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RULES OF THUMB : 5th ed.

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RULES OF THUMB :

A machine learning approach for regional geochemical data:Platinum-group element geochemistry vs geodynamic settings of the North Atlantic Igneous Province

2002年

作者： JAY SILVERMAN ELAINE hughes DIANA ROBERTS WIENBR

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Geoscience Frontiers 2021年第3期12卷 42-59页

作者： Jordan J.Lindsay Hannah S.R.hughes Christopher M.Yeomans Jens C.Ø.Andersen Iain McDonald Camborne School of Mines University of ExeterPenryn CampusPenrynCornwall TR109FEUnited Kingdom School of Earth and Ocean Sciences Main CollegeCardiff UniversityPark PlaceCardiff CF103ATUnited Kingdom

Whilst traditional approaches to geochemistry provide valuable insights into magmatic processes such as melting and element fractionation,by considering entire regional data sets on an objective basis using machine learning algorithms(MLAs),we can highlight new facets within the broader data structure and significantly enhance previous geochemical *** platinum-group element(PGE)budget of lavas in the North Atlantic Igneous Province(NAIP)has been shown to vary systematically according to age,geographic location and geodynamic *** the large multi-element geochemical data set available for the region,MLAs were employed to explore the magmatic controls on these shifting *** key advantage of using machine learning in analysis is its ability to cluster samples across multi-dimensional(i.e.,multi-element)*** NAIP data set is manipulated using Principal Component Analysis(PCA)and t-Distributed Stochastic Neighbour Embedding(t-SNE)techniques to increase separability in the data alongside clustering using the k-means *** new multi-element classification is compared to the original geographic classification to assess the performance of both *** workflow provides a means for creating an objective high-dimensional investigation on a geochemical data set and particularly enhances the identification of metallogenic anomalies across the *** techniques used highlight three distinct multi-element end-members which successfully capture the variability of the majority of elements included as input *** end-members are seen to fluctuate in prominence throughout the NAIP,which we propose reflects the changing geodynamic environment and melting ***,the variability of Pt and Pd are not reflected in MLA-based clustering trends,suggesting that they vary independently through controls not readily demonstrated by the NAIP major or trace element data structure(i.e.,other proxies for magmatic differe

关键词： Platinum-group elements Machine learning Plume Geochemistry Metallogenesis Mantle

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Refractory very early-onset inflammatory bowel disease associated with cytosolic isoleucyl-tRNA synthetase deficiency:A case report

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World Journal of Gastroenterology 2020年第15期26卷 1841-1846页

作者： Andrew Fagbemi William G Newman Stuart G Tangye Stephen M hughes Edmund Cheesman Peter D Arkwright Department of Paediatric Gastroenterology Royal Manchester Children’s HospitalManchester M199WLUnited Kingdom Department of Medical Genetics Manchester University NHS Foundation TrustManchester M139WLUnited Kingdom Evolution and Genomic Sciences University of ManchesterManchester M139WLUnited Kingdom Garvan Institute of Medical Research DarlinghurstNSW 2010Australia St Vincent’s Clinical School Faculty of MedicineUNSW AustraliaSydneyNSW 2010Australia Department of Paediatric Allergy and Immunology Royal Manchester Children’s HospitalManchester M139WLUnited Kingdom Department of Paediatric Histopathology St Mary’s HospitalManchester M139WLUnited Kingdom Lydia Becker Institute of Immunology and Inflammation University of ManchesterManchester M139WLUnited Kingdom

BACKGROUND Aminoacyl tRNA synthetases/ligases(ARSs)are highly conserved enzymes involved in attaching amino acids to tRNA promoting protein *** deficiencies of ARSs localized to the mitochondria classically present with neuropathology,the clinical features of cytosolic ARS deficiencies are more *** have previously been associated with neonatal hepatitis,but never with early-onset inflammatory bowel *** SUMMARY A nine-year-old Bangladeshi boy presented with neonatal liver failure and deranged clotting,transaminitis and *** parents were first *** older brothers and a sister were *** patient suffered from loose stools from early infancy which became more troublesome and persistent from five years old with ten bloody motions a *** endoscopies showed persistent pancolitis,which was refractory to mesalazine,corticosteroids,azathioprine,sirolimus and anti-TNF(adalimumab)therapy,but has improved recently with subcutaneous *** Genome Sequencing revealed a novel pathogenic missense variant(c.290A>G)in the cytosolic isoleucyl-tRNA synthetase gene,leading to an amino acid substitution(***97Gly).Pathogenic variants in other genes associated with inflammatory bowel disease(IBD)(ADAM17,EGFR,FOXP3,IL10RA,IL10RB,IL21R,NCF4,STAT3)were *** assays demonstrated markedly elevated IL-2,IL-5,IL-13,IL-9 and IL-10 by the patient’s CD4+T-cells,while IL-17A,IL-17F,IFNβwere lower,and TNFαnot significantly different when compared to healthy *** This case report provides evidence that recessive mutations in cytosolic isoleucyltRNA synthetase are a novel monogenic cause of IBD,which should be considered,particularly in infants and children with a history of neonatal hepatitis and very early-onset IBD poorly responsive to treatment.

关键词： Inflammatory bowel disease Hepatitis Gene Cytosolic isoleucine tRNA synthase

Effect of Burn Healing Liquid on keratinocyte and fibroblast proliferation and on collagen lattice contraction

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Chinese Medical Journal 1999年第8期 48-52页

作者：苏映军陈璧 PhanToanThang MargaretAhughes 徐修礼 GeorgeWCherry

Objectives To investigate the effect of Burn Healing Liquid (BHL) on the proliferation of keratinocytes and fibroblasts and to explore the potential effect of BHL on fibroblast contraction Methods Human keratinocytes and dermal fibroblasts were cultured in media containing serial dilutions of BHL followed by cell proliferation determination assessed with MTT (3 [4,5 dimehtylthiazol 2 yl] 2,5 diphenyl tetrazolium bromide) assay at different time intervals The in vitro collagen lattice contraction model was utilized for determining the contractility of fibroblasts cultured in BHL containing medium Results The 1∶10 7 dilution of BHL enhanced the growth of both keratinocytes and fibroblasts whereas the 1∶10 dilution increased the growth of keratinocytes only Collagen lattice contraction was inhibited dose dependently by BHL and such an inhibition could be reversed by switching BHL containing medium to normal medium containing 10% fetal calf serum Conclusion BHL enhances the growth of both keratinocytes and fibroblasts and reversibly inhibits the fibroblast contraction in collagen lattice

关键词： traditional Chinese medicine · wound healing · cell culture · keratinocytes · fibroblasts

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东方意大利藏在山水小城中的异域风情

度假旅游 2023年第5期 73-74页

作者：陶奕辰 Julia hughes(摄影) 不详

我不曾到过意大利,却因一座浙江山水小城,而对千里之外的文明古国魂牵梦蔡。这是位于浙江西南角的小县城一一青田,一座在瓯江碧波和群山包围中的秀丽小城,一座中意文化完美融合的缤纷都市。坊间流传着:三十万意大利华人,十万都是青田人... 详细信息

我不曾到过意大利,却因一座浙江山水小城,而对千里之外的文明古国魂牵梦蔡。这是位于浙江西南角的小县城一一青田,一座在瓯江碧波和群山包围中的秀丽小城,一座中意文化完美融合的缤纷都市。坊间流传着:三十万意大利华人,十万都是青田人。在这里,你不仅能听见带着乡音的吴侬软语,还能尚祥在嗨涩难懂的外语之中。在这里,你不仅能见到中国传统手工艺青田石雕,还能欣赏意大利原汁原味的烧制彩玻璃。在这里,你也许无法感受到大都市的车水马龙,却每走几步就闻到最地道的意式浓缩咖啡香气。在这里,你也许看不见熙熙的精致丽人,却能在菜市场和小商贩们用欧元买菜、谈论汇率。

关键词：吴侬软语异域风情青田石雕千里之外坊间流传菜市场原汁原味小城

Differential diagnosis of diarrhoea in patients with neuroendocrine tumours: A systematic review

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World Journal of Gastroenterology 2020年第30期26卷 4537-4556页

作者： Mohid S Khan Thomas Walter Amy Buchanan-hughes Emma Worthington Lucie Keeber Marion Feuilly Enrique Grande Department of Gastroenterology and Neuroendocrine Tumours University Hospital of WalesCardiff CF144XWUnited Kingdom Department d'Oncologie Médicale Hospices Civils de LyonLyon 69003France Evidence Development Costello MedicalCambridge CB12JHUnited Kingdom Medical Affairs IpsenSlough SL13XEUnited Kingdom Health Economics and Outcomes Research IpsenBoulogne-Billancourt 92100France Oncology Department MD Anderson Cancer CenterMadrid 28033Spain

BACKGROUND Approximately 20%of patients with neuroendocrine tumours(NETs)develop carcinoid syndrome(CS),characterised by flushing and *** analogues or telotristat can be used to control symptoms of CS through inhibition of serotonin *** CS is often the cause of diarrhoea among patients with gastroenteropancreatic NETs(GEP-NETs),other causes to consider include pancreatic enzyme insufficiency(PEI),bile acid malabsorption and small intestinal bacterial *** other causes of diarrhoea unrelated to serotonin secretion are mistaken for CS diarrhoea,these treatments may be ineffective against the diarrhoea,risking detrimental effects to patient quality of *** To identify and synthesise qualitative and quantitative evidence relating to the differential diagnosis of diarrhoea in patients with *** Electronic databases(MEDLINE,Embase and the Cochrane Library)were searched from inception to September 12,2018 using terms for NETs and ***,systematic literature review bibliographies and included articles were also *** study designs and publication types were eligible for inclusion if relevant data on a cause(s)of diarrhoea in patients with GEP-NETs were *** were screened by two independent reviewers at abstract and full-text *** synthesis was adapted to synthesise quantitative and qualitative *** definition of qualitative data was expanded to include all textual data in any section of relevant *** Forty-seven publications(44 studies)were included,comprising a variety of publication types,including observational studies,reviews,guidelines,case reports,interventional studies,and opinion *** reported on PEI on/after treatment with somatostatin analogs;9.5%-84%of patients with GEP-NETs had experienced steatorrhoea or confirmed *** reported,14.3%–50.7%of patients received pancreatic enzyme replacement *** causes of diarrhoea

关键词： Carcinoid syndrome Diarrhea Differential diagnosis Neuroendocrine tumours Serotonin Systematic review

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My Own True Family

英语角 2016年第6期 22-23页

作者： Ted hughes

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Homeless Gypsies

英语学习 1998年第4期 7-8页

作者： Jonas hughes

Thousands of gypsies have beentrying to emigrate to Canada *** say they are flee-ing persecution, but most havefound they are not welcome in these coun-tries *** have never had a

关键词： Homeless Gypsies

Thomas Edison Father of the Future

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英语学习 1997年第11期 11-14页

作者： Jonas hughes

Thomas Edison was the greatest inventor who ever *** gave the world the electric light,the motion picturecamera,and he made the first sound *** oneperson can be said to have led the world into the age of technologyit ... 详细信息

关键词： Thomas Edison Father of the Future 定语从句