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A pilot study for distinguishing basal cell carcinoma from normal human skin tissues using visible resonance Raman spectroscopy

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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 41-54页

作者： Cheng-hui Liu Binlin Wu Laura ASordillo Susie Boydston-White Vidyasagar Sriramoju ChunyuanZhang hugh beckman Lin Zhang Zhe Pei Lingyan Shi Robert RAlfano Institute for Ultrafast Spectroscopy and Lasers The City College of the City University of New YorkNew YorkNY 10031USA Physics Department and CSCU Center for Nanotechnology Southern Connecticut State UniversityNew HavenCT 06515USA Department of Electrical Engineering The Grove School of EngineeringThe City College of the City University of New YorkNew YorkNY 10031USA Science Department City University of New YorkBorough of Manhattan Community CollegeNew YorkNY 10007-1097USA Bermuda Village Dr. Boca RatonFlorida 33487-1041USA517150 Department of Chemistry Columbia UniversityNew YorkNY 10027USA

Aim: The aim of the study is to test visible resonance Raman (VRR) spectroscopy for rapid skin cancer diagnosis,and evaluate its effectiveness as a new optical biopsy method to distinguish basal cell carcinoma (BCC) from normal skin ***: The VRR spectroscopic technique was undertaken using 532 nm excitation. Normal and BCC human skin tissue samples were measured in seconds. The molecular fingerprints of various native biomolecules as biomarkers were analyzed. A principal component analysis - support vector machine (PCA-SVM) statistical analysis method based on the molecular fingerprints was developed for differentiating BCC from normal skin ***: VRR provides a rapid method and enhanced Raman signals from biomolecules with resonant and nearresonant absorption bands as compared with using a near-infrared excitation light source. The VRR technique revealed chemical composition changes of native biomarkers such as tryptophan, carotenoids, lipids and *** VRR spectra from BCC samples showed a strong enhancement in proteins including collagen type I combined with amide I and amino acids, and a decrease in carotenoids and lipids. The PCA-SVM statistical analysis based on the molecular fingerprints of the biomarkers yielded a 93.0% diagnostic sensitivity, 100% specificity, and 94.5%accuracy compared with histopathology ***: VRR can enhance molecular vibrational modes of various native biomarkers to allow for very fast display of Raman modes in seconds. It may be used as a label-free molecular pathology method for diagnosis of skin cancer and other diseases and be used for combined treatment with Mohs surgery for BCC.

关键词： Visible resonance Raman spectroscopy human skin basal cell carcinoma principal componentanalysis supports vector machine molecular fingerprints tryptophan carotenoids

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Ocular syphilis:a case series of four patients and a review of the literature

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Annals of Eye Science 2024年第2期9卷 62-70页

作者： Madeline beckman Lana M.Rifkin Department of Ophthalmology and Visual Sciences The Ohio State UniversityColumbusOHUSA Ophthalmic Consultants of Boston Uveitis ServiceBostonMAUSA

Background:The incidence of syphilis has been increasing in the United States over the last two decades,with a more recent increase among *** syphilis is an uncommon but important complication of syphilis,most often presenting as posterior or panuveitis in late or latent syphilis of unknown *** ocular syphilis may lead to permanent vision loss,underscoring the importance of appropriate evaluation and treatment of ocular *** Description:In a retrospective,non-contiguous case series,we highlight four patients diagnosed and treated with ocular syphilis at a single *** presentations of ocular syphilis are illustrated:anterior and intermediate uveitis,optic neuritis,posterior uveitis,and *** patients initially presented with a decreased visual acuity(VA).One patient had a previous diagnosis of human immunodeficiency virus(HIV).Three patients were treated with intravenous(IV)penicillin and one patient with IV *** had a return to their baseline VA after their course of ***:Syphilis may go undetected without a high index of clinical suspicion due to its nonspecific *** patients with ocular inflammation should have syphilis testing as a part of their infectious workup with both treponemal and non-treponemal *** diagnosed with syphilis and are not known to be HIV-negative should undergo testing for HIV due to the high rate of *** diagnosis and prompt treatment after onset of symptoms may contribute to a more favorable prognosis for ocular syphilis.

关键词： Ocular syphilis uveitis choroiditis intermediate uveitis case series

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New evidence-based adaptive clinical trial methods for optimally integrating predictive biomarkers into oncology clinical development programs

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Chinese Journal of Cancer 2013年第5期32卷 233-241页

作者： Robert A. beckman Cong Chen Oncology Clinical Research Daiichi Sankyo Pharmaceutical Development Center for Evolution and Cancer Helen Diller Family Cancer Center University of California at San Francisco Biostatistics and Research Decision Sciences Merck & Co.

Predictive biomarkers are important to the future of oncology; they can be used to identify patient populations who will benefit from therapy, increase the value of cancer medicines, and decrease the size and cost of clinical trials while increasing their chance of success. But predictive biomarkers do not always work. When unsuccessful, they add cost, complexity, and time to drug development. This perspective describes phases 2 and 3 development methods that efficiently and adaptively check the ability of a biomarker to predict clinical outcomes. In the end, the biomarker is emphasized to the extent that it can actually predict.

关键词：生物标志物临床试验药物开发预测试验方法肿瘤自适应基础

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Tolerance of disturbance by humans in long-time resident and recent colonist urban doves

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Chinese Birds 2015年第2期6卷 113-120页

作者： Jemma Gendall Alan Lill Juliey beckman Wildlife Ecology and Conservation Physiology School of Biological SciencesMonash University Clayton Campus School of Life Sciences La Trobe University College of Medicine Biology and Environment Australian National University

Background: A critical trait for successful urban dwelling by birds is the ability to tolerate high levels of disturbing stimulation by humans. If such tolerance is partly acquired gradually after colonization, species with a long history of residence in cities are likely to be more tolerant of such stimulation than recent urban colonists, but this has not often been ***: We tested whether introduced Rock(Columba livia) and Spotted(Streptopelis chinensis) Doves, historically long-term residents of Melbourne, Australia, were more tolerant of disturbance by humans than the very recent colonist, the native Crested Pigeon(Ochyphaps lophotes) by comparing the Flight Initiation Distances(FID) and time allocations to vigilance during foraging of all three species in urban Melbourne. That all three species are members of the Columbiformes reduces the possibility that any species differences in tolerance are simply phylogenetic in ***: Flight initiation distance was shorter in Rock Doves than in the other two species, which did not differ in approachability by a human. Rock Doves retreated from an approaching human mainly by walking a relatively short distance, Crested Pigeons mainly by running a relatively short distance and Spotted Doves primarily by flying a comparatively long distance. The time allocation to anti-predator vigilance of Rock Doves was smaller than that of the other two species, whose allocations were ***: The very recent colonist of eastern Melbourne, the Crested Pigeon, was not the least tolerant of disturbance by humans of the three related species. Natural selection for tolerance therefore probably cannot entirely explain the pattern of tolerance evident among these urban dove species and behavioural flexibility is probably involved. Length of residency in a city is not an infallible guide to a species' level of tolerance of disturbance by humans.

关键词： Doves Urban environment Flight initiation distance Vigilance Behavioural flexibility

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An Improved Deep Fusion CNN for Image Recognition

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Computers, Materials & Continua 2020年第11期65卷 1691-1706页

作者： Rongyu Chen Lili Pan Cong Li Yan Zhou Aibin Chen Eric beckman College of Computer Science and Information Technology Central South University of Forestry&TechnologyChangsha410114China China Chaplin School of Hospitality of Hospitality and Tourism Management Florida International UniversityNorth Miami33181USA

With the development of Deep Convolutional Neural Networks(DCNNs),the extracted features for image recognition tasks have shifted from low-level features to the high-level semantic features of *** studies have shown that the deeper the network is,the more abstract the features ***,the recognition ability of deep features would be limited by insufficient training *** address this problem,this paper derives an improved Deep Fusion Convolutional Neural Network(DF-Net)which can make full use of the differences and complementarities during network learning and enhance feature expression under the condition of limited ***,DF-Net organizes two identical subnets to extract features from the input image in parallel,and then a well-designed fusion module is introduced to the deep layer of DF-Net to fuse the subnet’s features in ***,the more complex mappings are created and the more abundant and accurate fusion features can be extracted to improve recognition ***,a corresponding training strategy is also proposed to speed up the convergence and reduce the computation overhead of network ***,DF-Nets based on the well-known ResNet,DenseNet and MobileNetV2 are evaluated on CIFAR100,Stanford Dogs,and *** analysis and experimental results strongly demonstrate that DF-Net enhances the performance of DCNNs and increases the accuracy of image recognition.

关键词： Deep convolutional neural networks deep features image recognition deep fusion feature fusion.

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The Current Acceptance,Accessibility and Recognition of Chinese and Ayurvedic Medicine in the United States in the Public,Governmental,and Industrial Sectors

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Chinese Journal of Integrative Medicine 2012年第6期18卷 405-408页

作者： Jongbae J.PARK Selena beckman-Harned Gayoung Cho Duckhee Kim Hangon Kim Asian Medicine and Acupuncture Research Department of Physical Medicine and RehabilitationUniversity of North Carolina at Chapel HillChapel HillNCUSA Institute AMOREPACIFIC CorporationYongin-siGyeonggi-doKorea446-729

To assess the current level of acceptance in the United States of complementary and alternative medicine, recent research into the prevalence, acceptance, accessibility, and recognition of complementary and alternative therapies were reviewed. Several signs point to an increasing acceptance of complementary and alternative medicine in the United States; the use of complementary and alternative medicine is significantly increasing, many aspects of Chinese medicine and Ayurveda are becoming mainstream, practitioners in the United States are beginning to be licensed, and insurance companies are beginning to cover some complementary and alternative therapies. Remaining challenges to true acceptance include the restrictive Western mindset, the absence of published studies, a lack of consistent manufacturing processes and quality standards, and a fear of adulteration. Although the field still faces many challenges, alternative and complementarymedicine, including Chinese medicine and Ayurvedic medicine, is becoming more accepted and accessible in the United States.

关键词： complementary therapies alternative medicine Chinese medicine Ayurvedic medicine United States

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Measuring Cities with Software-Defined Sensors

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Journal of Social Computing 2020年第1期1卷 14-27页

作者： Charlie Catlett Pete beckman Nicola Ferrier Howard Nusbaum Michael E.Papka Marc G.Berman Rajesh Sankaran University of Illinois Discovery Partners Institute ChicagoIL 60606USA Northwestern University EvanstonIL 60208USA University of Chicago ChicagoIL 60637USA Northern Illinois University DeKalbIL 60115USA Argonne National Laboratory

The Chicago Array of Things(AoT)project,funded by the US National Science Foundation,created an experimental,urban-scale measurement capability to support diverse scientific *** conceived as a traditional sensor network,collaborations with many science communities guided the project to design a system that is remotely programmable to implement Artificial Intelligence(AI)within the devices—at the“edge”of the network—as a means for measuring urban factors that heretofore had only been possible with human observers,such as human behavior including social *** concept of“software-defined sensors”emerged from these design discussions,opening new possibilities,such as stronger privacy protections and autonomous,adaptive measurements triggered by events or *** provide examples of current and planned social and behavioral science investigations uniquely enabled by software-defined sensors as part of the SAGE project,an expanded follow-on effort that includes AoT.

关键词： sensors edge computing computer vision urban science

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Living off the Fat of the Cell

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当代外语研究 2006年第2期 4-,10页

作者： Mary beckman 李春雷

沙眼衣原体会危害人体健康,但是人们对于它如何在人体细胞中繁殖却知之甚少。一项新研究发现,沙眼衣原体的繁殖方式如同性行为传播的病菌一样,它能够在一种名为液泡的细胞囊中繁殖,并且在这一繁殖过程中窃取脂质体中的脂肪并供其使用。... 详细信息

沙眼衣原体会危害人体健康,但是人们对于它如何在人体细胞中繁殖却知之甚少。一项新研究发现,沙眼衣原体的繁殖方式如同性行为传播的病菌一样,它能够在一种名为液泡的细胞囊中繁殖,并且在这一繁殖过程中窃取脂质体中的脂肪并供其使用。据此推测,衣原体的这种刺激脂肪分泌的特性或许能够解释,为什么慢性衣原体传染似乎与动脉堵塞和心脏病有关。

关键词：沙眼衣原体脂质体液泡人体健康繁殖方式动脉脂肪堵塞性行为体细胞

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Emergent reintubation following elective cervical surgery:A case series

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World Journal of Orthopedics 2017年第6期8卷 465-470页

作者： Joshua Schroeder Stephan N Salzmann Alexander P hughes James D beckman Jennifer Shue Federico P Girardi Spine Service Hospital for Special Surgery

AIM To review cases of emergent reintubation after cervical *** Patients who were emergently intubated in the postoperative period following cervical surgery were identified. The patients' prospectively documented demographic parameters, medical history and clinical symptoms were ascertained. Pre-operative radiographs were examined for the extent of their pathology. The details of the operative procedure were *** Eight hundred and eighty patients received anterioror combined anterior-posterior cervical surgery from 2008-2013. Nine patients(1.02%) required emergent reintubation. The interval between extubation to reintubation was 6.2 h [1-12]. Patients were kept intubated after reintubation for 2.3 d [2-3]. Seven patients displayed moderate postoperative edema. One patient was diagnosed with a compressive hematoma whichwas subsequently evacuated in the OR. Another patient was diagnosed with a pulmonary effusion and treated with diuretics. One patient received a late debridement for an infected hematoma. Six patients reported residual symptoms and three patients made a complete recovery. CONCLUSION Respiratory compromise is a rare but potentially life threatening complication following cervical surgery. Patients at increased risk should be monitored closely for extended periods of time post-operatively. If the airway is restored adequately in a timely manner through emergent re-intubation, the outcome of the patients is generally favorable.

关键词： Cervical surgery Complication Airway compromise Reintubation Hematoma

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The Birds,the Bees,and the Mites

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当代外语研究 2006年第11期 12-14页

作者： Mary beckman 李本强

众所周知,蜜蜂和一些鸟类可以通过授粉帮助植物繁殖。不过,根据《科学》杂志最新发表的一项研究,蜘蛛纲动物和跳虫等节肢动物可以帮助苔藓类植物繁殖。这一发现为苔藓类植物在于燥的环境下进行繁殖提供了一条新的途径,因为苔藓一般是通... 详细信息

众所周知,蜜蜂和一些鸟类可以通过授粉帮助植物繁殖。不过,根据《科学》杂志最新发表的一项研究,蜘蛛纲动物和跳虫等节肢动物可以帮助苔藓类植物繁殖。这一发现为苔藓类植物在于燥的环境下进行繁殖提供了一条新的途径,因为苔藓一般是通过游动的精子经过配于体表面的水层游进颈卵器内繁殖的,离不开有水的环境。这一发现的重大意义还在于证实了动植物在陆地上开始产生相互作用的时间可以追溯到更久远的年代。

关键词：节肢动物繁殖苔鲜植物苔藓类跳虫重大意义环境陆地帮助蜘蛛纲

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