊之后六个星期内死亡,超过5年的生存率不足1％。据报道,最近癌症专家们已了解到胰腺癌为什么具有如此强的攻击性的原因。

关键词：肿瘤抑制基因胰腺癌外科手术治疗乳腺癌危险性生存率攻击性前列腺癌生长抑制职工医学院

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Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela caire-Juvera Juan Manuel castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

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